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Kishimoto Hisanao  岸本 久直

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KISHIMOTO Hisanao  岸本 久直

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Researcher Number 80723600
Other IDs
Affiliation (Current) 2025: 東京薬科大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help 2023 – 2024: 東京薬科大学, 薬学部, 講師
2021 – 2022: 東京薬科大学, 薬学部, 助教
2016 – 2018: 東京薬科大学, 薬学部, 助教
2014 – 2015: 東京薬科大学, 薬学部, 助手
Review Section/Research Field
Principal Investigator
Basic Section 47060:Clinical pharmacy-related / Medical pharmacy
Except Principal Investigator
Basic Section 47060:Clinical pharmacy-related
Keywords
Principal Investigator
粘液層 / 中分子薬 / Mucin / 薬物吸収 / 膜結合型mucin / mucin / 非攪拌水層 / Mucinase / 吸収改善 / ゲノム編集 … More / 糖鎖 / 遺伝子編集 / mucin型糖鎖 / 脂溶性抗がん剤 / Mucin型糖鎖 / Mucin‐薬物相互作用 / 蛋白質 / 生体分子 / 薬学 / 相互作用 / 抗がん剤 / 腸管吸収 / MUC1 / 受動拡散 / 吸収促進剤 / 脂溶性薬物 / 一酸化窒素 / 吸収促進 / 消化管吸収 … More
Except Principal Investigator
トランスポーター / オリゴペプチドトランスポーター / 側底膜 / 促進拡散 / 小腸上皮細胞 / 機能制御 / 消化管上皮細胞 / 創薬モダリティ / SLC46A3 / リソソーム / エンドサイトーシス / 消化管 / 薬物動態 / 吸収 / 核酸 / 輸送 / ヌクレオシド / CD147 / 有機アニオン / オロト酸 / SLC16A5/MCT6 Less
  • Research Projects

    (8 results)
  • Research Products

    (64 results)
  • Co-Researchers

    (3 People)
  •  Elucidation of the molecular mechanism of Mucin-medium molecule drug interactionPrincipal Investigator

    • Principal Investigator
      岸本 久直
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Tokyo University of Pharmacy and Life Science
  •  Development of drug delivery technology using lysosomal transporters

    • Principal Investigator
      井上 勝央
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Tokyo University of Pharmacy and Life Science
  •  医薬品の吸収改善を目指すオリゴペプチドトランスポーターEOPTsの分子制御機構解明

    • Principal Investigator
      樋口 慧
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Tokyo University of Pharmacy and Life Science
  •  Absorption mechanism of nucleosides and their analogs in the gastrointestinal tract

    • Principal Investigator
      Inoue Katsuhisa
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Tokyo University of Pharmacy and Life Science
  •  Identification of novel equilibrative oligopeptide transporters that may regulate drug absorption in the gastrointestinal tract

    • Principal Investigator
      Higuchi Kei
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Tokyo University of Pharmacy and Life Science
  •  Evaluation of the molecular mechanism of membrane-bound mucins in intestinal drug absorption.Principal Investigator

    • Principal Investigator
      Kishimoto Hisanao
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Tokyo University of Pharmacy and Life Science
  •  Elucidation of the molecular mechanism and functions of mucus-glycoprotein in intestinal drug absorption.Principal Investigator

    • Principal Investigator
      Kishimoto Hisanao
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      Tokyo University of Pharmacy and Life Science
  •  Elucidation of the molecular mechanism of unstirred water layerPrincipal Investigator

    • Principal Investigator
      KISHIMOTO Hisanao
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Tokyo University of Pharmacy and Life Science

All 2024 2023 2022 2021 2019 2018 2017 2016 2015 Other

All Journal Article Presentation

  • [Journal Article] The Use of Carboxyfluorescein Reveals the Transport Function of MCT6/SLC16A5 Associated with CD147 as a Chloride-Sensitive Organic Anion Transporter in Mammalian Cells2024

    • Author(s)
      Sugiyama K, Shimano H, Takahashi M, Shimura Y, Shimura A, Furuya T, Tomabechi R, Shirasaka Y, Higuchi K, Kishimoto H, Inoue K
    • Journal Title

      Journal of Pharmaceutical Sciences

      Volume: 113 Issue: 4 Pages: 1113-1120

    • DOI

      10.1016/j.xphs.2023.12.023

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K06678
  • [Journal Article] Monocarboxylate Transporter 13 (MCT13/SLC16A13) Functions as a Novel Plasma Membrane Oligopeptide Transporter2023

    • Author(s)
      Higuchi K, Kunieda M, Sugiyama K, Tomabechi R, Kishimoto H, Inoue K
    • Journal Title

      Nutrients

      Volume: 15 Issue: 16 Pages: 3527-3527

    • DOI

      10.3390/nu15163527

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K06678, KAKENHI-PROJECT-21K06694
  • [Journal Article] Macrolide and Ketolide Antibiotics Inhibit the Cytotoxic Effect of Trastuzumab Emtansine in HER2-Positive Breast Cancer Cells: Implication of a Potential Drug-ADC Interaction in Cancer Chemotherapy2023

    • Author(s)
      Kiyomiya K, Tomabechi R, Saito N, Watai K, Takada T, Shirasaka Y, Kishimoto H, Higuchi K, Inoue K
    • Journal Title

      Molecular Pharmaceutics

      Volume: 20 Issue: 12 Pages: 6130-6139

    • DOI

      10.1021/acs.molpharmaceut.3c00490

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K06678, KAKENHI-PROJECT-20H00568
  • [Journal Article] Mammalian monocarboxylate transporter 7 (MCT7/Slc16a6) is a novel facilitative taurine transporter2022

    • Author(s)
      Higuchi K, Sugiyama K, Tomabechi R, Kishimoto H, Inoue K
    • Journal Title

      J Biol Chem

      Volume: 298 Issue: 4 Pages: 101800-101800

    • DOI

      10.1016/j.jbc.2022.101800

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K06678
  • [Journal Article] Identification of 5-Carboxyfluorescein as a Probe Substrate of SLC46A3 and Its Application in a Fluorescence-Based In Vitro Assay Evaluating the Interaction with SLC46A32022

    • Author(s)
      Tomabechi Ryuto、Miyasato Miki、Sato Taeka、Takada Tappei、Higuchi Kei、Kishimoto Hisanao、Shirasaka Yoshiyuki、Inoue Katsuhisa
    • Journal Title

      Molecular Pharmaceutics

      Volume: 20 Issue: 1 Pages: 491-499

    • DOI

      10.1021/acs.molpharmaceut.2c00741

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07165, KAKENHI-PROJECT-21K06678, KAKENHI-PROJECT-20H00568
  • [Journal Article] SLC46A3 is a lysosomal proton-coupled steroid conjugate and bile acid transporter involved in transport of active catabolites of T-DM12022

    • Author(s)
      Tomabechi Ryuto、Kishimoto Hisanao、Sato Taeka、Saito Naoki、Kiyomiya Keisuke、Takada Tappei、Higuchi Kei、Shirasaka Yoshiyuki、Inoue Katsuhisa
    • Journal Title

      PNAS Nexus

      Volume: 1 Issue: 3

    • DOI

      10.1093/pnasnexus/pgac063

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07165, KAKENHI-PROJECT-21K06678, KAKENHI-PROJECT-20H00568
  • [Journal Article] The Glycosylated N-Terminal Domain of MUC1 Is Involved in Chemoresistance by Modulating Drug Permeation Across the Plasma Membrane2022

    • Author(s)
      Miyazaki Kaori、Kishimoto Hisanao、Kobayashi Hanai、Suzuki Ayaka、Higuchi Kei、Shirasaka Yoshiyuki、Inoue Katsuhisa
    • Journal Title

      Molecular Pharmacology

      Volume: 103 Issue: 3 Pages: 166-175

    • DOI

      10.1124/molpharm.122.000597

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K07165, KAKENHI-PROJECT-21K06695
  • [Journal Article] Utilization of Sodium Nitroprusside as an Intestinal Permeation Enhancer for Lipophilic Drug Absorption Improvement in the Rat Proximal Intestine2021

    • Author(s)
      Kishimoto Hisanao、Miyazaki Kaori、Tedzuka Hiroshi、Ozawa Ryosuke、Kobayashi Hanai、Shirasaka Yoshiyuki、Inoue Katsuhisa
    • Journal Title

      Molecules

      Volume: 26 Issue: 21 Pages: 6396-6396

    • DOI

      10.3390/molecules26216396

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07165, KAKENHI-PROJECT-21K06678, KAKENHI-PROJECT-21K06695
  • [Journal Article] Kishimoto H, Miyazaki K, Takizawa Y, Shirasaka Y, Inoue K2016

    • Author(s)
      Absorption-enhancing effect of nitric oxide on the absorption of hydrophobic drugs in rat duodenum.
    • Journal Title

      J Pharm Sci

      Volume: 105 Issue: 2 Pages: 729-733

    • DOI

      10.1002/jps.24677

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K08082, KAKENHI-PROJECT-26460208
  • [Presentation] 乳がんに高発現する新規抗がん剤耐性トランスポーター2024

    • Author(s)
      國枝 美里、樋口 慧、大塚 唯斗、岸本 久直、井上 勝央
    • Organizer
      日本薬学会144年会
    • Data Source
      KAKENHI-PROJECT-21K06694
  • [Presentation] マクロライド系抗菌薬がトラスツズマブエムタンシンの殺細胞効果に与える影響2023

    • Author(s)
      清宮啓介、苫米地隆人、齊藤直希、渡井健太、高田龍平、白坂善之、 岸本久直、樋口 慧、井上勝央
    • Organizer
      日本薬学会第144年会
    • Data Source
      KAKENHI-PROJECT-21K06678
  • [Presentation] 脂溶性抗がん剤の細胞膜透過性に対するムチン型糖鎖の影響2023

    • Author(s)
      岸本 久直、伊勢 大地、鈴木 彩佳、宮崎 歌織、樋口 慧、井上 勝央
    • Organizer
      第67回薬学会関東支部会
    • Data Source
      KAKENHI-PROJECT-21K06695
  • [Presentation] アクセサリータンパク質によるSlc16a6/MCT7機能制御2023

    • Author(s)
      樋口 慧、國枝美里、岸本久直、井上勝央
    • Organizer
      第67回薬学会関東支部会
    • Data Source
      KAKENHI-PROJECT-21K06678
  • [Presentation] Impact of genetic polymorphisms in SLC46A3 on the transport function and efficacy of trastuzumab emtansine2023

    • Author(s)
      N. Saito, R. Tomabechi, Y. Kawakita, K. Kiyomiya, H. Kishimoto, K. Higuchi, K. Inoue
    • Organizer
      The international joint meeting of the 23rd International Conference on Cytochrome P450 (ICCP450) and the 38th Annual Meeting of the Japanese Society for the Study of Xenobiotics (JSSX)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06678
  • [Presentation] モノカルボン酸トランスポーター6(MCT6)の輸送解析2023

    • Author(s)
      杉山滉基、嶋野ひろ恵、樋口 慧、志村優太、岸本久直、井上勝央
    • Organizer
      日本薬剤学会第38年会
    • Data Source
      KAKENHI-PROJECT-21K06678
  • [Presentation] Trastuzumab emtansineの有効性に影響を及ぼすSLC46A3遺伝子多型の探索2023

    • Author(s)
      齊藤直希、苫米地隆人、川喜多佑香、清宮啓介、岸本久直、樋口 慧、井上勝央
    • Organizer
      日本薬学会第144年会
    • Data Source
      KAKENHI-PROJECT-21K06678
  • [Presentation] 蛍光基質を用いたSLC46A3機能評価系の構築と新規基質探索への応用2023

    • Author(s)
      苫米地隆人、井上勝央、宮里美希、佐藤妙華、高田龍平、樋口 慧、岸本久直、白坂善之
    • Organizer
      日本薬剤学会第38年会
    • Data Source
      KAKENHI-PROJECT-21K06678
  • [Presentation] アクセサリータンパク質によるSlc16a6/MCT7機能制御2023

    • Author(s)
      樋口 慧、國枝 美里、岸本 久直、井上 勝央
    • Organizer
      第67回日本薬学会関東支部大会
    • Data Source
      KAKENHI-PROJECT-21K06694
  • [Presentation] ムチン型糖鎖合成酵素阻害剤talniflumateは脂溶性抗がん剤の細胞膜透過を増強する2023

    • Author(s)
      伊勢 大地、岸本 久直、鈴木 彩佳、宮崎 歌織、樋口 慧、井上 勝央
    • Organizer
      日本薬剤学会第38年会
    • Data Source
      KAKENHI-PROJECT-21K06695
  • [Presentation] Methotrexate resistance by Slc16a6/MCT7 in cancer cells2023

    • Author(s)
      Misato Kunieda, Yuito Otsuka, Kei Higuchi, Hisanao Kishimoto, Katsuhisa Inoue
    • Organizer
      2023 International Joint Meeting of the 23rd International Conference on Cytochrome P450 and the 38th Annual Meeting of the Japanese Society for the Study of Xenobiotics
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06694
  • [Presentation] Regulation of localization and function of MCT7 by ancillary proteins CD147 and GP702023

    • Author(s)
      Kei Higuchi, Misato Kunieda, Hisanao Kishimoto, Katsuhisa Inoue
    • Organizer
      2023 International Joint Meeting of the 23rd International Conference on Cytochrome P450 and the 38th Annual Meeting of the Japanese Society for the Study of Xenobiotics
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06694
  • [Presentation] Substrate specificity of monocarboxylate transporter 6 (MCT6)2023

    • Author(s)
      K. Sugiyama, H. Shimano, K. Higuchi, H. Kishimoto, K. Inoue
    • Organizer
      The international joint meeting of the 23rd International Conference on Cytochrome P450 (ICCP450) and the 38th Annual Meeting of the Japanese Society for the Study of Xenobiotics (JSSX)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06678
  • [Presentation] Regulation of localization and function of MCT7 by ancillary proteins CD147 and GP702023

    • Author(s)
      K. Higuchi, M. Kunieda, H. Kishimoto, K. Inoue
    • Organizer
      The international joint meeting of the 23rd International Conference on Cytochrome P450 (ICCP450) and the 38th Annual Meeting of the Japanese Society for the Study of Xenobiotics (JSSX)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06678
  • [Presentation] SLC46A3遺伝子多型が輸送機能とトラスツズマブエムタンシンの殺細胞効果へ与える影響2023

    • Author(s)
      齊藤直希、苫米地隆人、川喜多佑香、清宮啓介、岸本久直、樋口 慧、井上勝央
    • Organizer
      日本薬剤学会第38年会
    • Data Source
      KAKENHI-PROJECT-21K06678
  • [Presentation] Inhibition of mucin-type glycosyltransferase enhances membrane permeation of lipophilic anticancer drugs2023

    • Author(s)
      H. Kishimoto, D. Ise, A. Suzuki, K. Miyazaki, K. Higuchi, K. Inoue
    • Organizer
      The international joint meeting of the 23rd International Conference on Cytochrome P450 (ICCP450) and the 38th Annual Meeting of the Japanese Society for the Study of Xenobiotics (JSSX)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06695
  • [Presentation] Methotrexate resistance by Slc16a6/MCT7 in cancer cells2023

    • Author(s)
      M. Kunieda, Y. Otsuka, K. Higuchi, H. Kishimoto, K. Inoue
    • Organizer
      The international joint meeting of the 23rd International Conference on Cytochrome P450 (ICCP450) and the 38th Annual Meeting of the Japanese Society for the Study of Xenobiotics (JSSX)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06678
  • [Presentation] 蛍光プローブを用いたMCT6/SLC16A5の基質特異性の評価2023

    • Author(s)
      杉山滉基、嶋野ひろ恵、樋口 慧、岸本久直、井上勝央
    • Organizer
      日本薬学会第144年会
    • Data Source
      KAKENHI-PROJECT-21K06678
  • [Presentation] オーファントランスポーターSLC46A3の機能同定2022

    • Author(s)
      苫米地 隆人、岸本 久直、佐藤 妙華、齊藤 直希、清宮 啓介、高田 龍平、樋口 慧、白坂 善之、井上 勝央
    • Organizer
      第16回トランスポーター研究会年会
    • Data Source
      KAKENHI-PROJECT-21K06678
  • [Presentation] 中分子環状ペプチドと高分子ゲル形成ムチン間での相互作用2022

    • Author(s)
      岸本 久直、C Ridley、D J. Thornton
    • Organizer
      日本薬剤学会第37年会
    • Data Source
      KAKENHI-PROJECT-21K06695
  • [Presentation] 脂溶性薬物の細胞膜透過性に対する糖鎖合成酵素阻害剤の効果2022

    • Author(s)
      岸本 久直、鈴木 彩佳、宮崎 歌織、樋口 慧、井上 勝央
    • Organizer
      第66回日本薬学会関東支部大会
    • Data Source
      KAKENHI-PROJECT-21K06695
  • [Presentation] リソソーム膜タンパク質SLC46A3の機能同定2022

    • Author(s)
      苫米地 隆人、岸本 久直、佐藤 妙華、齊藤 直希、清宮 啓介、高田 龍平、樋口 慧、白坂 善之、井上 勝央
    • Organizer
      日本薬剤学会第37年会
    • Data Source
      KAKENHI-PROJECT-21K06678
  • [Presentation] The extracellular domain of MUC1 confers anticancer drug resistance and modulates drug permeability.2022

    • Author(s)
      H Kishimoto, A Suzuki, K Miyazaki,K Higuchi, K Inoue
    • Organizer
      日本薬物動態学会第37年会
    • Data Source
      KAKENHI-PROJECT-21K06695
  • [Presentation] SLC46A3の蛍光基質の新規同定及び基質/阻害剤探索への応用2022

    • Author(s)
      苫米地 隆人、宮里 美希、佐藤 妙華、高田 龍平、樋口 慧、岸本 久直、白坂 善之、井上 勝央
    • Organizer
      日本薬学会第143年会
    • Data Source
      KAKENHI-PROJECT-21K06678
  • [Presentation] Functional identification of SLC46A3 and its implication in the efficacy of trastuzumab emtansine2022

    • Author(s)
      Ryuto Tomabechi, Hisanao Kishimoto, Taeka Sato, Naoki Saito, Keisuke Kiyomiya, Tappei Takada, Kei Higuchi, Yoshiyuki Shirasaka, Katsuhisa Inoue
    • Organizer
      日本薬物動態学会第37年会
    • Data Source
      KAKENHI-PROJECT-21K06678
  • [Presentation] Effect of talniflumate, a glycosyltransferase inhibitor, on mucus barrier function2022

    • Author(s)
      H Kishimoto, A Suzuki, K Miyazaki,K Higuchi, K Inoue
    • Organizer
      第16回次世代を担う若手医療薬科学シンポジウム
    • Data Source
      KAKENHI-PROJECT-21K06695
  • [Presentation] オーファントランスポーター MCT7/Slc16a6の内因性基質の同定2022

    • Author(s)
      國枝 美里、樋口 慧、岸本 久直、井上 勝央
    • Organizer
      日本薬剤学会第37年会
    • Data Source
      KAKENHI-PROJECT-21K06678
  • [Presentation] リソソームトランスポーターSLC46A3を介したトラスツズマブ エムタンシン-薬物相互作用に関する検討2022

    • Author(s)
      苫米地 隆人、岸本 久直、佐藤 妙華、齊藤 直希、清宮 啓介、高田 龍平、樋口 慧、白坂 善之、井上 勝央
    • Organizer
      医療薬学フォーラム2022 第30回クリニカルファーマシーシンポジウム
    • Data Source
      KAKENHI-PROJECT-21K06678
  • [Presentation] MCT6/SLC16A5の細胞内局在の解析と内因性基質の探索2022

    • Author(s)
      杉山滉基、樋口慧、志村優太、岸本久直、井上勝央
    • Organizer
      日本薬学会第141年会
    • Data Source
      KAKENHI-PROJECT-21K06678
  • [Presentation] モノカルボン酸トランスポーター6(MCT6)の輸送解析2022

    • Author(s)
      杉山 滉基、嶋野 ひろ恵、樋口 慧、志村 優太、岸本 久直、井上 勝央
    • Organizer
      日本薬剤学会第37年会
    • Data Source
      KAKENHI-PROJECT-21K06678
  • [Presentation] MCT6/SLC16A5 is a chloride sensitive organic anionic transporter2022

    • Author(s)
      Koki Sugiyama, Hiroko Shimano, Kei Higuchi, Hisanao Kishimoto, Katsuhisa Inoue
    • Organizer
      日本薬物動態学会第37年会
    • Data Source
      KAKENHI-PROJECT-21K06678
  • [Presentation] 抗がん剤の細胞内移行性に与える糖鎖合成酵素阻害剤の影響2022

    • Author(s)
      鈴木 彩佳、岸本 久直、宮崎 歌織、樋口 慧、井上 勝央
    • Organizer
      日本薬剤学会第37年会
    • Data Source
      KAKENHI-PROJECT-21K06695
  • [Presentation] Identification of an endogenous substrate of MCT62021

    • Author(s)
      Koki Sugiyama, Kei Higuchi, Yuta Shimura, Hisanao Kishimoto, Katsuhisa Inoue
    • Organizer
      日本薬物動態学会第36回年会
    • Data Source
      KAKENHI-PROJECT-21K06678
  • [Presentation] 気液界面を模倣する疎水性溶媒を用いた上皮系培養細胞における粘液産生と細胞形態への影響2021

    • Author(s)
      鷹野 遥、岸本 久直、樋口 慧、井上 勝央
    • Organizer
      日本薬剤学会第36年会
    • Data Source
      KAKENHI-PROJECT-21K06695
  • [Presentation] 抗がん剤の細胞膜透過性に対するmucin分子の抑制効果2019

    • Author(s)
      宮崎歌織、岸本久直、藤澤弘、白坂善之、井上勝央
    • Organizer
      日本薬学会 第139年会
    • Data Source
      KAKENHI-PROJECT-17K15522
  • [Presentation] Effect of mucus layer on the transcellular absorption of lipophilic drugs in rat small intestine2018

    • Author(s)
      Hisanao Kishimoto, Kaori Miyazaki, Yoshiyuki Shirasaka, Katsuhisa Inoue
    • Organizer
      Experimental Biology 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15522
  • [Presentation] 薬物の細胞膜透過過程における粘液層構成タンパク質MUC1の影響2018

    • Author(s)
      宮崎歌織、岸本久直、大森萌子、白坂善之、井上勝央
    • Organizer
      日本薬剤学会 第33年会
    • Data Source
      KAKENHI-PROJECT-17K15522
  • [Presentation] The relation between regional distribution of mucin molecules and intestinal drug absorption in rat small intestine2018

    • Author(s)
      Kaori Miyazaki, Hisanao Kishimoto, Yoshiyuki Shirasaka, Katsuhisa Inoue
    • Organizer
      The 2nd Workshop for Japan-Korea Young Scientists on Pharmaceutics
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15522
  • [Presentation] Evaluation of the transcellular transport of hydrophobic drugs in MUC1-knockout MDCKII cells2018

    • Author(s)
      Hisanao Kishimoto, Kaori Miyazaki, Yoshiyuki Shirasaka, Katsuhisa Inoue
    • Organizer
      第33回日本薬物動態学会/第22回MDOシンポジウム合同国際学会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15522
  • [Presentation] 内因性MUC1ノックアウトMDCKII細胞を用いた脂溶性薬物の経細胞輸送評価2018

    • Author(s)
      岸本久直、宮崎歌織、白坂善之、井上勝央
    • Organizer
      第40回 生体膜と薬物の相互作用シンポジウム
    • Data Source
      KAKENHI-PROJECT-17K15522
  • [Presentation] MUC1 is involved in the membrane permeation of hydrophobic drugs2018

    • Author(s)
      Kaori Miyazaki, Hisanao Kishimoto, Hiroshi Fujisawa, Yoshiyuki Shirasaka, Katsuhisa Inoue
    • Organizer
      第33回日本薬物動態学会/第22回MDOシンポジウム合同国際学会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15522
  • [Presentation] 薬物の生体膜透過機構における膜結合型mucinの影響2018

    • Author(s)
      宮崎歌織、岸本久直、白坂善之、井上勝央
    • Organizer
      第40回 生体膜と薬物の相互作用シンポジウム
    • Data Source
      KAKENHI-PROJECT-17K15522
  • [Presentation] 薬物の腸管吸収における粘液層構成タンパク質mucinの影響2018

    • Author(s)
      岸本久直
    • Organizer
      第3回トランスポーター研究会関東部会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K15522
  • [Presentation] 脂溶性薬物の腸管吸収における薬物-粘液間相互作用の評価2018

    • Author(s)
      田野文音、岸本久直、宮崎歌織、大森萌子、白坂善之、井上勝央
    • Organizer
      日本薬剤学会 第33年会
    • Data Source
      KAKENHI-PROJECT-17K15522
  • [Presentation] 薬物の経粘膜透過に与える粘液層の影響とその分子メカニズム解明に向けたアプローチ2017

    • Author(s)
      岸本久直、宮崎歌織、村谷美穂、白坂善之、井上勝央
    • Organizer
      第39回生体膜と薬物の相互作用シンポジウム
    • Data Source
      KAKENHI-PROJECT-17K15522
  • [Presentation] 脂溶性薬物の腸管膜透過性に及ぼす腸管粘液の影響及び mucin 発現解析2017

    • Author(s)
      宮崎 歌織、岸本 久直、村谷 美穂、田野 文音、白坂 善之、井上 勝央
    • Organizer
      日本薬剤学会第32年会
    • Place of Presentation
      大宮ソニックシティ(大宮)
    • Year and Date
      2017-05-11
    • Data Source
      KAKENHI-PROJECT-26460208
  • [Presentation] 脂溶性薬物の腸管膜透過性に及ぼす腸管粘液の影響及びmucin発現解析2017

    • Author(s)
      宮崎歌織、岸本久直、村谷美穂、田野文音、白坂善之、井上勝央
    • Organizer
      日本薬剤学会第32年会
    • Data Source
      KAKENHI-PROJECT-17K15522
  • [Presentation] Regional distribution of mucin molecules in rat small intestine2017

    • Author(s)
      宮崎歌織、岸本久直、白坂善之、井上勝央
    • Organizer
      日本薬物動態学会 第32回年会
    • Data Source
      KAKENHI-PROJECT-17K15522
  • [Presentation] Effects of Mucosal Protective Agents on the Expression Levels of Mucus Layer Components in Human Intestinal Cell Lines2016

    • Author(s)
      H. Kishimoto, N. Murata, M. Muratani, K. Miyazaki, Y. Shirasaka and K. Inoue.
    • Organizer
      日本薬物動態学会第31回年会
    • Place of Presentation
      キッセイ文化ホール(長野県松本文化会館)/ 松本市総合体育館(松本)
    • Year and Date
      2016-10-13
    • Data Source
      KAKENHI-PROJECT-26460208
  • [Presentation] 経粘膜透過を介した薬物の腸管吸収に及ぼす粘液層の影響2016

    • Author(s)
      宮崎歌織、岸本久直、村谷美穂、白坂善之、井上勝央
    • Organizer
      日本薬剤学会 第31年会
    • Place of Presentation
      長良川国際会議場(岐阜)
    • Year and Date
      2016-05-19
    • Data Source
      KAKENHI-PROJECT-26460208
  • [Presentation] 一酸化窒素による難吸収性薬物の腸管促進効果 に関する研究 に関する研究 に関する研究2016

    • Author(s)
      岸本久直
    • Organizer
      第33回製剤設計研究会
    • Place of Presentation
      東京薬科大学(東京)
    • Year and Date
      2016-09-10
    • Invited
    • Data Source
      KAKENHI-PROJECT-26460208
  • [Presentation] 経粘膜透過を介した薬物の腸管吸収に及ぼす粘液層の影響2016

    • Author(s)
      宮崎歌織、岸本久直、村谷美穂、白坂善之、井上勝央
    • Organizer
      日本薬剤学会第31年会
    • Place of Presentation
      長良川国際会議場(岐阜)
    • Year and Date
      2016-05-19
    • Data Source
      KAKENHI-PROJECT-26460208
  • [Presentation] Effect of nitric oxide on the intestinal absorption of lipophilic drugs in rat2015

    • Author(s)
      Hisanao Kishimoto, Kaori Miyazaki, Yusuke Takizawa, Yoshiyuki Shirasaka, Katsuhisa Inoue
    • Organizer
      日本薬物動態学会 第30回年会
    • Place of Presentation
      タワーホール船堀(東京)
    • Year and Date
      2015-11-12
    • Data Source
      KAKENHI-PROJECT-26460208
  • [Presentation] 経細胞輸送を介した薬物の消化管吸収に及ぼす一酸化窒素の影響2015

    • Author(s)
      宮崎歌織、岸本久直、瀧沢裕輔、白坂善之、井上勝央
    • Organizer
      日本薬剤学会 第30年会
    • Place of Presentation
      長崎ブリックホール(長崎)
    • Year and Date
      2015-05-21
    • Data Source
      KAKENHI-PROJECT-26460208
  • [Presentation] 経細胞輸送を介した薬物の消化管吸収に及ぼす一酸化窒素の影響

    • Author(s)
      宮崎 歌織、岸本 久直、瀧沢 裕輔、白坂 善之、井上 勝央
    • Organizer
      日本薬剤学会第30年会
    • Place of Presentation
      長崎ブリックホール
    • Year and Date
      2015-05-21 – 2015-05-23
    • Data Source
      KAKENHI-PROJECT-26460208
  • 1.  Inoue Katsuhisa (50315892)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 44 results
  • 2.  Higuchi Kei (10625304)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 37 results
  • 3.  SHIRASAKA Yoshiyuki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results

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