Kishimoto Hisanao 岸本久直

… Alternative Names

KISHIMOTO Hisanao 岸本久直

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Researcher Number	80723600
Other IDs
Affiliation (Current)	2025: 東京薬科大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2023 – 2024: 東京薬科大学, 薬学部, 講師 2021 – 2022: 東京薬科大学, 薬学部, 助教 2016 – 2018: 東京薬科大学, 薬学部, 助教 2014 – 2015: 東京薬科大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / Medical pharmacy Except Principal Investigator Basic Section 47060:Clinical pharmacy-related
Keywords	Principal Investigator 粘液層 / 中分子薬 / Mucin / 薬物吸収 / 膜結合型mucin / mucin / 非攪拌水層 / Mucinase / 吸収改善 / ゲノム編集 … More / 糖鎖 / 遺伝子編集 / mucin型糖鎖 / 脂溶性抗がん剤 / Mucin型糖鎖 / Mucin‐薬物相互作用 / 蛋白質 / 生体分子 / 薬学 / 相互作用 / 抗がん剤 / 腸管吸収 / MUC1 / 受動拡散 / 吸収促進剤 / 脂溶性薬物 / 一酸化窒素 / 吸収促進 / 消化管吸収 … More Except Principal Investigator トランスポーター / オリゴペプチドトランスポーター / 側底膜 / 促進拡散 / 小腸上皮細胞 / 機能制御 / 消化管上皮細胞 / 創薬モダリティ / SLC46A3 / リソソーム / エンドサイトーシス / 消化管 / 薬物動態 / 吸収 / 核酸 / 輸送 / ヌクレオシド / CD147 / 有機アニオン / オロト酸 / SLC16A5/MCT6 Less

Elucidation of the molecular mechanism of Mucin-medium molecule drug interactionPrincipal Investigator
- Principal Investigator
  
  岸本久直
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
Development of drug delivery technology using lysosomal transporters
- Principal Investigator
  
  井上勝央
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
医薬品の吸収改善を目指すオリゴペプチドトランスポーターEOPTsの分子制御機構解明
- Principal Investigator
  
  樋口慧
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
Absorption mechanism of nucleosides and their analogs in the gastrointestinal tract
- Principal Investigator
  
  Inoue Katsuhisa
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
Identification of novel equilibrative oligopeptide transporters that may regulate drug absorption in the gastrointestinal tract
- Principal Investigator
  
  Higuchi Kei
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
Evaluation of the molecular mechanism of membrane-bound mucins in intestinal drug absorption.Principal Investigator
- Principal Investigator
  
  Kishimoto Hisanao
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
Elucidation of the molecular mechanism and functions of mucus-glycoprotein in intestinal drug absorption.Principal Investigator
- Principal Investigator
  
  Kishimoto Hisanao
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
Elucidation of the molecular mechanism of unstirred water layerPrincipal Investigator
- Principal Investigator
  
  KISHIMOTO Hisanao
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science

All 2024 2023 2022 2021 2019 2018 2017 2016 2015 Other

All Journal Article Presentation

[Journal Article] The Use of Carboxyfluorescein Reveals the Transport Function of MCT6/SLC16A5 Associated with CD147 as a Chloride-Sensitive Organic Anion Transporter in Mammalian Cells2024
- Author(s)
  Sugiyama K, Shimano H, Takahashi M, Shimura Y, Shimura A, Furuya T, Tomabechi R, Shirasaka Y, Higuchi K, Kishimoto H, Inoue K
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 113 Issue: 4 Pages: 1113-1120
- DOI
  10.1016/j.xphs.2023.12.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06678
[Journal Article] Monocarboxylate Transporter 13 (MCT13/SLC16A13) Functions as a Novel Plasma Membrane Oligopeptide Transporter2023
- Author(s)
  Higuchi K, Kunieda M, Sugiyama K, Tomabechi R, Kishimoto H, Inoue K
- Journal Title
  
  Nutrients
  
  Volume: 15 Issue: 16 Pages: 3527-3527
- DOI
  10.3390/nu15163527
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06678, KAKENHI-PROJECT-21K06694
[Journal Article] Macrolide and Ketolide Antibiotics Inhibit the Cytotoxic Effect of Trastuzumab Emtansine in HER2-Positive Breast Cancer Cells: Implication of a Potential Drug-ADC Interaction in Cancer Chemotherapy2023
- Author(s)
  Kiyomiya K, Tomabechi R, Saito N, Watai K, Takada T, Shirasaka Y, Kishimoto H, Higuchi K, Inoue K
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 20 Issue: 12 Pages: 6130-6139
- DOI
  10.1021/acs.molpharmaceut.3c00490
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06678, KAKENHI-PROJECT-20H00568
[Journal Article] Mammalian monocarboxylate transporter 7 (MCT7/Slc16a6) is a novel facilitative taurine transporter2022
- Author(s)
  Higuchi K, Sugiyama K, Tomabechi R, Kishimoto H, Inoue K
- Journal Title
  
  J Biol Chem
  
  Volume: 298 Issue: 4 Pages: 101800-101800
- DOI
  10.1016/j.jbc.2022.101800
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06678
[Journal Article] Identification of 5-Carboxyfluorescein as a Probe Substrate of SLC46A3 and Its Application in a Fluorescence-Based In Vitro Assay Evaluating the Interaction with SLC46A32022
- Author(s)
  Tomabechi Ryuto、Miyasato Miki、Sato Taeka、Takada Tappei、Higuchi Kei、Kishimoto Hisanao、Shirasaka Yoshiyuki、Inoue Katsuhisa
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 20 Issue: 1 Pages: 491-499
- DOI
  10.1021/acs.molpharmaceut.2c00741
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07165, KAKENHI-PROJECT-21K06678, KAKENHI-PROJECT-20H00568
[Journal Article] SLC46A3 is a lysosomal proton-coupled steroid conjugate and bile acid transporter involved in transport of active catabolites of T-DM12022
- Author(s)
  Tomabechi Ryuto、Kishimoto Hisanao、Sato Taeka、Saito Naoki、Kiyomiya Keisuke、Takada Tappei、Higuchi Kei、Shirasaka Yoshiyuki、Inoue Katsuhisa
- Journal Title
  
  PNAS Nexus
  
  Volume: 1 Issue: 3
- DOI
  10.1093/pnasnexus/pgac063
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07165, KAKENHI-PROJECT-21K06678, KAKENHI-PROJECT-20H00568
[Journal Article] The Glycosylated N-Terminal Domain of MUC1 Is Involved in Chemoresistance by Modulating Drug Permeation Across the Plasma Membrane2022
- Author(s)
  Miyazaki Kaori、Kishimoto Hisanao、Kobayashi Hanai、Suzuki Ayaka、Higuchi Kei、Shirasaka Yoshiyuki、Inoue Katsuhisa
- Journal Title
  
  Molecular Pharmacology
  
  Volume: 103 Issue: 3 Pages: 166-175
- DOI
  10.1124/molpharm.122.000597
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07165, KAKENHI-PROJECT-21K06695
[Journal Article] Utilization of Sodium Nitroprusside as an Intestinal Permeation Enhancer for Lipophilic Drug Absorption Improvement in the Rat Proximal Intestine2021
- Author(s)
  Kishimoto Hisanao、Miyazaki Kaori、Tedzuka Hiroshi、Ozawa Ryosuke、Kobayashi Hanai、Shirasaka Yoshiyuki、Inoue Katsuhisa
- Journal Title
  
  Molecules
  
  Volume: 26 Issue: 21 Pages: 6396-6396
- DOI
  10.3390/molecules26216396
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07165, KAKENHI-PROJECT-21K06678, KAKENHI-PROJECT-21K06695
[Journal Article] Kishimoto H, Miyazaki K, Takizawa Y, Shirasaka Y, Inoue K2016
- Author(s)
  Absorption-enhancing effect of nitric oxide on the absorption of hydrophobic drugs in rat duodenum.
- Journal Title
  
  J Pharm Sci
  
  Volume: 105 Issue: 2 Pages: 729-733
- DOI
  10.1002/jps.24677
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08082, KAKENHI-PROJECT-26460208
[Presentation] 乳がんに高発現する新規抗がん剤耐性トランスポーター2024
- Author(s)
  國枝美里、樋口慧、大塚唯斗、岸本久直、井上勝央
- Organizer
  日本薬学会144年会
- Data Source
  KAKENHI-PROJECT-21K06694
[Presentation] マクロライド系抗菌薬がトラスツズマブエムタンシンの殺細胞効果に与える影響2023
- Author(s)
  清宮啓介、苫米地隆人、齊藤直希、渡井健太、高田龍平、白坂善之、岸本久直、樋口慧、井上勝央
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21K06678
[Presentation] 脂溶性抗がん剤の細胞膜透過性に対するムチン型糖鎖の影響2023
- Author(s)
  岸本久直、伊勢大地、鈴木彩佳、宮崎歌織、樋口慧、井上勝央
- Organizer
  第67回薬学会関東支部会
- Data Source
  KAKENHI-PROJECT-21K06695
[Presentation] アクセサリータンパク質によるSlc16a6/MCT7機能制御2023
- Author(s)
  樋口慧、國枝美里、岸本久直、井上勝央
- Organizer
  第67回薬学会関東支部会
- Data Source
  KAKENHI-PROJECT-21K06678
[Presentation] Impact of genetic polymorphisms in SLC46A3 on the transport function and efficacy of trastuzumab emtansine2023
- Author(s)
  N. Saito, R. Tomabechi, Y. Kawakita, K. Kiyomiya, H. Kishimoto, K. Higuchi, K. Inoue
- Organizer
  The international joint meeting of the 23rd International Conference on Cytochrome P450 (ICCP450) and the 38th Annual Meeting of the Japanese Society for the Study of Xenobiotics (JSSX)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06678
[Presentation] モノカルボン酸トランスポーター6（MCT6）の輸送解析2023
- Author(s)
  杉山滉基、嶋野ひろ恵、樋口慧、志村優太、岸本久直、井上勝央
- Organizer
  日本薬剤学会第38年会
- Data Source
  KAKENHI-PROJECT-21K06678
[Presentation] Trastuzumab emtansineの有効性に影響を及ぼすSLC46A3遺伝子多型の探索2023
- Author(s)
  齊藤直希、苫米地隆人、川喜多佑香、清宮啓介、岸本久直、樋口慧、井上勝央
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21K06678
[Presentation] 蛍光基質を用いたSLC46A3機能評価系の構築と新規基質探索への応用2023
- Author(s)
  苫米地隆人、井上勝央、宮里美希、佐藤妙華、高田龍平、樋口慧、岸本久直、白坂善之
- Organizer
  日本薬剤学会第38年会
- Data Source
  KAKENHI-PROJECT-21K06678
[Presentation] アクセサリータンパク質によるSlc16a6/MCT7機能制御2023
- Author(s)
  樋口　慧、國枝美里、岸本久直、井上勝央
- Organizer
  第67回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-21K06694
[Presentation] ムチン型糖鎖合成酵素阻害剤talniflumateは脂溶性抗がん剤の細胞膜透過を増強する2023
- Author(s)
  伊勢大地、岸本久直、鈴木彩佳、宮崎歌織、樋口慧、井上勝央
- Organizer
  日本薬剤学会第38年会
- Data Source
  KAKENHI-PROJECT-21K06695
[Presentation] Methotrexate resistance by Slc16a6/MCT7 in cancer cells2023
- Author(s)
  Misato Kunieda, Yuito Otsuka, Kei Higuchi, Hisanao Kishimoto, Katsuhisa Inoue
- Organizer
  2023 International Joint Meeting of the 23rd International Conference on Cytochrome P450 and the 38th Annual Meeting of the Japanese Society for the Study of Xenobiotics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06694
[Presentation] Regulation of localization and function of MCT7 by ancillary proteins CD147 and GP702023
- Author(s)
  Kei Higuchi, Misato Kunieda, Hisanao Kishimoto, Katsuhisa Inoue
- Organizer
  2023 International Joint Meeting of the 23rd International Conference on Cytochrome P450 and the 38th Annual Meeting of the Japanese Society for the Study of Xenobiotics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06694
[Presentation] Substrate specificity of monocarboxylate transporter 6 (MCT6)2023
- Author(s)
  K. Sugiyama, H. Shimano, K. Higuchi, H. Kishimoto, K. Inoue
- Organizer
  The international joint meeting of the 23rd International Conference on Cytochrome P450 (ICCP450) and the 38th Annual Meeting of the Japanese Society for the Study of Xenobiotics (JSSX)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06678
[Presentation] Regulation of localization and function of MCT7 by ancillary proteins CD147 and GP702023
- Author(s)
  K. Higuchi, M. Kunieda, H. Kishimoto, K. Inoue
- Organizer
  The international joint meeting of the 23rd International Conference on Cytochrome P450 (ICCP450) and the 38th Annual Meeting of the Japanese Society for the Study of Xenobiotics (JSSX)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06678
[Presentation] SLC46A3遺伝子多型が輸送機能とトラスツズマブエムタンシンの殺細胞効果へ与える影響2023
- Author(s)
  齊藤直希、苫米地隆人、川喜多佑香、清宮啓介、岸本久直、樋口慧、井上勝央
- Organizer
  日本薬剤学会第38年会
- Data Source
  KAKENHI-PROJECT-21K06678
[Presentation] Inhibition of mucin-type glycosyltransferase enhances membrane permeation of lipophilic anticancer drugs2023
- Author(s)
  H. Kishimoto, D. Ise, A. Suzuki, K. Miyazaki, K. Higuchi, K. Inoue
- Organizer
  The international joint meeting of the 23rd International Conference on Cytochrome P450 (ICCP450) and the 38th Annual Meeting of the Japanese Society for the Study of Xenobiotics (JSSX)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06695
[Presentation] Methotrexate resistance by Slc16a6/MCT7 in cancer cells2023
- Author(s)
  M. Kunieda, Y. Otsuka, K. Higuchi, H. Kishimoto, K. Inoue
- Organizer
  The international joint meeting of the 23rd International Conference on Cytochrome P450 (ICCP450) and the 38th Annual Meeting of the Japanese Society for the Study of Xenobiotics (JSSX)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06678
[Presentation] 蛍光プローブを用いたMCT6/SLC16A5の基質特異性の評価2023
- Author(s)
  杉山滉基、嶋野ひろ恵、樋口慧、岸本久直、井上勝央
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21K06678
[Presentation] オーファントランスポーターSLC46A3の機能同定2022
- Author(s)
  苫米地隆人、岸本久直、佐藤妙華、齊藤直希、清宮啓介、高田龍平、樋口慧、白坂善之、井上勝央
- Organizer
  第16回トランスポーター研究会年会
- Data Source
  KAKENHI-PROJECT-21K06678
[Presentation] 中分子環状ペプチドと高分子ゲル形成ムチン間での相互作用2022
- Author(s)
  岸本久直、C Ridley、D J. Thornton
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-21K06695
[Presentation] 脂溶性薬物の細胞膜透過性に対する糖鎖合成酵素阻害剤の効果2022
- Author(s)
  岸本久直、鈴木彩佳、宮崎歌織、樋口慧、井上勝央
- Organizer
  第66回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-21K06695
[Presentation] リソソーム膜タンパク質SLC46A3の機能同定2022
- Author(s)
  苫米地隆人、岸本久直、佐藤妙華、齊藤直希、清宮啓介、高田龍平、樋口慧、白坂善之、井上勝央
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-21K06678
[Presentation] The extracellular domain of MUC1 confers anticancer drug resistance and modulates drug permeability.2022
- Author(s)
  H Kishimoto, A Suzuki,　K Miyazaki,K Higuchi, K Inoue
- Organizer
  日本薬物動態学会第37年会
- Data Source
  KAKENHI-PROJECT-21K06695
[Presentation] SLC46A3の蛍光基質の新規同定及び基質/阻害剤探索への応用2022
- Author(s)
  苫米地隆人、宮里美希、佐藤妙華、高田龍平、樋口慧、岸本久直、白坂善之、井上勝央
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K06678
[Presentation] Functional identification of SLC46A3 and its implication in the efficacy of trastuzumab emtansine2022
- Author(s)
  Ryuto Tomabechi, Hisanao Kishimoto, Taeka Sato, Naoki Saito, Keisuke Kiyomiya, Tappei Takada, Kei Higuchi, Yoshiyuki Shirasaka, Katsuhisa Inoue
- Organizer
  日本薬物動態学会第37年会
- Data Source
  KAKENHI-PROJECT-21K06678
[Presentation] Effect of talniflumate, a glycosyltransferase inhibitor, on mucus barrier function2022
- Author(s)
  H Kishimoto, A Suzuki,　K Miyazaki,K Higuchi, K Inoue
- Organizer
  第16回次世代を担う若手医療薬科学シンポジウム
- Data Source
  KAKENHI-PROJECT-21K06695
[Presentation] オーファントランスポーター MCT7/Slc16a6の内因性基質の同定2022
- Author(s)
  國枝美里、樋口慧、岸本久直、井上勝央
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-21K06678
[Presentation] リソソームトランスポーターSLC46A3を介したトラスツズマブエムタンシン－薬物相互作用に関する検討2022
- Author(s)
  苫米地隆人、岸本久直、佐藤妙華、齊藤直希、清宮啓介、高田龍平、樋口慧、白坂善之、井上勝央
- Organizer
  医療薬学フォーラム2022 第30回クリニカルファーマシーシンポジウム
- Data Source
  KAKENHI-PROJECT-21K06678
[Presentation] MCT6/SLC16A5の細胞内局在の解析と内因性基質の探索2022
- Author(s)
  杉山滉基、樋口慧、志村優太、岸本久直、井上勝央
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-21K06678
[Presentation] モノカルボン酸トランスポーター6（MCT6）の輸送解析2022
- Author(s)
  杉山滉基、嶋野ひろ恵、樋口慧、志村優太、岸本久直、井上勝央
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-21K06678
[Presentation] MCT6/SLC16A5 is a chloride sensitive organic anionic transporter2022
- Author(s)
  Koki Sugiyama, Hiroko Shimano, Kei Higuchi, Hisanao Kishimoto, Katsuhisa Inoue
- Organizer
  日本薬物動態学会第37年会
- Data Source
  KAKENHI-PROJECT-21K06678
[Presentation] 抗がん剤の細胞内移行性に与える糖鎖合成酵素阻害剤の影響2022
- Author(s)
  鈴木彩佳、岸本久直、宮崎歌織、樋口慧、井上勝央
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-21K06695
[Presentation] Identification of an endogenous substrate of MCT62021
- Author(s)
  Koki Sugiyama, Kei Higuchi, Yuta Shimura, Hisanao Kishimoto, Katsuhisa Inoue
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-21K06678
[Presentation] 気液界面を模倣する疎水性溶媒を用いた上皮系培養細胞における粘液産生と細胞形態への影響2021
- Author(s)
  鷹野遥、岸本久直、樋口慧、井上勝央
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-21K06695
[Presentation] 抗がん剤の細胞膜透過性に対するmucin分子の抑制効果2019
- Author(s)
  宮崎歌織、岸本久直、藤澤弘、白坂善之、井上勝央
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K15522
[Presentation] Effect of mucus layer on the transcellular absorption of lipophilic drugs in rat small intestine2018
- Author(s)
  Hisanao Kishimoto, Kaori Miyazaki, Yoshiyuki Shirasaka, Katsuhisa Inoue
- Organizer
  Experimental Biology 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15522
[Presentation] 薬物の細胞膜透過過程における粘液層構成タンパク質MUC1の影響2018
- Author(s)
  宮崎歌織、岸本久直、大森萌子、白坂善之、井上勝央
- Organizer
  日本薬剤学会第33年会
- Data Source
  KAKENHI-PROJECT-17K15522
[Presentation] The relation between regional distribution of mucin molecules and intestinal drug absorption in rat small intestine2018
- Author(s)
  Kaori Miyazaki, Hisanao Kishimoto, Yoshiyuki Shirasaka, Katsuhisa Inoue
- Organizer
  The 2nd Workshop for Japan-Korea Young Scientists on Pharmaceutics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15522
[Presentation] Evaluation of the transcellular transport of hydrophobic drugs in MUC1-knockout MDCKII cells2018
- Author(s)
  Hisanao Kishimoto, Kaori Miyazaki, Yoshiyuki Shirasaka, Katsuhisa Inoue
- Organizer
  第33回日本薬物動態学会／第22回MDOシンポジウム合同国際学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15522
[Presentation] 内因性MUC1ノックアウトMDCKII細胞を用いた脂溶性薬物の経細胞輸送評価2018
- Author(s)
  岸本久直、宮崎歌織、白坂善之、井上勝央
- Organizer
  第40回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-17K15522
[Presentation] MUC1 is involved in the membrane permeation of hydrophobic drugs2018
- Author(s)
  Kaori Miyazaki, Hisanao Kishimoto, Hiroshi Fujisawa, Yoshiyuki Shirasaka, Katsuhisa Inoue
- Organizer
  第33回日本薬物動態学会／第22回MDOシンポジウム合同国際学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15522
[Presentation] 薬物の生体膜透過機構における膜結合型mucinの影響2018
- Author(s)
  宮崎歌織、岸本久直、白坂善之、井上勝央
- Organizer
  第40回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-17K15522
[Presentation] 薬物の腸管吸収における粘液層構成タンパク質mucinの影響2018
- Author(s)
  岸本久直
- Organizer
  第3回トランスポーター研究会関東部会
- Invited
- Data Source
  KAKENHI-PROJECT-17K15522
[Presentation] 脂溶性薬物の腸管吸収における薬物－粘液間相互作用の評価2018
- Author(s)
  田野文音、岸本久直、宮崎歌織、大森萌子、白坂善之、井上勝央
- Organizer
  日本薬剤学会第33年会
- Data Source
  KAKENHI-PROJECT-17K15522
[Presentation] 薬物の経粘膜透過に与える粘液層の影響とその分子メカニズム解明に向けたアプローチ2017
- Author(s)
  岸本久直、宮崎歌織、村谷美穂、白坂善之、井上勝央
- Organizer
  第39回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-17K15522
[Presentation] 脂溶性薬物の腸管膜透過性に及ぼす腸管粘液の影響及び mucin 発現解析2017
- Author(s)
  宮崎歌織、岸本久直、村谷美穂、田野文音、白坂善之、井上勝央
- Organizer
  日本薬剤学会第32年会
- Place of Presentation
  大宮ソニックシティ（大宮）
- Year and Date
  2017-05-11
- Data Source
  KAKENHI-PROJECT-26460208
[Presentation] 脂溶性薬物の腸管膜透過性に及ぼす腸管粘液の影響及びmucin発現解析2017
- Author(s)
  宮崎歌織、岸本久直、村谷美穂、田野文音、白坂善之、井上勝央
- Organizer
  日本薬剤学会第32年会
- Data Source
  KAKENHI-PROJECT-17K15522
[Presentation] Regional distribution of mucin molecules in rat small intestine2017
- Author(s)
  宮崎歌織、岸本久直、白坂善之、井上勝央
- Organizer
  日本薬物動態学会第32回年会
- Data Source
  KAKENHI-PROJECT-17K15522
[Presentation] Effects of Mucosal Protective Agents on the Expression Levels of Mucus Layer Components in Human Intestinal Cell Lines2016
- Author(s)
  H. Kishimoto, N. Murata, M. Muratani, K. Miyazaki, Y. Shirasaka and K. Inoue.
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール（長野県松本文化会館）/ 松本市総合体育館（松本）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-26460208
[Presentation] 経粘膜透過を介した薬物の腸管吸収に及ぼす粘液層の影響2016
- Author(s)
  宮崎歌織、岸本久直、村谷美穂、白坂善之、井上勝央
- Organizer
  日本薬剤学会第31年会
- Place of Presentation
  長良川国際会議場（岐阜）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-26460208
[Presentation] 一酸化窒素による難吸収性薬物の腸管促進効果に関する研究に関する研究に関する研究2016
- Author(s)
  岸本久直
- Organizer
  第33回製剤設計研究会
- Place of Presentation
  東京薬科大学（東京）
- Year and Date
  2016-09-10
- Invited
- Data Source
  KAKENHI-PROJECT-26460208
[Presentation] 経粘膜透過を介した薬物の腸管吸収に及ぼす粘液層の影響2016
- Author(s)
  宮崎歌織、岸本久直、村谷美穂、白坂善之、井上勝央
- Organizer
  日本薬剤学会第31年会
- Place of Presentation
  長良川国際会議場（岐阜）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-26460208
[Presentation] Effect of nitric oxide on the intestinal absorption of lipophilic drugs in rat2015
- Author(s)
  Hisanao Kishimoto, Kaori Miyazaki, Yusuke Takizawa, Yoshiyuki Shirasaka, Katsuhisa Inoue
- Organizer
  日本薬物動態学会第30回年会
- Place of Presentation
  タワーホール船堀（東京）
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-26460208
[Presentation] 経細胞輸送を介した薬物の消化管吸収に及ぼす一酸化窒素の影響2015
- Author(s)
  宮崎歌織、岸本久直、瀧沢裕輔、白坂善之、井上勝央
- Organizer
  日本薬剤学会第30年会
- Place of Presentation
  長崎ブリックホール（長崎）
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26460208
[Presentation] 経細胞輸送を介した薬物の消化管吸収に及ぼす一酸化窒素の影響
- Author(s)
  宮崎　歌織、岸本　久直、瀧沢　裕輔、白坂　善之、井上　勝央
- Organizer
  日本薬剤学会第30年会
- Place of Presentation
  長崎ブリックホール
- Year and Date
  2015-05-21 – 2015-05-23
- Data Source
  KAKENHI-PROJECT-26460208

1. Inoue Katsuhisa (50315892)

# of Collaborated Projects: 7 results

# of Collaborated Products: 44 results
2. Higuchi Kei (10625304)

# of Collaborated Projects: 6 results

# of Collaborated Products: 37 results
3. SHIRASAKA Yoshiyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results

Kishimoto Hisanao 岸本 久直

KISHIMOTO Hisanao 岸本 久直

Research Projects

Research Products

Co-Researchers

Elucidation of the molecular mechanism of Mucin-medium molecule drug interactionPrincipal Investigator

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Development of drug delivery technology using lysosomal transporters

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医薬品の吸収改善を目指すオリゴペプチドトランスポーターEOPTsの分子制御機構解明

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Absorption mechanism of nucleosides and their analogs in the gastrointestinal tract

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Identification of novel equilibrative oligopeptide transporters that may regulate drug absorption in the gastrointestinal tract

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Evaluation of the molecular mechanism of membrane-bound mucins in intestinal drug absorption.Principal Investigator

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Elucidation of the molecular mechanism and functions of mucus-glycoprotein in intestinal drug absorption.Principal Investigator

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Elucidation of the molecular mechanism of unstirred water layerPrincipal Investigator

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[Journal Article] The Use of Carboxyfluorescein Reveals the Transport Function of MCT6/SLC16A5 Associated with CD147 as a Chloride-Sensitive Organic Anion Transporter in Mammalian Cells2024

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[Journal Article] Monocarboxylate Transporter 13 (MCT13/SLC16A13) Functions as a Novel Plasma Membrane Oligopeptide Transporter2023

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[Journal Article] Macrolide and Ketolide Antibiotics Inhibit the Cytotoxic Effect of Trastuzumab Emtansine in HER2-Positive Breast Cancer Cells: Implication of a Potential Drug-ADC Interaction in Cancer Chemotherapy2023

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[Journal Article] Mammalian monocarboxylate transporter 7 (MCT7/Slc16a6) is a novel facilitative taurine transporter2022

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[Journal Article] Identification of 5-Carboxyfluorescein as a Probe Substrate of SLC46A3 and Its Application in a Fluorescence-Based In Vitro Assay Evaluating the Interaction with SLC46A32022

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[Journal Article] SLC46A3 is a lysosomal proton-coupled steroid conjugate and bile acid transporter involved in transport of active catabolites of T-DM12022

Author(s)

Kishimoto Hisanao 岸本久直

KISHIMOTO Hisanao 岸本久直