Nakamura Takumi 中村琢洋

… Alternative Names

中村琢洋ナカムラタクミ

NAKAMURA Takumi 中村琢洋

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Researcher Number	80744193
Other IDs	https://orcid.org/0000-0001-5125-8579
Affiliation (Current)	2025: 群馬大学, 医学部附属病院, 助教
Affiliation (based on the past Project Information) *help	2023: 群馬大学, 医学部附属病院, 助教 2022: 群馬大学, 医学部附属病院, 医員 2017: 弘前大学, 医学部附属病院, 助手 2017: 弘前大学, 医学部附属病院, 助教
Review Section/Research Field	Except Principal Investigator Neurology / Basic Section 52020:Neurology-related
Keywords	Except Principal Investigator Abeta / Alzheimer病 / NMDA receptor / fyn / アミロイド / アルツハイマー病 / lipid rafts / tau / Alzheimer's disease / transgenic mouse … More / prion / Alzheimer / exosome / apolipoprotein E / neurofilament / phosphryleted tau / 家族性アルツハイマー病 / 病態修飾薬 / Western blot / ELISA / 病理 / 認知機能 / 脳アミロイド / 認知症 / sinaptosome / oligomer / synapse / タウ / 神経毒性 / vaccine / Abeta oligomer Less

Analysis of Alzheimer's disease targeting lipid rafts and exosome
- Principal Investigator
  
  瓦林毅
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Gunma University
Identification of neurotoxic Abeta oligomers and development of therapy against them
- Principal Investigator
  
  Kawarabayashi Takeshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Hirosaki University
Development and clinical application of disease modifying drug for Alzheimer's Disease
- Principal Investigator
  
  Shoji Mikio
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Hirosaki University

All 2023 2022 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Annual stability of the plasma A?40/42 ratio and associated factors2023
- Author(s)
  Nakamura Takumi、Kawarabayashi Takeshi、Nakahata Naoko、Itoh Ken、Ihara Kazushige、Nakaji Shigeyuki、Ikeda Yoshio、Takatama Masamitsu、Shoji Mikio
- Journal Title
  
  Annals of Clinical and Translational Neurology
  
  Volume: 10 Issue: 6 Pages: 879-891
- DOI
  10.1002/acn3.51770
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07511
[Journal Article] Plasma ApoE4 Levels Are Lower than ApoE2 and ApoE3 Levels, and Not Associated with Plasma Aβ 40/42 Ratio as a Biomarker of Amyloid-β Amyloidosis in Alzheimer’s Disease2023
- Author(s)
  Nakamura Takumi、Kawarabayashi Takeshi、Ueda Tetsuya、Shimomura Sachiko、Hoshino Masaki、Itoh Ken、Ihara Kazushige、Nakaji Shigeyuki、Takatama Masamitsu、Ikeda Yoshio、Shoji Mikio
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: Online ahead of print Issue: 1 Pages: 1-16
- DOI
  10.3233/jad-220996
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07511
[Journal Article] Clinical Evaluation of Cerebrospinal Fluid p217tau and Neurofilament Light Chain Levels in Patients with Alzheimer’s Disease or Other Neurological Diseases2023
- Author(s)
  Kawarabayashi Takeshi、Nakamura Takumi、Miyashita Kazuya、Segawa Tatsuya、Fukamachi Isamu、Sugawara Takashi、Oka Hironori、Ishizawa Kunihiko、Amari Masakuni、Kasahara Hiroo、Makioka Kouki、Ikeda Yoshio、Takatama Masamitsu、Shoji Mikio
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 96 Issue: 4 Pages: 1623-1638
- DOI
  10.3233/jad-230419
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07511
[Journal Article] Lipid Rafts Act as a Common Platform for Amyloid-β Oligomer-Induced Alzheimer’s Disease Pathology2022
- Author(s)
  Kawarabayashi Takeshi、Nakamura Takumi、Sato Kaoru、Seino Yusuke、Ichii Sadanobu、Nakahata Naoko、Takatama Masamitsu、Westaway David、George-Hyslop Peter St.、Shoji Mikio
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 87 Issue: 3 Pages: 1189-1203
- DOI
  10.3233/jad-215662
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07511
[Journal Article] Case of elderly-onset multiple acyl-CoA dehydrogenase deficiency with a novel ETFDH mutation shows progressive muscle weakness and rhabdomyosis2018
- Author(s)
  Seino Y, Nakamura T, Kawarabayashi T, Wakasaya Y, Hayashi YK, Okubo M, Nishino I, Shoji M
- Journal Title
  
  Neurology and Clinical Neuroscience
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09305
[Journal Article] Case of elderly-onset multiple acyl-CoA dehydrogenase deficiency with a novel ETFDH mutation shows progressive muscle weakness and rhabdomyosis2018
- Author(s)
  Seino Y, Nakamura T, Kawarabayashi T, Wakasaya Y, Hayashi YK, Okubo M, Nishino I, Shoji M
- Journal Title
  
  Neurology and Clinical Neuroscience
  
  Volume: 6 Issue: 2 Pages: 39-41
- DOI
  10.1111/ncn3.12177
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09306
[Journal Article] Disappearance of MRI imaging signals in a patient with neuronal intranuclear inclusion disease2018
- Author(s)
  Kawarabayashi T, Nakamura T, Seino Y, Hirohata M, Mori F, Wakabayashi K, Ono S, Harigaya Y, Shoji M
- Journal Title
  
  J Neurol Sci
  
  Volume: 388 Pages: 1-3
- DOI
  10.1016/j.jns.2018.02.038
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09305, KAKENHI-PROJECT-15K09306, KAKENHI-PROJECT-17K07088
[Journal Article] A case of hereditary neuropathy with liability to pressure palsies due to push-up exercise2017
- Author(s)
  Nakamura T, Kawarabayashi T, Seino Y, Shoji M
- Journal Title
  
  Rinsho Shinkeigaku
  
  Volume: 57 Issue: 7 Pages: 383-386
- DOI
  10.5692/clinicalneurol.cn-001023
- NAID
  130005873378
- ISSN
  0009-918X, 1882-0654
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09306
[Journal Article] Increases in plasma Abeta40 levels and the Abeta 40/42 ratio in patients with diabetes mellitus and dementia2016
- Author(s)
  Ueno Y, Nagaoka M, Nakamura T, Abe N, Nakata T, Wakasaya Y, Matsubara E, Kawarabayashi T, Shoji M
- Journal Title
  
  Hiroski Medical J
  
  Volume: 66 Pages: 110-119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09306
[Journal Article] Increases in plasma Abeta40 levels and the Abeta40/42 ratio in patients with diabetes mellitus and dementia．2016
- Author(s)
  Ueno Y, Nagaoka M, Nakamura T, Abe N, Nakata T, Wakasaya Y, Matsubara E, Kawarabayashi T, Shoji M
- Journal Title
  
  Hirosaki Medical J
  
  Volume: 66 Pages: 110-119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09305
[Presentation] Age-related cognitive decline and prevalence of MCI in the Iwaki Health Promotion Project2023
- Author(s)
  Takeshi Kawarabayashi, Naoko Nakahata, Takumi Nakamura, Masamitsu Takatama, Mikio Shoji
- Organizer
  AAIC2023 ALZHEIMER’S ASSOCIATION INTERNATIONAL CONFERENCE
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07511
[Presentation] 血漿中ApoE4は，ApoE2およびApoE3より低値である2023
- Author(s)
  中村琢洋，瓦林毅，柴田真，笠原浩生，牧岡幸樹，池田佳生，東海林幹夫
- Organizer
  第64回日本神経学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07511
[Presentation] Lipid rafts act as a common platform for Aβ oligomer-induced Alzheimer’s pathology2022
- Author(s)
  Takeshi Kawarabayashi, Takumi Nakamura, Masamitsu Takatama, Mikio Shoji
- Organizer
  AAIC2022 ALZHEIMER’S ASSOCIATION INTERNATIONAL CONFERENCE
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07511
[Presentation] Lipid rafts act as a common platform for Aβ oligomer-induced Alzheimer’s pathology2022
- Author(s)
  Takeshi Kawarabayashi, Takumi Nakamura, Kaoru Sato, Yusuke Seino, Sadanobu Ichii, Naoko Nakahata, Masamitsu Takatama, Mikio Shoj
- Organizer
  第63回日本神経学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07511
[Presentation] Alzheimer病の病態カスケードはlipid raftを共通のプラットフォームとして進行する2022
- Author(s)
  瓦林毅、中村琢洋、高玉真光、東海林幹夫
- Organizer
  第41回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07511
[Presentation] Abeta oligomers in synaptic lipid rafts induce phosphorylated tau and impair signal transduction.2017
- Author(s)
  Takeshi Kawarabayashi, Sakiko Narita, Kaoru Sato, Takumi, Nakamura, Mie Hirohata, Naoko Nakahata, and Mikio Shoji
- Organizer
  Neuroscience 2017, the Society for Neuroscience, 47th Annual Meeting
- Data Source
  KAKENHI-PROJECT-15K09305
[Presentation] Factors affecting plasma Abeta levels in IHP Project and second year follow2017
- Author(s)
  Takumi Nakamura, Mikio Shoji,
- Organizer
  Annual meeting of American Academy of Neurology, Boston, April 23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09306
[Presentation] Abeta oligomers in synaptic lipid rafts induce phosphorylated tau and impair signal transduction2017
- Author(s)
  Takeshi Kawarabayashi, Sakiko Narita, Kaoru Sato, Takumi, Nakamura, Mie Hirohata, Naoko Nakahata, and Mikio Shoji
- Organizer
  Neuroscience 2017, the Society for Neuroscience, 47th Annual Meeting, Washington D.C, Nov 11-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09306
[Presentation] Abeta oligomerはシナプスのlipid raftsでtauを誘発する2017
- Author(s)
  瓦林毅，成田早希子，佐藤薫，中村琢洋，廣畑美枝，清野祐輔，中畑直子，東海林幹夫
- Organizer
  第36回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09305
[Presentation] DIAN-Japan HUGSM 710 site, Hirosaki, Japan,2017
- Author(s)
  Mikio Shoji, Naoko Nakahata, Tomoyo Shirato, Sakiko Narita, Takumi Nakamura, Seino Yusuke, Mie Hirohata, Takeshi Kawarabayashi
- Organizer
  2017 DIAD Family Conference, London, July 15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09306
[Presentation] Induction of Phosphorylated Tau and Fyn-NMDA Receptor Transduction Pathway by Aß Oligomers in Synapse2017
- Author(s)
  Takeshi Kawarabayashi, Takumi Nakamura, Mie Hirohata, Yusuke Seino, and Mikio Shoji
- Organizer
  XXIII World Congress of Neurology
- Data Source
  KAKENHI-PROJECT-15K09305
[Presentation] Cerebrospinal fluid and blood biomarkers in neurological diseases2017
- Author(s)
  Yusuke Seino, Sakiko Narita, Takumi Nakamura, Mie Hirohata, Takeshi Kawarabayashi, Mikio Shoji
- Organizer
  DIAN Family Conference
- Data Source
  KAKENHI-PROJECT-15K09305
[Presentation] Cerebrospinal fluid and blood biomarkers in neurological diseases.2017
- Author(s)
  Yusuke Seino, Takumi Nakamura, Mie Hirohata, Takeshi Kawarabayashi, Mikio Shoji
- Organizer
  XXIII World Congress of Neurology
- Data Source
  KAKENHI-PROJECT-15K09305
[Presentation] Induction of Phosphorylated Tau and Fyn-NMDA Receptor Transduction Pathway by Abuta Oligomers in Synapse2017
- Author(s)
  Takeshi Kawarabayashi, Takumi Nakamura, Mie Hirohata, Yusuke Seino, and Mikio Shoji
- Organizer
  XXIII World Congress of Neurology, Kyoto, Sep 16-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09306
[Presentation] Cerebrospinal fluid and blood biomarkers in neurological diseases2017
- Author(s)
  Yusuke Seino, Takumi Nakamura, Mie Hirohata, Takeshi Kawarabayashi, Mikio Shoji
- Organizer
  ⅩⅩⅢ World Congress of Neurology, Kyoto, Sep 16-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09306
[Presentation] 血漿アミロイドbetaの影響因子の解析．2016
- Author(s)
  中村琢洋，瓦林毅，若佐谷保仁，中畑直子，東海林幹夫，高橋一平，中路重之
- Organizer
  第35回日本認知症学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都・千代田区）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-15K09305
[Presentation] CSF and plasma biomarkers for diagnosing dementia in outpatient clinic.2016
- Author(s)
  Masayuki Orikasa, Takeshi Kawarabayashi, Yasuhito Wakasaya, Takumi Nakamura, Naoko Nakahata, Mikio Shoji
- Organizer
  Alzheimer’s Association International Conference, AAIC 2016
- Place of Presentation
  Tronto（カナダ）
- Year and Date
  2016-07-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09305
[Presentation] Abeta oligomerによるシナプス障害の解析．2016
- Author(s)
  瓦林毅，成田早希子，中村琢洋，若佐谷保仁，中畑直子，東海林幹夫
- Organizer
  第35回日本認知症学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都・千代田区）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-15K09305
[Presentation] Induction of phosphorylated tau in synapse by accumulation of Abeta oligomers.2016
- Author(s)
  Takeshi Kawarabayashi, Takumi Nakamura, Yasuhito Wakasaya, Mikio Shoji
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸国際会議場（兵庫県・神戸市）
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-15K09305
[Presentation] Plasma Aβ levels are correlated with cognitive and motor functions in Iwaki Health Promotion Project2016
- Author(s)
  Takumi Nakamura, Takeshi Kawarabayashi, Yasuhito Wakasaya, Naoko Nakahata, Sakiko Narita, Mikio Shoji, Ippei Takahashi, Shigeyuki Nakaji
- Organizer
  68th Annual Meeting of American Academy of Neurology
- Place of Presentation
  バンクーバー（カナダ）
- Year and Date
  2016-04-15
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09306
[Presentation] Early induction of phosphorylated tau in synapse from APP transgenic mice.2016
- Author(s)
  Takeshi Kawarabayashi, Sakiko Narita, Takumi Nakamura, Yasuhito Wakasaya, Naoko Nakahata, Mikio Shoji
- Organizer
  Neuroscience 2016, the Society for Neuroscience, 46th Annual Meeting
- Place of Presentation
  San Diego　（アメリカ合衆国）
- Year and Date
  2016-06-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09305
[Presentation] 脳アミロイドアンギオパチーのマウスモデルを用いた検討．2016
- Author(s)
  成田早希子，瓦林毅，中村琢洋，若佐谷保仁，中畑直子，東海林幹夫
- Organizer
  第35回日本認知症学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都・千代田区）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-15K09305
[Presentation] Plasma amyloid beta levels are correlated with cognitive and motor functions.2016
- Author(s)
  Takumi Nakamura, Takeshi Kawarabayashi, Yasuhito Wakasaya, Mikio Shoji
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸国際会議場（兵庫県・神戸市）
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-15K09305
[Presentation] 地域におけるMCI診断の試みアンケート結果の検討2016
- Author(s)
  中畑直子,成田早希子,中村琢洋,若佐谷保仁, 瓦林毅, 東海林幹夫，高橋一平,中路重之
- Organizer
  第35回日本認知症学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都・千代田区）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-15K09305
[Presentation] Plasma Abeta levels are correlated with cognitive and motor functions in Iwaki Health Promotion Project.2016
- Author(s)
  Takumi Nakamura, Takeshi Kawarabayashi, Yasuhito Wakasaya, Naoko Nakahata, Sakiko Narita, Mikio Shoji, Ippei Takahashi, Shigeyuki Nakaji
- Organizer
  68th Annual Meeting of American Academy of Neurology
- Place of Presentation
  Vancouver（カナダ）
- Year and Date
  2016-04-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09305
[Presentation] Induction of phosphorylated tau in synapse from AD model mice.2015
- Author(s)
  Takeshi Kawarabayashi, Yasuhito Wakasaya, Takumi Nakamura, Naoko Nakahata, Mikio Shoji
- Organizer
  Neuroscience 2015, the Society for Neuroscience, 45th Annual Meeting
- Place of Presentation
  United States of America, Chicago
- Year and Date
  2015-11-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09305
[Presentation] Abeta oligomerの神経毒性の検討．2015
- Author(s)
  瓦林毅，中村琢洋，仲田崇，若佐谷保仁，中畑直子，東海林幹夫
- Organizer
  第34回日本認知症学会学術集会
- Place of Presentation
  リンクステーションホール青森（青森県・青森市）
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-15K09305

1. Kawarabayashi Takeshi (90186156)

# of Collaborated Projects: 3 results

# of Collaborated Products: 35 results
2. SHOJI Mikio (60171021)

# of Collaborated Projects: 2 results

# of Collaborated Products: 27 results

Nakamura Takumi 中村 琢洋

中村 琢洋 ナカムラ タクミ

NAKAMURA Takumi 中村 琢洋

Research Projects

Research Products

Co-Researchers

Analysis of Alzheimer's disease targeting lipid rafts and exosome

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of neurotoxic Abeta oligomers and development of therapy against them

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development and clinical application of disease modifying drug for Alzheimer's Disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Annual stability of the plasma A?40/42 ratio and associated factors2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Plasma ApoE4 Levels Are Lower than ApoE2 and ApoE3 Levels, and Not Associated with Plasma Aβ 40/42 Ratio as a Biomarker of Amyloid-β Amyloidosis in Alzheimer’s Disease2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical Evaluation of Cerebrospinal Fluid p217tau and Neurofilament Light Chain Levels in Patients with Alzheimer’s Disease or Other Neurological Diseases2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lipid Rafts Act as a Common Platform for Amyloid-β Oligomer-Induced Alzheimer’s Disease Pathology2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Case of elderly-onset multiple acyl-CoA dehydrogenase deficiency with a novel ETFDH mutation shows progressive muscle weakness and rhabdomyosis2018

Author(s)

Journal Title

Data Source

[Journal Article] Case of elderly-onset multiple acyl-CoA dehydrogenase deficiency with a novel ETFDH mutation shows progressive muscle weakness and rhabdomyosis2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Disappearance of MRI imaging signals in a patient with neuronal intranuclear inclusion disease2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A case of hereditary neuropathy with liability to pressure palsies due to push-up exercise2017

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Increases in plasma Abeta40 levels and the Abeta 40/42 ratio in patients with diabetes mellitus and dementia2016

Author(s)

Journal Title

Data Source

[Journal Article] Increases in plasma Abeta40 levels and the Abeta40/42 ratio in patients with diabetes mellitus and dementia．2016

Author(s)

Journal Title

Data Source

[Presentation] Age-related cognitive decline and prevalence of MCI in the Iwaki Health Promotion Project2023

Author(s)

Organizer

Data Source

[Presentation] 血漿中ApoE4は，ApoE2およびApoE3より低値である2023

Author(s)

Nakamura Takumi 中村琢洋

中村琢洋ナカムラタクミ

NAKAMURA Takumi 中村琢洋

[Presentation] Induction of Phosphorylated Tau and Fyn-NMDA Receptor Transduction Pathway by Aß Oligomers in Synapse2017