Sugiura Daisuke 杉浦大祐

Researcher Number	80743963
Other IDs
Affiliation (Current)	2025: 東京大学, 定量生命科学研究所, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 東京大学, 定量生命科学研究所, 准教授 2021 – 2022: 東京大学, 定量生命科学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
Keywords	Principal Investigator PD-1 / 免疫補助受容体 / 液性免疫応答 / 濾胞性T細胞 / 自己免疫疾患 / CTLA-4 / T細胞

Molecular mechanisms of regulation of humoral immune responses by immune co-receptorsPrincipal Investigator
- Principal Investigator
  
  杉浦大祐
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  The University of Tokyo
Analysis of cis-PD-L1/CD80 interaction in autoimmune diseasesPrincipal Investigator
- Principal Investigator
  
  Sugiura Daisuke
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  The University of Tokyo

All 2022 2021

All Journal Article Presentation

[Journal Article] PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity2022
- Author(s)
  Sugiura Daisuke、Okazaki Il-mi、Maeda Takeo K.、Maruhashi Takumi、Shimizu Kenji、Arakaki Rieko、Takemoto Tatsuya、Ishimaru Naozumi、Okazaki Taku
- Journal Title
  
  Nature Immunology
  
  Volume: 23 Issue: 3 Pages: 399-410
- DOI
  10.1038/s41590-021-01125-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09859, KAKENHI-PROJECT-17H03607, KAKENHI-PLANNED-18H05415, KAKENHI-PLANNED-18H05417, KAKENHI-PROJECT-19H01029, KAKENHI-PROJECT-19H01070, KAKENHI-PROJECT-19H03423, KAKENHI-PROJECT-21K06526, KAKENHI-PROJECT-21K07076, KAKENHI-PROJECT-21K19270, KAKENHI-PROJECT-21K19605
[Journal Article] Binding of LAG-3 to stable peptide-MHC class II limits T?cell function and suppresses autoimmunity and anti-cancer immunity2022
- Author(s)
  Maruhashi Takumi、Sugiura Daisuke、Okazaki Il-mi、Shimizu Kenji、Maeda Takeo K.、Ikubo Jun、Yoshikawa Harunori、Maenaka Katsumi、Ishimaru Naozumi、Kosako Hidetaka、Takemoto Tatsuya、Okazaki Taku
- Journal Title
  
  Immunity
  
  Volume: - Issue: 5 Pages: 912-924
- DOI
  10.1016/j.immuni.2022.03.013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05417, KAKENHI-PROJECT-19H01029, KAKENHI-PROJECT-19H03423, KAKENHI-PROJECT-20K06628, KAKENHI-PROJECT-21K07076, KAKENHI-PROJECT-19H01070, KAKENHI-PROJECT-21K19270, KAKENHI-PROJECT-21K19605, KAKENHI-PLANNED-18H05415, KAKENHI-PROJECT-21K06526
[Journal Article] PD-1 preferentially inhibits the activation of low-affinity T cells2021
- Author(s)
  Shimizu Kenji、Sugiura Daisuke、Okazaki Il-mi、Maruhashi Takumi、Takemoto Tatsuya、Okazaki Taku
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 118 Issue: 35
- DOI
  10.1073/pnas.2107141118
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03607, KAKENHI-PLANNED-18H05415, KAKENHI-PLANNED-18H05417, KAKENHI-PROJECT-19H01029, KAKENHI-PROJECT-19H03423, KAKENHI-PROJECT-21K06526, KAKENHI-PROJECT-21K07076, KAKENHI-PROJECT-21K19270
[Journal Article] T-cell-intrinsic and -extrinsic regulation of PD-1 function2021
- Author(s)
  Sugiura Daisuke、Shimizu Kenji、Maruhashi Takumi、Okazaki Il-mi、Okazaki Taku
- Journal Title
  
  International Immunology
  
  Volume: 33 Issue: 12 Pages: 693-698
- DOI
  10.1093/intimm/dxab077
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05417, KAKENHI-PROJECT-19H01029, KAKENHI-PROJECT-19H03423, KAKENHI-PROJECT-21K06526, KAKENHI-PROJECT-21K07076
[Presentation] PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity2022
- Author(s)
  Daisuke Sugiura、Il-mi Okazaki、Takumi Maruhashi、Kenji Shimizu、 Naozumi Ishimaru、Taku Okazaki
- Organizer
  第51回　日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K06526
[Presentation] PD-1 elicitation by the dissociation of cis-PD-L1/CD80 duplex inhibits T cell activation and alleviates autoimmunity2021
- Author(s)
  Sugiura Daisuke、Okazaki Il-mi、Maruhashi Takumi、Shimizu Kenji、Arakaki Rieko、Ishimaru Naozumi、Okazaki Taku
- Organizer
  The 50th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-21K06526

1. ARAKAKI Rieko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. TAKEMOTO Tatsuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 岡崎拓

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Sugiura Daisuke 杉浦 大祐

Research Projects

Research Products

Co-Researchers

Molecular mechanisms of regulation of humoral immune responses by immune co-receptorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of cis-PD-L1/CD80 interaction in autoimmune diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Binding of LAG-3 to stable peptide-MHC class II limits T?cell function and suppresses autoimmunity and anti-cancer immunity2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PD-1 preferentially inhibits the activation of low-affinity T cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] T-cell-intrinsic and -extrinsic regulation of PD-1 function2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity2022

Author(s)

Organizer

Data Source

[Presentation] PD-1 elicitation by the dissociation of cis-PD-L1/CD80 duplex inhibits T cell activation and alleviates autoimmunity2021

Author(s)

Organizer

Data Source

Sugiura Daisuke 杉浦大祐