Hasegawa Atsushi 長谷川敦史

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Atsushi Hasegawa 長谷川敦史

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Researcher Number	80747460
Other IDs
Affiliation (Current)	2025: 東北大学, 東北メディカル・メガバンク機構, 助教
Affiliation (based on the past Project Information) *help	2022 – 2023: 東北大学, 東北メディカル・メガバンク機構, 助教 2019 – 2022: 東北大学, 医学系研究科, 助教 2017 – 2019: 東北大学, 事業支援機構, 助教 2016: 東北大学, 加齢医学研究所, JSPS特別研究員(PD) 2015: 東北大学, 加齢医学研究所, 特別研究員(PD)
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Tumor biology Except Principal Investigator Basic Section 52010:General internal medicine-related
Keywords	Principal Investigator DCML欠損症 / GATA2 / 血球分化 / DS-AMKL / 白血病幹細胞 Except Principal Investigator 純赤白血病 / 純席白血病 / ドライバー変異 / Ras変異 / GATA1 … More / 純赤白血病発 / 遺伝的素因 / 転写因子 / 白血病 Less

GATA2-mediated regulation of hematopoietic stem/progenitor cell differentiation involved in immunodeficiency syndromePrincipal Investigator
- Principal Investigator
  
  Hasegawa Atsushi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Tohoku University
Modifiers for the Gata1.05 leukemogenesis.
- Principal Investigator
  
  Shimizu Ritsuko
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Tohoku University
GATA2-mediated regulation of immune cell differentiation involved in immunodeficiencyPrincipal Investigator
- Principal Investigator
  
  Hasegawa Atsushi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Tohoku University
Molecular characterization of the leukemic stem cells maintaining GATA1-related DS-AMKLPrincipal Investigator
- Principal Investigator
  
  Atsushi Hasegawa
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Tohoku University

All 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Loss of <i>Atg2b</i> and <i>Gskip</i> Impairs the Maintenance of the Hematopoietic Stem Cell Pool Size2022
- Author(s)
  Sakai Shun-suke、Hasegawa Atsushi、Ishimura Ryosuke、Tamura Naoki、Kageyama Shun、Komatsu-Hirota Satoko、Abe Manabu、Ling Yiwei、Okuda Shujiro、Funayama Manabu、Kikkawa Mika、Miura Yoshiki、Sakimura Kenji、Narita Ichiei、Waguri Satoshi、Shimizu Ritsuko、Komatsu Masaaki
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 42 Issue: 1 Pages: 1-17
- DOI
  10.1128/mcb.00024-21
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01972, KAKENHI-PROJECT-19K08003, KAKENHI-PROJECT-19K16478, KAKENHI-PROJECT-20K16161, KAKENHI-PLANNED-19H05706, KAKENHI-PROJECT-21H04771, KAKENHI-PROJECT-19H03555, KAKENHI-PROJECT-20H03415, KAKENHI-PROJECT-21H04163, KAKENHI-PROJECT-18KK0458, KAKENHI-PROJECT-21K17850
[Journal Article] Heterozygous variants in GATA2 contribute to DCML deficiency in mice by disrupting tandem protein binding.2022
- Author(s)
  Hasegawa A, Hayasaka Y, Morita M, Takenaka Y, Hosaka Y, Hirano I, Yamamoto M, Shimizu R.
- Journal Title
  
  Commun Biol.
  
  Volume: - Issue: 1 Pages: 376-376
- DOI
  10.1038/s42003-022-03316-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03555, KAKENHI-PROJECT-21K08364, KAKENHI-PROJECT-19K07341
[Journal Article] GATA2 hypomorphism induces chronic myelomonocytic leukemia in mice2019
- Author(s)
  Harada Nobuhiko、Hasegawa Atsushi、Hirano Ikuo、Yamamoto Masayuki、Shimizu Ritsuko
- Journal Title
  
  Cancer Science
  
  Volume: 110 Issue: 4 Pages: 1183-1193
- DOI
  10.1111/cas.13959
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-15H02507, KAKENHI-PROJECT-19H03555
[Journal Article] GATA1 activity governed by configulations of cis-acting elements.2017
- Author(s)
  Hasegawa A, Shimizu R.
- Journal Title
  
  Front. Oncol
  
  Volume: 73 Pages: 221-227
- DOI
  10.3389/fonc.2016.00269
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04759, KAKENHI-PROJECT-15J04864, KAKENHI-PROJECT-15K18395
[Journal Article] GATA1 binding kinetics on conformation-specific binding sites elicit differential transcriptional regulation.2016
- Author(s)
  Hasegawa A, Kaneko H, Ishihara, D, Nakamura M, Watanabe A, Yamamoto M, Trainor CD, Shimizu R.
- Journal Title
  
  Mol Cell Biol.
  
  Volume: 36 Issue: 16 Pages: 2051-2067
- DOI
  10.1128/mcb.00017-16
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04759, KAKENHI-PROJECT-15K18395
[Presentation] 変異タンパク質によるGATA2の機能障害が惹起する免疫細胞産生異常2022
- Author(s)
  長谷川敦史, 保坂優奈, 山本雅之, 清水律子
- Organizer
  第26回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-21K08364
[Presentation] 変異タンパク質によるGATA2の機能障害が惹起する免疫細胞産生異常2022
- Author(s)
  長谷川敦史, 保坂優奈, 山本雅之, 清水律子
- Organizer
  第26回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-19H03555
[Presentation] GATA2変異が引き起こす細胞機能の変化2021
- Author(s)
  保坂優奈, 長谷川敦史, 山本雅之, 清水律子
- Organizer
  第87回日本生化学会東北支部会
- Data Source
  KAKENHI-PROJECT-19H03555
[Presentation] GATA2変異が引き起こす細胞機能の変化2021
- Author(s)
  保坂優奈, 長谷川敦史, 山本雅之, 清水律子
- Organizer
  第87回日本生化学会東北支部例会・シンポジウム
- Data Source
  KAKENHI-PROJECT-21K08364
[Presentation] GATA2変異に起因する遺伝子発現調節異常の網羅的解析2020
- Author(s)
  竹中佑太, 長谷川敦史, 清水律子
- Organizer
  日本生化学会東北支部会
- Data Source
  KAKENHI-PROJECT-19H03555
[Presentation] GATA2変異に起因する遺伝子発現調節異常の網羅的解析2020
- Author(s)
  竹中佑太, 長谷川敦史, 保坂優奈, 山本雅之, 清水律子
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H03555
[Presentation] GATA2変異に起因する遺伝子発現調節異常の網羅的解析2020
- Author(s)
  竹中佑太, 長谷川敦史, 保坂優奈, 山本雅之, 清水律子
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K16074
[Presentation] GATA2変異に起因する遺伝子発現調節異常の網羅的解析2020
- Author(s)
  竹中佑太, 長谷川敦史, 清水律子
- Organizer
  日本生化学会東北支部第86回例会・シンポジウム
- Data Source
  KAKENHI-PROJECT-18K16074
[Presentation] GATA2による系列特異的な免疫細胞産生制御2019
- Author(s)
  長谷川敦史, 竹中佑太, 保坂優奈, 山本雅之, 清水律子
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K16074
[Presentation] DCML欠損症発症に関与する変異GATA2の分子機能解析2018
- Author(s)
  藤田優城, 長谷川敦史, 平野育生, 清水律子
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K16074
[Presentation] GATA2による系列特異的な免疫細胞産生制御2018
- Author(s)
  長谷川敦史, 藤田優城, 山本雅之, 清水律子
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K16074
[Presentation] シス配列パターンに依存した転写因子GATA1のDNA結合親和性修飾機構2017
- Author(s)
  長谷川敦史
- Organizer
  日本生化学会東北支部第83回例会・シンポジウム
- Data Source
  KAKENHI-PROJECT-15K18395
[Presentation] シス配列構造に依存した GATA1-DNA 結合様式修飾と転写活性調節2016
- Author(s)
  長谷川敦史, 金子寛, 石原大詞, 中村正裕, 渡辺亮, 山本雅之, Cecelia D Trainor, 清水律子
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台市
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-15K18395
[Presentation] Cis-element configuration dependent dynamics in DNA-binding and transactivation activity of GATA12016
- Author(s)
  Atsushi Hasegawa, Hiroshi Kaneko, Daishi Ishihara, Masahiro Nakamura, Akira Watanabe, Cecelia D. Trainor, Masayuki Yamamoto, Ritsuko Shimizu
- Organizer
  The 20th Hemoglobin Switching Conference
- Place of Presentation
  Pacific Grove, USA
- Year and Date
  2016-09-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18395

1. Shimizu Ritsuko (40226262)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
2. 平野育生 (00708117)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. 阿部学

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 山本雅之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hasegawa Atsushi 長谷川 敦史

Atsushi Hasegawa 長谷川 敦史

Research Projects

Research Products

Co-Researchers

GATA2-mediated regulation of hematopoietic stem/progenitor cell differentiation involved in immunodeficiency syndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Modifiers for the Gata1.05 leukemogenesis.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

GATA2-mediated regulation of immune cell differentiation involved in immunodeficiencyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular characterization of the leukemic stem cells maintaining GATA1-related DS-AMKLPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Loss of <i>Atg2b</i> and <i>Gskip</i> Impairs the Maintenance of the Hematopoietic Stem Cell Pool Size2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Heterozygous variants in GATA2 contribute to DCML deficiency in mice by disrupting tandem protein binding.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] GATA2 hypomorphism induces chronic myelomonocytic leukemia in mice2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] GATA1 activity governed by configulations of cis-acting elements.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] GATA1 binding kinetics on conformation-specific binding sites elicit differential transcriptional regulation.2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] 変異タンパク質によるGATA2の機能障害が惹起する免疫細胞産生異常2022

Author(s)

Organizer

Data Source

[Presentation] 変異タンパク質によるGATA2の機能障害が惹起する免疫細胞産生異常2022

Author(s)

Organizer

Data Source

[Presentation] GATA2変異が引き起こす細胞機能の変化2021

Author(s)

Organizer

Data Source

[Presentation] GATA2変異が引き起こす細胞機能の変化2021

Author(s)

Organizer

Data Source

[Presentation] GATA2変異に起因する遺伝子発現調節異常の網羅的解析2020

Author(s)

Organizer

Data Source

[Presentation] GATA2変異に起因する遺伝子発現調節異常の網羅的解析2020

Author(s)

Organizer

Data Source

[Presentation] GATA2変異に起因する遺伝子発現調節異常の網羅的解析2020

Author(s)

Hasegawa Atsushi 長谷川敦史

Atsushi Hasegawa 長谷川敦史