Shirakawa Kotaro 白川康太郎

Researcher Number	80728270
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 講師
Affiliation (based on the past Project Information) *help	2023: 京都大学, 医学研究科, 講師 2016 – 2022: 京都大学, 医学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 49060:Virology-related / Virology Except Principal Investigator Basic Section 50010:Tumor biology-related / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
Keywords	Principal Investigator HIV感染症 / 潜伏感染 / CRISPRスクリーン / HIV潜伏感染 / HIV-1 / shock and kill / HIV / マイトファジー / ミトコンドリア / HIV感染症根治療法 … More / 潜伏感染再活性化薬 / トランスクリプトーム解析 / CRISPR/Cas9 / CAGE法 / 再活性化 / mTOR経路 / CRISPRスクリーニング / トランスクリプトーム / シチジン脱アミノ化酵素 / HDAC3 / アセチル化 / APOBEC3G / HIV-1 Vif / DNAシトシン脱アミノ化酵素APOBEC3G / ヒストン脱アセチル化酵素 / Vif … More Except Principal Investigator 癌の不均一性 / シングルセル解析 / CAGE法 / APOBEC signature / マウスモデル / 治療抵抗性 / 癌の多様性 / 癌のクローン進化 / APOBEC3 / C-to-T変異 / シチジン脱アミノ化 / ゲノム変異 / クローン進化 / がん / APOBEC / ゲノム解析 / 腫瘍 / NET-CAGE法 / 造血器腫瘍 / 次世代シークエンサー / 遺伝子発現制御 / ゲノム科学 / バイオインフォマティクス / 次世代シークエンシング / ノンコーディングゲノム・RNA / ヒトゲノム科学 / 造血器悪性腫瘍 / NET-CAGE / 転写ネットワーク / バイオマーカー / ゲノム解析技術 / エンハンサー / 白血病 Less

CRISPR screen to identify novel molecular mechanisms of HIV-1 latencyPrincipal Investigator
- Principal Investigator
  
  白川康太郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Kyoto University
Transcriptome analysis of HIV-1 latently infected cellsPrincipal Investigator
- Principal Investigator
  
  Shirakawa Kotaro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Kyoto University
APOBEC3B-induced genome mutations and its contribution to clonal evolution in cancers
- Principal Investigator
  
  Takaori-Kondo Akifumi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kyoto University
Comprehensive enhancer analysis and molecular pathogenesis of leukemia using our novel technology
- Principal Investigator
  
  Murakawa Yasuhiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Institute of Physical and Chemical Research
Role of A3G acetylation and Vif/HDAC3 complex in HIV-1 infectionPrincipal Investigator
- Principal Investigator
  
  Shirakawa Kotaro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Kyoto University

All 2024 2022 2021 2020 2019

All Journal Article Presentation Patent

[Journal Article] ILF2 enhances the DNA cytosine deaminase activity of tumor mutator APOBEC3B in multiple myeloma cells2022
- Author(s)
  Kazuma Yasuhiro、Shirakawa Kotaro、Tashiro Yusuke、Yamazaki Hiroyuki、Nomura Ryosuke、Horisawa Yoshihito、Takeuchi Suguru、Stanford Emani、Konishi Yoshinobu、Matsui Hiroyuki、Matsumoto Tadahiko、Tanabe Fumiko、Morishita Ryo、Ito Shinji、Takaori-Kondo Akifumi
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 2278-2278
- DOI
  10.1038/s41598-022-06226-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03502, KAKENHI-PROJECT-20J01623
[Journal Article] CAGE-Seq Reveals that HIV-1 Latent Infection Does Not Trigger Unique Cellular Responses in a Jurkat T Cell Model2021
- Author(s)
  Matsui Hiroyuki、Shirakawa Kotaro、Konishi Yoshinobu、Hirabayashi Shigeki、Sarca Anamaria Daniela、Fukuda Hirofumi、Nomura Ryosuke、Stanford Emani、Horisawa Yoshihito、Kazuma Yasuhiro、Matsumoto Tadahiko、Yamazaki Hiroyuki、Murakawa Yasuhiro、Battivelli Emilie、Verdin Eric、Koyanagi Yoshio、Takaori-Kondo Akifumi
- Journal Title
  
  Journal of Virology
  
  Volume: 95 Issue: 8 Pages: 1-18
- DOI
  10.1128/jvi.02394-20
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20J01623, KAKENHI-PROJECT-19K07591, KAKENHI-PROJECT-20K21407, KAKENHI-PROJECT-20KK0186
[Journal Article] APOBEC3B is preferentially expressed at the G2/M phase of cell cycle2021
- Author(s)
  Hirabayashi Shigeki、Shirakawa Kotaro、Horisawa Yoshihito、Matsumoto Tadahiko、Matsui Hiroyuki、Yamazaki Hiroyuki、Sarca Anamaria Daniela、Kazuma Yasuhiro、Nomura Ryosuke、Konishi Yoshinobu、Takeuchi Suguru、Stanford Emani、Kawaji Hideya、Murakawa Yasuhiro、Takaori-Kondo Akifumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 546 Pages: 178-184
- DOI
  10.1016/j.bbrc.2021.02.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03992, KAKENHI-PROJECT-19H03502, KAKENHI-PROJECT-20J01623, KAKENHI-PROJECT-19K07591, KAKENHI-PROJECT-20K21407, KAKENHI-PROJECT-20KK0186
[Journal Article] FRET-Based Detection and Quantification of HIV-1 Virion Maturation2021
- Author(s)
  Sarca Anamaria D.、Sardo Luca、Fukuda Hirofumi、Matsui Hiroyuki、Shirakawa Kotaro、Horikawa Kazuki、Takaori-Kondo Akifumi、Izumi Taisuke
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 12 Pages: 1-13
- DOI
  10.3389/fmicb.2021.647452
- NAID
  120007180366
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07591, KAKENHI-PLANNED-18H05415
[Journal Article] Critical role of PP2A-B56 family protein degradation in HIV-1 Vif mediated G2 cell cycle arrest2020
- Author(s)
  Nagata Kayoko、Shindo Keisuke、Matsui Yusuke、Shirakawa Kotaro、Takaori-Kondo Akifumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 527 Issue: 1 Pages: 257-263
- DOI
  10.1016/j.bbrc.2020.04.123
- NAID
  120006865708
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08807, KAKENHI-PROJECT-19K07591
[Journal Article] APOBEC3B reporter myeloma cell lines identify DNA damage response pathways leading to APOBEC3B expression2020
- Author(s)
  Yamazaki Hiroyuki、Shirakawa Kotaro、Matsumoto Tadahiko、Kazuma Yasuhiro、Matsui Hiroyuki、Horisawa Yoshihito、Stanford Emani、Sarca Anamaria Daniela、Shirakawa Ryutaro、Shindo Keisuke、Takaori-Kondo Akifumi
- Journal Title
  
  PLOS ONE
  
  Volume: 15 Issue: 1 Pages: e0223463-e0223463
- DOI
  10.1371/journal.pone.0223463
- NAID
  120006786934
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07342, KAKENHI-PROJECT-19H03502
[Journal Article] Alternative splicing of APOBEC3D generates functional diversity and its role as a DNA mutator2020
- Author(s)
  Takei Hisashi、Fukuda Hirofumi、Pan Gilbert、Yamazaki Hiroyuki、Matsumoto Tadahiko、Kazuma Yasuhiro、Fujii Masanori、Nakayama Sohei、Kobayashi Ikei S.、Shindo Keisuke、Yamashita Riu、Shirakawa Kotaro、Takaori-Kondo Akifumi、Kobayashi Susumu S.
- Journal Title
  
  International Journal of Hematology
  
  Volume: 112 Issue: 3 Pages: 395-408
- DOI
  10.1007/s12185-020-02904-y
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23930, KAKENHI-PROJECT-19H03502, KAKENHI-PROJECT-16K21746, KAKENHI-PROJECT-19K07591
[Journal Article] Protein kinase A inhibits tumor mutator APOBEC3B through phosphorylation2019
- Author(s)
  Matsumoto Tadahiko、Shirakawa Kotaro、Yokoyama Masaru、Fukuda Hirofumi、Sarca Anamaria Daniela、Koyabu Sukenao、Yamazaki Hiroyuki、Kazuma Yasuhiro、Matsui Hiroyuki、Maruyama Wataru、Nagata Kayoko、Tanabe Fumiko、Kobayashi Masayuki、Shindo Keisuke、Morishita Ryo、Sato Hironori、Takaori-Kondo Akifumi
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 8307-8307
- DOI
  10.1038/s41598-019-44407-9
- NAID
  120006644044
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03502
[Journal Article] Endogenous APOBEC3B Overexpression Constitutively Generates DNA Substitutions and Deletions in Myeloma Cells2019
- Author(s)
  Yamazaki Hiroyuki、Shirakawa Kotaro、Matsumoto Tadahiko、Hirabayashi Shigeki、Murakawa Yasuhiro、Kobayashi Masayuki、Sarca Anamaria Daniela、Kazuma Yasuhiro、Matsui Hiroyuki、Maruyama Wataru、Fukuda Hirofumi、Shirakawa Ryutaro、Shindo Keisuke、Ri Masaki、Iida Shinsuke、Takaori-Kondo Akifumi
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 7122-7122
- DOI
  10.1038/s41598-019-43575-y
- NAID
  120006629181
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07342, KAKENHI-PROJECT-19H03502
[Journal Article] NET-CAGE characterizes the dynamics and topology of human transcribed cis-regulatory elements2019
- Author(s)
  Hirabayashi Shigeki、Bhagat Shruti、Matsuki Yu、Takegami Yujiro、Uehata Takuya、Kanemaru Ai、Itoh Masayoshi、Shirakawa Kotaro、Takaori-Kondo Akifumi、Takeuchi Osamu、Carninci Piero、Katayama Shintaro、Hayashizaki Yoshihide、Kere Juha、Kawaji Hideya、Murakawa Yasuhiro
- Journal Title
  
  Nature Genetics
  
  Volume: 51 Issue: 9 Pages: 1369-1379
- DOI
  10.1038/s41588-019-0485-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-18H03992, KAKENHI-PROJECT-16H02902, KAKENHI-PROJECT-18K15185
[Patent] 潜伏感染しているＨＩＶを再活性化するための組成物2024
- Inventor(s)
  白川康太郎、高折晃史、遊佐宏介、松井宏行、野村亮介
- Industrial Property Rights Holder
  白川康太郎、高折晃史、遊佐宏介、松井宏行、野村亮介
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2024-029993
- Filing Date
  2024
- Acquisition Date
  2024
- Data Source
  KAKENHI-PROJECT-22K07085
[Presentation] HIV-1潜伏感染の成立と維持に関与する分子機構2021
- Author(s)
  白川康太郎
- Organizer
  第35回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-19K07591
[Presentation] シトシン脱アミノ化酵素APOBEC3Bの活性はILF2とhnRNPA1により亢進する2021
- Author(s)
  数馬安浩, 白川康太郎, 小西義延, 松井宏行, 松本忠彦, 高折晃史
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03502
[Presentation] HIV-1 latent infection does not trigger cellular transcriptional responses in T-cells2020
- Author(s)
  Hiroyuki Matsui, Kotaro Shirakawa, Shigeki Hirabayashi, Anamaria D. Sarca, Hirofumi Fukuda, Yasuhiro Murakawa, Emilie Battivelli, Eric Verdin, Akifumi Takaori-Kondo
- Organizer
  Keystone Symposia 2020 HIV Pathogenesis and Cure X6
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07591
[Presentation] がんの内在性変異源APOBEC3Bの非コードRNAに結合能力はレトロエレメントを阻害に必要である.2019
- Author(s)
  松本忠彦, 白川康太郎, 小薮助直, 数馬安浩, 山崎寛章, 松井宏行, 高折晃史
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03502
[Presentation] Tumor mutaor APOBEC3B binds to cellular non-coding RNAs to inhibit retroelements.2019
- Author(s)
  松本忠彦, 白川康太郎, 小薮助直, Sarca AD, Stanford E, 福田寛文, 松井宏行, 山崎寛章, 数馬安浩, 堀澤欣史, 高折晃史
- Organizer
  第33回日本エイズ学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03502
[Presentation] シトシン脱アミノ化酵素APOBEC3Bの相互作用蛋白の同定と機能的解析.2019
- Author(s)
  数馬安浩, 白川康太郎, 松井宏行, 山崎寛章, 松本忠彦, 伊藤慎二, 高折晃史
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03502

1. Murakawa Yasuhiro (50765469)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. Takaori-Kondo Akifumi (20324626)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
3. 白川龍太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 新堂啓祐

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 藤井昌学

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 竹内理

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 植畑拓也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shirakawa Kotaro 白川 康太郎

Research Projects

Research Products

Co-Researchers

CRISPR screen to identify novel molecular mechanisms of HIV-1 latencyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Transcriptome analysis of HIV-1 latently infected cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

APOBEC3B-induced genome mutations and its contribution to clonal evolution in cancers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Comprehensive enhancer analysis and molecular pathogenesis of leukemia using our novel technology

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of A3G acetylation and Vif/HDAC3 complex in HIV-1 infectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] ILF2 enhances the DNA cytosine deaminase activity of tumor mutator APOBEC3B in multiple myeloma cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CAGE-Seq Reveals that HIV-1 Latent Infection Does Not Trigger Unique Cellular Responses in a Jurkat T Cell Model2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] APOBEC3B is preferentially expressed at the G2/M phase of cell cycle2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] FRET-Based Detection and Quantification of HIV-1 Virion Maturation2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Critical role of PP2A-B56 family protein degradation in HIV-1 Vif mediated G2 cell cycle arrest2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] APOBEC3B reporter myeloma cell lines identify DNA damage response pathways leading to APOBEC3B expression2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Alternative splicing of APOBEC3D generates functional diversity and its role as a DNA mutator2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Protein kinase A inhibits tumor mutator APOBEC3B through phosphorylation2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Endogenous APOBEC3B Overexpression Constitutively Generates DNA Substitutions and Deletions in Myeloma Cells2019

Author(s)

Shirakawa Kotaro 白川康太郎