MIZUMOTO TERUHIKO 水本輝彦

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Mizumoto Teruhiko 水本輝彦

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Researcher Number	80749193
Other IDs
Affiliation (Current)	2025: 熊本大学, 大学院生命科学研究部(医), 助教
Affiliation (based on the past Project Information) *help	2025: 熊本大学, 大学院生命科学研究部(医), 助教 2019 – 2023: 熊本大学, 大学院生命科学研究部(医), 助教 2016 – 2018: 熊本大学, 医学部附属病院, 特任助教 2015: 熊本大学, 医学部附属病院, その他
Review Section/Research Field	Principal Investigator Basic Section 53040:Nephrology-related / Kidney internal medicine
Keywords	Principal Investigator 糸球体障害 / 糖尿病性腎症 / エクソソーム阻害薬 / エクソソーム / 炎症 / 糸球体上皮細胞 / 慢性炎症 / マクロファージ / MRP8 / 糸球体傷害 … More / 上皮細胞 / アポトーシス / カモスタット / プロテアーゼ / セリンプロテアーゼ / メタボリックシンドローム / 尿蛋白 Less

腹膜透析における中皮細胞のp38 MAPKの意義Principal Investigator
- Principal Investigator
  
  水本輝彦
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Kumamoto University
糖尿病性腎症進展抑制を目指したエクソソーム阻害薬投与効果の検討Principal Investigator
- Principal Investigator
  
  水本輝彦
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Kumamoto University
Investigating compounds that act on interglomerular crosstalk in diabetic nephropathy.Principal Investigator
- Principal Investigator
  
  Mizumoto Teruhiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Kumamoto University
Elucidation of the role of MRP8 through inflammation and ER stress in metabolic syndrome related nephropathyPrincipal Investigator
- Principal Investigator
  
  Mizumoto Teruhiko
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kumamoto University
Functional elucidation and therapeutic application of protease in kidney injury by metabolic syndromePrincipal Investigator
- Principal Investigator
  
  Mizumoto Teruhiko
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kumamoto University

All 2022 2021 2020 2019 2018 2016 2015

All Journal Article Presentation

[Journal Article] A Novel VCP modulator KUS121 exerts renoprotective effects in ischemia-reperfusion injury with retaining ATP and restoring ERAD-processing capacity.2022
- Author(s)
  Hata Yusuke、Date Ryosuke、Fujimoto Daisuke、Ikeda Hanako Ohashi、Umemoto Shuro、Kanki Tomoko、Nishiguchi Yoshihiko、Mizumoto Teruhiko、Hayata Manabu、Kakizoe Yutaka、Izumi Yuichiro、Kakizuka Akira、Mukoyama Masashi、Kuwabara Takashige
- Journal Title
  
  American Journal of Physiology-Renal Physiology
  
  Volume: - Issue: 5 Pages: F577-F586
- DOI
  10.1152/ajprenal.00392.2021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08728, KAKENHI-PROJECT-21K08280, KAKENHI-PROJECT-22K08311, KAKENHI-PROJECT-22K08357, KAKENHI-PROJECT-22K16223, KAKENHI-PROJECT-20K08611, KAKENHI-PROJECT-19H03435
[Journal Article] A serine protease inhibitor camostat mesilate prevents podocyte apoptosis and attenuates podocyte injury in metabolic syndrome model rats2021
- Author(s)
  Mizumoto Teruhiko、Kakizoe Yutaka、Nakagawa Terumasa、Iwata Yasunobu、Miyasato Yoshikazu、Uchimura Kohei、Adachi Masataka、Deng Qinyuan、Hayata Manabu、Morinaga Jun、Miyoshi Taku、Izumi Yuichiro、Kuwabara Takashige、Sakai Yoshiki、Tomita Kimio、Kitamura Kenichiro、Mukoyama Masashi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 146 Issue: 4 Pages: 192-199
- DOI
  10.1016/j.jphs.2021.04.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08728, KAKENHI-PROJECT-19K08729, KAKENHI-PROJECT-20K08611, KAKENHI-PROJECT-21K08280
[Journal Article] The predictive role of serum calprotectin on mortality in hemodialysis patients with high phosphoremia2020
- Author(s)
  Kanki Tomoko、Kuwabara Takashige、Morinaga Jun、Fukami Hirotaka、Umemoto Shuro、Fujimoto Daisuke、Mizumoto Teruhiko、Hayata Manabu、Kakizoe Yutaka、Izumi Yuichiro、Tajiri Saeko、Tajiri Tetsuya、Kitamura Kenichiro、Mukoyama Masashi
- Journal Title
  
  BMC Nephrology
  
  Volume: 21 Issue: 1 Pages: 158-158
- DOI
  10.1186/s12882-020-01812-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08728, KAKENHI-PROJECT-17K09706, KAKENHI-PROJECT-19K08729, KAKENHI-PROJECT-20K08611, KAKENHI-PROJECT-18K08247
[Journal Article] Suppressed ER-associated degradation by intraglomerular cross talk between mesangial cells and podocytes causes podocyte injury in diabetic kidney disease.2020
- Author(s)
  Fujimoto D, Kuwabara T, Hata Y, Umemoto S, Kanki T, Nishiguchi Y, Mizumoto T, Hayata M, Kakizoe Y, Izumi Y, Takahashi S, Mukoyama M.
- Journal Title
  
  FASEB J
  
  Volume: 34 Issue: 11 Pages: 854-860
- DOI
  10.1096/fj.202000078rr
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08728, KAKENHI-PROJECT-19K08729, KAKENHI-PROJECT-20K08611, KAKENHI-PROJECT-18K08247
[Journal Article] Circulating angiopoietin-like protein 2 levels and mortality risk in patients receiving maintenance hemodialysis: a prospective cohort study2019
- Author(s)
  Morinaga J, Kakuma T, Fukami H, Hayata M, Uchimura K, Mizumoto T, Kakizoe Y, Miyoshi T, Shiraishi N, Adachi M, Izumi Y, Kuwabara T, Okadome Y, Sato M, Horiguchi H, Sugizaki T, Kadomatsu T, Miyata K, Tajiri S, Tajiri T, Tomita K, Kitamura K, Oike Y, Mukoyama M.
- Journal Title
  
  Nephrology Dialysis Transplantation
  
  Volume: 印刷中 Issue: 5 Pages: 854-860
- DOI
  10.1093/ndt/gfz236
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08247, KAKENHI-PROJECT-19K08560, KAKENHI-PROJECT-19K08728, KAKENHI-PROJECT-19K17607, KAKENHI-PROJECT-18H02809, KAKENHI-PROJECT-17K09704, KAKENHI-PROJECT-17K09705, KAKENHI-PROJECT-17K09706, KAKENHI-PROJECT-19K08729, KAKENHI-PROJECT-20K08611
[Journal Article] Doxycycline attenuates cisplatin-induced acute kidney injury through pleiotropic effects2018
- Author(s)
  Nakagawa T, Kakizoe Y, Iwata Y, Miyasato Y, Mizumoto T, Adachi M, Izumi Y, Kuwabara T, Suenaga N, Narita Y, Jono H, Saito H, Kitamura K, Mukoyama M
- Journal Title
  
  Am J Physiol Renal Physiol
  
  Volume: 315 Issue: 5 Pages: 1347-1357
- DOI
  10.1152/ajprenal.00648.2017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09705, KAKENHI-PROJECT-17K09706, KAKENHI-PROJECT-18K08247, KAKENHI-PROJECT-17K15509, KAKENHI-PROJECT-17K16090
[Journal Article] A serine protease inhibitor attenuates aldosterone-induced kidney injuries via the suppression of plasmin activity.2016
- Author(s)
  Y. Kakizoe, Y. Miyasato, T. Onoue, T. Nakagawa, M. Hayata, K. Uchimura, J. Morinaga, T. Mizumoto, M. Adachi, T. Miyoshi, Y. Sakai, K. Tomita, M. Mukoyama, K. Kitamura
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 132 Issue: 2 Pages: 145-153
- DOI
  10.1016/j.jphs.2016.09.005
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461226, KAKENHI-PROJECT-15K19459, KAKENHI-PROJECT-15K19460
[Journal Article] Combination therapy with renin-angiotensin-aldosterone system inhibitor telmisartan and serine protease inhibitor camostat mesilate provides further renoprotection in a rat chronic kidney disease model.2016
- Author(s)
  Yuki Narita, Miki Ueda, Kohei Uchimura, Yutaka Kakizoe, Yoshikazu Miyasato, Teruhiko Mizumoto, Jun Morinaga, Manabu Hayata, Terumasa Nakagawa, Masataka Adachi, Taku Miyoshi, Yoshiki Sakai, Daisuke Kadowaki, Sumio Hirata, Masashi Mukoyama, Kenichiro Kitamura
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 130 Issue: 2 Pages: 110-116
- DOI
  10.1016/j.jphs.2016.01.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461226, KAKENHI-PROJECT-26461234, KAKENHI-PROJECT-15K19459, KAKENHI-PROJECT-15K19460, KAKENHI-PROJECT-15K08100
[Journal Article] The serine protease inhibitor camostat mesilate attenuates the progression of chronic kidney disease through its antioxidant effects.2015
- Author(s)
  Miki Ueda, Kohei Uchimura, Yuki Narita, Yoshikazu Miyasato, Teruhiko Mizumoto, Jun Morinaga, Manabu Hayata, Yutaka Kakizoe, Masataka Adachi, Taku Miyoshi, Naoki Shiraishi, Daisuke Kadowaki, Y Sakai, Masashi Mukoyama, Kenichiro Kitamura
- Journal Title
  
  Nephron
  
  Volume: 129 Issue: 3 Pages: 223-232
- DOI
  10.1159/000375308
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461226, KAKENHI-PROJECT-26461234, KAKENHI-PROJECT-15K19459, KAKENHI-PROJECT-15K19460
[Presentation] 糖尿病性腎臓病進展に果たすメサンギウム　ポドサイト連関による小胞体関連分解(ERAD)不全の意義2020
- Author(s)
  藤本大介, 桑原孝成, 秦雄介, 梅本周朗, 神吉智子, 西口佳彦, 水本輝彦, 早田学, 泉裕一郎, 柿添豊, 向山政志
- Organizer
  第57回日本臨床分子医学会
- Data Source
  KAKENHI-PROJECT-19K08729
[Presentation] 糖尿病においてメサンギウム細胞との細胞連関がポドサイトの正常な小胞体関連分解を阻害し腎症を進展させる2020
- Author(s)
  藤本大介, 桑原孝成, 秦雄介, 梅本周朗, 神吉智子, 西口佳彦, 水本輝彦, 早田学, 泉裕一郎, 柿添豊, 向山政志
- Organizer
  第63回日本腎臓学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08729
[Presentation] Intraglomerular Cross-Talk Between Mesangial Cells and Podocytes Inhibits Normal Endoplasmic Reticulum-Associated Degradation Processes and Induces Podocyte Injury in Diabetes2019
- Author(s)
  Daisuke Fujimoto, Takashige Kuwabara, Yusuke Hata, Shuro Umemoto, Tomoko Kanki, Yoshihiko Nishiguchi, Teruhiko Mizumoto, Manabu Hayata, Yuichiro Izumi, Yutaka Kakizoe, Masashi Mukoyama
- Organizer
  American Society of Nephrology, Kidney Week 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08729
[Presentation] 糖尿病においてメサンギウム細胞との細胞連関がポドサイトの正常な小胞体関連分解を阻害し腎症を悪化させる2019
- Author(s)
  藤本大介, 桑原孝成, 秦雄介, 梅本周朗, 神吉智子, 西口佳彦, 水本輝彦, 早田学, 泉裕一郎, 柿添豊, 向山政志
- Organizer
  第62回日本腎臓学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08729
[Presentation] The Predictive Role of Serum MRP8/14 (S100A8/A9) on Mortality in Hemodialysis Patients2019
- Author(s)
  Tomoko Kanki, Takashige Kuwabara, Jun Morinaga, Hirotaka Fukami, Shuro Umemoto, Daisuke Fujimoto, Teruhiko Mizumoto, Manabu Hayata, Yutaka Kakizoe, Yuichiro Izumi, Masashi Mukoyama.
- Organizer
  American Society of Nephrology, Kidney Week 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08729
[Presentation] CKDにおけるMRP8の化学修飾の探索とその意義の検討2018
- Author(s)
  神吉智子、桒原孝成、梅本周朗、藤本大介、水本輝彦、早田学、中山憲司、宮崎有、井上貴博、小川修、向山政志
- Organizer
  日本腎臓学会
- Data Source
  KAKENHI-PROJECT-17K16090
[Presentation] 糸球体内クロストークにおけるメサンギウム細胞由来因子によるポドサイトERストレス応答の検討2018
- Author(s)
  藤本大介、桒原孝成、梅本周朗、神吉智子、水本輝彦、早田学、泉裕一郎、柿添豊、向山政志
- Organizer
  日本腎臓学会
- Data Source
  KAKENHI-PROJECT-17K16090
[Presentation] Intraglomerular crosstalk between mesangial cells and podocytes inhibits normal ER-associated degradation processes and induces podocyte injury in diabetic nephropathy.2018
- Author(s)
  Daisuke Fujimoto, Takashige Kuwabara, Yusuke Hata, Shuro Umemoto, Tomoko Kanki, Yoshihiko Nishiguchi, Teruhiko Mizumoto, Manabu Hayata, Yuichiro Izumi, Yutaka Kakizoe, Masashi Mukoyama
- Organizer
  American Society of Nephrology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16090

1. Mukoyama Masashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
2. Kuwabara Takashige

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. Umemoto Syuro

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. Fujimoto Daisuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. Kanki Tomoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. IZUMI Yuichiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 森潔

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
8. 桑原孝成

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
9. 柿添豊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MIZUMOTO TERUHIKO 水本 輝彦

Mizumoto Teruhiko 水本 輝彦

Research Projects

Research Products

Co-Researchers

腹膜透析における中皮細胞のp38 MAPKの意義Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

糖尿病性腎症進展抑制を目指したエクソソーム阻害薬投与効果の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigating compounds that act on interglomerular crosstalk in diabetic nephropathy.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the role of MRP8 through inflammation and ER stress in metabolic syndrome related nephropathyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional elucidation and therapeutic application of protease in kidney injury by metabolic syndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A Novel VCP modulator KUS121 exerts renoprotective effects in ischemia-reperfusion injury with retaining ATP and restoring ERAD-processing capacity.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A serine protease inhibitor camostat mesilate prevents podocyte apoptosis and attenuates podocyte injury in metabolic syndrome model rats2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The predictive role of serum calprotectin on mortality in hemodialysis patients with high phosphoremia2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Suppressed ER-associated degradation by intraglomerular cross talk between mesangial cells and podocytes causes podocyte injury in diabetic kidney disease.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Circulating angiopoietin-like protein 2 levels and mortality risk in patients receiving maintenance hemodialysis: a prospective cohort study2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Doxycycline attenuates cisplatin-induced acute kidney injury through pleiotropic effects2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A serine protease inhibitor attenuates aldosterone-induced kidney injuries via the suppression of plasmin activity.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Combination therapy with renin-angiotensin-aldosterone system inhibitor telmisartan and serine protease inhibitor camostat mesilate provides further renoprotection in a rat chronic kidney disease model.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The serine protease inhibitor camostat mesilate attenuates the progression of chronic kidney disease through its antioxidant effects.2015

Author(s)

Journal Title

DOI

Data Source

MIZUMOTO TERUHIKO 水本輝彦

Mizumoto Teruhiko 水本輝彦

[Presentation] 糖尿病性腎臓病進展に果たすメサンギウム　ポドサイト連関による小胞体関連分解(ERAD)不全の意義2020