Sakata Hiroyuki 坂田洋之

Researcher Number	80722305
Other IDs
Affiliation (Current)	2020: 東北大学, 医学系研究科, 非常勤講師
Affiliation (based on the past Project Information) *help	2017 – 2020: 東北大学, 医学系研究科, 非常勤講師 2016: 東北大学, 医工学研究科, 助教 2014 – 2015: 東北大学, 医学(系)研究科(研究院), 非常勤講師
Review Section/Research Field	Principal Investigator Neurosurgery / Basic Section 56010:Neurosurgery-related Except Principal Investigator Neurosurgery / Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 56010:Neurosurgery-related
Keywords	Principal Investigator 脳梗塞 / 神経再生 / Muse細胞 / 白質再建 / 移植・再生医療 / 脳血管障害学 / 神経科学 / 脳神経疾患 / 再生医学 / Efferocytosis / 頚動脈狭窄症 / 分子標的治療 / バイオマーカー … More Except Principal Investigator … More

Development of Muse cell therapy for dementiaOngoing
- Principal Investigator
  
  新妻邦泰
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Tohoku University
シロスタゾールを用いたもやもや病における内因性幹細胞賦活と血管新生促進療法の開発Ongoing
- Principal Investigator
  
  藤村幹
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Tohoku University
Efferocytosisを利用した頚動脈狭窄症の脳梗塞リスク診断と分子標的治療Principal InvestigatorOngoing
- Principal Investigator
  
  坂田洋之
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Tohoku University
重症型もやもや病に対する多能性幹細胞Museを用いた血管新生療法の開発Ongoing
- Principal Investigator
  
  藤村幹
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Tohoku University
Platform for regenerative therapy of central nervous system using Muse cellsOngoing
- Principal Investigator
  
  冨永悌二
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurosurgery
- Research Institution
  Tohoku University
New concept of local chemo- and cell-therapy for spinal cord injury using convection-enhanced drug delivery
- Principal Investigator
  
  Sugiyama Shinichiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Tohoku University
Reconstruction of Neuronal Circuitry by Muse cell transplantation in lacunar strokePrincipal Investigator
- Principal Investigator
  
  Sakata Hiroyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Neurosurgery
- Research Institution
  Tohoku University
Establishment of the stem cell transplantation therapy by MUSE for moyamoya disease
- Principal Investigator
  
  Miki Fujimura
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Tohoku University

All 2017 2016 2015 2014

All Journal Article Presentation

[Journal Article] Transient global cerebral ischemia induces RNF213, a moyamoya disease susceptibility gene, in vulnerable neurons of the rat hippocampus CA1 sub-region and ischemic cortex2017
- Author(s)
  Sato-Maeda M, Fujimura M, Rashad S, Morita-Fujimura Y, Niizuma K, Sakata H, Ikawa S, Tominaga T.
- Journal Title
  
  J Stroke Cerebrovasc Dis
  
  Volume: 26 Pages: 1904-1911
- DOI
  10.1016/j.jstrokecerebrovasdis.2017.06.032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07152, KAKENHI-PROJECT-17K10815
[Journal Article] De novo development of moyamoya disease in an adult female with a genetic variant of the RNF-213 gene: case report2017
- Author(s)
  Tashiro R, Fujimura M, Niizuma K, Endo H, Sakata H, Sato-Maeda M, Tominaga T
- Journal Title
  
  J Stroke Cerebrovasc Dis
  
  Volume: 26
- DOI
  10.1016/j.jstrokecerebrovasdis.2016.09.035
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462150
[Journal Article] Uneven cerebral hemodynamic change as a cause of neurological deterioration in the acute stage after direct revascularization for moyamoya disease: cerebral hyperperfusion and remote ischemia caused by the 'watershed shift'.2017
- Author(s)
  Tu XK, Fujimura M, Rashad S, Mugikura S, Sakata H, Niizuma K, Tominaga T
- Journal Title
  
  Neurosurg Rev.
  
  Volume: - Pages: 507-512
- DOI
  10.1007/s10143-017-0845-9
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462150, KAKENHI-PROJECT-26461877, KAKENHI-PROJECT-17K10815, KAKENHI-PROJECT-17H04255
[Journal Article] Navigation-guided clipping of a de novo aneurysm associated with superficial temporal artery-middle cerebral artery bypass combined with indirect pial synangiosis in a patient with moyamoya disease2017
- Author(s)
  Aburakawa D, Fujimura M, Niizuma K, Sakata H, Endo H, Tominaga T
- Journal Title
  
  Neurosurg Rev
  
  Volume: 40 Pages: 517-521
- DOI
  10.1007/s10143-017-0866-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10815
[Journal Article] Hypoxic preconditioning enhances neural stem cell transplantation therapy after intracerebral hemorrhage in mice2016
- Author(s)
  Wakai T, Narasimhan P, Sakata H, Wang E, Yoshioka H, Kinouchi H, Chan PH.
- Journal Title
  
  Journal of Cerebral Blood Flow & Metabolism
  
  Volume: 36 Pages: 2134-2145
- DOI
  10.1177/0271678x15613798
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05680, KAKENHI-PROJECT-26462155
[Journal Article] Temporal profile of magnetic resonance angiography and decreased ratio of regulatory T cells after immunological adjuvant administration to mice lacking RNF213, a susceptibility gene for moyamoya disease2016
- Author(s)
  Kanoke A, Fujimura M, Niizuma K, Fujimura T, Kakizaki A, Ito A, Sakata H, Sato-Maeda M, Kure S, Tominaga T.
- Journal Title
  
  Brain Res
  
  Volume: 1642 Pages: 1-9
- DOI
  10.1016/j.brainres.2016.03.009
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04871, KAKENHI-PROJECT-26462150, KAKENHI-PROJECT-15K15385
[Journal Article] Transplantation of unique subpopulation of fibroblasts, muse cells, ameliorates experimental stroke possibly via robust neuronal differentiation.2016
- Author(s)
  Satow, T., Kawase, T., Kitamura, A. , Kajitani ,Y. , Yamaguchi, T. , Tanabe, N. , Otoi, R. , Komuro, T. , Kobayashi, A. , Nagata, H. , Mima, T.,
- Journal Title
  
  Stem Cells.
  
  Volume: 34 Pages: 160-173
- DOI
  10.1002/stem.2206
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-INTERNATIONAL-15K21731, KAKENHI-PLANNED-15H05879, KAKENHI-PROJECT-26860126, KAKENHI-PROJECT-25282245, KAKENHI-PROJECT-26290001, KAKENHI-PROJECT-26293058, KAKENHI-ORGANIZER-15H05871, KAKENHI-PROJECT-15H05680
[Journal Article] Temporal profile of the vascular anatomy evaluated by 9.4-tesla magnetic resonance angiography and histological analysis in mice with the R4859K mutation of RNF213, the susceptibility gene for moyamoya disease.2015
- Author(s)
  Kanoke A, Fujimura M, Niizuma K, Ito A, Sakata H, Sato-Maeda M, Morita-Fujimura Y, Kure S, and Tominaga T.
- Journal Title
  
  Brain Res.
  
  Volume: 1624 Pages: 497-505
- DOI
  10.1016/j.brainres.2015.07.039
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462150, KAKENHI-PROJECT-15K15385, KAKENHI-PROJECT-15H04871
[Journal Article] Local vasogenic edema without cerebral hyperperfusion after direct revascularization surgery for moyamoya disease2015
- Author(s)
  Sakata H, Fujimura M, Mugikura S, Sato K, Tominaga T.
- Journal Title
  
  J Stroke Cerebrovasc Dis
  
  Volume: 24 Pages: 179-184
- DOI
  10.1016/j.jstrokecerebrovasdis.2015.03.050
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462150, KAKENHI-PROJECT-25462204
[Journal Article] Enhanced post-ischemic angiogenesis in mice lacking RNF213; a susceptibility gene for moyamoya disease2015
- Author(s)
  Ito A, Fujimura M, Niizuma K, Kanoke A, Sakata H, Morita-Fujimura Y, Kikuchi A, Kure S, Tominaga T.
- Journal Title
  
  Brain Res.
  
  Volume: 16 Pages: 310-320
- DOI
  10.1016/j.brainres.2014.11.014
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25670470, KAKENHI-PROJECT-26462150, KAKENHI-PROJECT-15K15385, KAKENHI-PROJECT-15H04871
[Journal Article] Experimental model of small subcortical infarcts in mice with long-lasting functional disabilities.2015
- Author(s)
  Uchida H, Sakata H, Fujimura M, Niizuma K, Kushida Y, Dezawa M, Tominaga T
- Journal Title
  
  Brain Research
  
  Volume: 1629 Pages: 318-328
- DOI
  10.1016/j.brainres.2015.10.039
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05680, KAKENHI-PROJECT-26860126
[Journal Article] Genetics and Biomarkers of Moyamoya Disease: Significance of RNF213 as a susceptibility gene2014
- Author(s)
  FUJIMURA M, Sonobe S, Nishijima Y, Niizuma K, Sakata H, Kure S, Tominaga T
- Journal Title
  
  J Stroke
  
  Volume: 16 Pages: 65-72
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462150
[Presentation] もやもや病に対する直接間接複合血行再建術：頭蓋形成における生体性吸収性プレート併用法の長期成績2017
- Author(s)
  藤村幹，遠藤英徳，新妻邦泰，坂田洋之，冨永悌二
- Organizer
  第９回日本整容脳神経外科研究会（甲府）
- Data Source
  KAKENHI-PROJECT-17K10815
[Presentation] Outcome of revascularization surgery for elderly patients with moyamoya disease over the age of 60 years: Single institute experience.2015
- Author(s)
  Fujimura M, Niizuma K, Endo H, Sakata H, Tominaga T.
- Organizer
  4th International Moyamoya Meeting.
- Place of Presentation
  Berlin, Germany
- Year and Date
  2015-07-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462150
[Presentation] Prophylactic blood pressure lowering with intravenous minocycline administration as secure and effective postoperative management after revascularization surgery for moyamoya disease.2015
- Author(s)
  Fujimura M, Niizuma K, Endo H, Sakata H, Tominaga T.
- Organizer
  15th Interim Meeting of the World Federation of Neurological Societies.
- Place of Presentation
  Rome, Italy
- Year and Date
  2015-09-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462150

1. 新妻邦泰 (10643330)

# of Collaborated Projects: 7 results

# of Collaborated Products: 13 results
2. 冨永悌二 (00217548)

# of Collaborated Projects: 6 results

# of Collaborated Products: 2 results
3. Miki Fujimura (00361098)

# of Collaborated Projects: 5 results

# of Collaborated Products: 13 results
4. Sugiyama Shinichiro (30623152)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 遠藤俊毅 (00535370)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 船本健一 (70451630)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 出沢真理 (50272323)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 後藤昌史 (50400453)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Rashad Sherif (00824088)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 伊藤明 (90867863)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 麦倉俊司 (20375017)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. DEZAWA Mari

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. WATANABE Mika

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. NAKAGAWA Atsuhiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. Chan Pak H.

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. YOSHIYA Matsuzaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 富永悌二

# of Collaborated Projects: 0 results

# of Collaborated Products: 12 results
18. 呉繁夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
19. 佐藤健一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 井川俊太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 吉岡秀幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 美馬達哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 虫明元

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 串田良祐

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Sakata Hiroyuki 坂田 洋之

Research Projects

Research Products

Co-Researchers

Development of Muse cell therapy for dementiaOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

シロスタゾールを用いたもやもや病における内因性幹細胞賦活と血管新生促進療法の開発Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Efferocytosisを利用した頚動脈狭窄症の脳梗塞リスク診断と分子標的治療Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

重症型もやもや病に対する多能性幹細胞Museを用いた血管新生療法の開発Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Platform for regenerative therapy of central nervous system using Muse cellsOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

New concept of local chemo- and cell-therapy for spinal cord injury using convection-enhanced drug delivery

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Reconstruction of Neuronal Circuitry by Muse cell transplantation in lacunar strokePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of the stem cell transplantation therapy by MUSE for moyamoya disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Transient global cerebral ischemia induces RNF213, a moyamoya disease susceptibility gene, in vulnerable neurons of the rat hippocampus CA1 sub-region and ischemic cortex2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] De novo development of moyamoya disease in an adult female with a genetic variant of the RNF-213 gene: case report2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Uneven cerebral hemodynamic change as a cause of neurological deterioration in the acute stage after direct revascularization for moyamoya disease: cerebral hyperperfusion and remote ischemia caused by the 'watershed shift'.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Navigation-guided clipping of a de novo aneurysm associated with superficial temporal artery-middle cerebral artery bypass combined with indirect pial synangiosis in a patient with moyamoya disease2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hypoxic preconditioning enhances neural stem cell transplantation therapy after intracerebral hemorrhage in mice2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Temporal profile of magnetic resonance angiography and decreased ratio of regulatory T cells after immunological adjuvant administration to mice lacking RNF213, a susceptibility gene for moyamoya disease2016

Author(s)

Journal Title

Sakata Hiroyuki 坂田洋之