Sakata Hiroyuki 坂田洋之

Researcher Number	80722305
Other IDs
Affiliation (Current)	2022: 東北大学, 医学系研究科, 非常勤講師
Affiliation (based on the past Project Information) *help	2017 – 2021: 東北大学, 医学系研究科, 非常勤講師 2016: 東北大学, 医工学研究科, 助教 2014 – 2015: 東北大学, 医学(系)研究科(研究院), 非常勤講師
Review Section/Research Field	Principal Investigator Neurosurgery / Basic Section 56010:Neurosurgery-related Except Principal Investigator Neurosurgery / Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 56010:Neurosurgery-related
Keywords	Principal Investigator 脳梗塞 / 神経再生 / Muse細胞 / 白質再建 / 移植・再生医療 / 脳血管障害学 / 神経科学 / 脳神経疾患 / 再生医学 / 頚動脈狭窄症 … More Except Principal Investigator もやもや病 / 血管新生 / 幹細胞移植 / 再生医療 / 頭蓋外内バイパス術 / Muse細胞 / 多能性幹細胞 / moyamoya disease / RNF213 / MUSE細胞 / 再生療法 / drug delivery / cell therapy / ドラッグデリバリー / 神経再生 / ドラッグ・デリバリー・デリバリー / 脊髄損傷 / 組織修復 / 細胞移植治療 / 中枢神経疾患 / 認知症 / 細胞治療 / 血管新生療法 / 血行再建術 Less

Development of Muse cell therapy for dementia
- Principal Investigator
  
  新妻邦泰
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Tohoku University
シロスタゾールを用いたもやもや病における内因性幹細胞賦活と血管新生促進療法の開発
- Principal Investigator
  
  藤村幹
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Tohoku University
Efferocytosisを利用した頚動脈狭窄症の脳梗塞リスク診断と分子標的治療Principal Investigator
- Principal Investigator
  
  坂田洋之
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Tohoku University
Neo-angiogenesis induction by pluripotent stem cell Muse as a new therapeutic strategy for severer form of moyamoya disease
- Principal Investigator
  
  Miki Fujimura
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Tohoku University
Platform for regenerative therapy of central nervous system using Muse cells
- Principal Investigator
  
  TOMINAGA TEIJI
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurosurgery
- Research Institution
  Tohoku University
New concept of local chemo- and cell-therapy for spinal cord injury using convection-enhanced drug delivery
- Principal Investigator
  
  Sugiyama Shinichiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Tohoku University
Reconstruction of Neuronal Circuitry by Muse cell transplantation in lacunar strokePrincipal Investigator
- Principal Investigator
  
  Sakata Hiroyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Neurosurgery
- Research Institution
  Tohoku University
Establishment of the stem cell transplantation therapy by MUSE for moyamoya disease
- Principal Investigator
  
  Miki Fujimura
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Tohoku University

All 2021 2020 2019 2017 2016 2015 2014

All Journal Article Presentation

[Journal Article] Carotid artery stenting in a patient with an incidentally found double aortic arch: A case report2021
- Author(s)
  Kitamura Yuki、Sakata Hiroyuki、Ezura Masayuki、Ishida Tomohisa、Endo Hidenori、Inoue Takashi、Tominaga Teiji
- Journal Title
  
  Interventional Neuroradiology
  
  Volume: －
- DOI
  10.1177/15910199211001717
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K18414
[Journal Article] Bow hunter's syndrome due to an embolic mechanism: illustrative case2021
- Author(s)
  Shingai Yuto, Sakata Hiroyuki, Endo Toshiki, Suzuki Shinsuke, Ezura Masayuki, Tominaga Teiji
- Journal Title
  
  Journal of Neurosurgery Case Lessons
  
  Volume: －
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18414
[Journal Article] Symptomatic Cerebral Hyperperfusion After Cerebral Vasospasm Associated with Aneurysmal Subarachnoid Hemorrhage2020
- Author(s)
  Sakata H, Endo H, Fujimura M, Niizuma K, Tominaga T
- Journal Title
  
  World Neurosurgery
  
  Volume: 137 Pages: 379-383
- DOI
  10.1016/j.wneu.2020.02.092
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18414
[Journal Article] Identification of HLA-DRB1*04:10 allele as risk allele for Japanese moyamoya disease and its association with autoimmune thyroid disease: A case-control study2019
- Author(s)
  Tashiro R, Niizuma K, Khor SS, Tokunaga K, Fujimura M, Sakata H, Endo H, Inoko H, Ogasawara K, Tominaga T
- Journal Title
  
  PLoS One
  
  Volume: 14
- DOI
  10.1371/journal.pone.0220858
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10815
[Journal Article] Genetic analysis of Ring Finger Protein 213 (RNF213) c.14576G>A polymorphism in patients with vertebral artery dissection: a comparative study with moyamoya disease2019
- Author(s)
  Tashiro R, Fujimura M, Sakata H, Endo H, Tomata Y, Sato-Maeda M, Niizuma K, Tominaga T
- Journal Title
  
  Neurol Res
  
  Volume: 41 Pages: 811-816
- DOI
  10.1080/01616412.2019.1615726
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10815
[Journal Article] Navigation-guided clipping of a de novo aneurysm associated with superficial temporal artery-middle cerebral artery bypass combined with indirect pial synangiosis in a patient with moyamoya disease2017
- Author(s)
  Aburakawa D, Fujimura M, Niizuma K, Sakata H, Endo H, Tominaga T
- Journal Title
  
  Neurosurg Rev
  
  Volume: 40 Pages: 517-521
- DOI
  10.1007/s10143-017-0866-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10815
[Journal Article] Uneven cerebral hemodynamic change as a cause of neurological deterioration in the acute stage after direct revascularization for moyamoya disease: cerebral hyperperfusion and remote ischemia caused by the 'watershed shift'.2017
- Author(s)
  Tu XK, Fujimura M, Rashad S, Mugikura S, Sakata H, Niizuma K, Tominaga T
- Journal Title
  
  Neurosurg Rev.
  
  Volume: - Pages: 507-512
- DOI
  10.1007/s10143-017-0845-9
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462150, KAKENHI-PROJECT-26461877, KAKENHI-PROJECT-17K10815, KAKENHI-PROJECT-17H04255
[Journal Article] De novo development of moyamoya disease in an adult female with a genetic variant of the RNF-213 gene: case report2017
- Author(s)
  Tashiro R, Fujimura M, Niizuma K, Endo H, Sakata H, Sato-Maeda M, Tominaga T
- Journal Title
  
  J Stroke Cerebrovasc Dis
  
  Volume: 26
- DOI
  10.1016/j.jstrokecerebrovasdis.2016.09.035
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462150
[Journal Article] Transient global cerebral ischemia induces RNF213, a moyamoya disease susceptibility gene, in vulnerable neurons of the rat hippocampus CA1 sub-region and ischemic cortex2017
- Author(s)
  Sato-Maeda M, Fujimura M, Rashad S, Morita-Fujimura Y, Niizuma K, Sakata H, Ikawa S, Tominaga T.
- Journal Title
  
  J Stroke Cerebrovasc Dis
  
  Volume: 26 Pages: 1904-1911
- DOI
  10.1016/j.jstrokecerebrovasdis.2017.06.032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07152, KAKENHI-PROJECT-17K10815
[Journal Article] Hypoxic preconditioning enhances neural stem cell transplantation therapy after intracerebral hemorrhage in mice2016
- Author(s)
  Wakai T, Narasimhan P, Sakata H, Wang E, Yoshioka H, Kinouchi H, Chan PH.
- Journal Title
  
  Journal of Cerebral Blood Flow & Metabolism
  
  Volume: 36 Pages: 2134-2145
- DOI
  10.1177/0271678x15613798
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05680, KAKENHI-PROJECT-26462155
[Journal Article] Transplantation of Unique Subpopulation of Fibroblasts, Muse Cells, Ameliorates Experimental Stroke Possibly via Robist neuronal Differentiation.2016
- Author(s)
  Satow, T., Kawase, T., Kitamura, A. , Kajitani ,Y. , Yamaguchi, T. , Tanabe, N. , Otoi, R. , Komuro, T. , Kobayashi, A. , Nagata, H. , Mima, T.,
- Journal Title
  
  Stem Cells.
  
  Volume: 34 Pages: 160-173
- DOI
  10.1002/stem.2206
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-INTERNATIONAL-15K21731, KAKENHI-PLANNED-15H05879, KAKENHI-PROJECT-26860126, KAKENHI-PROJECT-25282245, KAKENHI-PROJECT-26290001, KAKENHI-PROJECT-26293058, KAKENHI-ORGANIZER-15H05871, KAKENHI-PROJECT-15H05680
[Journal Article] Temporal profile of magnetic resonance angiography and decreased ratio of regulatory T cells after immunological adjuvant administration to mice lacking RNF213, a susceptibility gene for moyamoya disease2016
- Author(s)
  Kanoke A, Fujimura M, Niizuma K, Fujimura T, Kakizaki A, Ito A, Sakata H, Sato-Maeda M, Kure S, Tominaga T.
- Journal Title
  
  Brain Res
  
  Volume: 1642 Pages: 1-9
- DOI
  10.1016/j.brainres.2016.03.009
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04871, KAKENHI-PROJECT-26462150, KAKENHI-PROJECT-15K15385
[Journal Article] Experimental model of small subcortical infarcts in mice with long-lasting functional disabilities.2015
- Author(s)
  Uchida H, Sakata H, Fujimura M, Niizuma K, Kushida Y, Dezawa M, Tominaga T
- Journal Title
  
  Brain Research
  
  Volume: 1629 Pages: 318-328
- DOI
  10.1016/j.brainres.2015.10.039
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05680, KAKENHI-PROJECT-26860126
[Journal Article] Local vasogenic edema without cerebral hyperperfusion after direct revascularization surgery for moyamoya disease2015
- Author(s)
  Sakata H, Fujimura M, Mugikura S, Sato K, Tominaga T.
- Journal Title
  
  J Stroke Cerebrovasc Dis
  
  Volume: 24 Pages: 179-184
- DOI
  10.1016/j.jstrokecerebrovasdis.2015.03.050
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462150, KAKENHI-PROJECT-25462204
[Journal Article] Temporal profile of the vascular anatomy evaluated by 9.4-tesla magnetic resonance angiography and histological analysis in mice with the R4859K mutation of RNF213, the susceptibility gene for moyamoya disease.2015
- Author(s)
  Kanoke A, Fujimura M, Niizuma K, Ito A, Sakata H, Sato-Maeda M, Morita-Fujimura Y, Kure S, and Tominaga T.
- Journal Title
  
  Brain Res.
  
  Volume: 1624 Pages: 497-505
- DOI
  10.1016/j.brainres.2015.07.039
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462150, KAKENHI-PROJECT-15K15385, KAKENHI-PROJECT-15H04871
[Journal Article] Enhanced post-ischemic angiogenesis in mice lacking RNF213; a susceptibility gene for moyamoya disease2015
- Author(s)
  Ito A, Fujimura M, Niizuma K, Kanoke A, Sakata H, Morita-Fujimura Y, Kikuchi A, Kure S, Tominaga T.
- Journal Title
  
  Brain Res.
  
  Volume: 16 Pages: 310-320
- DOI
  10.1016/j.brainres.2014.11.014
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25670470, KAKENHI-PROJECT-26462150, KAKENHI-PROJECT-15K15385, KAKENHI-PROJECT-15H04871
[Journal Article] Genetics and Biomarkers of Moyamoya Disease: Significance of RNF213 as a susceptibility gene2014
- Author(s)
  FUJIMURA M, Sonobe S, Nishijima Y, Niizuma K, Sakata H, Kure S, Tominaga T
- Journal Title
  
  J Stroke
  
  Volume: 16 Pages: 65-72
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462150
[Presentation] 頚動脈ステント留置術後の過灌流に対するミノサイクリン塩酸塩を用いた周術期管理2021
- Author(s)
  坂田洋之、江面正幸、井上敬、遠藤英徳、上之原広司、冨永悌二
- Organizer
  第50回日本脳卒中の外科学会学術集会
- Data Source
  KAKENHI-PROJECT-19K18414
[Presentation] 高齢者に対する機械的血栓回収療法の現状2021
- Author(s)
  坂田洋之、江面正幸、石田朋久、遠藤英徳、井上敬、上之原広司、冨永悌二
- Organizer
  第34回日本老年脳神経外科学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K18414
[Presentation] 2D perfusion angiographyを用いた頚動脈ステント留置術後の過灌流予測2020
- Author(s)
  坂田洋之、江面正幸、阿部考貢、井上敬、遠藤英徳、遠藤俊毅、上之原広司、冨永悌二
- Organizer
  第36回日本脳神経血管内治療学会
- Data Source
  KAKENHI-PROJECT-19K18414
[Presentation] 頚動脈ステント留置術後の過灌流に対するミノサイクリン塩酸塩を用いた周術期管理2020
- Author(s)
  坂田洋之、江面正幸、井上敬、遠藤英徳、上之原広司、冨永悌二
- Organizer
  第79回日本脳神経外科学会総会
- Data Source
  KAKENHI-PROJECT-19K18414
[Presentation] もやもや病に対する直接間接複合血行再建術：頭蓋形成における生体性吸収性プレート併用法の長期成績2017
- Author(s)
  藤村幹，遠藤英徳，新妻邦泰，坂田洋之，冨永悌二
- Organizer
  第９回日本整容脳神経外科研究会（甲府）
- Data Source
  KAKENHI-PROJECT-17K10815
[Presentation] Prophylactic blood pressure lowering with intravenous minocycline administration as secure and effective postoperative management after revascularization surgery for moyamoya disease.2015
- Author(s)
  Fujimura M, Niizuma K, Endo H, Sakata H, Tominaga T.
- Organizer
  15th Interim Meeting of the World Federation of Neurological Societies.
- Place of Presentation
  Rome, Italy
- Year and Date
  2015-09-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462150
[Presentation] Outcome of revascularization surgery for elderly patients with moyamoya disease over the age of 60 years: Single institute experience.2015
- Author(s)
  Fujimura M, Niizuma K, Endo H, Sakata H, Tominaga T.
- Organizer
  4th International Moyamoya Meeting.
- Place of Presentation
  Berlin, Germany
- Year and Date
  2015-07-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462150

1. 新妻邦泰 (10643330)

# of Collaborated Projects: 7 results

# of Collaborated Products: 15 results
2. TOMINAGA TEIJI (00217548)

# of Collaborated Projects: 6 results

# of Collaborated Products: 2 results
3. Miki Fujimura (00361098)

# of Collaborated Projects: 5 results

# of Collaborated Products: 15 results
4. Sugiyama Shinichiro (30623152)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 遠藤俊毅 (00535370)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 船本健一 (70451630)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 出沢真理 (50272323)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 後藤昌史 (50400453)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Rashad Sherif (00824088)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 伊藤明 (90867863)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 麦倉俊司 (20375017)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. DEZAWA Mari

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. WATANABE Mika

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. NAKAGAWA Atsuhiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. Chan Pak H.

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. YOSHIYA Matsuzaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 串田良祐

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
18. 富永悌二

# of Collaborated Projects: 0 results

# of Collaborated Products: 14 results
19. 佐藤健一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 吉岡秀幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 美馬達哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 虫明元

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 呉繁夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
24. 井川俊太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sakata Hiroyuki 坂田 洋之

Research Projects

Research Products

Co-Researchers

Development of Muse cell therapy for dementia

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

シロスタゾールを用いたもやもや病における内因性幹細胞賦活と血管新生促進療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Efferocytosisを利用した頚動脈狭窄症の脳梗塞リスク診断と分子標的治療Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Neo-angiogenesis induction by pluripotent stem cell Muse as a new therapeutic strategy for severer form of moyamoya disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Platform for regenerative therapy of central nervous system using Muse cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

New concept of local chemo- and cell-therapy for spinal cord injury using convection-enhanced drug delivery

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Reconstruction of Neuronal Circuitry by Muse cell transplantation in lacunar strokePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of the stem cell transplantation therapy by MUSE for moyamoya disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Carotid artery stenting in a patient with an incidentally found double aortic arch: A case report2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bow hunter's syndrome due to an embolic mechanism: illustrative case2021

Author(s)

Journal Title

Data Source

[Journal Article] Symptomatic Cerebral Hyperperfusion After Cerebral Vasospasm Associated with Aneurysmal Subarachnoid Hemorrhage2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of HLA-DRB1*04:10 allele as risk allele for Japanese moyamoya disease and its association with autoimmune thyroid disease: A case-control study2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genetic analysis of Ring Finger Protein 213 (RNF213) c.14576G>A polymorphism in patients with vertebral artery dissection: a comparative study with moyamoya disease2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Navigation-guided clipping of a de novo aneurysm associated with superficial temporal artery-middle cerebral artery bypass combined with indirect pial synangiosis in a patient with moyamoya disease2017

Author(s)

Journal Title

DOI

Sakata Hiroyuki 坂田洋之