Kiwamoto Takumi 際本拓未

Researcher Number	80724773
Other IDs	https://orcid.org/0000-0003-3918-9878
Affiliation (Current)	2025: 筑波大学, 医学医療系, 講師
Affiliation (based on the past Project Information) *help	2018 – 2024: 筑波大学, 医学医療系, 講師 2014 – 2016: 筑波大学, 医学医療系, 講師
Review Section/Research Field	Principal Investigator Basic Section 53030:Respiratory medicine-related / Respiratory organ internal medicine
Keywords	Principal Investigator 喘息 / HAS2 / 小胞体ストレス / COPD / IL-17 / ヒアルロン酸 / 小胞体ストレス応答 / Siglec-E / マウス / TLR4 … More / TGF-β / CD44 / 高分子量ヒアルロン酸 / 気管支喘息 / Has2 / 好酸球 / Muc4 / Muc5b / Siglec / 気道リモデリング / Siglec-F Less

HAS2異常に伴う全身併存症合併炎症性肺疾患患者の表現型解明と臨床応用Principal Investigator
- Principal Investigator
  
  際本拓未
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  University of Tsukuba
Mechanisms and targeted therapeutics for inflammatory lung diseases associated with changes in the hyaluronan environment.Principal Investigator
- Principal Investigator
  
  Kiwamoto Takumi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  University of Tsukuba
An attempt to elucidate novel mechanism of Has2-Siglec mediated asthmatic airway inflammation.Principal Investigator
- Principal Investigator
  
  Kiwamoto Takumi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  University of Tsukuba
Dysfunction of Siglec regulated eosinophilic airway inflammation induce airway remodeling.Principal Investigator
- Principal Investigator
  
  Kiwamoto Takumi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  University of Tsukuba

All 2022 2021 2020 2019 2018 2017 2016 2015 2014

All Journal Article Presentation

[Journal Article] Has2 Regulates the Development of Ovalbumin-Induced Airway Remodeling and Steroid Insensitivity in Mice2022
- Author(s)
  Sherpa Mingma Thsering、Kiwamoto Takumi、Matsuyama Masashi、Tsunoda Yoshiya、Yazaki Kai、Yoshida Kazufumi、Nakajima Masayuki、Matsuno Yosuke、Morishima Yuko、Ishii Yukio、Hizawa Nobuyuki
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 12
- DOI
  10.3389/fimmu.2021.770305
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08150
[Journal Article] Has2遺伝子欠損マウスにおけるOVA誘導性気道炎症と過敏性の増強2021
- Author(s)
  際本拓未、檜澤伸之
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 76 Pages: 240-244
- Data Source
  KAKENHI-PROJECT-21K08150
[Journal Article] Has2 deficiency enhances OVA-induced airway inflammation and hyperresponsiveness in mice2021
- Author(s)
  Yoshiya Tsunoda, Mingma Thsering Sherpa, Takumi Kiwamoto, Masashi Matsuyama, Hajime Osawa, Hirofumi Sakurai, Shigen Hayashi, Yosuke Matsuno, Yuko Morishima, Yukio Ishii, Nobuyuki Hizawa
- Journal Title
  
  Allergy
  
  Volume: - Issue: 7 Pages: 2214-2218
- DOI
  10.1111/all.14715
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18J21289, KAKENHI-PROJECT-18K08139, KAKENHI-PROJECT-18H03173
[Journal Article] Airway glycomic and allergic inflammatory consequences resulting from keratan sulfate galactose 6-O-sulfotransferase (CHST1) deficiency2018
- Author(s)
  Kumagai Tadahiro、Kiwamoto Takumi、Brummet Mary E、Wu Fan、Aoki Kazuhiro、Zhu Zhou、Bochner Bruce S、Tiemeyer Michael
- Journal Title
  
  Glycobiology
  
  Volume: 28 Issue: 6 Pages: 406-417
- DOI
  10.1093/glycob/cwy025
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08139
[Journal Article] Sialylated glycans carried by airway mucins Muc5b and Muc4 selectively bind to mouse Siglec-F and control eosinophilic airway inflammation.2016
- Author(s)
  Takumi Kiwamoto, Toshihiko Katoh, Christopher M. Evans, Zhou Zhu, Michael Tiemeyer, Bruce S. Bochner
- Journal Title
  
  Proceedings of the 30th Symposium of the Collegium Internationale Allergologicum.
  
  Volume: - Pages: 29-32
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860596
[Journal Article] Reply: To PMID 25497369.2015
- Author(s)
  Bruce S. Bochner, Takumi Kiwamoto, Toshihiko Katoh, Zhou Zhu, Michael Tiemeyer
- Journal Title
  
  Journal of Allergy and Clinical Immunology
  
  Volume: 135 Issue: 6 Pages: 1662-3
- DOI
  10.1016/j.jaci.2015.02.028
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860596
[Journal Article] Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis.2015
- Author(s)
  Takumi Kiwamoto, Toshihiko Katoh, Christopher M. Evans, William J. Janssen, Mary E. Brummet, Sherry A. Hudson, Zhou Zhu, Michael Tiemeyer, Bruce S. Bochner
- Journal Title
  
  Journal of Allergy and Clinical Immunology
  
  Volume: 135 Issue: 5 Pages: 1329-40
- DOI
  10.1016/j.jaci.2014.10.027
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860596
[Journal Article] Siglec-Fとムチン相互作用による好酸球炎症制御2015
- Author(s)
  加藤紀彦, 際本拓未
- Journal Title
  
  The lung perspectives
  
  Volume: 23 Pages: 180-185
- Data Source
  KAKENHI-PROJECT-26860596
[Journal Article] Siglecとアレルギー性気道炎症制御2015
- Author(s)
  際本拓未, 檜澤伸之
- Journal Title
  
  雑誌「呼吸」
  
  Volume: 34 Pages: 21-24
- Data Source
  KAKENHI-PROJECT-26860596
[Presentation] 気管支喘息における糖鎖を介した炎症細胞制御機構2022
- Author(s)
  際本拓未
- Organizer
  第31回国際喘息学会日本・北アジア部会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08150
[Presentation] Hyaluronan synthase 2 attenuates airway inflammation and remodeling in an ovalbumin induced chronic mouse model of asthma.2020
- Author(s)
  M. Sherpa, T. Kiwamoto, Y. Tsunoda, K. Yoshida, H. Osawa, M. Nakajima, M. Matsuyama, Y. Matsuno, Y. Morishima, Y. Ishii, N. Hizawa.
- Organizer
  第60回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-18K08139
[Presentation] Hyaluronan synthase 2 attenuates airway inflammation and remodeling in an ovalbumin induced chronic mouse model of asthma.2020
- Author(s)
  M. Sherpa, T. Kiwamoto, Y. Tsunoda, K. Yoshida, H. Osawa, M. Nakajima, M. Matsuyama, Y. Matsuno, Y. Morishima, Y. Ishii, N. Hizawa.
- Organizer
  JSA/WAO Joint Congress 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08139
[Presentation] Hyaluronan Synthase 2 Attenuates Airway Inflammation and Remodeling in an Ovalbumin Induced chronic model of asthma.2020
- Author(s)
  M. Sherpa, T. Kiwamoto, Y. Tsunoda, K. Yoshida, H. Osawa, M. Nakajima, M. Matsuyama, Y. Matsuno, Y. Morishima, Y. Ishii, N. Hizawa.
- Organizer
  ATS Conference 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08139
[Presentation] Hyaluronan Synthase 2 (HAS2) Mediates Elastase-Induced Airway Inflammation and Emphysema in Mice.2020
- Author(s)
  H. Osawa, T. Kiwamoto, M. Sherpa, Y. Tsunoda, K. Yazaki, K. Yoshida, M. Nakajima, M. Matsuyama, Y. Matsuno, Y. Morishima, Y. Ishii, N. Hizawa
- Organizer
  ATS Conference 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08139
[Presentation] 次世代シーケンサーを用いたHAS2異常に伴う喘息病態増悪機構解明の試み2019
- Author(s)
  角田義弥、際本拓未、松山政史、Sherpa Mingma、櫻井啓文、林士元、松野洋輔、森島祐子、石井幸雄、檜澤伸之
- Organizer
  第59回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-18K08139
[Presentation] HAS2 mediates airway inflammation and remodeling in chronic OVA model of asthma.2019
- Author(s)
  M. Sherpa , T. Kiwamoto, Y. Tsunoda, K. Yoshida, M. Nakajima, M. Matsuyama, Y. Matsuno, Y. Morishima, Y. Ishii, N. Hizawa
- Organizer
  第59回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-18K08139
[Presentation] Hyaluronan Synthase 2 (HAS2) Mediates Airway Inflammation and Remodeling in Chronic Ovalbumin Model of Asthma2019
- Author(s)
  M. Sherpa, T. Kiwamoto, Y. Tsunoda, K. Yoshida, H. Osawa, M. Nakajima, M. Matsuyama, Y. Matsuno, Y. Morishima, Y. Ishii, N. Hizawa
- Organizer
  ATS Conference 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08139
[Presentation] Hyaluronan Synthase 2 (HAS2) Mediates Airway Inflammation and Remodeling in Chronic Ovalbumin Model of Asthma2019
- Author(s)
  M. Sherpa, T. Kiwamoto, Y. Tsunoda, K. Yoshida, H. Osawa, M. Nakajima, M. Matsuyama, Y. Matsuno, Y. Morishima, Y. Ishii, N. Hizawa
- Organizer
  第68回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-18K08139
[Presentation] ヒアルロン酸合成酵素異常に伴う気管支喘息発症増悪メカニズムの解明2019
- Author(s)
  際本拓未
- Organizer
  第59回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-18K08139
[Presentation] Hyaluronan synthase 2 (HAS2) dysfunction induce severe eosinophilic airway inflammation via inflammatory cytokines and chemokines.2018
- Author(s)
  T. Kiwamoto, Y. Tsunoda, M. Sherpa, H. Sakurai, S. Lin, M. Matsuyama, Y. Matsuno, Y. Morishima, Y. Ishii, N. Hizawa
- Organizer
  ATS Conference 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08139
[Presentation] 好酸球性気道炎症病態下におけるヒアルロン酸合成酵素HAS2の役割2017
- Author(s)
  角田義弥、際本拓未、櫻井啓文、林士元、松野洋輔、川口未央、森島祐子、石井幸雄、檜澤伸之
- Organizer
  第57回日本呼吸器学会学術講演会
- Place of Presentation
  東京国際フォーラム(東京都、千代田区)
- Data Source
  KAKENHI-PROJECT-26860596
[Presentation] Attenuation of Hyaluronan synthase 2 (HAS2) enhance eosinophilic airway inflammation.2017
- Author(s)
  Yoshiya Tsunoda, Takumi Kiwamoto, Hirofumi Sakurai, Lin Shin-Yuan, Yosuke Matsuno, Mio Kawaguchi, Yuko Morishima, Yukio Ishii, Nobuyuki Hizawa
- Organizer
  ATS International Conference 2017
- Place of Presentation
  ワシントンDC(米国)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860596
[Presentation] Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis.2015
- Author(s)
  Takumi Kiwamoto, Toshihiko Katoh, Christopher M. Evans, William J. Janssen, Mary E. Brummet, Sherry A. Hudson, Zhou Zhu, Michael Tiemeyer, Bruce S. Bochner
- Organizer
  第64回日本アレルギー学会学術大会
- Place of Presentation
  グランドプリンスホテル新高輪国際館パミール
- Year and Date
  2015-05-26
- Data Source
  KAKENHI-PROJECT-26860596
[Presentation] Mouse airway Muc5b and Muc4 carry glycans that induce eosinophil apoptosis via Siglec-F.2015
- Author(s)
  Takumi Kiwamoto, Toshihiko Katoh, Christopher M. Evans, William J. Janssen, Mary E. Brummet, Sherry A. Hudson, Zhou Zhu, Michael Tiemeyer, Bruce S. Bochner
- Organizer
  2015 KAAACI & EAAS Joint International Congress
- Place of Presentation
  ソウル（韓国）
- Year and Date
  2015-05-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860596
[Presentation] Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis2014
- Author(s)
  Kiwamoto T, Katoh T, Evans CM, Janssen WJ, Brummet ME, Hudson SA, Zhu Z, Tiemeyer M, Bochner BS.
- Organizer
  SFG & JSCR 2014 Joint Annual Meeting
- Place of Presentation
  米国（ホノルル）
- Year and Date
  2014-11-17
- Data Source
  KAKENHI-PROJECT-26860596
[Presentation] 気道粘液Muc5b/Muc4によるSiglec-Fを介した好酸球炎症制御機構2014
- Author(s)
  際本拓未, 加藤紀彦, Christopher Evans, Mary Brummet, Sherry Hudson, Zhou Zhu, Michael Tiemeyer, Bruce Bochner
- Organizer
  第54回日本呼吸器学会学術講演会
- Place of Presentation
  大阪
- Year and Date
  2014-04-25
- Data Source
  KAKENHI-PROJECT-26860596

1. SHERPA MINGMA

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Kiwamoto Takumi 際本 拓未

Research Projects

Research Products

Co-Researchers

HAS2異常に伴う全身併存症合併炎症性肺疾患患者の表現型解明と臨床応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanisms and targeted therapeutics for inflammatory lung diseases associated with changes in the hyaluronan environment.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

An attempt to elucidate novel mechanism of Has2-Siglec mediated asthmatic airway inflammation.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Dysfunction of Siglec regulated eosinophilic airway inflammation induce airway remodeling.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Has2 Regulates the Development of Ovalbumin-Induced Airway Remodeling and Steroid Insensitivity in Mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Has2遺伝子欠損マウスにおけるOVA誘導性気道炎症と過敏性の増強2021

Author(s)

Journal Title

Data Source

[Journal Article] Has2 deficiency enhances OVA-induced airway inflammation and hyperresponsiveness in mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Airway glycomic and allergic inflammatory consequences resulting from keratan sulfate galactose 6-O-sulfotransferase (CHST1) deficiency2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sialylated glycans carried by airway mucins Muc5b and Muc4 selectively bind to mouse Siglec-F and control eosinophilic airway inflammation.2016

Author(s)

Journal Title

Data Source

[Journal Article] Reply: To PMID 25497369.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Siglec-Fとムチン相互作用による好酸球炎症制御2015

Author(s)

Journal Title

Data Source

[Journal Article] Siglecとアレルギー性気道炎症制御2015

Author(s)

Journal Title

Data Source

[Presentation] 気管支喘息における糖鎖を介した炎症細胞制御機構2022

Author(s)

Organizer

Data Source

[Presentation] Hyaluronan synthase 2 attenuates airway inflammation and remodeling in an ovalbumin induced chronic mouse model of asthma.2020

Author(s)

Organizer

Data Source

[Presentation] Hyaluronan synthase 2 attenuates airway inflammation and remodeling in an ovalbumin induced chronic mouse model of asthma.2020

Author(s)

Organizer

Kiwamoto Takumi 際本拓未