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Shibata Tomonori  柴田 知範

ORCIDConnect your ORCID iD *help
Researcher Number 80711960
Other IDs
Affiliation (Current) 2025: 大阪大学, 産業科学研究所, 招へい教員
Affiliation (based on the past Project Information) *help 2022 – 2023: 大阪大学, 産業科学研究所, 招へい教員
2017 – 2023: 大阪大学, 産業科学研究所, 助教
2016: 大阪大学, 産業科学研究所, 特任助教(常勤)
2015: 大阪大学, 産業科学研究所, 特任助教
2014: 京都大学, iPS細胞研究所, 研究員
Review Section/Research Field
Principal Investigator
Medium-sized Section 37:Biomolecular chemistry and related fields / Basic Section 37030:Chemical biology-related / Chemical biology / Bio-related chemistry
Except Principal Investigator
Medium-sized Section 37:Biomolecular chemistry and related fields
Keywords
Principal Investigator
リピートRNA / 脊髄小脳変性症 / RNA結合性低分子 / UGGAAリピート / 脊髄小脳変性症31型 / RNA / 組織透明化 / CAGリピート結合分子 / 全脳イメージング / ハンチントン病 … More / CAGリピート / 経鼻投与 / RNA標的低分子 / 核酸結合性分子 / ケミカルバイオロジー / マイクロサテライトリピート病 / RNA結合性分子 / ペンタヌクレオチドリピート / RNA結合タンパク質 / 脊髄小脳失調症31型 / リピート病 / ナノマシン / 分子ロボット / RNAナノ構造 / 核酸ナノ構造 / RNA-タンパク質複合体 / RNAナノテクノロジー / 核酸ナノテクノロジー / タンパク質 … More
Except Principal Investigator
化学修飾 / シトシン / 異常伸長 / DNA / 短縮機構解明 / 経路探索 / 結合分子 / ミスマッチ / スリップアウト構造 / 低分子 / 修復酵素 / リピート Less
  • Research Projects

    (5 results)
  • Research Products

    (29 results)
  • Co-Researchers

    (4 People)
  •  Elucidation of the binding pathway of mismatch-binding molecules to abnormally elongated repeat sequences and their shortening-inducing effects

    • Principal Investigator
      中谷 和彦
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 37:Biomolecular chemistry and related fields
    • Research Institution
      Osaka University
  •  Elucidation of intracerebral distribution of CAG repeat binding molecules after intranasal administration and verification of effect on repeat contraction.Principal Investigator

    • Principal Investigator
      Shibata Tomonori
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 37:Biomolecular chemistry and related fields
    • Research Institution
      Osaka University
  •  脊髄小脳変性症31型を標的とする低分子の作用機序解明と毒性リピートRNA機能抑制Principal Investigator

    • Principal Investigator
      柴田 知範
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 37030:Chemical biology-related
    • Research Institution
      Osaka University
  •  Elucidation of action mechanism of repeat RNA-binding small molecules that improve disease phenotype in spinocerebellar ataxia type 31Principal Investigator

    • Principal Investigator
      Shibata Tomonori
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Chemical biology
    • Research Institution
      Osaka University
  •  Functional molecular robot using RNA/RNP nanostructuresPrincipal Investigator

    • Principal Investigator
      Shibata Tomonori
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Bio-related chemistry
    • Research Institution
      Osaka University
      Kyoto University

All 2023 2022 2021 2019 2018 2015 Other

All Journal Article Presentation Book Patent

  • [Book] Methods in Molecular Biology 1316 (Chapter 14)2015

    • Author(s)
      Tomonori Shibata, Yuki Suzuki, Hiroshi Sugiyama, Masayuki Endo, and Hirohide Saito
    • Publisher
      Human press
    • Data Source
      KAKENHI-PROJECT-26810089
  • [Book] Methods Mol Biol.2015

    • Author(s)
      Shibata T, Suzuki Y, Sugiyama H, Endo M, Saito H
    • Publisher
      Humana Press
    • Data Source
      KAKENHI-PROJECT-26810089
  • [Journal Article] A small molecule binding to TGGAA pentanucleotide repeats that cause spinocerebellar ataxia type 312023

    • Author(s)
      Shibata Tomonori、Nakatani Kazuhiko
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 79 Pages: 129082-129082

    • DOI

      10.1016/j.bmcl.2022.129082

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K19049, KAKENHI-PROJECT-19H00924, KAKENHI-PROJECT-20H02880, KAKENHI-PROJECT-22H00351
  • [Journal Article] Fluorescent indicator displacement assay for the discovery of UGGAA repeat-targeted small molecules2023

    • Author(s)
      Shibata Tomonori、Matsumoto Yasumasa、Iihara Akiko、Yamada Kazunori、Ochiai Hiroshi、Saito Ryo、Kusaka Shinichi、Kume Toshiyuki
    • Journal Title

      Chemical Communications

      Volume: 59 Issue: 34 Pages: 5071-5074

    • DOI

      10.1039/d3cc00837a

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H02880
  • [Journal Article] Intracerebral Distribution of CAG Repeat-Binding Small Molecule Visualized by Whole-Brain Imaging2023

    • Author(s)
      Murakami Eitaro、Nakamori Masayuki、Nakatani Kazuhiko、Shibata Tomonori、Tainaka Kazuki
    • Journal Title

      Bioconjugate Chemistry

      Volume: 34 Issue: 12 Pages: 2187-2193

    • DOI

      10.1021/acs.bioconjchem.3c00470

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K22597, KAKENHI-PROJECT-21K19049, KAKENHI-PROJECT-22H00351, KAKENHI-PROJECT-23K24198
  • [Journal Article] Small molecule targeting r(UGGAA)n disrupts RNA foci and alleviates disease phenotype in Drosophila model2021

    • Author(s)
      Shibata Tomonori、Nagano Konami、Ueyama Morio、Ninomiya Kensuke、Hirose Tetsuro、Nagai Yoshitaka、Ishikawa Kinya、Kawai Gota、Nakatani Kazuhiko
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 1-13

    • DOI

      10.1038/s41467-020-20487-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K06478, KAKENHI-PROJECT-19K22254, KAKENHI-PROJECT-19H00924, KAKENHI-PROJECT-17K01962, KAKENHI-PLANNED-20H05927, KAKENHI-PROJECT-20H00448, KAKENHI-PROJECT-20H02880
  • [Journal Article] Short Tandem Repeat Contractions during In Vitro DNA Synthesis by Repeat-binding Molecules2021

    • Author(s)
      Hagihara Masaki、Dohno Chikara、Saito Kaoru、Sugimoto Kazuhiro、Hishinuma Yuta、Sohma Yuri、Shibata Tomonori、Nakatani Kazuhiko
    • Journal Title

      Chemistry Letters

      Volume: 50 Issue: 11 Pages: 1848-1851

    • DOI

      10.1246/cl.210415

    • NAID

      130008113718

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H00924, KAKENHI-PROJECT-18H02107, KAKENHI-PROJECT-20H02880
  • [Patent] 脊髄小脳変性症31型抑制剤2018

    • Inventor(s)
      中谷和彦、柴田知範、永井義隆、上山盛夫
    • Industrial Property Rights Holder
      中谷和彦、柴田知範、永井義隆、上山盛夫
    • Industrial Property Rights Type
      実用新案
    • Filing Date
      2018
    • Acquisition Date
      2018
    • Data Source
      KAKENHI-PROJECT-17K01962
  • [Presentation] RNA反復配列を標的とした光応答性リガンドによる細胞内RNA fociの形成制御2023

    • Author(s)
      藤原 侑亮、柴田 知範、堂野 主税、中谷 和彦
    • Organizer
      日本化学会第103春季年会
    • Data Source
      KAKENHI-PROJECT-21K19049
  • [Presentation] RNA反復配列を標的とした光応答性リガンドによる細胞内RNA fociの形成制御2023

    • Author(s)
      藤原 侑亮、柴田 知範、堂野 主税、中谷 和彦
    • Organizer
      日本化学会第103春季年会
    • Data Source
      KAKENHI-PROJECT-20H02880
  • [Presentation] Evaluation of APOBEC-catalyzed cytosine deamination for the repeat DNAs2022

    • Author(s)
      Luyan Zhang, Tomonori Shibata, Asako Murata, Kazuhiko Nakatani
    • Organizer
      The 49th International Symposium on Nucleic Acids Chemistry
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K19049
  • [Presentation] Control of RNA Foci Formation by Photo-Switchable Ligands2022

    • Author(s)
      Yusuke Fujiwara, Tomonori Shibata, Chikara Dohno, Kazuhiko Nakatani
    • Organizer
      The 49th International Symposium on Nucleic Acids Chemistry(国際学会)
    • Data Source
      KAKENHI-PROJECT-20H02880
  • [Presentation] 全脳イメージングを用いたCAGリピート結合分子の脳内分布解析2022

    • Author(s)
      村上英太郎、柴田知範、中森雅之、田井中一貴、中谷和彦
    • Organizer
      RNAフロンティアミーティング
    • Data Source
      KAKENHI-PROJECT-20H02880
  • [Presentation] Control of RNA Foci Formation by Photo-Switchable Ligands2022

    • Author(s)
      Yusuke Fujiwara, Tomonori Shibata, Chikara Dohno, Kazuhiko Nakatani
    • Organizer
      The 49th International Symposium on Nucleic Acids Chemistry
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K19049
  • [Presentation] Alleviation of RNA toxicity by a small molecule targeting UGGAA repeat in spinocerebellar ataxia type 312022

    • Author(s)
      Tomonori Shibata, Konami Nagano, Morio Ueyama, Kensuke Ninomiya, Tetsuro Hirose, Yoshitaka Nagai, Kinya Ishikawa, Gota Kawai, Kazuhiko Nakatani
    • Organizer
      NEURO2022
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K19049
  • [Presentation] Alleviation of RNA toxicity by a small molecule targeting UGGAA repeat in spinocerebellar ataxia type 312022

    • Author(s)
      Tomonori Shibata, Konami Nagano, Morio Ueyama, Kensuke Ninomiya, Tetsuro Hirose, Yoshitaka Nagai, Kinya Ishikawa, Gota Kawai, Kazuhiko Nakatani
    • Organizer
      NEURO2022
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H02880
  • [Presentation] 全脳イメージングを用いたCAGリピート結合分子の脳内分布解析2022

    • Author(s)
      村上英太郎、柴田知範、中森雅之、田井中一貴、中谷和彦
    • Organizer
      RNAフロンティアミーティング
    • Data Source
      KAKENHI-PROJECT-21K19049
  • [Presentation] Evaluation of APOBEC-catalyzed cytosine deamination for the repeat DNAs2022

    • Author(s)
      Luyan Zhang, Tomonori Shibata, Asako Murata, Kazuhiko Nakatani
    • Organizer
      The 49th International Symposium on Nucleic Acids Chemistry(国際学会)
    • Data Source
      KAKENHI-PROJECT-20H02880
  • [Presentation] Small molecule targeting r(UGGAA)n in spinocerebellar ataxia type 312021

    • Author(s)
      ○Tomonori Shibata, Konami Nagano, Morio Ueyama, Kensuke Ninomiya, Tetsuro Hirose, Yoshitaka Nagai, Kinya Ishikawa, Gota Kawai, Kazuhiko Nakatani
    • Organizer
      Pacifichem 2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H02880
  • [Presentation] 全脳イメージングを用いたCAGリピート結合分子の薬物動態解析2021

    • Author(s)
      ○村上英太郎、柴田知範、中森雅之、田井中一貴、中谷和彦
    • Organizer
      日本ケミカルバイオロジー学会 第15回年会
    • Data Source
      KAKENHI-PROJECT-21K19049
  • [Presentation] Small molecule targeting UGGAA pentanucleotide repeat alleviates disease phenotype in spinocerebellar ataxia type 312021

    • Author(s)
      ○Tomonori Shibata, Konami Nagano, Morio Ueyama, Kensuke Ninomiya, Tetsuro Hirose, Yoshitaka Nagai, Kinya Ishikawa, Gota Kawai, Kazuhiko Nakatani
    • Organizer
      ISNAC2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H02880
  • [Presentation] A small molecule targeting UGGAA pentanucleotide repeats that cause spinocerebellar ataxia type 312021

    • Author(s)
      ○Tomonori Shibata, Konami Nagano, Morio Ueyama, Kensuke Ninomiya, Tetsuro Hirose, Yoshitaka Nagai, Kinya Ishikawa, Gota Kawai, Kazuhiko Nakatani
    • Organizer
      The 44th Annual Meeting of the Molecular Biology Society of Japan (MBSJ2021)
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H02880
  • [Presentation] RNA binding small molecule that mitigates disease phenotype in spinocerebellar ataxia type 312019

    • Author(s)
      Tomonori Shibata, Konami Nagano, Morio Ueyama, Yoshitaka Nagai, Kinya Ishikawa, Gota Kawai, Kazuhiko Nakatani
    • Organizer
      The Commemorative International Symposium of the Japan Society of Nucleic Acids Chemistry (CISNAC 2019)
    • Data Source
      KAKENHI-PROJECT-17K01962
  • [Presentation] 脊髄小脳変性症 31 型を標的とする RNA 結合性低分子2019

    • Author(s)
      柴田知範、長野来南、上山盛夫、永井義隆、石川欽也、河合剛太、中谷和彦
    • Organizer
      日本ケミカルバイオロジー学会 第14回年会
    • Data Source
      KAKENHI-PROJECT-17K01962
  • [Presentation] A small molecule that alleviates RNA-mediated neurodegeneration in spinocerebellar ataxia type 312018

    • Author(s)
      Tomonori Shibata
    • Organizer
      Aptamer in Boulder
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K01962
  • [Presentation] Synthetic RNA-protein nano machines that function in vitro and in live cell2015

    • Author(s)
      ○Shibata T, Suzuki Y, Sugiyama H, Endo M, Saito H
    • Organizer
      ISNAC20
    • Place of Presentation
      イーグレ姫路 (兵庫県 姫路市)
    • Year and Date
      2015-09-23
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26810089
  • [Presentation] タンパク質応答性RNAナノマシン2015

    • Author(s)
      ○柴田知範、鈴木勇輝、杉山弘、遠藤政幸、齊藤博英
    • Organizer
      日本RNA学会年会
    • Place of Presentation
      ホテルライフォート札幌 (北海道 札幌市)
    • Year and Date
      2015-07-15
    • Data Source
      KAKENHI-PROJECT-26810089
  • [Presentation] A RNA-protein-based nanomachine for controlling functional RNAs

    • Author(s)
      Tomonori Shibata, Yuki Suzuki, Hiroshi Sugiyama, Masayuki Endo, Hirohide Saito
    • Organizer
      The 41st International Symposium on Nucleic Acids Chemistry 2014
    • Place of Presentation
      北九州
    • Year and Date
      2014-11-05 – 2014-11-07
    • Data Source
      KAKENHI-PROJECT-26810089
  • [Presentation] Photo-regulation of RNA-protein-based nanostructures

    • Author(s)
      Tomonori Shibata, Kenzo Fujimoto, Yuki Suzuki, Hiroshi Sugiyama, Masayuki Endo, Masahiro Takinoue, Hirohide Saito
    • Organizer
      20th International Conference on DNA computing and Molecular Programming
    • Place of Presentation
      京都
    • Year and Date
      2014-09-22 – 2014-09-26
    • Data Source
      KAKENHI-PROJECT-26810089
  • 1.  中谷 和彦 (70237303)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 2.  山田 剛史 (80633263)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  二宮 賢介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  中森 雅之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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