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Shirakawa Kotaro  白川 康太郎

ORCIDConnect your ORCID iD *help
Researcher Number 80728270
Other IDs
Affiliation (Current) 2025: 京都大学, 医学研究科, 講師
Affiliation (based on the past Project Information) *help 2023: 京都大学, 医学研究科, 講師
2016 – 2022: 京都大学, 医学研究科, 助教
Review Section/Research Field
Principal Investigator
Basic Section 49060:Virology-related / Virology
Except Principal Investigator
Basic Section 50010:Tumor biology-related / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
Keywords
Principal Investigator
HIV感染症 / 潜伏感染 / CRISPRスクリーン / HIV潜伏感染 / HIV-1 / shock and kill / HIV / マイトファジー / ミトコンドリア / HIV感染症根治療法 … More / 潜伏感染再活性化薬 / トランスクリプトーム解析 / CRISPR/Cas9 / CAGE法 / 再活性化 / mTOR経路 / CRISPRスクリーニング / トランスクリプトーム / シチジン脱アミノ化酵素 / HDAC3 / アセチル化 / APOBEC3G / HIV-1 Vif / DNAシトシン脱アミノ化酵素APOBEC3G / ヒストン脱アセチル化酵素 / Vif … More
Except Principal Investigator
癌の不均一性 / シングルセル解析 / CAGE法 / APOBEC signature / マウスモデル / 治療抵抗性 / 癌の多様性 / 癌のクローン進化 / APOBEC3 / C-to-T変異 / シチジン脱アミノ化 / ゲノム変異 / クローン進化 / がん / APOBEC / ゲノム解析 / 腫瘍 / NET-CAGE法 / 造血器腫瘍 / 次世代シークエンサー / 遺伝子発現制御 / ゲノム科学 / バイオインフォマティクス / 次世代シークエンシング / ノンコーディングゲノム・RNA / ヒトゲノム科学 / 造血器悪性腫瘍 / NET-CAGE / 転写ネットワーク / バイオマーカー / ゲノム解析技術 / エンハンサー / 白血病 Less
  • Research Projects

    (5 results)
  • Research Products

    (17 results)
  • Co-Researchers

    (7 People)
  •  CRISPR screen to identify novel molecular mechanisms of HIV-1 latencyPrincipal Investigator

    • Principal Investigator
      白川 康太郎
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49060:Virology-related
    • Research Institution
      Kyoto University
  •  Transcriptome analysis of HIV-1 latently infected cellsPrincipal Investigator

    • Principal Investigator
      Shirakawa Kotaro
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49060:Virology-related
    • Research Institution
      Kyoto University
  •  APOBEC3B-induced genome mutations and its contribution to clonal evolution in cancers

    • Principal Investigator
      Takaori-Kondo Akifumi
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Kyoto University
  •  Comprehensive enhancer analysis and molecular pathogenesis of leukemia using our novel technology

    • Principal Investigator
      Murakawa Yasuhiro
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
    • Research Institution
      Institute of Physical and Chemical Research
  •  Role of A3G acetylation and Vif/HDAC3 complex in HIV-1 infectionPrincipal Investigator

    • Principal Investigator
      Shirakawa Kotaro
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Virology
    • Research Institution
      Kyoto University

All 2024 2022 2021 2020 2019

All Journal Article Presentation Patent

  • [Journal Article] ILF2 enhances the DNA cytosine deaminase activity of tumor mutator APOBEC3B in multiple myeloma cells2022

    • Author(s)
      Kazuma Yasuhiro、Shirakawa Kotaro、Tashiro Yusuke、Yamazaki Hiroyuki、Nomura Ryosuke、Horisawa Yoshihito、Takeuchi Suguru、Stanford Emani、Konishi Yoshinobu、Matsui Hiroyuki、Matsumoto Tadahiko、Tanabe Fumiko、Morishita Ryo、Ito Shinji、Takaori-Kondo Akifumi
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 2278-2278

    • DOI

      10.1038/s41598-022-06226-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H03502, KAKENHI-PROJECT-20J01623
  • [Journal Article] CAGE-Seq Reveals that HIV-1 Latent Infection Does Not Trigger Unique Cellular Responses in a Jurkat T Cell Model2021

    • Author(s)
      Matsui Hiroyuki、Shirakawa Kotaro、Konishi Yoshinobu、Hirabayashi Shigeki、Sarca Anamaria Daniela、Fukuda Hirofumi、Nomura Ryosuke、Stanford Emani、Horisawa Yoshihito、Kazuma Yasuhiro、Matsumoto Tadahiko、Yamazaki Hiroyuki、Murakawa Yasuhiro、Battivelli Emilie、Verdin Eric、Koyanagi Yoshio、Takaori-Kondo Akifumi
    • Journal Title

      Journal of Virology

      Volume: 95 Issue: 8 Pages: 1-18

    • DOI

      10.1128/jvi.02394-20

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20J01623, KAKENHI-PROJECT-19K07591, KAKENHI-PROJECT-20K21407, KAKENHI-PROJECT-20KK0186
  • [Journal Article] APOBEC3B is preferentially expressed at the G2/M phase of cell cycle2021

    • Author(s)
      Hirabayashi Shigeki、Shirakawa Kotaro、Horisawa Yoshihito、Matsumoto Tadahiko、Matsui Hiroyuki、Yamazaki Hiroyuki、Sarca Anamaria Daniela、Kazuma Yasuhiro、Nomura Ryosuke、Konishi Yoshinobu、Takeuchi Suguru、Stanford Emani、Kawaji Hideya、Murakawa Yasuhiro、Takaori-Kondo Akifumi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 546 Pages: 178-184

    • DOI

      10.1016/j.bbrc.2021.02.008

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H03992, KAKENHI-PROJECT-19H03502, KAKENHI-PROJECT-20J01623, KAKENHI-PROJECT-19K07591, KAKENHI-PROJECT-20K21407, KAKENHI-PROJECT-20KK0186
  • [Journal Article] FRET-Based Detection and Quantification of HIV-1 Virion Maturation2021

    • Author(s)
      Sarca Anamaria D.、Sardo Luca、Fukuda Hirofumi、Matsui Hiroyuki、Shirakawa Kotaro、Horikawa Kazuki、Takaori-Kondo Akifumi、Izumi Taisuke
    • Journal Title

      Frontiers in Microbiology

      Volume: 12 Pages: 1-13

    • DOI

      10.3389/fmicb.2021.647452

    • NAID

      120007180366

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07591, KAKENHI-PLANNED-18H05415
  • [Journal Article] Critical role of PP2A-B56 family protein degradation in HIV-1 Vif mediated G2 cell cycle arrest2020

    • Author(s)
      Nagata Kayoko、Shindo Keisuke、Matsui Yusuke、Shirakawa Kotaro、Takaori-Kondo Akifumi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 527 Issue: 1 Pages: 257-263

    • DOI

      10.1016/j.bbrc.2020.04.123

    • NAID

      120006865708

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08807, KAKENHI-PROJECT-19K07591
  • [Journal Article] APOBEC3B reporter myeloma cell lines identify DNA damage response pathways leading to APOBEC3B expression2020

    • Author(s)
      Yamazaki Hiroyuki、Shirakawa Kotaro、Matsumoto Tadahiko、Kazuma Yasuhiro、Matsui Hiroyuki、Horisawa Yoshihito、Stanford Emani、Sarca Anamaria Daniela、Shirakawa Ryutaro、Shindo Keisuke、Takaori-Kondo Akifumi
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 1 Pages: e0223463-e0223463

    • DOI

      10.1371/journal.pone.0223463

    • NAID

      120006786934

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07342, KAKENHI-PROJECT-19H03502
  • [Journal Article] Alternative splicing of APOBEC3D generates functional diversity and its role as a DNA mutator2020

    • Author(s)
      Takei Hisashi、Fukuda Hirofumi、Pan Gilbert、Yamazaki Hiroyuki、Matsumoto Tadahiko、Kazuma Yasuhiro、Fujii Masanori、Nakayama Sohei、Kobayashi Ikei S.、Shindo Keisuke、Yamashita Riu、Shirakawa Kotaro、Takaori-Kondo Akifumi、Kobayashi Susumu S.
    • Journal Title

      International Journal of Hematology

      Volume: 112 Issue: 3 Pages: 395-408

    • DOI

      10.1007/s12185-020-02904-y

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K23930, KAKENHI-PROJECT-19H03502, KAKENHI-PROJECT-16K21746, KAKENHI-PROJECT-19K07591
  • [Journal Article] Protein kinase A inhibits tumor mutator APOBEC3B through phosphorylation2019

    • Author(s)
      Matsumoto Tadahiko、Shirakawa Kotaro、Yokoyama Masaru、Fukuda Hirofumi、Sarca Anamaria Daniela、Koyabu Sukenao、Yamazaki Hiroyuki、Kazuma Yasuhiro、Matsui Hiroyuki、Maruyama Wataru、Nagata Kayoko、Tanabe Fumiko、Kobayashi Masayuki、Shindo Keisuke、Morishita Ryo、Sato Hironori、Takaori-Kondo Akifumi
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 8307-8307

    • DOI

      10.1038/s41598-019-44407-9

    • NAID

      120006644044

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H03502
  • [Journal Article] Endogenous APOBEC3B Overexpression Constitutively Generates DNA Substitutions and Deletions in Myeloma Cells2019

    • Author(s)
      Yamazaki Hiroyuki、Shirakawa Kotaro、Matsumoto Tadahiko、Hirabayashi Shigeki、Murakawa Yasuhiro、Kobayashi Masayuki、Sarca Anamaria Daniela、Kazuma Yasuhiro、Matsui Hiroyuki、Maruyama Wataru、Fukuda Hirofumi、Shirakawa Ryutaro、Shindo Keisuke、Ri Masaki、Iida Shinsuke、Takaori-Kondo Akifumi
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 7122-7122

    • DOI

      10.1038/s41598-019-43575-y

    • NAID

      120006629181

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07342, KAKENHI-PROJECT-19H03502
  • [Journal Article] NET-CAGE characterizes the dynamics and topology of human transcribed cis-regulatory elements2019

    • Author(s)
      Hirabayashi Shigeki、Bhagat Shruti、Matsuki Yu、Takegami Yujiro、Uehata Takuya、Kanemaru Ai、Itoh Masayoshi、Shirakawa Kotaro、Takaori-Kondo Akifumi、Takeuchi Osamu、Carninci Piero、Katayama Shintaro、Hayashizaki Yoshihide、Kere Juha、Kawaji Hideya、Murakawa Yasuhiro
    • Journal Title

      Nature Genetics

      Volume: 51 Issue: 9 Pages: 1369-1379

    • DOI

      10.1038/s41588-019-0485-9

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-18H03992, KAKENHI-PROJECT-16H02902, KAKENHI-PROJECT-18K15185
  • [Patent] 潜伏感染しているHIVを再活性化するための組成物2024

    • Inventor(s)
      白川康太郎、高折晃史、遊佐宏介、松井宏行、野村亮介
    • Industrial Property Rights Holder
      白川康太郎、高折晃史、遊佐宏介、松井宏行、野村亮介
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2024-029993
    • Filing Date
      2024
    • Acquisition Date
      2024
    • Data Source
      KAKENHI-PROJECT-22K07085
  • [Presentation] HIV-1潜伏感染の成立と維持に関与する分子機構2021

    • Author(s)
      白川康太郎
    • Organizer
      第35回日本エイズ学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-19K07591
  • [Presentation] シトシン脱アミノ化酵素APOBEC3Bの活性はILF2とhnRNPA1により亢進する2021

    • Author(s)
      数馬安浩, 白川康太郎, 小西義延, 松井宏行, 松本忠彦, 高折晃史
    • Organizer
      第80回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19H03502
  • [Presentation] HIV-1 latent infection does not trigger cellular transcriptional responses in T-cells2020

    • Author(s)
      Hiroyuki Matsui, Kotaro Shirakawa, Shigeki Hirabayashi, Anamaria D. Sarca, Hirofumi Fukuda, Yasuhiro Murakawa, Emilie Battivelli, Eric Verdin, Akifumi Takaori-Kondo
    • Organizer
      Keystone Symposia 2020 HIV Pathogenesis and Cure X6
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07591
  • [Presentation] がんの内在性変異源APOBEC3Bの非コードRNAに結合能力はレトロエレメントを阻害に必要である.2019

    • Author(s)
      松本忠彦, 白川康太郎, 小薮助直, 数馬安浩, 山崎寛章, 松井宏行, 高折晃史
    • Organizer
      第78回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19H03502
  • [Presentation] Tumor mutaor APOBEC3B binds to cellular non-coding RNAs to inhibit retroelements.2019

    • Author(s)
      松本忠彦, 白川康太郎, 小薮助直, Sarca AD, Stanford E, 福田寛文, 松井宏行, 山崎寛章, 数馬安浩, 堀澤欣史, 高折晃史
    • Organizer
      第33回日本エイズ学会学術集会
    • Data Source
      KAKENHI-PROJECT-19H03502
  • [Presentation] シトシン脱アミノ化酵素APOBEC3Bの相互作用蛋白の同定と機能的解析.2019

    • Author(s)
      数馬安浩, 白川康太郎, 松井宏行, 山崎寛章, 松本忠彦, 伊藤慎二, 高折晃史
    • Organizer
      第78回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19H03502
  • 1.  Murakawa Yasuhiro (50765469)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 2.  Takaori-Kondo Akifumi (20324626)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 3.  白川 龍太郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 4.  新堂 啓祐
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  藤井 昌学
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  竹内 理
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  植畑 拓也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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