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Sakata Hiroyuki  坂田 洋之

ORCIDConnect your ORCID iD *help
Researcher Number 80722305
Other IDs
Affiliation (Current) 2022: 東北大学, 医学系研究科, 非常勤講師
Affiliation (based on the past Project Information) *help 2017 – 2021: 東北大学, 医学系研究科, 非常勤講師
2016: 東北大学, 医工学研究科, 助教
2014 – 2015: 東北大学, 医学(系)研究科(研究院), 非常勤講師
Review Section/Research Field
Principal Investigator
Neurosurgery / Basic Section 56010:Neurosurgery-related
Except Principal Investigator
Neurosurgery / Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 56010:Neurosurgery-related
Keywords
Principal Investigator
脳梗塞 / 神経再生 / Muse細胞 / 白質再建 / 移植・再生医療 / 脳血管障害学 / 神経科学 / 脳神経疾患 / 再生医学 / 頚動脈狭窄症 … More / バイオマーカー / efferocytosis / Mfge8 / Efferocytosis / 分子標的治療 … More
Except Principal Investigator
もやもや病 / 血管新生 / 幹細胞移植 / 再生医療 / 頭蓋外内バイパス術 / Muse細胞 / 多能性幹細胞 / moyamoya disease / RNF213 / MUSE細胞 / 再生療法 / drug delivery / cell therapy / ドラッグデリバリー / 神経再生 / ドラッグ・デリバリー・デリバリー / 脊髄損傷 / 組織修復 / 細胞移植治療 / 中枢神経疾患 / 認知症 / 細胞治療 / 血管新生療法 / 血行再建術 Less
  • Research Projects

    (8 results)
  • Research Products

    (24 results)
  • Co-Researchers

    (24 People)
  •  Development of Muse cell therapy for dementia

    • Principal Investigator
      新妻 邦泰
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 51030:Pathophysiologic neuroscience-related
    • Research Institution
      Tohoku University
  •  シロスタゾールを用いたもやもや病における内因性幹細胞賦活と血管新生促進療法の開発

    • Principal Investigator
      藤村 幹
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Tohoku University
  •  Efferocytosisを利用した頚動脈狭窄症の脳梗塞リスク診断と分子標的治療Principal Investigator

    • Principal Investigator
      坂田 洋之
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Tohoku University
  •  Neo-angiogenesis induction by pluripotent stem cell Muse as a new therapeutic strategy for severer form of moyamoya disease

    • Principal Investigator
      Miki Fujimura
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurosurgery
    • Research Institution
      Tohoku University
  •  Platform for regenerative therapy of central nervous system using Muse cells

    • Principal Investigator
      TOMINAGA TEIJI
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Neurosurgery
    • Research Institution
      Tohoku University
  •  New concept of local chemo- and cell-therapy for spinal cord injury using convection-enhanced drug delivery

    • Principal Investigator
      Sugiyama Shinichiro
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurosurgery
    • Research Institution
      Tohoku University
  •  Reconstruction of Neuronal Circuitry by Muse cell transplantation in lacunar strokePrincipal Investigator

    • Principal Investigator
      Sakata Hiroyuki
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (A)
    • Research Field
      Neurosurgery
    • Research Institution
      Tohoku University
  •  Establishment of the stem cell transplantation therapy by MUSE for moyamoya disease

    • Principal Investigator
      Miki Fujimura
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurosurgery
    • Research Institution
      Tohoku University

All 2021 2020 2019 2017 2016 2015 2014

All Journal Article Presentation

  • [Journal Article] Carotid artery stenting in a patient with an incidentally found double aortic arch: A case report2021

    • Author(s)
      Kitamura Yuki、Sakata Hiroyuki、Ezura Masayuki、Ishida Tomohisa、Endo Hidenori、Inoue Takashi、Tominaga Teiji
    • Journal Title

      Interventional Neuroradiology

      Volume: -

    • DOI

      10.1177/15910199211001717

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K18414
  • [Journal Article] Bow hunter's syndrome due to an embolic mechanism: illustrative case2021

    • Author(s)
      Shingai Yuto, Sakata Hiroyuki, Endo Toshiki, Suzuki Shinsuke, Ezura Masayuki, Tominaga Teiji
    • Journal Title

      Journal of Neurosurgery Case Lessons

      Volume: -

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K18414
  • [Journal Article] Symptomatic Cerebral Hyperperfusion After Cerebral Vasospasm Associated with Aneurysmal Subarachnoid Hemorrhage2020

    • Author(s)
      Sakata H, Endo H, Fujimura M, Niizuma K, Tominaga T
    • Journal Title

      World Neurosurgery

      Volume: 137 Pages: 379-383

    • DOI

      10.1016/j.wneu.2020.02.092

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K18414
  • [Journal Article] Identification of HLA-DRB1*04:10 allele as risk allele for Japanese moyamoya disease and its association with autoimmune thyroid disease: A case-control study2019

    • Author(s)
      Tashiro R, Niizuma K, Khor SS, Tokunaga K, Fujimura M, Sakata H, Endo H, Inoko H, Ogasawara K, Tominaga T
    • Journal Title

      PLoS One

      Volume: 14

    • DOI

      10.1371/journal.pone.0220858

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10815
  • [Journal Article] Genetic analysis of Ring Finger Protein 213 (RNF213) c.14576G>A polymorphism in patients with vertebral artery dissection: a comparative study with moyamoya disease2019

    • Author(s)
      Tashiro R, Fujimura M, Sakata H, Endo H, Tomata Y, Sato-Maeda M, Niizuma K, Tominaga T
    • Journal Title

      Neurol Res

      Volume: 41 Pages: 811-816

    • DOI

      10.1080/01616412.2019.1615726

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K10815
  • [Journal Article] Navigation-guided clipping of a de novo aneurysm associated with superficial temporal artery-middle cerebral artery bypass combined with indirect pial synangiosis in a patient with moyamoya disease2017

    • Author(s)
      Aburakawa D, Fujimura M, Niizuma K, Sakata H, Endo H, Tominaga T
    • Journal Title

      Neurosurg Rev

      Volume: 40 Pages: 517-521

    • DOI

      10.1007/s10143-017-0866-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K10815
  • [Journal Article] Uneven cerebral hemodynamic change as a cause of neurological deterioration in the acute stage after direct revascularization for moyamoya disease: cerebral hyperperfusion and remote ischemia caused by the 'watershed shift'.2017

    • Author(s)
      Tu XK, Fujimura M, Rashad S, Mugikura S, Sakata H, Niizuma K, Tominaga T
    • Journal Title

      Neurosurg Rev.

      Volume: - Pages: 507-512

    • DOI

      10.1007/s10143-017-0845-9

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462150, KAKENHI-PROJECT-26461877, KAKENHI-PROJECT-17K10815, KAKENHI-PROJECT-17H04255
  • [Journal Article] De novo development of moyamoya disease in an adult female with a genetic variant of the RNF-213 gene: case report2017

    • Author(s)
      Tashiro R, Fujimura M, Niizuma K, Endo H, Sakata H, Sato-Maeda M, Tominaga T
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: 26

    • DOI

      10.1016/j.jstrokecerebrovasdis.2016.09.035

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26462150
  • [Journal Article] Transient global cerebral ischemia induces RNF213, a moyamoya disease susceptibility gene, in vulnerable neurons of the rat hippocampus CA1 sub-region and ischemic cortex2017

    • Author(s)
      Sato-Maeda M, Fujimura M, Rashad S, Morita-Fujimura Y, Niizuma K, Sakata H, Ikawa S, Tominaga T.
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: 26 Pages: 1904-1911

    • DOI

      10.1016/j.jstrokecerebrovasdis.2017.06.032

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K07152, KAKENHI-PROJECT-17K10815
  • [Journal Article] Hypoxic preconditioning enhances neural stem cell transplantation therapy after intracerebral hemorrhage in mice2016

    • Author(s)
      Wakai T, Narasimhan P, Sakata H, Wang E, Yoshioka H, Kinouchi H, Chan PH.
    • Journal Title

      Journal of Cerebral Blood Flow & Metabolism

      Volume: 36 Pages: 2134-2145

    • DOI

      10.1177/0271678x15613798

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05680, KAKENHI-PROJECT-26462155
  • [Journal Article] Transplantation of Unique Subpopulation of Fibroblasts, Muse Cells, Ameliorates Experimental Stroke Possibly via Robist neuronal Differentiation.2016

    • Author(s)
      Satow, T., Kawase, T., Kitamura, A. , Kajitani ,Y. , Yamaguchi, T. , Tanabe, N. , Otoi, R. , Komuro, T. , Kobayashi, A. , Nagata, H. , Mima, T.,
    • Journal Title

      Stem Cells.

      Volume: 34 Pages: 160-173

    • DOI

      10.1002/stem.2206

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-INTERNATIONAL-15K21731, KAKENHI-PLANNED-15H05879, KAKENHI-PROJECT-26860126, KAKENHI-PROJECT-25282245, KAKENHI-PROJECT-26290001, KAKENHI-PROJECT-26293058, KAKENHI-ORGANIZER-15H05871, KAKENHI-PROJECT-15H05680
  • [Journal Article] Temporal profile of magnetic resonance angiography and decreased ratio of regulatory T cells after immunological adjuvant administration to mice lacking RNF213, a susceptibility gene for moyamoya disease2016

    • Author(s)
      Kanoke A, Fujimura M, Niizuma K, Fujimura T, Kakizaki A, Ito A, Sakata H, Sato-Maeda M, Kure S, Tominaga T.
    • Journal Title

      Brain Res

      Volume: 1642 Pages: 1-9

    • DOI

      10.1016/j.brainres.2016.03.009

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H04871, KAKENHI-PROJECT-26462150, KAKENHI-PROJECT-15K15385
  • [Journal Article] Experimental model of small subcortical infarcts in mice with long-lasting functional disabilities.2015

    • Author(s)
      Uchida H, Sakata H, Fujimura M, Niizuma K, Kushida Y, Dezawa M, Tominaga T
    • Journal Title

      Brain Research

      Volume: 1629 Pages: 318-328

    • DOI

      10.1016/j.brainres.2015.10.039

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05680, KAKENHI-PROJECT-26860126
  • [Journal Article] Local vasogenic edema without cerebral hyperperfusion after direct revascularization surgery for moyamoya disease2015

    • Author(s)
      Sakata H, Fujimura M, Mugikura S, Sato K, Tominaga T.
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: 24 Pages: 179-184

    • DOI

      10.1016/j.jstrokecerebrovasdis.2015.03.050

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26462150, KAKENHI-PROJECT-25462204
  • [Journal Article] Temporal profile of the vascular anatomy evaluated by 9.4-tesla magnetic resonance angiography and histological analysis in mice with the R4859K mutation of RNF213, the susceptibility gene for moyamoya disease.2015

    • Author(s)
      Kanoke A, Fujimura M, Niizuma K, Ito A, Sakata H, Sato-Maeda M, Morita-Fujimura Y, Kure S, and Tominaga T.
    • Journal Title

      Brain Res.

      Volume: 1624 Pages: 497-505

    • DOI

      10.1016/j.brainres.2015.07.039

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26462150, KAKENHI-PROJECT-15K15385, KAKENHI-PROJECT-15H04871
  • [Journal Article] Enhanced post-ischemic angiogenesis in mice lacking RNF213; a susceptibility gene for moyamoya disease2015

    • Author(s)
      Ito A, Fujimura M, Niizuma K, Kanoke A, Sakata H, Morita-Fujimura Y, Kikuchi A, Kure S, Tominaga T.
    • Journal Title

      Brain Res.

      Volume: 16 Pages: 310-320

    • DOI

      10.1016/j.brainres.2014.11.014

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25670470, KAKENHI-PROJECT-26462150, KAKENHI-PROJECT-15K15385, KAKENHI-PROJECT-15H04871
  • [Journal Article] Genetics and Biomarkers of Moyamoya Disease: Significance of RNF213 as a susceptibility gene2014

    • Author(s)
      FUJIMURA M, Sonobe S, Nishijima Y, Niizuma K, Sakata H, Kure S, Tominaga T
    • Journal Title

      J Stroke

      Volume: 16 Pages: 65-72

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26462150
  • [Presentation] 頚動脈ステント留置術後の過灌流に対するミノサイクリン塩酸塩を用いた周術期管理2021

    • Author(s)
      坂田洋之、江面正幸、井上敬、遠藤英徳、上之原広司、冨永悌二
    • Organizer
      第50回日本脳卒中の外科学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K18414
  • [Presentation] 高齢者に対する機械的血栓回収療法の現状2021

    • Author(s)
      坂田洋之、江面正幸、石田朋久、遠藤英徳、井上敬、上之原広司、冨永悌二
    • Organizer
      第34回日本老年脳神経外科学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K18414
  • [Presentation] 2D perfusion angiographyを用いた頚動脈ステント留置術後の過灌流予測2020

    • Author(s)
      坂田洋之、江面正幸、阿部考貢、井上敬、遠藤英徳、遠藤俊毅、上之原広司、冨永悌二
    • Organizer
      第36回日本脳神経血管内治療学会
    • Data Source
      KAKENHI-PROJECT-19K18414
  • [Presentation] 頚動脈ステント留置術後の過灌流に対するミノサイクリン塩酸塩を用いた周術期管理2020

    • Author(s)
      坂田洋之、江面正幸、井上敬、遠藤英徳、上之原広司、冨永悌二
    • Organizer
      第79回日本脳神経外科学会総会
    • Data Source
      KAKENHI-PROJECT-19K18414
  • [Presentation] もやもや病に対する直接間接複合血行再建術:頭蓋形成における生体性吸収性プレート併用法の長期成績2017

    • Author(s)
      藤村幹,遠藤英徳,新妻邦泰,坂田洋之,冨永悌二
    • Organizer
      第9回日本整容脳神経外科研究会(甲府)
    • Data Source
      KAKENHI-PROJECT-17K10815
  • [Presentation] Prophylactic blood pressure lowering with intravenous minocycline administration as secure and effective postoperative management after revascularization surgery for moyamoya disease.2015

    • Author(s)
      Fujimura M, Niizuma K, Endo H, Sakata H, Tominaga T.
    • Organizer
      15th Interim Meeting of the World Federation of Neurological Societies.
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2015-09-08
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462150
  • [Presentation] Outcome of revascularization surgery for elderly patients with moyamoya disease over the age of 60 years: Single institute experience.2015

    • Author(s)
      Fujimura M, Niizuma K, Endo H, Sakata H, Tominaga T.
    • Organizer
      4th International Moyamoya Meeting.
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2015-07-02
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462150
  • 1.  新妻 邦泰 (10643330)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 15 results
  • 2.  TOMINAGA TEIJI (00217548)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 2 results
  • 3.  Miki Fujimura (00361098)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 15 results
  • 4.  Sugiyama Shinichiro (30623152)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  遠藤 俊毅 (00535370)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  船本 健一 (70451630)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  出沢 真理 (50272323)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 8.  後藤 昌史 (50400453)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  Rashad Sherif (00824088)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  伊藤 明 (90867863)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  麦倉 俊司 (20375017)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 12.  DEZAWA Mari
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 13.  WATANABE Mika
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  NAKAGAWA Atsuhiro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  Chan Pak H.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 16.  YOSHIYA Matsuzaka
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  串田 良祐
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 18.  富永 悌二
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 14 results
  • 19.  佐藤 健一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 20.  吉岡 秀幸
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 21.  美馬 達哉
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 22.  虫明 元
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 23.  呉 繁夫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 24.  井川 俊太郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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