Takahashi Naoki 高橋直紀

Researcher Number	80722842
Other IDs
Affiliation (Current)	2019: 新潟大学, 医歯学総合病院, 助教
Affiliation (based on the past Project Information) *help	2018 – 2019: 新潟大学, 医歯学総合病院, 助教 2017: 新潟大学, 医歯学総合研究科, 特任講師 2016: 新潟大学, 医歯学総合研究科, 特任助教 2015: 新潟大学, 医歯学系, 特任助教 2015: 新潟大学, 医歯学系, 特別研究員 2014: 新潟大学, 医歯学系, 特別研究員(PD)
Review Section/Research Field	Principal Investigator Periodontology / Basic Section 57030:Conservative dentistry-related Except Principal Investigator Periodontology / Basic Section 57030:Conservative dentistry-related / Medium-sized Section 57:Oral science and related fields
Keywords	Principal Investigator 歯周炎 / 歯周病 / 歯肉上皮細胞 / イオンチャネル / TRPV1 / CGRP / カプサイシン / 歯周炎モデル / 破骨細胞分化 / 神経ペプチド … More Except Principal Investigator 歯周病 / ワクチン / IgA / PCSK9 / 核酸抗原 / 核酸医薬 / 唾液 / 歯学 / 免疫学 / 歯周炎 / 生体応答 / 高齢者 / スケーリング / 光治療 / 菌血症 / 歯周治療学 / 歯周病医薬 / 機能ペプチド / バイオフィルム / ナノカプセル / 根面う蝕 Less

Peptide drugs derived from food material for periodontal disease preventing flail and AMROngoing
- Principal Investigator
  
  多部田康一
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Niigata University
口腔－腸管連関の新展開：嚥下された歯周病原細菌は腸炎を悪化させるか？Principal InvestigatorOngoing
- Principal Investigator
  
  高橋直紀
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Niigata University
Therapeutic biofilmによる歯周病・根面う蝕治療アプローチの転換Ongoing
- Principal Investigator
  
  多部田康一
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Niigata University
TRPチャネルタンパクによる自然免疫チューニング機構の解明と歯周炎治療への応用Principal InvestigatorOngoing
- Principal Investigator
  
  高橋直紀
- Project Period (FY)
  2018
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
- Research Field
  
  Periodontology
- Research Institution
  Niigata University
スケーリング後菌血症に対する高齢者生体応答の解析と光治療による予防法の確立Ongoing
- Principal Investigator
  
  両角俊哉
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontology
- Research Institution
  Niigata University
歯周炎病態形成におけるTRPチャネルを介した神経－骨代謝ネットワークの解明Principal InvestigatorOngoing
- Principal Investigator
  
  高橋直紀
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontology
- Research Institution
  Niigata University
Vaccines against periodontitis using DNA ORIGAMI and imidazoquinolines
- Principal Investigator
  
  KOICHI TABETA
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Periodontology
- Research Institution
  Niigata University
The Effect of TRPV1 channel in the pathogenesis of periodontitis.Principal Investigator
- Principal Investigator
  
  Takahashi Naoki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Periodontology
- Research Institution
  Niigata University

All 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Increased serum PCSK9, a potential biomarker to screen for periodontitis, and decreased total bilirubin associated with probing depth in a Japanese community survey2018
- Author(s)
  Tabeta K.、Hosojima M.、Nakajima M.、Miyauchi S.、Miyazawa H.、Takahashi N.、Matsuda Y.、Sugita N.、Komatsu Y.、Sato K.、Ishikawa T.、Akiishi K.、Yamazaki K.、Kato K.、Saito A.、Yoshie H.
- Journal Title
  
  Journal of Periodontal Research
  
  Volume: 印刷中
- DOI
  10.1111/jre.12533
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02578, KAKENHI-PROJECT-15H05052, KAKENHI-PROJECT-17H06700, KAKENHI-PROJECT-17H06701
[Journal Article] An ENU-induced splice site mutation of mouse Col1a1 causing recessive osteogenesis imperfecta and revealing a novel splicing rescue2017
- Author(s)
  Tabeta K, Du X, Arimatsu K, Yokoji M, Takahashi N, Amizuka N, Hasegawa T, Crozat K, Maekawa T, Miyauchi S, Matsuda Y, Ida T, Kaku M, Hoebe K, Ohno K, Yoshie H, Yamazaki K, Moresco EMY, Beutler B
- Journal Title
  
  Sci Rep.
  
  Volume: 7(1) Pages: 0-0
- DOI
  10.1038/s41598-017-10343-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11827, KAKENHI-PROJECT-15K15704, KAKENHI-PROJECT-17K19747, KAKENHI-PROJECT-15KK0337, KAKENHI-PROJECT-26293407, KAKENHI-PROJECT-15H02578, KAKENHI-PROJECT-15H04840, KAKENHI-PROJECT-16H06272, KAKENHI-PROJECT-17H06701
[Journal Article] Aggravation of collagen-induced arthritis by orally administered Porphyromonas gingivalis through modulation of the gut microbiota and gut immune system2017
- Author(s)
  Sato K, Takahashi N, Kato T, Matsuda Y, Yokoji M, Yamada M, Nakajima T, Kondo N, Endo N, Yamamoto R, Noiri Y, Ohno H, Yamazaki K
- Journal Title
  
  Scientific reports
  
  Volume: 7(1) Pages: 1-13
- DOI
  10.1038/s41598-017-07196-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11827, KAKENHI-PROJECT-15H02578, KAKENHI-PROJECT-15H05021, KAKENHI-PROJECT-16H05554, KAKENHI-PROJECT-17H06701
[Journal Article] Brazilian propolis mitigates impaired glucose and lipid metabolism in experimental periodontitis in mice.2016
- Author(s)
  Nakajima M, Arimatsu K, Minagawa T, Matsuda Y, Sato K, Takahashi N, Nakajima T, Yamazaki K.
- Journal Title
  
  BMC Complement. Altern. Med.
  
  Volume: 16 Pages: 329-329
- DOI
  10.1186/s12906-016-1305-8
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15763, KAKENHI-PROJECT-16K11827
[Journal Article] ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation2016
- Author(s)
  de Jong PR, Taniguchi K, Harris AR, Bertin S, Takahashi N, Duong J, Campos AD, Powis G, Corr M, Karin M, Raz E
- Journal Title
  
  Nat. Commun
  
  Volume: 17 Pages: 11551-11551
- DOI
  10.1038/ncomms11551
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11827
[Journal Article] Neuronal TRPV1 activation regulates alveolar bone resorption by suppressing osteoclastogenesis via CGRP2016
- Author(s)
  Takahashi N, Matsuda Y, Sato K, de Jong PR, Bertin S, Tabeta K, Yamazaki K
- Journal Title
  
  Sci. Rep
  
  Volume: 6 Pages: 29294-29294
- DOI
  10.1038/srep29294
- Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11827
[Journal Article] The TRPA1 ion channel is expressed in CD4+ T cells and restrains T-cell-mediated colitis through inhibition of TRPV1.2016
- Author(s)
  Bertin S, Aoki-Nonaka Y, Lee J, de Jong PR, Kim P, Han T, Yu T, To K, Takahashi N, Boland BS, Chang JT, Ho SB, Herdman S, Corr M, Franco A, Sharma S, Dong H, Akopian AN, Raz E
- Journal Title
  
  Gut
  
  Volume: 2015 Pages: 310710-310710
- DOI
  10.1136/gutjnl-2015-310710
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11827
[Journal Article] Oral Administration of P. gingivalis Induces Dysbiosis of Gut Microbiota and Impaired Barrier Function Leading to Dissemination of Enterobacteria to the Liver.2016
- Author(s)
  3.Matsuda Y, Kato T, Takahashi N, Nakajima M, Arimatsu K, Minagawa T, Sato K, Ohno H, Yamazaki K.
- Journal Title
  
  J. Periodont. Res.
  
  Volume: 51 Pages: 639-646
- DOI
  10.1111/jre.12344
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H02578, KAKENHI-PROJECT-25463216, KAKENHI-PROJECT-26861808, KAKENHI-PROJECT-16K11827
[Journal Article] Epithelial TRPV1 signaling accelerates gingival epithelial cell proliferation．2014
- Author(s)
  Takahashi N, Matsuda Y, Yamada H, Tabeta K, Nakajima T, Murakami S, Yamazaki K
- Journal Title
  
  J Dent Res
  
  Volume: 93(11) Pages: 1141-1147
- DOI
  10.1177/0022034514552826
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-13J04959, KAKENHI-PROJECT-25463216, KAKENHI-PROJECT-26861808
[Presentation] 歯周病と全身疾患の関連メカニズム―腸内細菌叢を介する新たな仮説―2017
- Author(s)
  高橋直紀
- Organizer
  第71回日本口腔科学会学術集会
- Data Source
  KAKENHI-PROJECT-16K11827
[Presentation] Effect of resveratrol on occlusal trauma-induced bone loss in mice.2017
- Author(s)
  Matsuda Y, Okui T, Minagawa T, Tabeta K, Takahashi N, Sato K, Yamada M, Yokoji M, Nakajima T, Yamazaki K
- Organizer
  95th General Session & Exhibition of the IADR
- Place of Presentation
  米国サンフランシスコ
- Year and Date
  2017-03-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11827
[Presentation] A novel mechanism linking periodontitis and rheumatoid arthritis.2017
- Author(s)
  Sato K, Takahashi N, Matsuda Y, Yamada M, Yokoji M, Tabeta K, Nakajima T, Yamazaki K
- Organizer
  95th General Session & Exhibition of the IADR
- Place of Presentation
  米国サンフランシスコ
- Year and Date
  2017-03-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11827
[Presentation] 歯肉縁下細菌と血清抗体価を用いた慢性歯周炎進行の評価：24ヵ月多施設前向きコホート研究2017
- Author(s)
  両角俊哉、角田衣理加、野村義明、中川種昭、野口和行、原宜興、西村英紀、梅田誠、野口俊英、吉成伸夫、沼部幸博、伊藤公一、和泉雄一、小方頼昌、三邉正人、齋藤淳、佐藤聡、高橋慶壮、川浪雅光、花田信弘、高柴正悟、吉江弘正
- Organizer
  第60回春季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-17K11984
[Presentation] 歯肉縁下細菌と血清抗体価による慢性歯周炎進行の予知判定：24ヵ月多施設前向きコホート研究2017
- Author(s)
  両角俊哉,中川種昭,野口和行,原宜興,西村英紀,梅田誠,野口俊英,吉成伸夫,沼部幸博, 伊藤公一,和泉雄一,小方頼昌,三邉正人,齋藤淳,佐藤聡,高橋慶壮,川浪雅光,花田信弘, 高柴正悟,吉江弘正
- Organizer
  日本歯科保存学会2017年度春季学術大会
- Data Source
  KAKENHI-PROJECT-17K11984
[Presentation] Neuronal TRPV1 activation inhibits alveolar bone resorption via neuropeptide release.2017
- Author(s)
  Takahashi N, Matsuda Y, Sato K, Tabeta K, Yamazaki K, Maeda T
- Organizer
  95th General Session & Exhibition of the IADR
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11827
[Presentation] Neuronal TRPV1 activation regulates alveolar bone resorption by suppressing osteoclastogenesis via CGRP.2017
- Author(s)
  Takahashi N
- Organizer
  International Symposium on Development of Human Resources in Practical Oral Health and Treatment
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11827
[Presentation] A bacterial metabolite ameliorates P. gingivalis-induced gingival epithelial barrier disruption.2017
- Author(s)
  Yamada M, Takahashi N, Matsuda Y, Sato K, Yokoji M, Tabeta K, Nakajima T, Yamazaki K
- Organizer
  95th General Session & Exhibition of the IADR
- Place of Presentation
  米国サンフランシスコ
- Year and Date
  2017-03-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11827
[Presentation] 細菌抗原によるPCSK9産生の誘導機構2016
- Author(s)
  横地麻衣, 多部田康一, 宮澤春菜, 野中由香莉, 高橋直紀, 松田由実, 佐藤圭祐, 山田実生, 伊藤晴江, 中島貴子, 山崎和久
- Organizer
  日本歯科保存学会2016年度秋季学術大会
- Place of Presentation
  キッセイ文化ホール（長野県松本市）
- Year and Date
  2016-10-28
- Data Source
  KAKENHI-PROJECT-15H05052
[Presentation] Neuronal TRPV1 activation regulates alveolar bone resorption by osteoclasts via CGRP2015
- Author(s)
  Takahashi N, Matsuda Y, Sato K, Tabeta K, Yamazaki K
- Organizer
  63nd Annual meeting of JADR
- Place of Presentation
  福岡国際会議場(福岡県福岡市)
- Year and Date
  2015-10-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26861808
[Presentation] Neuronal TRPV1 prevents alveolar bone resorption in experimental periodontitis mice model.2015
- Author(s)
  Takahashi N, Matsuda Y, Sato K, Yamada H, Tabeta K, Yamazaki K
- Organizer
  11th Asian Pacific Society of Periodontology Meeting
- Place of Presentation
  Bali (Indonesia)
- Year and Date
  2015-10-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26861808
[Presentation] 歯肉上皮細胞におけるカプサイシン受容体TRPV1の発現および機能解析2014
- Author(s)
  高橋直紀、松田由実、山田ひとみ、中島貴子、多部田康一、村上伸也、山崎和久
- Organizer
  日本歯科保存学会2014年度春季学術大会（第140回）
- Place of Presentation
  大津市
- Year and Date
  2014-06-19
- Data Source
  KAKENHI-PROJECT-26861808
[Presentation] TRPV1 Signaling Accelerates Cell Proliferation of Gingival Epithelial Cells.
- Author(s)
  Takahashi N, Matsuda Y, Tabeta K, Yamazaki K
- Organizer
  92nd General session of the IADR
- Place of Presentation
  Cape Town
- Year and Date
  2014-06-25 – 2014-06-28
- Data Source
  KAKENHI-PROJECT-26861808

1. KOICHI TABETA (20401763)

# of Collaborated Projects: 5 results

# of Collaborated Products: 9 results
2. 寺尾豊 (50397717)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. 野中由香莉 (40710520)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 藤本啓二 (70229045)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. YAMAZAKI Kazuhisa (00182478)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
6. 両角俊哉 (20444151)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 小松康高 (40422597)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 谷口正之 (00163634)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 片倉響子 (70423788)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YAMADA Hitomi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. MATSUDA Yumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. YAMAMOTO Reiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 加来賢

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 大野博司

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
15. 大野欽司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 加藤完

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
17. 中島貴子

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
18. 野杁由一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takahashi Naoki 高橋 直紀

Research Projects

Research Products

Co-Researchers

Peptide drugs derived from food material for periodontal disease preventing flail and AMROngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

口腔－腸管連関の新展開：嚥下された歯周病原細菌は腸炎を悪化させるか？Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Therapeutic biofilmによる歯周病・根面う蝕治療アプローチの転換Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

TRPチャネルタンパクによる自然免疫チューニング機構の解明と歯周炎治療への応用Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

スケーリング後菌血症に対する高齢者生体応答の解析と光治療による予防法の確立Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

歯周炎病態形成におけるTRPチャネルを介した神経－骨代謝ネットワークの解明Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Vaccines against periodontitis using DNA ORIGAMI and imidazoquinolines

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The Effect of TRPV1 channel in the pathogenesis of periodontitis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Increased serum PCSK9, a potential biomarker to screen for periodontitis, and decreased total bilirubin associated with probing depth in a Japanese community survey2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An ENU-induced splice site mutation of mouse Col1a1 causing recessive osteogenesis imperfecta and revealing a novel splicing rescue2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Aggravation of collagen-induced arthritis by orally administered Porphyromonas gingivalis through modulation of the gut microbiota and gut immune system2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Brazilian propolis mitigates impaired glucose and lipid metabolism in experimental periodontitis in mice.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Neuronal TRPV1 activation regulates alveolar bone resorption by suppressing osteoclastogenesis via CGRP2016

Author(s)

Journal Title

Takahashi Naoki 高橋直紀