Kofuku Yutaka 幸福裕

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KOFUKU Yutaka 幸福裕

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Researcher Number	80737940
Other IDs
Affiliation (Current)	2025: 東京大学, 大学院薬学系研究科(薬学部), 講師
Affiliation (based on the past Project Information) *help	2025: 東京大学, 大学院薬学系研究科(薬学部), 講師 2019 – 2024: 東京大学, 大学院薬学系研究科(薬学部), 助教 2014 – 2018: 東京大学, 大学院薬学系研究科(薬学部), 特任助教
Review Section/Research Field	Principal Investigator Physical pharmacy / Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Basic Section 43020:Structural biochemistry-related / Transformative Research Areas, Section (II) / Medium-sized Section 47:Pharmaceutical sciences and related fields / Complex systems / Structural biochemistry / Biological Sciences
Keywords	Principal Investigator シグナル伝達 / 膜タンパク質 / 核磁気共鳴法 / 生物物理 / 薬学 / 蛋白質 / 構造生物学 / Gタンパク質共役型受容体 / 安定同位体標識 / 相互作用 … More / 免疫学 / 脂質二重膜 / 脂質 / GPCR / NMR Less

多様なリガンドによるGタンパク質共役型受容体の活性制御機構の解明Principal Investigator
- Principal Investigator
  
  幸福裕
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  The University of Tokyo
NMR法を用いたリガンドー受容体間の弱い相互作用によるシグナル伝達制御機構の解明Principal Investigator
- Principal Investigator
  
  幸福裕
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  The University of Tokyo
核磁気共鳴法を用いたGタンパク質共役型受容体によるシグナル制御機構の解明Principal Investigator
- Principal Investigator
  
  幸福裕
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  The University of Tokyo
Novel techniques to investigate function-related dynamics of membrane proteinsPrincipal Investigator
- Principal Investigator
  
  Kofuku Yutaka
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokyo
GPCR細胞内シグナル伝達の立体構造に基づく定量的解析Principal Investigator
- Principal Investigator
  
  幸福裕
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  The University of Tokyo
Structural basis of signal transduction mediated by various GPCRsPrincipal Investigator
- Principal Investigator
  
  Kofuku Yutaka
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  The University of Tokyo
リポクオリティ依存的なGPCRのシグナル伝達の構造生物学的解明Principal Investigator
- Principal Investigator
  
  幸福裕
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Structural basis of biased signaling mediated by pharmacologically important GPCRsPrincipal Investigator
- Principal Investigator
  
  KOFUKU Yutaka
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  The University of Tokyo
バイアスリガンドによるGPCRのシグナル伝達制御機構の解明Principal Investigator
- Principal Investigator
  
  幸福裕
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Physical pharmacy
- Research Institution
  The University of Tokyo

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Activation mechanism of the μ-opioid receptor by an allosteric modulator.2022
- Author(s)
  Kaneko S, Imai S, Asao N, Kofuku Y, Ueda T, Shimada I.
- Journal Title
  
  Proc. Natl. Acad. Sci. U. S. A.
  
  Volume: 119 Issue: 16
- DOI
  10.1073/pnas.2121918119
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-21H05509, KAKENHI-PROJECT-20H03375, KAKENHI-PROJECT-20K21473, KAKENHI-PROJECT-17H06097, KAKENHI-PROJECT-23K21289
[Journal Article] GPCRのNMR・ESR解析2021
- Author(s)
  幸福裕、今井駿輔、上田卓見、嶋田一夫
- Journal Title
  
  細胞
  
  Volume: 53 Pages: 280-284
- Data Source
  KAKENHI-PROJECT-17H04999
[Journal Article] Function-Related Dynamics in Multi-Spanning Helical Membrane Proteins Revealed by Solution NMR2021
- Author(s)
  Takeuchi Koh、Kofuku Yutaka、Imai Shunsuke、Ueda Takumi、Tokunaga Yuji、Toyama Yuki、Shiraishi Yutaro、Shimada Ichio
- Journal Title
  
  Membranes
  
  Volume: 11 Issue: 8 Pages: 604-604
- DOI
  10.3390/membranes11080604
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21494, KAKENHI-PUBLICLY-20H04722, KAKENHI-PROJECT-18H02393, KAKENHI-PROJECT-21H02619, KAKENHI-PROJECT-20K21473, KAKENHI-PROJECT-17H06097, KAKENHI-PUBLICLY-21H05509, KAKENHI-PROJECT-20H03375, KAKENHI-PROJECT-20H03378, KAKENHI-PROJECT-23K21289
[Journal Article] GPCRのNMR・ESR解析2021
- Author(s)
  幸福裕、今井駿輔、上田卓見、嶋田一夫
- Journal Title
  
  細胞
  
  Volume: 53 Pages: 280-284
- Data Source
  KAKENHI-PROJECT-20K21473
[Journal Article] GPCRのNMR・ESR解析2021
- Author(s)
  幸福裕、今井駿輔、上田卓見、嶋田一夫
- Journal Title
  
  細胞
  
  Volume: 53 Pages: 280-284
- Data Source
  KAKENHI-PUBLICLY-19H04946
[Journal Article] Biphasic activation of β-arrestin 1 upon interaction with a GPCR revealed by methyl-TROSY NMR2021
- Author(s)
  Shiraishi Yutaro、Kofuku Yutaka、Ueda Takumi、Pandey Shubhi、Dwivedi-Agnihotri Hemlata、Shukla Arun K.、Shimada Ichio
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 7158-7158
- DOI
  10.1038/s41467-021-27482-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21473, KAKENHI-PROJECT-17H06097, KAKENHI-PUBLICLY-21H05509, KAKENHI-PROJECT-20H03375, KAKENHI-PROJECT-23K21289
[Journal Article] Activation of adenosine A2A receptor by lipids from docosahexaenoic acid revealed by NMR2020
- Author(s)
  Takuya Mizumura, Keita Kondo, Masatoshi Kurita, Yutaka Kofuku, Mei Natsume, Shunsuke Imai, Yutaro Shiraishi, Takumi Ueda, Ichio Shimada
- Journal Title
  
  Science Advances
  
  Volume: 6 Issue: 12
- DOI
  10.1126/sciadv.aay8544
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-18H04540, KAKENHI-PUBLICLY-19H04946, KAKENHI-PUBLICLY-19H04951, KAKENHI-PROJECT-17H04999, KAKENHI-PROJECT-17H06097, KAKENHI-PROJECT-20H03375
[Journal Article] Structural equilibrium underlying ligand-dependent activation of b2-adrenoreceptor2020
- Author(s)
  Shunsuke Imai, Tomoki Yokomizo, Yutaka Kofuku, Yutaro Shiraishi, Takumi Ueda, Ichio Shimada
- Journal Title
  
  Nature Chemical Biology
  
  Volume: 16 Issue: 4 Pages: 430-439
- DOI
  10.1038/s41589-019-0457-5
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-18H04540, KAKENHI-PUBLICLY-19H04946, KAKENHI-PUBLICLY-19H04951, KAKENHI-PROJECT-17H04999, KAKENHI-PROJECT-17H06097, KAKENHI-PROJECT-20H03375
[Journal Article] Phosphorylation-induced conformation of β2-adrenoceptor related to arrestin recruitment revealed by NMR2018
- Author(s)
  Yutaro Shiraishi, Mei Natsume, Yutaka Kofuku, Shunsuke Imai, Kunio Nakata, Toshimi Mizukoshi, Takumi Ueda, Hideo Iwai, Ichio Shimada
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 164-164
- DOI
  10.1038/s41467-017-02632-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08191, KAKENHI-PROJECT-17H06097, KAKENHI-PUBLICLY-16H01353, KAKENHI-PUBLICLY-16H01531, KAKENHI-PROJECT-17H04999, KAKENHI-PROJECT-17J11420
[Journal Article] GPCR drug discovery: integrating solution NMR data with crystal and cryo-EM structures2018
- Author(s)
  Shimada Ichio、Ueda Takumi、Kofuku Yutaka、Eddy Matthew T.、Wuthrich Kurt
- Journal Title
  
  Nature Reviews Drug Discovery
  
  Volume: 18 Issue: 1 Pages: 59-82
- DOI
  10.1038/nrd.2018.180
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04540, KAKENHI-PROJECT-17H04999, KAKENHI-PROJECT-16K08191, KAKENHI-PROJECT-17H06097
[Journal Article] Deuteration and Selective Labeling of Alanine Methyl Groups of β 2-Adrenergic Receptor Expressed in a Baculovirus-Insect Cell Expression System2018
- Author(s)
  Yutaka Kofuku, Tomoki Yokomizo, Shunsuke Imai, Yutaro Shiraishi, Mei Natsume, Hiroaki Itoh, Masayuki Inoue, Kunio Nakata, Shunsuke Igarashi, Hideyuki Yamaguchi, Toshimi Mizukoshi, Ei-Ichiro Suzuki, Takumi Ueda, Ichio Shimada
- Journal Title
  
  Journal of Biomolecular NMR
  
  Volume: 印刷中 Issue: 3 Pages: 185-192
- DOI
  10.1007/s10858-018-0174-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08191, KAKENHI-PROJECT-17K15421, KAKENHI-PROJECT-17H06097, KAKENHI-PUBLICLY-16H01353, KAKENHI-PUBLICLY-16H01531, KAKENHI-PROJECT-17H06110, KAKENHI-PROJECT-17H04999, KAKENHI-PROJECT-17J11420, KAKENHI-PUBLICLY-18H04540
[Journal Article] Utilization of paramagnetic relaxation enhancements for structural analysis of actin-binding proteins in complex with actin.2016
- Author(s)
  Huang S, Umemoto R, Tamura Y, Kofuku Y, Uyeda TQP, Nishida N, Shimada I
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 33690-33690
- DOI
  10.1038/srep33690
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-24117008, KAKENHI-PLANNED-26119005, KAKENHI-PROJECT-15K18843, KAKENHI-PUBLICLY-16H01353
[Journal Article] Conductance of P2X4 receptor is determined by conformational equilibrium in the transmembrane region2016
- Author(s)
  Minato Y, Suzuki S , Hara T, Kofuku Y, Kasuya G, Fujiwara Y, Igarashi S, Suzuki E, Nureki O, Hattori M, Ueda T, Shimada I
- Journal Title
  
  Proc. Natl. Acad. Sci.
  
  Volume: 発行中 Issue: 17 Pages: 4741-4746
- DOI
  10.1073/pnas.1600519113
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460033, KAKENHI-PROJECT-25670108, KAKENHI-PUBLICLY-26120506, KAKENHI-PUBLICLY-16H01389, KAKENHI-PROJECT-26291030, KAKENHI-PROJECT-15K18843, KAKENHI-PROJECT-16K08191, KAKENHI-PROJECT-16K15180, KAKENHI-PUBLICLY-16H01353
[Journal Article] Identification of a Conformational Equilibrium That Determines the Efficacy and Functional Selectivity of the μ-Opioid Receptor.2015
- Author(s)
  Junya Okude, Takumi Ueda, Yutaka Kofuku, Motohiko Sato, Naoyuki Nobuyama, Keita Kondo, Yutaro Shiraishi, Takuya Mizumura, Kento Onishi, Mei Natsume, Masahiro Maeda, Hideki Tsujishita, Takefumi Kuranaga, Masayuki Inoue, Ichio Shimada
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 21 Issue: 52 Pages: 15771-15776
- DOI
  10.1002/anie.201508794
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K18843, KAKENHI-PROJECT-26253003, KAKENHI-PROJECT-15J12409, KAKENHI-PROJECT-25460033, KAKENHI-PUBLICLY-26120506
[Journal Article] Elucidation of the CCR1- and CCR5-binding modes of MIP-1α by application of an NMR spectra reconstruction method to the transferred cross-saturation experiments.2015
- Author(s)
  Chie Yoshiura, Takumi Ueda, Yutaka Kofuku, Masahiko Matsumoto, Junya Okude, Keita Kondo, Yutaro Shiraishi, Ichio Shimada
- Journal Title
  
  Journal of Biomolecular NMR
  
  Volume: 63 Issue: 4 Pages: 333-340
- DOI
  10.1007/s10858-015-9992-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K18843, KAKENHI-PROJECT-15J12409, KAKENHI-PROJECT-25460033, KAKENHI-PUBLICLY-26120506
[Journal Article] Development of a method for reconstruction of crowded NMR spectra from undersampled time-domain data2015
- Author(s)
  Ueda T, Yoshiura C, Matsumoto M, Kofuku Y, Okude J, Kondo K, Shiraishi Y, Takeuchi K, Shimada I
- Journal Title
  
  J. Biomol. NMR
  
  Volume: 印刷中 Issue: 1 Pages: 31-41
- DOI
  10.1007/s10858-015-9908-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-25121708, KAKENHI-PROJECT-25460033, KAKENHI-PROJECT-26893041, KAKENHI-PROJECT-15K18843, KAKENHI-PUBLICLY-26120506, KAKENHI-PROJECT-15J12409
[Journal Article] Functional dynamics of deuterated β2 -adrenergic receptor in lipid bilayers revealed by NMR spectroscopy2014
- Author(s)
  Kofuku Y, Ueda T, Okude J, Shiraishi Y, Kondo K, Mizumura T, Suzuki S, Shimada I
- Journal Title
  
  Angew Chem Int Ed Engl
  
  Volume: 53 Issue: 49 Pages: 13376-13379
- DOI
  10.1002/anie.201406603
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-21121001, KAKENHI-PUBLICLY-25121708, KAKENHI-PROJECT-25460033, KAKENHI-PROJECT-26893041, KAKENHI-PUBLICLY-26120506
[Presentation] 真核細胞発現系における安定同位体標識法の開発2023
- Author(s)
  幸福裕，山本泰雅，魚返祐太朗，徳永裕二，上田卓見，嶋田一夫，竹内恒
- Organizer
  第62回NMR討論会
- Data Source
  KAKENHI-PUBLICLY-23H04055
[Presentation] Function-related conformational dynamics of eukaryotic membrane proteins in lipid bilayers revealed by solution NMR with novel stable isotope labeling methods2023
- Author(s)
  Yutaka Kofuku
- Organizer
  第62回NMR討論会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21289
[Presentation] 真核細胞発現系における安定同位体標識法の開発2023
- Author(s)
  幸福裕，山本泰雅，魚返祐太朗，徳永裕二，上田卓見，嶋田一夫，竹内恒
- Organizer
  第62回NMR討論会
- Data Source
  KAKENHI-PROJECT-23K21289
[Presentation] Function-related conformational dynamics of eukaryotic membrane proteins in lipid bilayers revealed by solution NMR with novel stable isotope labeling methods2023
- Author(s)
  Yutaka Kofuku
- Organizer
  第62回NMR討論会
- Invited
- Data Source
  KAKENHI-PUBLICLY-23H04055
[Presentation] 膜タンパク質の機能解明に向けた哺乳細胞発現系における安定同位体標識法の確立2023
- Author(s)
  山本泰雅，幸福裕，魚返祐太朗，徳永裕二，上田卓見，嶋田一夫，竹内恒
- Organizer
  第62回NMR討論会
- Data Source
  KAKENHI-PROJECT-23K21289
[Presentation] 膜タンパク質の機能解明に向けた哺乳細胞発現系における安定同位体標識法の確立2023
- Author(s)
  山本泰雅，幸福裕，魚返祐太朗，徳永裕二，上田卓見，嶋田一夫，竹内恒
- Organizer
  第62回NMR討論会
- Data Source
  KAKENHI-PUBLICLY-23H04055
[Presentation] 昆虫細胞発現系におけるアラニン選択標識法の開発2022
- Author(s)
  幸福裕，横溝智貴，今井駿輔，白石勇太郎，五十嵐俊介，山口秀幸，水越利巳，鈴木榮一郎，嶋田一夫
- Organizer
  第61回NMR討論会
- Data Source
  KAKENHI-PROJECT-20K21473
[Presentation] ミューオピオイド受容体のアロステリックモジュレーターによる活性化機構の解明2022
- Author(s)
  金子舜，今井駿輔，浅尾信央，幸福裕，上田卓見，嶋田一夫
- Organizer
  第61回NMR討論会
- Data Source
  KAKENHI-PROJECT-20K21473
[Presentation] アデノシンA2A受容体とリガンドの滞在時間を規定する構造基盤の解明2022
- Author(s)
  上田卓見，土田知輝，栗田政稔，水村拓也，今井駿輔，白石勇太郎，幸福裕，竹内恒，嶋田一夫
- Organizer
  第61回NMR討論会
- Data Source
  KAKENHI-PROJECT-20K21473
[Presentation] 昆虫細胞発現系におけるアラニン選択標識法の開発2022
- Author(s)
  幸福裕，横溝智貴，今井駿輔，白石勇太郎，五十嵐俊介，山口秀幸，水越利巳，鈴木榮一郎，嶋田一夫
- Organizer
  第61回NMR討論会
- Data Source
  KAKENHI-PROJECT-23K21289
[Presentation] アデノシンA2A受容体とリガンドの滞在時間を規定する構造基盤の解明2022
- Author(s)
  上田卓見，土田知輝，栗田政稔，水村拓也，今井駿輔，白石勇太郎，幸福裕，竹内恒，嶋田一夫
- Organizer
  第61回NMR討論会
- Data Source
  KAKENHI-PROJECT-23K21289
[Presentation] ミューオピオイド受容体のアロステリックモジュレーターによる活性化機構の解明2022
- Author(s)
  金子舜，今井駿輔，浅尾信央，幸福裕，上田卓見，嶋田一夫
- Organizer
  第61回NMR討論会
- Data Source
  KAKENHI-PROJECT-23K21289
[Presentation] 動的構造平衡に基づいたμオピオイド受容体の活性化機構の解明2021
- Author(s)
  金子舜、今井駿輔、浅尾信央、幸福裕、上田卓見、嶋田一夫
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-17H04999
[Presentation] 昆虫細胞－バキュロウイルス発現系での安定同位体標識と膜タンパク質のNMR解析への応用2021
- Author(s)
  幸福裕
- Organizer
  蛋白研セミナー基礎から学ぶ最新NMR解析法第3回ワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-20K21473
[Presentation] 動的構造平衡に基づいたμオピオイド受容体の活性化機構の解明2021
- Author(s)
  金子舜、今井駿輔、浅尾信央、幸福裕、上田卓見、嶋田一夫
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PUBLICLY-19H04946
[Presentation] 動的構造平衡に基づいたμオピオイド受容体の活性化機構の解明2021
- Author(s)
  金子舜、今井駿輔、浅尾信央、幸福裕、上田卓見、嶋田一夫
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K21473
[Presentation] Dynamics of G protein-coupled receptor related to various signaling revealed by NMR2019
- Author(s)
  Kofuku Y, Shiraishi Y, Natsume M, Okude J, Sato M, Imai S, Kondo K, Mizumura T, Maeda M, Tsujishita H, Kuranaga T, Inoue M, Nakata K, Mizukoshi T, Ueda T, Iwai H, Shimada I
- Organizer
  第57回日本生物物理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-17H04999
[Presentation] Dynamics of G protein-coupled receptor related to various signaling revealed by NMR2019
- Author(s)
  Kofuku Y, Shiraishi Y, Natsume M, Okude J, Sato M, Imai S, Kondo K, Mizumura T, Maeda M, Tsujishita H, Kuranaga T, Inoue M, Nakata K, Mizukoshi T, Ueda T, Iwai H, Shimada I
- Organizer
  第57回日本生物物理学会年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H04946
[Presentation] アラニン側鎖メチル基を観測対象としたβ2-アドレナリン受容体のシグナル伝達機構の解明2018
- Author(s)
  横溝智貴、今井俊輔、幸福裕、上田卓見、白石勇太郎、夏目芽依、中田國夫、五十嵐俊介、水越利巳、鈴木榮一郎、嶋田一夫
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PUBLICLY-16H01353
[Presentation] β2アドレナリン受容体のリン酸化によるシグナル制御機構の解明2018
- Author(s)
  夏目芽依、白石勇太郎、幸福裕、今井駿輔、中田國夫、水越利巳、上田卓見、岩井秀夫、嶋田一夫
- Organizer
  第91回生化学会大会
- Data Source
  KAKENHI-PROJECT-17H04999
[Presentation] β2アドレナリン受容体のリン酸化によるシグナル制御機構の解明2018
- Author(s)
  夏目芽依、白石勇太郎、幸福裕、今井駿輔、中田國夫、水越利巳、上田卓見、岩井秀夫、嶋田一夫
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PUBLICLY-16H01353
[Presentation] 区分同位体標識を用いたβ2アドレナリン受容体のリン酸化によるシグナル制御機構の解明2018
- Author(s)
  白石勇太郎、夏目芽依、幸福裕、今井駿輔、中田國夫、水越利巳、上田卓見、岩井秀夫、嶋田一夫
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17H04999
[Presentation] Deuteration and selective labeling of alanine methyl groups of β2-adrenergic receptor expressed in a baculovirus-insect cell expression system2018
- Author(s)
  Yutaka Kofuku, Tomoki Yokomizo, Shunsuke Imai, Yutaro Shiraishi, Mei Natsume, Hiroaki Itoh, Masayuki Inoue, Kunio Nakata, Shunsuke Igarashi, Hideyuki Yamaguchi, Toshimi Mizukoshi, Ei-Ichiro Suzuki, Takumi Ueda and Ichio Shimada
- Organizer
  XXVIII International Conference on Magnetic Resonance in Biological Systems
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04999
[Presentation] Phosphorylation-induced conformation of β2-adrenoceptor related to arrestin recruitment revealed by NMR2018
- Author(s)
  Yutaro Shiraishi, Mei Natsume, Yutaka Kofuku, Shunsuke Imai, Kunio Nakata, Toshimi Mizukoshi, Takumi Ueda, Hideo Iwai and Ichio Shimada
- Organizer
  XXVIII International Conference on Magnetic Resonance in Biological Systems
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04999
[Presentation] 昆虫細胞発現系におけるアラニン選択的安定同位体標識法の開発と脂質二重膜中のβ2-アドレナリン受容体への応用2018
- Author(s)
  中田國夫、五十嵐俊介、幸福裕、上田卓見、白石勇太郎、夏目芽依、横溝智貴、今井俊輔、水越利巳、鈴木榮一郎、嶋田一夫
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17H04999
[Presentation] 昆虫細胞発現系におけるアラニン選択的安定同位体標識法の開発と脂質二重膜中のβ2-アドレナリン受容体への応用2018
- Author(s)
  中田國夫、五十嵐俊介、幸福裕、上田卓見、白石勇太郎、夏目芽依、横溝智貴、今井俊輔、水越利巳、鈴木榮一郎、嶋田一夫
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PUBLICLY-16H01353
[Presentation] β2アドレナリン受容体のリン酸化によるシグナル制御機構の解明2018
- Author(s)
  夏目芽依、白石勇太郎、幸福裕、今井駿輔、中田國夫、水越利巳、上田卓見、岩井秀夫、嶋田一夫
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17H04999
[Presentation] アラニン側鎖メチル基を観測対象としたβ2-アドレナリン受容体のシグナル伝達機構の解明2018
- Author(s)
  横溝智貴、今井俊輔、幸福裕、上田卓見、白石勇太郎、夏目芽依、中田國夫、五十嵐俊介、水越利巳、鈴木榮一郎、嶋田一夫
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17H04999
[Presentation] 区分同位体標識を用いたβ2アドレナリン受容体のリン酸化によるシグナル制御機構の解明2018
- Author(s)
  白石勇太郎、夏目芽依、幸福裕、今井駿輔、中田國夫、水越利巳、上田卓見、岩井秀夫、嶋田一夫
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PUBLICLY-16H01353
[Presentation] 区分同位体標識を用いたβ2アドレナリン受容体のリン酸化によるシグナル制御機構の解明2018
- Author(s)
  白石勇太郎、夏目芽依、幸福裕、今井駿輔、中田國夫、水越利巳、上田卓見、岩井秀夫、嶋田一夫
- Organizer
  第91回生化学会大会
- Data Source
  KAKENHI-PROJECT-17H04999
[Presentation] 細胞遊走因子、ケモカイン受容体の動的構造研究と創薬研究への展望2017
- Author(s)
  幸福裕
- Organizer
  第87回日本衛生学会学術総会
- Place of Presentation
  シーガイアコンベンションセンター（宮崎県宮崎市）
- Year and Date
  2017-03-26
- Invited
- Data Source
  KAKENHI-PROJECT-15K18843
[Presentation] 動的構造に着目したGタンパク質共役型受容体の機能解明2017
- Author(s)
  幸福裕、上田卓見、嶋田一夫
- Organizer
  第61回日本薬学会関東支部大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-16H01353
[Presentation] Identification of a Conformational Equilibrium That Determines the Efficacy and Functional Selectivity of the μ-Opioid Receptor2017
- Author(s)
  Yutaro Shiraishi, Junya Okude, Takumi Ueda, Yutaka Kofuku, Motohiko Sato, Naoyuki Nobuyama, Keita Kondo, Takuya Mizumura, Mei Natsume, Masahiro Maeda, Hideki Tsujishita, Takefumi Kuranaga, Masayuki Inoue, Ichio Shimada
- Organizer
  58th Experimental Nuclear Magnetic Resonance Conference
- Place of Presentation
  Pacific Grove（アメリカ合衆国）
- Year and Date
  2017-03-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18843
[Presentation] Conductance of P2X4 purinergic receptor is determined by conformational equilibrium in the transmembrane region2017
- Author(s)
  Takumi Ueda, Tomoaki Hara, Yuichi Minato, Shiho Suzuki, Yutaka Kofuku, Go Kasuya, Yuichiro Fujiwara, Shunsuke Igarashi, Ei-ichiro Suzuki, Osamu Nureki, Motoyuki Hattori, Ichio Shimada
- Organizer
  58th Experimental Nuclear Magnetic Resonance Conference
- Place of Presentation
  Pacific Grove（アメリカ合衆国）
- Year and Date
  2017-03-26
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18843
[Presentation] Functional dynamics of deuterated β2-adrenergic receptor in lipid bilayers revealed by NMR spectroscopy2017
- Author(s)
  Mei Natsume, Yutaka Kofuku, Takumi Ueda, Junya Okude, Yutaro Shiraishi, Keita Kondo, Takuya Mizumura, Shiho Suzuki, Ichio Shimada
- Organizer
  58th Experimental Nuclear Magnetic Resonance Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01353
[Presentation] 細胞遊走因子、ケモカイン受容体の動的構造研究と創薬研究への展望2017
- Author(s)
  幸福裕
- Organizer
  第87回日本衛生学会学術総会
- Invited
- Data Source
  KAKENHI-PUBLICLY-16H01353
[Presentation] Functional dynamics of deuterated β2-adrenergic receptor in lipid bilayers revealed by NMR spectroscopy2017
- Author(s)
  Mei Natsume, Yutaka Kofuku, Takumi Ueda, Junya Okude, Yutaro Shiraishi, Keita Kondo, Takuya Mizumura, Shiho Suzuki, Ichio Shimada
- Organizer
  58th Experimental Nuclear Magnetic Resonance Conference
- Place of Presentation
  Pacific Grove（アメリカ合衆国）
- Year and Date
  2017-03-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18843
[Presentation] Conductance of P2X4 purinergic receptor is determined by conformational equilibrium in the transmembrane region2017
- Author(s)
  Takumi Ueda, Tomoaki Hara, Yuichi Minato, Shiho Suzuki, Yutaka Kofuku, Go Kasuya, Yuichiro Fujiwara, Shunsuke Igarashi, Ei-ichiro Suzuki, Osamu Nureki, Motoyuki Hattori, Ichio Shimada
- Organizer
  58th Experimental Nuclear Magnetic Resonance Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01353
[Presentation] 動的構造に着目したGタンパク質共役型受容体の機能解明2017
- Author(s)
  幸福裕、上田卓見、嶋田一夫
- Organizer
  第61回日本薬学会関東支部大会
- Invited
- Data Source
  KAKENHI-PROJECT-17H04999
[Presentation] Identification of a conformational equilibrium that determines the efficacy and functional selectivity of the μ-opioid receptor2017
- Author(s)
  Yutaro Shiraishi, Junya Okude, Takumi Ueda, Yutaka Kofuku, Motohiko Sato, Naoyuki Nobuyama, Keita Kondo, Takuya Mizumura, Mei Natsume, Masahiro Maeda, Hideki Tsujishita, Takefumi Kuranaga, Masayuki Inoue, Ichio Shimada
- Organizer
  58th Experimental Nuclear Magnetic Resonance Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01353
[Presentation] Conductance of P2X4 purinergic receptor is determined by conformational equilibrium in the transmembrane region,2016
- Author(s)
  Tomoaki Hara, Yuichi Minato, Shiho Suzuki, Yutaka Kofuku, Go Kasuya, Yuichiro Fujiwara, Shunsuke Igarashi, Ei-ichiro Suzuki, Osamu Nureki, Motoyuki Hattori, Takumi Ueda, Ichio Shimada
- Organizer
  XXVIIth International Conference on Magnetic Resonance in Biological Systems
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01353
[Presentation] 昆虫細胞発現系における高度重水素標識を用いた脂質二重膜中のGタンパク質共役型受容体の動的構造解析2016
- Author(s)
  幸福裕、上田卓見、奥出順也、白石勇太郎、近藤啓太、水村拓也、鈴木志歩、嶋田一夫
- Organizer
  第55回NMR討論会
- Data Source
  KAKENHI-PUBLICLY-16H01353
[Presentation] Development of an NMR reconstruction method to elucidate the CCR1- and CCR5-binding modes of MIP-1a2016
- Author(s)
  Takumi Ueda, Chie Yoshiura, Yutaka Kofuku, Masahiko Matsumoto, Junya Okude, Keita Kondo, Yutaro Shiraishi, Koh Takeuchi, Ichio Shimada
- Organizer
  XXVIIth International Conference on Magnetic Resonance in Biological Systems
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01353
[Presentation] δオピオイド受容体（δOR）の活性制御機構の解明2016
- Author(s)
  佐藤元彦、奥出順也、延山尚幸、上田卓見、幸福裕、倉永健史、井上将行、嶋田一夫
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K18843
[Presentation] Identification of a Conformational Equilibrium That Determines the Efficacy and Functional Selectivity of the μ-Opioid Receptor2016
- Author(s)
  Junya Okude, Takumi Ueda, Yutaka Kofuku, Motohiko Sato, Naoyuki Nobuyama, Keita Kondo, Yutaro Shiraishi, Takuya Mizumura, Mei Natsume, Masahiro Maeda, Hideki Tsujishita, Takefumi Kuranaga, Masayuki Inoue, Ichio Shimada
- Organizer
  XXVIIth International Conference on Magnetic Resonance in Biological Systems
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18843
[Presentation] SDF-1との二段階結合によるCXCR4のシグナル伝達機構の解明2016
- Author(s)
  大西健人、幸福裕、塚本宇信、鈴木志歩、上田卓見、嶋田一夫
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K18843
[Presentation] 昆虫細胞発現系における高度重水素標識を用いた脂質二重膜中のGタンパク質共役型受容体の動的構造解析2016
- Author(s)
  幸福裕、上田卓見、奥出順也、白石勇太郎、近藤啓太、水村拓也、鈴木志歩、嶋田一夫
- Organizer
  第55回NMR討論会
- Place of Presentation
  広島国際会議場（広島県広島市）
- Year and Date
  2016-11-16
- Data Source
  KAKENHI-PROJECT-15K18843
[Presentation] Identification of a conformational equilibrium that determines the efficacy and functional selectivity of the μ-opioid receptor2016
- Author(s)
  Junya Okude, Takumi Ueda, Yutaka Kofuku, Motohiko Sato, Naoyuki Nobuyama, Keita Kondo, Yutaro Shiraishi, Takuya Mizumura, Mei Natsume, Masahiro Maeda, Hideki Tsujishita, Takefumi Kuranaga, Masayuki Inoue, Ichio Shimada
- Organizer
  XXVIIth International Conference on Magnetic Resonance in Biological Systems
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01353
[Presentation] Conductance of P2X4 purinergic receptor is determined by conformational equilibrium in the transmembrane region2016
- Author(s)
  Tomoaki Hara, Yuichi Minato, Shiho Suzuki, Yutaka Kofuku, Go Kasuya, Yuichiro Fujiwara, Shunsuke Igarashi, Ei-ichiro Suzuki, Osamu Nureki, Motoyuki Hattori, Takumi Ueda, Ichio Shimada
- Organizer
  XXVIIth International Conference on Magnetic Resonance in Biological Systems
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18843
[Presentation] Development of an NMR reconstruction method to elucidate the CCR1- and CCR5-bincing modes of MIP-1a2016
- Author(s)
  Takumi Ueda, Chie Yoshiura, Yutaka Kofuku, Masahiko Matsumoto, Junya Okude, Keita Kondo, Yutaro Shiraishi, Koh Takeuchi, Ichio Shimada
- Organizer
  XXVIIth International Conference on Magnetic Resonance in Biological Systems
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18843
[Presentation] 区分同位体標識を用いたβ2-アドレナリン受容体のリン酸化のNMR解析2015
- Author(s)
  白石勇太郎、幸福裕、上田卓見、夏目芽衣、岩井秀夫、嶋田一夫
- Organizer
  第53回日本生物物理学会年会
- Place of Presentation
  金沢大学角間キャンパス自然科学本館（石川県金沢市）
- Year and Date
  2015-09-13
- Data Source
  KAKENHI-PROJECT-15K18843
[Presentation] リガンドとの相互作用に伴う膜蛋白質の動的立体構造変化2015
- Author(s)
  上田卓見、幸福裕、嶋田一夫
- Organizer
  第53回日本生物物理学会年会
- Place of Presentation
  金沢大学角間キャンパス自然科学本館（石川県金沢市）
- Year and Date
  2015-09-13
- Invited
- Data Source
  KAKENHI-PROJECT-15K18843
[Presentation] NMR法を用いた脂質二重膜中のGPCRの動的構造解析2015
- Author(s)
  幸福裕、上田卓見、奥出順也、白石勇太郎、近藤啓太、鈴木志歩、嶋田一夫
- Organizer
  第53回日本生物物理学会年会
- Place of Presentation
  金沢大学角間キャンパス自然科学本館（石川県金沢市）
- Year and Date
  2015-09-13
- Invited
- Data Source
  KAKENHI-PROJECT-15K18843
[Presentation] 脂質によるGPCRの活性制御機構の解明2015
- Author(s)
  水村拓也、近藤啓太、上田卓見、幸福裕、嶋田一夫
- Organizer
  第53回日本生物物理学会年会
- Place of Presentation
  金沢大学角間キャンパス自然科学本館（石川県金沢市）
- Year and Date
  2015-09-13
- Data Source
  KAKENHI-PROJECT-15K18843
[Presentation] NMRを用いたGPCRの動的構造解析
- Author(s)
  幸福裕
- Organizer
  第53回日本生物物理学会年会
- Place of Presentation
  金沢大学角間キャンパス自然科学本館（石川県金沢市）
- Year and Date
  2015-09-13 – 2015-09-15
- Data Source
  KAKENHI-PROJECT-26893041

1. 嶋田一夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
2. 竹内恒

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 徳永裕二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 上田卓見

# of Collaborated Projects: 0 results

# of Collaborated Products: 8 results
5. 上田太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kofuku Yutaka 幸福 裕

KOFUKU Yutaka 幸福 裕

Research Projects

Research Products

Co-Researchers

多様なリガンドによるGタンパク質共役型受容体の活性制御機構の解明Principal Investigator

Principal Investigator

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NMR法を用いたリガンドー受容体間の弱い相互作用によるシグナル伝達制御機構の解明Principal Investigator

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核磁気共鳴法を用いたGタンパク質共役型受容体によるシグナル制御機構の解明Principal Investigator

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Novel techniques to investigate function-related dynamics of membrane proteinsPrincipal Investigator

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GPCR細胞内シグナル伝達の立体構造に基づく定量的解析Principal Investigator

Principal Investigator

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Structural basis of signal transduction mediated by various GPCRsPrincipal Investigator

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リポクオリティ依存的なGPCRのシグナル伝達の構造生物学的解明Principal Investigator

Principal Investigator

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Structural basis of biased signaling mediated by pharmacologically important GPCRsPrincipal Investigator

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バイアスリガンドによるGPCRのシグナル伝達制御機構の解明Principal Investigator

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[Journal Article] Activation mechanism of the μ-opioid receptor by an allosteric modulator.2022

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DOI

Data Source

[Journal Article] GPCRのNMR・ESR解析2021

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Data Source

[Journal Article] Function-Related Dynamics in Multi-Spanning Helical Membrane Proteins Revealed by Solution NMR2021

Author(s)

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DOI

Data Source

[Journal Article] GPCRのNMR・ESR解析2021

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Data Source

[Journal Article] GPCRのNMR・ESR解析2021

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Kofuku Yutaka 幸福裕

KOFUKU Yutaka 幸福裕