Takahashi Saori 高橋沙央里

Researcher Number	80748856
Other IDs
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 研究員
Affiliation (based on the past Project Information) *help	2024 – 2025: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 研究員 2020: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 研究員 2018 – 2019: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 基礎科学特別研究員 2016: 国立研究開発法人理化学研究所, 多細胞システム形成研究センター, 研究員 2015: 大阪大学, たんぱく質研究所, 招へい研究員
Review Section/Research Field	Principal Investigator Transformative Research Areas, Section (III) / Basic Section 43010:Molecular biology-related / Basic Section 43050:Genome biology-related / Genome biology
Keywords	Principal Investigator マウス初期胚 / 複製フォーク / DNA複製 / シングルセル / 複製タイミング / エピゲノム / 核内構造 / 細胞分化 / scRepli-seq / マウス初期胚発生 … More / ES細胞分化 / 1細胞解析 / 初期胚発生 / 核内コンパートメント / DNA複製タイミング / ヒドロキシメチル化シトシン / エピジェネティクス / ヒストン修飾 / ヒドロキシメチルシトシン / DNA脱メチル化 / DNAメチル化 Less

マウス初期胚におけるDNA複製プログラム制御機構の解明Principal Investigator
- Principal Investigator
  
  高橋沙央里
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Institute of Physical and Chemical Research
マウス初期胚における複製オリジンの発火とフォーク伸長機構の解明Principal Investigator
- Principal Investigator
  
  高橋沙央里
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Institute of Physical and Chemical Research
Prediction of the nuclear compartment dynamics during embryonic development by single-cell replication sequencingPrincipal Investigator
- Principal Investigator
  
  Takahashi Saori
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  Institute of Physical and Chemical Research
Establishent of two independent methods to analyze 5hmC at single base resolutionPrincipal Investigator
- Principal Investigator
  
  Takahashi Saori
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Genome biology
- Research Institution
  Institute of Physical and Chemical Research
  Osaka University

All 2021 2020 2019 2018 2016 2015

All Journal Article Presentation Book

[Book] 実験医学別冊・クロマチン解析実践プロトコール2020
- Author(s)
  高橋沙央里、三浦尚、平谷伊智朗
- Total Pages
  270
- Publisher
  羊土社
- ISBN
  9784758122481
- Data Source
  KAKENHI-PROJECT-18K14681
[Journal Article] The Temporal Order of DNA Replication Shaped by Mammalian DNA Methyltransferases2021
- Author(s)
  Takebayashi Shin-ichiro、Ryba Tyrone、Wimbish Kelsey、Hayakawa Takuya、Sakaue Morito、Kuriya Kenji、Takahashi Saori、Ogata Shin、Hiratani Ichiro、Okumura Katsuzumi、Okano Masaki、Ogata Masato
- Journal Title
  
  Cells
  
  Volume: 10 Issue: 2 Pages: 266-266
- DOI
  10.3390/cells10020266
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06610, KAKENHI-PROJECT-19K08324, KAKENHI-PROJECT-20K20582, KAKENHI-PLANNED-18H05530, KAKENHI-PUBLICLY-20H05386, KAKENHI-PROJECT-18K14681
[Journal Article] Dynamics of transcription-mediated conversion from euchromatin to facultative heterochromatin at the Xist promoter by Tsix2021
- Author(s)
  Ohhata Tatsuya、Yamazawa Kazuki、Miura-Kamio Asuka、Takahashi Saori、Sakai Satoshi、Tamura Yuka、Uchida Chiharu、Kitagawa Kyoko、Niida Hiroyuki、Hiratani Ichiro、Kobayashi Hisato、Kimura Hiroshi、Wutz Anton、Kitagawa Masatoshi
- Journal Title
  
  Cell Reports
  
  Volume: 34 Issue: 13 Pages: 108912-108912
- DOI
  10.1016/j.celrep.2021.108912
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20582, KAKENHI-PLANNED-18H05527, KAKENHI-PLANNED-18H05530, KAKENHI-PROJECT-18K14681, KAKENHI-PROJECT-17K08727, KAKENHI-PROJECT-19H03628, KAKENHI-PROJECT-20K07043, KAKENHI-PROJECT-20K07378, KAKENHI-PROJECT-20K06541
[Journal Article] Mapping replication timing domains genome wide in single mammalian cells with single-cell DNA replication sequencing2020
- Author(s)
  Miura Hisashi、Takahashi Saori、Shibata Takahiro、Nagao Koji、Obuse Chikashi、Okumura Katsuzumi、Ogata Masato、Hiratani Ichiro、Takebayashi Shin-ichiro
- Journal Title
  
  Nature Protocols
  
  Volume: 15 Issue: 12 Pages: 4058-4100
- DOI
  10.1038/s41596-020-0378-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06610, KAKENHI-PROJECT-20K08698, KAKENHI-PROJECT-20K20582, KAKENHI-PLANNED-18H05530, KAKENHI-PLANNED-18H05532, KAKENHI-PUBLICLY-20H05386, KAKENHI-PROJECT-19H03156, KAKENHI-PROJECT-18K14681
[Journal Article] Enhanced processivity of Dnmt1 by monoubiquitinated histone H32020
- Author(s)
  Y. Mishima, L. Brueckner, S. Takahashi, T. Kawakami, J. Otani, A. Shinohara, K. Takeshita, R. G. Garvilles, M. Watanabe, N. Sakai, H. Takeshima, C. Nachtegael, A. Nishiyama, M. Nakanishi, K. Arita, K. Nakashima, H. Hojo, I. Suetake
- Journal Title
  
  Genes Cells
  
  Volume: 25 Issue: 1 Pages: 22-32
- DOI
  10.1111/gtc.12732
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05316, KAKENHI-PROJECT-18K06095, KAKENHI-PROJECT-18K14681, KAKENHI-PROJECT-19K17878, KAKENHI-PLANNED-15H05973, KAKENHI-PROJECT-18H02392, KAKENHI-PROJECT-19H04048, KAKENHI-PROJECT-18K15211, KAKENHI-PLANNED-19H05740, KAKENHI-PLANNED-19H05741, KAKENHI-PROJECT-17H01398, KAKENHI-PROJECT-19H00981, KAKENHI-ORGANIZER-19H05739
[Journal Article] Single-cell DNA Replication Profiling Identifies Spatiotemporal Developmental Dynamics of Chromosome Organization.2019
- Author(s)
  Miura H, Takahashi S, Poonperm R, Tanigawa A, Takebayashi S I, and Hiratani I.
- Journal Title
  
  Nature Genetics
  
  Volume: 51 Issue: 9 Pages: 1356-1368
- DOI
  10.1038/s41588-019-0474-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06610, KAKENHI-PROJECT-18K14681, KAKENHI-PLANNED-18H05530, KAKENHI-PROJECT-17K08879
[Journal Article] Genome-wide stability of the DNA replication program in single mammalian cells2019
- Author(s)
  Saori Takahashi, Hisashi Miura, Takahiro Shibata, Koji Nagao, Katsuzumi Okumura, Masato Ogata, Chikashi Obuse, Shin-ichiro Takebayashi and Ichiro Hiratani
- Journal Title
  
  Nature Genetics
  
  Volume: 51 Issue: 3 Pages: 529-540
- DOI
  10.1038/s41588-019-0347-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14681, KAKENHI-PLANNED-17H06426, KAKENHI-PUBLICLY-18H04713, KAKENHI-PLANNED-18H05530, KAKENHI-PLANNED-18H05532, KAKENHI-PROJECT-16H04739
[Journal Article] DNA replication timing enters the single-cell era2019
- Author(s)
  Ichiro Hiratani and Saori Takahashi
- Journal Title
  
  Genes
  
  Volume: 10 Issue: 3 Pages: 221-221
- DOI
  10.3390/genes10030221
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14681, KAKENHI-PLANNED-18H05530
[Journal Article] Practical Analysis of Hi-C Data: Generating A/B Compartment Profiles2018
- Author(s)
  Hisashi Miura, Rawin Poonperm, Saori Takahashi and Ichiro Hiratani
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 1861 Pages: 221-245
- DOI
  10.1007/978-1-4939-8766-5_16
- ISBN
  9781493987658, 9781493987665
- Open Access
- Data Source
  KAKENHI-PROJECT-18K14681, KAKENHI-PLANNED-18H05530
[Journal Article] Simple and accurate single base resolution analysis of 5-hydroxymethylcytosine by catalytic oxidative bisulfite sequencing using micelle incarcerated oxidants2016
- Author(s)
  Seketsu Fukuzawa, Saori Takahashi. Kazoo Tachibana, Shoji Tajima, Isao Suetake
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 24 Issue: 18 Pages: 4254-4262
- DOI
  10.1016/j.bmc.2016.07.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K18456
[Journal Article] Live imaging of X chromosome reactivation dynamics in early mouse development can discriminate naive from primed pluripotent stem cells.2016
- Author(s)
  Kobayashi S, Hosoi Y, Shiura H, Yamagata K, Takahashi S, Fujihara Y, Kohda T, Okabe M, Ishino F.
- Journal Title
  
  Development
  
  Volume: 143 Issue: 16 Pages: 2958-2964
- DOI
  10.1242/dev.136739
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05573, KAKENHI-PROJECT-25712035, KAKENHI-PROJECT-15K18456, KAKENHI-PROJECT-26430087, KAKENHI-PUBLICLY-15H01468
[Journal Article] A novel method to analyze 5-hydroxymethylcytosine in CpG sequences using maintenance DNA methyltransferase, DNMT12015
- Author(s)
  Saori Takahashi, Isao Suetake, Jan Engelhardt, Shoji Tajima
- Journal Title
  
  FEBS Open Bio
  
  Volume: 5 Issue: 1 Pages: 741-747
- DOI
  10.1016/j.fob.2015.09.003
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18456, KAKENHI-PROJECT-15K14478, KAKENHI-PROJECT-25291025
[Journal Article] Dual functions of the RFTS domain of Dnmt1 in replication-coupled DNA methylation and in protection of the genome from aberrant methylation2015
- Author(s)
  Ronald Garingalao Garvilles, Takashi Hasegawa, Hironobu Kimura, Jafar Sharif, Masahiro Muto, Haruhiko Koseki, Saori Takahashi, Isao Suetake, and Shoji Tajima
- Journal Title
  
  PLoS ONE
  
  Volume: 10 Issue: 9 Pages: e0137509-e0137509
- DOI
  10.1371/journal.pone.0137509
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K18456, KAKENHI-PROJECT-25650007, KAKENHI-PROJECT-25291025
[Presentation] 1細胞解析で明らかにされたDNA複製ドメインの細胞間の安定性と不均一性2019
- Author(s)
  高橋沙央里，三浦尚，柴田隆豊，長尾恒治，小布施力史，竹林慎一郎，平谷伊智朗
- Organizer
  第19回日本蛋白質科学会年会・第71回日本細胞生物学会大会合同年次大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K14681
[Presentation] マウスES細胞分化および初期胚発生過程における1細胞全ゲノムDNA複製タイミング解析2019
- Author(s)
  高橋沙央里，三浦尚，柴田隆豊，長尾恒治，小布施力史，竹林慎一郎，平谷伊智朗
- Organizer
  第42回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-18K14681
[Presentation] Single-cell DNA replication sequencing and its application to studies of early mouse embryonic development2019
- Author(s)
  Saori Takahashi, Hisashi Miura, Takahiro Shibata, Koji Nagao, Chikashi Obuse, Shin-ichiro Takebayashi and Ichiro Hiratani
- Organizer
  第13回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-18K14681
[Presentation] 分化前後のES細胞における複製ドメインは細胞間で極めて均一なプロファイルを示す2018
- Author(s)
  高橋沙央里、三浦尚、柴田隆豊、長尾恒治、小布施力史、竹林慎一郎、平谷伊智朗
- Organizer
  第12回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-18K14681
[Presentation] Genome-wide single-cell DNA replication sequencing reveals cell-type specific signatures that are conserved from cell to cell2018
- Author(s)
  Saori Takahashi, Hisashi Miura, Takahiro Shibata, Koji Nagao, Chikashi Obuse, Shin-ichiro Takebayashi and Ichiro Hiratani
- Organizer
  EMBL Symposium: Principles of Chromosome Structure and Function
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14681
[Presentation] DNA脱メチル化制御機構の解析2016
- Author(s)
  高橋沙央里、末武勲
- Organizer
  第16回日本蛋白質科学会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Invited
- Data Source
  KAKENHI-PROJECT-15K18456
[Presentation] 組換えDNMT1を利用した1塩基解像度での5hmCの新規解析方法の開発とゲノムへの応用2015
- Author(s)
  高橋沙央里，末武勲，Jan Engelhardt，田嶋正二
- Organizer
  日本分子生物学会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-15K18456
[Presentation] 組換えDNMT1を用いた簡便なヒドロキシメチルシトシン一塩基解像度の検出方法2015
- Author(s)
  高橋沙央里，末武勲，Jan Engelhardt，田嶋正二
- Organizer
  日本エピジェネティクス研究会
- Place of Presentation
  東京都
- Year and Date
  2015-05-15
- Data Source
  KAKENHI-PROJECT-15K18456

1. FUJIHARA Yoshitaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 竹林慎一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
3. 平谷伊智朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
4. 川上徹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takahashi Saori 高橋 沙央里

Research Projects

Research Products

Co-Researchers

マウス初期胚におけるDNA複製プログラム制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

マウス初期胚における複製オリジンの発火とフォーク伸長機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Prediction of the nuclear compartment dynamics during embryonic development by single-cell replication sequencingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishent of two independent methods to analyze 5hmC at single base resolutionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 実験医学別冊・クロマチン解析実践プロトコール2020

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] The Temporal Order of DNA Replication Shaped by Mammalian DNA Methyltransferases2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dynamics of transcription-mediated conversion from euchromatin to facultative heterochromatin at the Xist promoter by Tsix2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mapping replication timing domains genome wide in single mammalian cells with single-cell DNA replication sequencing2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enhanced processivity of Dnmt1 by monoubiquitinated histone H32020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Single-cell DNA Replication Profiling Identifies Spatiotemporal Developmental Dynamics of Chromosome Organization.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genome-wide stability of the DNA replication program in single mammalian cells2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DNA replication timing enters the single-cell era2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Practical Analysis of Hi-C Data: Generating A/B Compartment Profiles2018

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Simple and accurate single base resolution analysis of 5-hydroxymethylcytosine by catalytic oxidative bisulfite sequencing using micelle incarcerated oxidants2016

Author(s)

Journal Title

DOI

Data Source

Takahashi Saori 高橋沙央里