Sakaue Hiroaki 坂上弘明

Researcher Number	80734855
Other IDs
Affiliation (Current)	2025: 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究員
Affiliation (based on the past Project Information) *help	2021 – 2023: 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究員 2017 – 2023: 東京薬科大学, 薬学部, 助教 2016: 国際医療福祉大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Applied health science Except Principal Investigator Basic Section 59040:Nutrition science and health science-related
Keywords	Principal Investigator D-アミノ酸 / アトピー性皮膚炎 / 天然保湿因子 / ショットガンプロテオミクス / 表皮角化細胞 / フィラグリン / 皮膚バリア機能 / タンパク質 / アスパラギン酸残基の異性化 / 紫外線 / 異性化 / アスパラギン酸 … More Except Principal Investigator … More ドパミン / 日光 / 紫外線 / うつ / 神経伝達物質 / 精神的ストレス / 鬱 / アクネ / ざ瘡 / ストレス / 光刺激 / 中枢神経 / 皮膚 / 精神疾患 / UVA / 太陽光 Less

Effects of free D-amino acids for skin barrier functionPrincipal Investigator
- Principal Investigator
  
  Sakaue Hiroaki
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  National Institute of Advanced Industrial Science and Technology
  Tokyo University of Pharmacy and Life Science
Effects of Sunlight on Mental Health
- Principal Investigator
  
  Mizuno Koji
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
  National Center for Geriatrics and Gerontology
Investigation of isomerization mechanism of aspartic acid involved in the development of cataractPrincipal Investigator
- Principal Investigator
  
  Sakaue Hiroaki
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied health science
- Research Institution
  Tokyo University of Pharmacy and Life Science
  International University of Health and Welfare

All 2024 2023 2022 2021 2020 2018 2017

All Journal Article Presentation Patent

[Journal Article] Near‐infrared radiation causes sebaceous gland enlargement along with an ROS‐dependent augmentation of epidermal growth factor receptor expression in hamsters2023
- Author(s)
  Tanaka Shiho、Sakaue Hiroaki、Koiwai Toshikazu、Okuda Natsuki、Okuyama Katsuki、Horioka Yoshihiko、Hiramatsu Yasunari、Kawashima Makoto、Ishiguro Naoko、Sato Takashi
- Journal Title
  
  Experimental Dermatology
  
  Volume: 32 Issue: 10 Pages: 1717-1724
- DOI
  10.1111/exd.14878
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K19719
[Journal Article] Molecular mechanisms of cyclic phosphatidic acid-induced lymphangiogenic actions in vitro2022
- Author(s)
  Okuyama Katsuki、Mizuno Koji、Nittami Keisuke、Sakaue Hiroaki、Sato Takashi
- Journal Title
  
  Microvascular Research
  
  Volume: 139 Pages: 104273-104273
- DOI
  10.1016/j.mvr.2021.104273
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11652
[Journal Article] An increase in normetanephrine in hair follicles of acne lesions through the sympatho‐adrenal medullary system in acne patients with anxiety2021
- Author(s)
  Mizuno Koji、Sakaue Hiroaki、Kohsaka Keita、Takeda Hidetomo、Hayashi Nobukazu、Sato Takashi
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 48 Issue: 8 Pages: 1281-1285
- DOI
  10.1111/1346-8138.15935
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K11652
[Journal Article] D-Alanine Is Reduced by Ocular Hypertension in the Rat Retina.2020
- Author(s)
  Takashi Kanamoto, Hiroaki Sakaue, Yasushi Kitaoka, Ryo Asaoka, Kei Tobiume, and Yoshiaki Kiuchi
- Journal Title
  
  Current Eye Research
  
  Volume: 45 Issue: 4 Pages: 490-495
- DOI
  10.1080/02713683.2019.1666995
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K16605, KAKENHI-PROJECT-18K09813
[Journal Article] D-Amino acids in protein: The mirror of life as a molecular index of aging2018
- Author(s)
  Fujii Noriko、Takata Takumi、Fujii Norihiko、Aki Kenzo、Sakaue Hiroaki
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
  
  Volume: in press Issue: 7 Pages: 840-847
- DOI
  10.1016/j.bbapap.2018.03.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K13221, KAKENHI-PROJECT-16K16605
[Journal Article] Isomeric Replacement of a Single Aspartic Acid Induces a Marked Change in Protein Function: The Example of Ribonuclease A2017
- Author(s)
  Sakaue H, Kinouchi T, Fujii N, Takumi T, Fujii N.
- Journal Title
  
  ACS Omega
  
  Volume: 2 Issue: 1 Pages: 260-267
- DOI
  10.1021/acsomega.6b00346
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25288075, KAKENHI-PROJECT-15K16514, KAKENHI-PROJECT-16K00600, KAKENHI-PROJECT-16K16605, KAKENHI-PROJECT-17K13221
[Patent] イソアスパラギン酸(Lβーアスパラギン酸)残基を標識する方法2024
- Inventor(s)
  坂上弘明、久野敦
- Industrial Property Rights Holder
  国立研究開発法人産業技術総合研究所
- Industrial Property Rights Type
  特許
- Filing Date
  2024
- Overseas
- Data Source
  KAKENHI-PROJECT-20K19719
[Patent] イソアスパラギン酸（Ｌβ－アスパラギン酸）残基を標識する方法2023
- Inventor(s)
  坂上弘明、久野敦
- Industrial Property Rights Holder
  国立研究開発法人　産業技術総合研究所
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-115213
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-20K19719
[Presentation] Lβ-Asp化ペプチドの網羅的ラベル化とデータベース検索を利用した大規模解析2024
- Author(s)
  坂上弘明、久野敦
- Organizer
  日本薬学会
- Data Source
  KAKENHI-PROJECT-20K19719
[Presentation] タンパク質中のアミノ酸異性体解析技術の開発2023
- Author(s)
  坂上弘明、久野敦
- Organizer
  日本プロテオーム学会
- Data Source
  KAKENHI-PROJECT-20K19719
[Presentation] データベース検索を指向したLβ-Asp化ペプチドの大規模解析技術の開発2023
- Author(s)
  坂上弘明、久野敦
- Organizer
  D-アミノ酸学会
- Data Source
  KAKENHI-PROJECT-20K19719
[Presentation] A single aspartyl isomer at a specific site induces a change in protein function.2017
- Author(s)
  Hiroaki Sakaue
- Organizer
  The 3rd International Conference of D-Amino Acid Research
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K16605

1. Mizuno Koji (10551046)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 高田匠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 木野内忠稔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 藤井紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sakaue Hiroaki 坂上 弘明

Research Projects

Research Products

Co-Researchers

Effects of free D-amino acids for skin barrier functionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Effects of Sunlight on Mental Health

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of isomerization mechanism of aspartic acid involved in the development of cataractPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Near‐infrared radiation causes sebaceous gland enlargement along with an ROS‐dependent augmentation of epidermal growth factor receptor expression in hamsters2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular mechanisms of cyclic phosphatidic acid-induced lymphangiogenic actions in vitro2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An increase in normetanephrine in hair follicles of acne lesions through the sympatho‐adrenal medullary system in acne patients with anxiety2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] D-Alanine Is Reduced by Ocular Hypertension in the Rat Retina.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] D-Amino acids in protein: The mirror of life as a molecular index of aging2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Isomeric Replacement of a Single Aspartic Acid Induces a Marked Change in Protein Function: The Example of Ribonuclease A2017

Author(s)

Journal Title

DOI

Data Source

[Patent] イソアスパラギン酸(Lβーアスパラギン酸)残基を標識する方法2024

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Patent] イソアスパラギン酸（Ｌβ－アスパラギン酸）残基を標識する方法2023

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Presentation] Lβ-Asp化ペプチドの網羅的ラベル化とデータベース検索を利用した大規模解析2024

Author(s)

Organizer

Data Source

[Presentation] タンパク質中のアミノ酸異性体解析技術の開発2023

Author(s)

Organizer

Data Source

[Presentation] データベース検索を指向したLβ-Asp化ペプチドの大規模解析技術の開発2023

Author(s)

Organizer

Data Source

[Presentation] A single aspartyl isomer at a specific site induces a change in protein function.2017

Author(s)

Organizer

Sakaue Hiroaki 坂上弘明