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Isobe Yosuke  磯部 洋輔

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ISOBE Yosuke  磯部 洋輔

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Researcher Number 80724335
Other IDs
Affiliation (Current) 2025: 国立研究開発法人理化学研究所, 生命医科学研究センター, 副チームディレクター
Affiliation (based on the past Project Information) *help 2021 – 2023: 国立研究開発法人理化学研究所, 生命医科学研究センター, 副チームリーダー
2020: 国立研究開発法人理化学研究所, 生命医科学研究センター, 研究員
2015: 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 基礎科学特別研究員
2014: 独立行政法人理化学研究所, 統合生命医科学研究センター, 特別研究員
Review Section/Research Field
Principal Investigator
Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / 0701:Biology at molecular to cellular levels, and related fields / Biological pharmacy
Keywords
Principal Investigator
脂質修飾 / ケミカルバイオロジー / 標的同定 / リポキシデーション / 好酸球 / 12/15-LOX / ケミカルプロテオミクス / 脂肪酸代謝 / 脂質由来親電子性物質 / 反応性代謝物 … More / タンパク質修飾 / 親電子性代謝物 / マクロファージ / リピドミクス / 線維芽細胞 / ω3脂肪酸 / シトクロムP450 / 抗炎症作用 / オメガ3脂肪酸 Less
  • Research Projects

    (3 results)
  • Research Products

    (11 results)
  • Co-Researchers

    (3 People)
  •  好酸球に内在の脂肪酸代謝によるタンパク質修飾の網羅的解析Principal Investigator

    • Principal Investigator
      磯部 洋輔
    • Project Period (FY)
      2021 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
    • Research Institution
      Institute of Physical and Chemical Research
  •  Elucidation of the mechanisms underlying maintaining macrophage homeostasis with lipid-derived electrophilesPrincipal Investigator

    • Principal Investigator
      Isobe Yosuke
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Review Section
      0701:Biology at molecular to cellular levels, and related fields
    • Research Institution
      Institute of Physical and Chemical Research
  •  Functional elucidation of anti-inflammatory effect of omega-3 PUFAs focusing on the omega-3 PUFA specific metabolic pathwayPrincipal Investigator

    • Principal Investigator
      ISOBE Yosuke
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      Institute of Physical and Chemical Research

All 2023 2021 2015 2014 Other

All Journal Article Presentation Other

  • [Journal Article] Total synthesis of four stereoisomers of (4Z,7Z,10Z,12E,16Z,18E)-14,20-dihydroxy-4,7,10,12,16,18-docosahexaenoic acid and their anti-inflammatory activities.2015

    • Author(s)
      Goto T, Urabe D, Masuda K, Isobe Y, Arita M, Inoue M.
    • Journal Title

      J Org Chem

      Volume: 80 Issue: 15 Pages: 7713-7726

    • DOI

      10.1021/acs.joc.5b01461

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-15H05897, KAKENHI-PUBLICLY-26102716, KAKENHI-PROJECT-26253003, KAKENHI-PROJECT-25460007, KAKENHI-PROJECT-26860034, KAKENHI-PLANNED-15H05898
  • [Journal Article] Total synthesis of four stereoisomers of (5Z,8Z,10E,14Z)-12-hydroxy-17,18-epoxy-5,8,10,14-eicosatetraenoic acid and their anti-Inflammatory activities2015

    • Author(s)
      Goto, T.; Urabe, D.; Isobe, Y.; Arita, M.; Inoue, M.
    • Journal Title

      Tetrahedron

      Volume: 71 Issue: 43 Pages: 8320-8332

    • DOI

      10.1016/j.tet.2015.08.047

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-26102716, KAKENHI-PROJECT-26253003, KAKENHI-PROJECT-25460007, KAKENHI-PROJECT-26860034
  • [Presentation] Comprehensive analysis of lipid modifications of proteins using chemical proteomics approaches2023

    • Author(s)
      Yosuke Isobe, Kazuya Tsumagari, Koshi Imami, Makoto Arita
    • Organizer
      日本プロテオーム学会2023
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K06557
  • [Presentation] 脂質修飾研究を切り拓く最先端のプロテオーム解析手法2023

    • Author(s)
      磯部洋輔、津曲和哉、今見考志、有田誠
    • Organizer
      第65回日本脂質生化学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K06557
  • [Presentation] 脂肪酸オキシゲナーゼを介して生成する脂質修飾タンパク質の包括的解析2023

    • Author(s)
      磯部洋輔、Kaiyuan Deng、津曲和哉、今見考志、有田誠
    • Organizer
      第96回日本生化学会
    • Data Source
      KAKENHI-PROJECT-21K06557
  • [Presentation] 代謝物の標的タンパク質を同定するケミカルプロテオミクスの新技術2021

    • Author(s)
      磯部洋輔、Daniel K. Nomura、有田誠
    • Organizer
      日本プロテオーム学会2021年大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K22641
  • [Presentation] Identification of novel omega-3 EPA-derived anti-inflammatory mediators using a targeted lipidomics approach2015

    • Author(s)
      Yosuke Isobe, Tadafumi Kubota, Hiroyuki Arai, Daisuke Urabe, Masayuki Inoue, Makoto Arita
    • Organizer
      PLM2015
    • Place of Presentation
      京王プラザホテル(東京都・新宿区)
    • Year and Date
      2015-02-11
    • Data Source
      KAKENHI-PROJECT-26860034
  • [Presentation] オメガ3脂肪酸の抗炎症作用についての包括的メタボローム解析2015

    • Author(s)
      磯部 洋輔、有田 誠
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学(兵庫県・神戸市)
    • Year and Date
      2015-03-26
    • Invited
    • Data Source
      KAKENHI-PROJECT-26860034
  • [Presentation] Identification of novel EPA-derived anti-inflammatory metabolites using a targeted lipidomics approach2014

    • Author(s)
      Yosuke Isobe, Makoto Arita
    • Organizer
      5th European Workshop on Lipid Mediator
    • Place of Presentation
      イスタンブール(トルコ)
    • Year and Date
      2014-10-24
    • Data Source
      KAKENHI-PROJECT-26860034
  • []

  • []

  • 1.  URABE Daisuke
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 2.  有田 誠
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 3.  有田 正規
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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