Ito Ryo 伊藤亮

Researcher Number	80733815
Other IDs
Affiliation (based on the past Project Information) *help	2019 – 2023: 東北大学, 医学系研究科, 助教 2017: 東北大学, 大学院医学系研究科, 助教 2016 – 2017: 東北大学, 医学系研究科, 助教 2014 – 2015: 東北大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Endocrinology / Basic Section 59040:Nutrition science and health science-related / Basic Section 54040:Metabolism and endocrinology-related Except Principal Investigator Endocrinology
Keywords	Principal Investigator 遺伝子発現制御 / エピゲノム / 内分泌 / 脂肪組織 / 血管内皮 / 骨格筋 / 代謝 / サルコペニア肥満 / 脂肪 / エネルギー代謝 … More / プロテオミクス / リン酸化 / 脂肪細胞 / 脱リン酸化 / 熱産生 / 副腎 / プロテオーム / 発現制御 … More Except Principal Investigator スクリーニング / 創薬 / 糖質応答転写因子 / 化合物ライブラリー / ハイスループットスクリーニング / 糖尿病性腎症 / ChREBP / CRISPR/Cas9システム Less

Understanding of sarcopenia obesity by epigenomic regulationPrincipal Investigator
- Principal Investigator
  
  Ito Ryo
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Tohoku University
Regulatory mechanism of beige adipocyte-differentiation by protein phosphatase.Principal Investigator
- Principal Investigator
  
  Ito Ryo
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Tohoku University
Understanding of molecular mechanism for overgrowth of the cells in adrenal zona glomerulosaPrincipal Investigator
- Principal Investigator
  
  ITO Ryo
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Endocrinology
- Research Institution
  Tohoku University
Innovation of novel therapeutics against diabetic nephropathy targeting ChREBP
- Principal Investigator
  
  Sugawara Akira
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Endocrinology
- Research Institution
  Tohoku University
Establishment of the isolation-method of adrenal zona gromerulosa and the analysis of CYP11B2 gene regulation.Principal Investigator
- Principal Investigator
  
  Ito Ryo
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Endocrinology
- Research Institution
  Tohoku University

All 2022 2021 2020 2018 2017 2015

All Journal Article Presentation Patent

[Journal Article] MYPT1-PP1β phosphatase negatively regulates both chromatin landscape and co-activator recruitment for beige adipogenesis2022
- Author(s)
  Takahashi H, Yang G, Yoneshiro T, Abe Y, Ito R, Yang C, et al.
- Journal Title
  
  Nat Commun
  
  Volume: 13 Issue: 1 Pages: 5715-5715
- DOI
  10.1038/s41467-022-33363-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08548, KAKENHI-PROJECT-21K11692, KAKENHI-PROJECT-22K06178, KAKENHI-PROJECT-22K18411, KAKENHI-PROJECT-20KK0174, KAKENHI-PROJECT-21H04826, KAKENHI-PROJECT-20K21747, KAKENHI-PROJECT-21K21211, KAKENHI-PLANNED-19H05744
[Journal Article] Discovery of a chemical compound that suppresses expression of BEX2, a dormant cancer stem cell-related protein2021
- Author(s)
  Saijoh S, Nakamura-Shima M, Shibuya-Takahashi R, Ito R, Sugawara A, Yamazaki T, Imai T, Asada Y, Matsuura K, Iwai W, Wakui Y, Abue M, Kawamura S, Katayose Y, Fujimori H, Mochizuki M, Yasuda J, Yamaguchi K, Sugamura K,Satoh K, Katori Y, Tamai K.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 537 Pages: 132-139
- DOI
  10.1016/j.bbrc.2020.11.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03795, KAKENHI-PROJECT-20H03756, KAKENHI-PROJECT-20H04099, KAKENHI-PROJECT-17K07193, KAKENHI-PROJECT-19K22793, KAKENHI-PROJECT-21K09665, KAKENHI-PROJECT-19K17952
[Journal Article] Spatiotemporal dynamics of SETD5-containing NCoR-HDAC3 complex determines enhancer activation for adipogenesis2021
- Author(s)
  Matsumura Y, Ito R, Yajima A, Yamaguchi R, Tanaka T, Kawamura T, Magoori K, Abe Y, Uchida A, Yoneshiro T, Hirakawa H, Zhang J, Arai M, Yang C, Yang G, Takahashi H, Fujihashi H, Nakaki R, Yamamoto S, Ota S, Tsutsumi S, Inoue SI, Kimura H, Wada Y, Kodama T, Inagaki T, Osborne TF, Aburatani H, Node K, Sakai J.
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 7045-7045
- DOI
  10.1038/s41467-021-27321-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06390, KAKENHI-PLANNED-19H05744, KAKENHI-PROJECT-19H01031, KAKENHI-PROJECT-21K08548, KAKENHI-PROJECT-21K11692, KAKENHI-PROJECT-20K22647, KAKENHI-PROJECT-20H03729
[Journal Article] Comparative proteomic analysis to identify the novel target gene of angiotensin II in adrenocortical H295R cells2021
- Author(s)
  Ito Ryo、Shima Hiroki、Masuda Koji、Sato Ikuko、Shimada Hiroki、Yokoyama Atsushi、Shirahige Katsuhiko、Igarashi Kazuhiko、Sugawara Akira
- Journal Title
  
  Endocr J
  
  Volume: 68 Issue: 4 Pages: 441-450
- DOI
  10.1507/endocrj.EJ20-0144
- NAID
  130008030764
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07321, KAKENHI-PROJECT-20H04099, KAKENHI-PROJECT-19K22793, KAKENHI-PROJECT-21K19692, KAKENHI-PROJECT-19K17952
[Journal Article] FABP7 Regulates Acetyl-CoA Metabolism Through the Interaction with ACLY in the Nucleus of Astrocytes2020
- Author(s)
  Kagawa Y, Umaru BA, Shima H, Ito R, Zama R, Islam A, Kanno S, Yasui A, Sato S, Jozaki K, Shil SK, Miyazaki H, Kobayashi S, Yamamoto Y, Kogo H, Shimamoto-Mitsuyama C, Sugawara A, Sugino N, Kanamori M, Tominaga T, Yoshikawa T, Fukunaga K, Igarashi K, Owada Y
- Journal Title
  
  Molecular Neurobiology
  
  Volume: 57 Issue: 12 Pages: 4891-4910
- DOI
  10.1007/s12035-020-02057-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05899, KAKENHI-PROJECT-19K07262, KAKENHI-PROJECT-20K07321, KAKENHI-PROJECT-20K11527, KAKENHI-PROJECT-20K11609, KAKENHI-PROJECT-20K21743, KAKENHI-PROJECT-20H04099, KAKENHI-PROJECT-18K09262, KAKENHI-PROJECT-19K22793, KAKENHI-PROJECT-19K17952
[Journal Article] The establishment of a novel high-throughput screening system using RNA-guided genome editing to identify chemicals that suppress aldosterone synthase expression2020
- Author(s)
  Ito R, Morita M, Nakano T, Sato I, Yokoyama A, Sugawara A
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 534 Pages: 672-679
- DOI
  10.1016/j.bbrc.2020.11.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07341, KAKENHI-PROJECT-20H04099, KAKENHI-PROJECT-19K22793, KAKENHI-PROJECT-19K17952
[Journal Article] The reduction of heparan sulphate in the glomerular basement membrane does not augment urinary albumin excretion2018
- Author(s)
  Satoshi Aoki, Akiko Saito-Hakoda, Takeo Yoshikawa, Kyoko Shimizu, Kiyomi Kisu, Susumu Suzuki, Kiyoshi Takagi, Shuji Mizumoto, Shuhei Yamada, Toin H. van Kuppevelt, Atsushi Yokoyama, Taiji Matsusaka, Hiroshi Sato, Sadayoshi Ito, and Akira Sugawara
- Journal Title
  
  Nephrology Dialysis Transplantation
  
  Volume: 33 Issue: 1 Pages: 26-33
- DOI
  10.1093/ndt/gfx218
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08251, KAKENHI-PROJECT-16K08606, KAKENHI-PROJECT-16K08645, KAKENHI-PROJECT-15K07951, KAKENHI-PROJECT-15K09420, KAKENHI-PROJECT-16K15492, KAKENHI-PROJECT-16H03252
[Journal Article] High glucose stimulates expression of aldosterone synthase (CYP11B2) and secretion of aldosterone in human adrenal cells2017
- Author(s)
  Shimada Hiroki、Kogure Naotaka、Noro Erika、Kudo Masataka、Sugawara Kaori、Sato Ikuko、Shimizu Kyoko、Kobayashi Makoto、Suzuki Dai、Parvin Rehana、Saito-Ito Takako、Uruno Akira、Saito-Hakoda Akiko、Rainey William E.、Ito Sadayoshi、Yokoyama Atsushi、Sugawara Akira
- Journal Title
  
  FEBS Open Bio
  
  Volume: 7 Issue: 9 Pages: 1410-1421
- DOI
  10.1002/2211-5463.12277
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08606, KAKENHI-PROJECT-16K09600, KAKENHI-PROJECT-17K01837, KAKENHI-PROJECT-16H03252, KAKENHI-PROJECT-15K09420, KAKENHI-PROJECT-16K15492
[Journal Article] A ubiquitin-proteasome inhibitor bortezomib suppresses the expression of CYP11B2, a key enzyme of aldosterone synthesis2017
- Author(s)
  Ito Ryo、Sato Ikuko、Tsujita Tadayuki、Yokoyama Atsushi、Sugawara Akira
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 489 Issue: 1 Pages: 21-28
- DOI
  10.1016/j.bbrc.2017.05.109
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08606, KAKENHI-PROJECT-17K19916, KAKENHI-PROJECT-16H05922, KAKENHI-PROJECT-16K19550
[Journal Article] Suppressive effects of RXR agonist PA024 on adrenal CYP11B2 expression, aldosterone secretion and blood pressure2017
- Author(s)
  Suzuki Dai、Saito-Hakoda Akiko、Ito Ryo、Shimizu Kyoko、Parvin Rehana、Shimada Hiroki、Noro Erika、Suzuki Susumu、Fujiwara Ikuma、Kagechika Hiroyuki、Rainey William E.、Kure Shigeo、Ito Sadayoshi、Yokoyama Atsushi、Sugawara Akira
- Journal Title
  
  PLoS One
  
  Volume: 12 Issue: 8 Pages: e0181055-e0181055
- DOI
  10.1371/journal.pone.0181055
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08606, KAKENHI-PROJECT-16H03252, KAKENHI-PROJECT-15K09420, KAKENHI-PROJECT-16K15492, KAKENHI-PROJECT-16K19550
[Journal Article] Role of NeuroD1 on the negative regulation of Pomc expression by glucocorticoid.2017
- Author(s)
  Parvin R, Saito-Hakoda A, Shimada H, Shimizu K, Noro E, Iwasaki Y, Fujiwara K, Yokoyama A, Sugawara A.
- Journal Title
  
  PLoS One.
  
  Volume: 12(4) Issue: 4 Pages: e0175435-e0175435
- DOI
  10.1371/journal.pone.0175435
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03252, KAKENHI-PROJECT-15K09420, KAKENHI-PROJECT-16K15492
[Patent] アルドステロン合成酵素発現阻害剤2017
- Inventor(s)
  菅原明、伊藤亮
- Industrial Property Rights Holder
  国立大学法人東北大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-064702
- Filing Date
  2017-03-29
- Data Source
  KAKENHI-PROJECT-16K19550
[Presentation] Histone demethylation activity of JMJD1A is required for mitochondrial biogenesis and adaptive thermogenesis.2022
- Author(s)
  謝詩雨、伊藤亮、ミャグマルトゥメンジャルガル、楊超然、高橋宙大、米代武、松村欣宏、酒井寿郎
- Organizer
  第95回　日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K11692
[Presentation] SETD5-NCoR-HDAC3 複合体による時空間特異的なエンハンサー活性調節による脂肪細胞分化機構の解明2022
- Author(s)
  伊藤亮, 松村欣宏, 矢島あゆむ, 山口玲, 田中十志也, 川村猛, 馬郡健太, 阿部陽平, 内田あおい, 米代武司, 張吉, 荒井誠, 楊超然, 楊歌, 高橋宙大, 堤修一, 稲垣毅, 油谷浩幸, 野出孝一, 酒井寿郎
- Organizer
  第25回アディポサイエンスシンポジウム
- Data Source
  KAKENHI-PROJECT-21K11692
[Presentation] 褐色脂肪組織と白色脂肪組織で異なるヒストン脱メチル化酵素JMJD1Aの寒冷適応に対する役割2022
- Author(s)
  伊藤亮、謝詩雨、ミャグマルトゥメンジャルガル、米代武司、松村欣宏、酒井寿郎
- Organizer
  第99回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-21K11692
[Presentation] Signal sensing histone demethylase regulates a concerted thermogenic response in brown adipose tissue and subcutaneous white adipose tissue in animals2022
- Author(s)
  伊藤亮、謝詩雨、ミャグマルトゥメンジャルガル、楊超然、高橋宙大、米代武、松村欣宏、酒井寿郎
- Organizer
  第65回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K11692
[Presentation] Different role of signal sensing histone demethylase JMJD1A for adaptive thermogenesis in brown adipose tissue and subcutaneous white adipose tissue in animals2022
- Author(s)
  伊藤亮、謝詩雨、ミャグマルトゥメンジャルガル、楊超然、高橋宙大、米代武、松村欣宏、酒井寿郎
- Organizer
  第95回内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K11692
[Presentation] ヒストン脱メチル化酵素JMJD1Aの酵素活性は褐色脂肪組織の熱産生には不要であり白色脂肪組織における熱産生に必要である2021
- Author(s)
  伊藤亮、謝詩雨、ミャグマルトゥメンジャルガル、米代武司、松村欣宏、酒井寿郎
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K11692
[Presentation] MEKT1, a novel PPAR-gamma agonist, significantly suppressed Pomc expression/ACTH secretion in AtT20 cells2018
- Author(s)
  Rehana Parvin, Akiko Saito-Hakoda, Hiroki Shimada, Erika Noro, Susumu Suzuki, Hiroyuki Miyachi Atsushi Yokoyama, Akira Sugawara
- Organizer
  ENDO2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15492
[Presentation] Generation and functional analyses of stable H295R cell lines expressing mutants KCNJ5 proteins2018
- Author(s)
  Ryo Ito, Ikuko Sato, Keita Hoshi, Akira Sugawara
- Organizer
  ENDO2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15492
[Presentation] 化合物スクリーニングを用いたアルドステロン合成酵素CYP11B2遺伝子発現制御機構の解析2017
- Author(s)
  伊藤　亮、佐藤　郁子、菅原　明
- Organizer
  第９０回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K19550
[Presentation] アルドステロン合成酵素遺伝子CYP11B2の発現抑制化合物の探索2015
- Author(s)
  伊藤　亮
- Organizer
  創薬等支援技術基盤プラットフォーム事業東北大拠点第二回公開シンポジウム
- Place of Presentation
  東北大学（宮城県仙台市）
- Year and Date
  2015-11-21
- Invited
- Data Source
  KAKENHI-PROJECT-26893012

1. Sugawara Akira (90270834)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
2. SAWATUBASHI Shun (70535103)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. TAKEMOTO Tatsuya (30443899)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. YAMAMOTO Yasuhiko (20313637)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. TAKAGI Kiyoshi (80595562)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Sato Horoshi (60215829)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. Yokoyama Atsushi (20572332)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
8. DOI Takayuki (90212076)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. YAMAMOTO YUI

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. SHIMA hiroki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. NORO erika

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. MIZUMOTO Shuji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. SHIMADA hiroki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. MORITA Masanobu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 大和田祐二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 菅原一幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 山田修平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 米代武司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 安田純

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 川村猛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 酒井寿郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 松村欣宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ito Ryo 伊藤 亮

Research Projects

Research Products

Co-Researchers

Understanding of sarcopenia obesity by epigenomic regulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulatory mechanism of beige adipocyte-differentiation by protein phosphatase.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Understanding of molecular mechanism for overgrowth of the cells in adrenal zona glomerulosaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Innovation of novel therapeutics against diabetic nephropathy targeting ChREBP

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of the isolation-method of adrenal zona gromerulosa and the analysis of CYP11B2 gene regulation.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] MYPT1-PP1β phosphatase negatively regulates both chromatin landscape and co-activator recruitment for beige adipogenesis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Discovery of a chemical compound that suppresses expression of BEX2, a dormant cancer stem cell-related protein2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Spatiotemporal dynamics of SETD5-containing NCoR-HDAC3 complex determines enhancer activation for adipogenesis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comparative proteomic analysis to identify the novel target gene of angiotensin II in adrenocortical H295R cells2021

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] FABP7 Regulates Acetyl-CoA Metabolism Through the Interaction with ACLY in the Nucleus of Astrocytes2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The establishment of a novel high-throughput screening system using RNA-guided genome editing to identify chemicals that suppress aldosterone synthase expression2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The reduction of heparan sulphate in the glomerular basement membrane does not augment urinary albumin excretion2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High glucose stimulates expression of aldosterone synthase (CYP11B2) and secretion of aldosterone in human adrenal cells2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A ubiquitin-proteasome inhibitor bortezomib suppresses the expression of CYP11B2, a key enzyme of aldosterone synthesis2017

Author(s)

Journal Title

Ito Ryo 伊藤亮