Ohnuki Shinsuke 大貫慎輔

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OHNUKI Shinsuke 大貫慎輔

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Researcher Number	80739756
Affiliation (based on the past Project Information) *help	2020 – 2022: 東京大学, 大学院新領域創成科学研究科, 特任助教 2014 – 2015: 東京大学, 新領域創成科学研究科, 特任研究員
Review Section/Research Field	Principal Investigator Basic Section 43040:Biophysics-related / Chemical biology
Keywords	Principal Investigator CalMorph / 細胞形態 / 出芽酵母 / 遺伝的相互作用 / 一細胞フェノーム / シミュレーション / プールド培養液 / 遺伝子破壊株 / 顕微鏡画像 / DNAバーコード … More / DNA barcode / 大規模解析 / 次世代シーケンサ / Bar-seq / FACS / iIACS / 相互作用 / ハイコンテントイメージング / 交絡因子 / 多様性 / 表現型解析 / 一般化線形モデル Less

Large scale parallelization of single cell phenomicsPrincipal Investigator
- Principal Investigator
  
  Ohnuki Shinsuke
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  The University of Tokyo
Statistical modeling of the gene function and the drug response by single cell phenomics in Saccharomyces cerevisiaePrincipal Investigator
- Principal Investigator
  
  OHNUKI Shinsuke
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Chemical biology
- Research Institution
  The University of Tokyo

All 2023 2022 2021 2020 2015 2014

All Journal Article Presentation

[Journal Article] Prediction of ethanol fermentation under stressed conditions using yeast morphological data.2023
- Author(s)
  Itto-Nakama K, Watanabe S, Ohnuki S, Kondo N, Kikuchi R, Nakamura T, Ogasawara W, Kasahara K, Ohya Y.
- Journal Title
  
  J Biosci Bioeng.
  
  Volume: 135 Issue: 3 Pages: 210-216
- DOI
  10.1016/j.jbiosc.2022.12.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06584
[Journal Article] Jerveratrum-Type Steroidal Alkaloids Inhibit β-1,6-Glucan Biosynthesis in Fungal Cell Walls2022
- Author(s)
  Kubo Karen、Itto-Nakama Kaori、Ohnuki Shinsuke、Yashiroda Yoko、Li Sheena C.、Kimura Hiromi、Kawamura Yumi、Shimamoto Yasuhiro、Tominaga Ken-Ichi、Yamanaka Daisuke、Adachi Yoshiyuki、Takashima Shinichiro、Noda Yoichi、Boone Charles、Ohya Yoshikazu
- Journal Title
  
  Microbiology Spectrum
  
  Volume: 10 Issue: 1
- DOI
  10.1128/spectrum.00873-21
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05764, KAKENHI-PLANNED-17H06411, KAKENHI-PROJECT-20K06584, KAKENHI-PROJECT-20K07487
[Journal Article] High-throughput platform for yeast morphological profiling predicts the targets of bioactive compounds2022
- Author(s)
  Ohnuki, S., Ogawa, I., Itto-Nakama, K., Lu, F., Ranjan, A., Kabbage, M., Gebre, AA., Yamashita, M., Li, SC., Yashiroda, Y., Yoshida, S., Usui, T., Piotrowski, JS., Andrews, BJ., Boone, C., Brown, GW., Ralph, J., Ohya, Y.
- Journal Title
  
  npj Systems Biology and Applications
  
  Volume: 8 Issue: 1 Pages: 3-3
- DOI
  10.1038/s41540-022-00212-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06411, KAKENHI-PROJECT-20K06584
[Journal Article] Assignment of unimodal probability distribution models for quantitative morphological phenotyping.2022
- Author(s)
  Ghanegolmohammadi F, Ohnuki S, Ohya Y.
- Journal Title
  
  BMC Biol.
  
  Volume: 20 Issue: 1 Pages: 81-81
- DOI
  10.1186/s12915-022-01283-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06584
[Journal Article] Intelligent sort‐timing prediction for image‐activated cell sorting2022
- Author(s)
  Zhao Yaqi、Isozaki Akihiro、Herbig Maik、Hayashi Mika、Hiramatsu Kotaro、Yamazaki Sota、Kondo Naoko、Ohnuki Shinsuke、Ohya Yoshikazu、Nitta Nao、Goda Keisuke
- Journal Title
  
  Cytometry Part A
  
  Volume: 103 Issue: 1 Pages: 88-97
- DOI
  10.1002/cyto.a.24664
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H05633, KAKENHI-PROJECT-20H00317, KAKENHI-PROJECT-20K06584
[Journal Article] Deep imaging flow cytometry.2022
- Author(s)
  Huang K, Matsumura H, Zhao Y, Herbig M, Yuan D, Mineharu Y, Harmon J, Findinier J, Yamagishi M, Ohnuki S, Nitta N, Grossman AR, Ohya Y, Mikami H, Isozaki A, Goda K.
- Journal Title
  
  Lab Chip.
  
  Volume: 22 Issue: 5 Pages: 876-889
- DOI
  10.1039/d1lc01043c
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06584, KAKENHI-PROJECT-19H05633, KAKENHI-PROJECT-20H00317
[Journal Article] AI-based forecasting of ethanol fermentation using yeast morphological data.2021
- Author(s)
  Itto-Nakama K, Watanabe S, Kondo N, Ohnuki S, Kikuchi R, Nakamura T, Ogasawara W, Kasahara K, Ohya Y.
- Journal Title
  
  Biosci Biotechnol Biochem.
  
  Volume: 86 Issue: 1 Pages: 125-134
- DOI
  10.1093/bbb/zbab188
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06584, KAKENHI-PROJECT-19H03205
[Journal Article] Defining Functions of Mannoproteins in Saccharomyces cerevisiae by High-Dimensional Morphological Phenotyping.2021
- Author(s)
  Ghanegolmohammadi F, Okada H, Liu Y, Itto-Nakama K, Ohnuki S, Savchenko A, Bi E, Yoshida S, Ohya Y.
- Journal Title
  
  J Fungi (Basel).
  
  Volume: 7 Issue: 9 Pages: 769-769
- DOI
  10.3390/jof7090769
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06584, KAKENHI-PROJECT-19H03205
[Journal Article] Genome Editing to Generate Sake Yeast Strains with Eight Mutations That Confer Excellent Brewing Characteristics.2021
- Author(s)
  Chadani T, Ohnuki S, Isogai A, Goshima T, Kashima M, Ghanegolmohammadi F, Nishi T, Hirata D, Watanabe D, Kitamoto K, Akao T, Ohya Y.
- Journal Title
  
  Cells
  
  Volume: 10 Issue: 6 Pages: 1299-1299
- DOI
  10.3390/cells10061299
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06584, KAKENHI-PROJECT-19H03205
[Journal Article] Poacic acid, a β-1,3-glucan-binding antifungal agent, inhibits cell-wall remodeling and activates transcriptional responses regulated by the cell-wall integrity and high-osmolarity glycerol pathways in yeast.2021
- Author(s)
  Garcia R, Itto-Nakama K, Rodriguez-Pena JM, Chen X, Sanz AB, de Lorenzo A, Pavon-Verges M, Kubo K, Ohnuki S, Nombela C, Popolo L, Ohya Y, Arroyo J.
- Journal Title
  
  FASEB J.
  
  Volume: 10 Issue: 9 Pages: 1299-1299
- DOI
  10.1096/fj.202100278r
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06584, KAKENHI-PROJECT-19H03205
[Journal Article] Are droplets really suitable for single-cell analysis? A case study on yeast in droplets.2021
- Author(s)
  Nakagawa Y, Ohnuki S, Kondo N, Itto-Nakama K, Ghanegolmohammadi F, Isozaki A, Ohya Y, Goda K.
- Journal Title
  
  Lab Chip.
  
  Volume: 21 Issue: 19 Pages: 3793-3803
- DOI
  10.1039/d1lc00469g
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06584, KAKENHI-PROJECT-19H03205
[Journal Article] Sequentially addressable dielectrophoretic array for high-throughput sorting of large-volume biological compartments2020
- Author(s)
  A Isozaki, Y Nakagawa, M H Loo, Y Shibata, N Tanaka, D L Setyaningrum, J-W Park, Y Shirasaki, H Mikami, D Huang, H Tsoi, C T Riche, T Ota, H Miwa, Y Kanda, T Ito, K Yamada, O Iwata, K Suzuki, S Ohnuki, Y Ohya, Y Kato, T Hasunuma, S Matsusaka, M Yamagishi, M Yazawa, S Uemura, K Nagasawa, H Watarai, D Di Carlo, K Goda
- Journal Title
  
  Science Advances
  
  Volume: 29 Issue: 22 Pages: 1-11
- DOI
  10.1126/sciadv.aba6712
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06584, KAKENHI-PROJECT-20K21522, KAKENHI-PROJECT-18K14101, KAKENHI-PROJECT-19H03205
[Journal Article] 6 Virtual-freezing fluorescence imaging flow cytometry.2020
- Author(s)
  Mikami H, Kawaguchi M, Huang CJ, Matsumura H, Sugimura T, Huang K, Lei C, Ueno S, Miura T, Ito T, Nagasawa K, Maeno T, Watarai H, Yamagishi M, Uemura S, Ohnuki S, Ohya Y, Kurokawa H, Matsusaka S, Sun CW, Ozeki Y, Goda K.
- Journal Title
  
  Nat Commun.
  
  Volume: 6 Issue: 1 Pages: 1162-1162
- DOI
  10.1038/s41467-020-14929-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03205, KAKENHI-PROJECT-20K06584, KAKENHI-PROJECT-19H05633
[Journal Article] Intelligent image-activated cell sorting 2.02020
- Author(s)
  Isozaki Akihiro, Hiraki Kei, et al.
- Journal Title
  
  Lab on a Chip
  
  Volume: 1 Issue: 13 Pages: 1-11
- DOI
  10.1039/d0lc00080a
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H01714, KAKENHI-PROJECT-20K06584, KAKENHI-PROJECT-19F19716, KAKENHI-PROJECT-19H05633
[Journal Article] Quantification of Cell, Actin, and Nuclear DNA Morphology with High-Throughput Microscopy and CalMorph.2015
- Author(s)
  Okada H, Ohnuki S, Ohya Y.
- Journal Title
  
  Cold Spring Harb Protoc.
  
  Volume: 2015 (4) Issue: 4 Pages: 408-412
- DOI
  10.1101/pdb.prot078667
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26882019, KAKENHI-PROJECT-15H04402
[Journal Article] Profiling of the effects of antifungal agents on yeast cells based on morphometric analysis.2015
- Author(s)
  Gebre AA, Okada H, Kim C, Kubo K, Ohnuki S, Ohya Y.
- Journal Title
  
  FEMS Yeast Res.
  
  Volume: 15 Issue: 5 Pages: fov040-fov040
- DOI
  10.1093/femsyr/fov040
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04483, KAKENHI-PROJECT-26882019
[Journal Article] Unveiling nonessential gene deletions that confer significant morphological phenotypes beyond natural yeast strains2014
- Author(s)
  Yang M, Ohnuki S, Ohya Y
- Journal Title
  
  BMC Genomics
  
  Volume: 15 Issue: 1 Pages: 932-932
- DOI
  10.1186/1471-2164-15-932
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24370002, KAKENHI-PROJECT-26882019
[Presentation] ストレス条件下における細胞形態からエタノール発酵量を予測するAIの開発2022
- Author(s)
  一刀かおり、渡部峻、大貫慎輔、近藤直子、菊地亮太、中村徹、小笠原渉、笠原堅、大矢禎一
- Organizer
  酵母遺伝学フォーラム
- Data Source
  KAKENHI-PROJECT-20K06584
[Presentation] 機械学習を用いた遺伝子機能に共通する形態特徴量の抽出2020
- Author(s)
  大貫慎輔、徐聴涛、大矢禎一
- Organizer
  酵母遺伝学フォーラム
- Data Source
  KAKENHI-PROJECT-20K06584
[Presentation] Application of Generalized Linear Model to Reveal Nonessential Genes of Deletion Mutants with Significant Morphological Phenotypes beyond Natural Yeast Strains2015
- Author(s)
  Shinsuke Ohnuki, Ming Yang, Yoshikazu Ohya
- Organizer
  27th International conference on yeast genetics and molecular biology
- Place of Presentation
  Trentino (Italy)
- Year and Date
  2015-09-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26882019
[Presentation] 一般化線形モデルを使った自然界には存在しない形態を持つ出芽酵母の解析2015
- Author(s)
  大貫慎輔、楊明、大矢禎一
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸ポートアイランド（神戸）
- Year and Date
  2015-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26882019
[Presentation] 一般化線形モデルを使った自然界には存在しない形態を持つ出芽酵母の解析2015
- Author(s)
  大貫慎輔、楊明、大矢禎一
- Organizer
  酵母遺伝学フォーラム
- Place of Presentation
  広島大学（広島）
- Year and Date
  2015-09-01
- Data Source
  KAKENHI-PROJECT-26882019
[Presentation] 出芽酵母必須遺伝子の半数以上はヘテロ破壊によりハプロ不全性を示す2014
- Author(s)
  大貫　慎輔、大矢　禎一
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-25
- Data Source
  KAKENHI-PROJECT-26882019

1. 野田陽一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 八代田陽子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. BOONE CHARLES

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 大矢禎一

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
5. 合田圭介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 平木敬

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohnuki Shinsuke 大貫 慎輔

OHNUKI Shinsuke 大貫 慎輔

Research Projects

Research Products

Co-Researchers

Large scale parallelization of single cell phenomicsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Statistical modeling of the gene function and the drug response by single cell phenomics in Saccharomyces cerevisiaePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Prediction of ethanol fermentation under stressed conditions using yeast morphological data.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Jerveratrum-Type Steroidal Alkaloids Inhibit β-1,6-Glucan Biosynthesis in Fungal Cell Walls2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High-throughput platform for yeast morphological profiling predicts the targets of bioactive compounds2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Assignment of unimodal probability distribution models for quantitative morphological phenotyping.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intelligent sort‐timing prediction for image‐activated cell sorting2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Deep imaging flow cytometry.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] AI-based forecasting of ethanol fermentation using yeast morphological data.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Defining Functions of Mannoproteins in Saccharomyces cerevisiae by High-Dimensional Morphological Phenotyping.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genome Editing to Generate Sake Yeast Strains with Eight Mutations That Confer Excellent Brewing Characteristics.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Poacic acid, a β-1,3-glucan-binding antifungal agent, inhibits cell-wall remodeling and activates transcriptional responses regulated by the cell-wall integrity and high-osmolarity glycerol pathways in yeast.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Are droplets really suitable for single-cell analysis? A case study on yeast in droplets.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sequentially addressable dielectrophoretic array for high-throughput sorting of large-volume biological compartments2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 6 Virtual-freezing fluorescence imaging flow cytometry.2020

Author(s)

Journal Title

Ohnuki Shinsuke 大貫慎輔

OHNUKI Shinsuke 大貫慎輔