Hara Satoshi 原怜史

Researcher Number	80749820
Other IDs	https://orcid.org/0000-0002-3640-4133
Affiliation (Current)	2025: 金沢大学, 附属病院, 助教
Affiliation (based on the past Project Information) *help	2023: 金沢大学, 附属病院, 助教 2017 – 2023: 金沢大学, 医学系, 助教 2016: 金沢大学, 附属病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 53040:Nephrology-related / Kidney internal medicine Except Principal Investigator Basic Section 54020:Connective tissue disease and allergy-related / Basic Section 53040:Nephrology-related / Basic Section 58010:Medical management and medical sociology-related / Collagenous pathology/Allergology
Keywords	Principal Investigator 糸球体硬化 / galectin-8 / ポドサイト / 補体 / IgG4関連腎臓病 / 慢性腎臓病 / 糸球体内皮細胞 / Integrin / integrinα6 / 臨床 … More / 蛋白質 / 病理学 / 内科 / マクロファージ / トランスジェニックマウス / 発現ベクター / 軽鎖 … More Except Principal Investigator IgG4関連疾患 / 動脈周囲/後腹膜病変 / モデルマウス / 喫煙 / IgG4関連循環器/後腹膜病変 / crystal tubulopathy / podocytopathy / MGRS / クリスタル / ポドサイト / 軽鎖 / 免疫グロブリン / LCPT / 信頼性 / 客観的臨床能力試験 / G係数 / 一般化可能性理論 / Post-CC OSCE / 診療参加型臨床実習後客観的臨床能力試験 / Toll-like receptor / ガレクチン３ / Galectin-3 / Toll-like receptor-9 / 自然免疫 Less

Targeting galectin-8 in glomerular endothelial cells as a novel mechanism for progression of glomerulosclerosisPrincipal Investigator
- Principal Investigator
  
  原怜史
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Kanazawa University
補体経路に着目したIgG4関連腎臓病の病態解析と特異的治療開発Principal Investigator
- Principal Investigator
  
  原怜史
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Kanazawa University
モデルマウスを用いたIgG4関連疾患における喫煙の影響の解明と疾病予防的指針の確立
- Principal Investigator
  
  水島伊知郎
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Kanazawa University
免疫グロブリン軽鎖による腎障害の病態解明
- Principal Investigator
  
  伊藤清亮
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Kanazawa University
Targeting integrins as a novel mechanism for progression of glomerulosclerosisPrincipal Investigator
- Principal Investigator
  
  Hara Satoshi
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Kanazawa University
Study on improving reliability of objective structured clinical examination after clinical clerkship in a medical school
- Principal Investigator
  
  Hideki Nomura
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58010:Medical management and medical sociology-related
- Research Institution
  Kanazawa University
The Role of Innate Immunity in IgG4-Related Diseases and the Search for Novel Therapeutic Targets
- Principal Investigator
  
  YAMADA Kazunori
- Project Period (FY)
  2017 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Kanazawa Medical University
  Kanazawa University
The analysis of pathogensis and therapy deveolpment of kidney involvement of monoclonal kappa chain-induced crystal-storing histiocytosisPrincipal Investigator
- Principal Investigator
  
  Hara Satoshi
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kanazawa University

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Pediatric IgG4-related disease: a descriptive review.2024
- Author(s)
  Hara S, Yoshida M, Sanada H, Suzuki Y, Sato Y, Mizushima I, Kawano M.
- Journal Title
  
  Expert Rev Clin Immunol
  
  Volume: 20 Issue: 1 Pages: 97-119
- DOI
  10.1080/1744666x.2023.2274358
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17904, KAKENHI-PROJECT-21K08473, KAKENHI-PROJECT-23K07907
[Journal Article] High serum IgA levels in patients with IgG4-related disease are associated with mild inflammation, sufficient disease-specific features, and favourable responses to treatments.2024
- Author(s)
  Tsuge S, Mizushima I, Horita M, Kawahara H, Sanada H, Yoshida M, Takahashi Y, Zoshima T, Nishioka R, Hara S, Suzuki Y, Ito K, Kawano M.
- Journal Title
  
  Mod Rheumatol
  
  Volume: 34 Issue: 3 Pages: 621-631
- DOI
  10.1093/mr/road056
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17904, KAKENHI-PROJECT-21K08473, KAKENHI-PROJECT-23K07907
[Journal Article] Solitary recurrence of IgG4-related giant coronary aneurysm: Case report and review of the literature focusing on treatment strategies and complications.2023
- Author(s)
  Kawahara H, Mizushima I, Matsumoto Y, Sakata K, Takamura M, Inoue D, Kasashima S, Kawano M.
- Journal Title
  
  Mod Rheumatol Case Rep
  
  Volume: 8 Issue: 1 Pages: 182-194
- DOI
  10.1093/mrcr/rxad065
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17904, KAKENHI-PROJECT-20K08129, KAKENHI-PROJECT-21K08473, KAKENHI-PROJECT-23K07907, KAKENHI-PROJECT-23K08227
[Journal Article] Impact of gut microbiome on serum IgG4 levels in the general population: Shika-machi super preventive health examination results2023
- Author(s)
  Koshida Aoi、Karashima Shigehiro、Ogura Kohei、Miyajima Yuna、Ogai Kazuhiro、Mizoguchi Ren、Ikagawa Yasuo、Hara Satoshi、Mizushima Ichiro、Fujii Hiroshi、Kawano Mitsuhiro、Tsujiguchi Hiromasa、Hara Akinori、Nakamura Hiroyuki、Okamoto Shigefumi
- Journal Title
  
  Frontiers in Cellular and Infection Microbiology
  
  Volume: 13 Pages: 1272398-1272398
- DOI
  10.3389/fcimb.2023.1272398
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19686, KAKENHI-PROJECT-22K19706, KAKENHI-PROJECT-19K17904, KAKENHI-PROJECT-21K08473, KAKENHI-PROJECT-21K11720, KAKENHI-PROJECT-23K07907
[Journal Article] Clues to mortality trends and their related factors in IgG4-related disease: A Japanese single-centre retrospective study2022
- Author(s)
  Kawahara Hiroyuki、Mizushima Ichiro、Tsuge Shunsuke、Shin Seung、Yoshinobu Takahiro、Hoshiba Ryohei、Nishioka Ryo、Zoshima Takeshi、Hara Satoshi、Ito Kiyoaki、Kawano Mitsuhiro
- Journal Title
  
  Modern Rheumatology
  
  Volume: - Issue: 6 Pages: 1154-1161
- DOI
  10.1093/mr/roac132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08327, KAKENHI-PROJECT-19K17904, KAKENHI-PROJECT-21K08473, KAKENHI-PROJECT-23K07907, KAKENHI-PROJECT-18K08236
[Journal Article] Serum IgG4 levels at diagnosis can predict unfavorable outcomes of untreated patients with IgG4-related disease2021
- Author(s)
  Mizushima Ichiro、Konishi Masahiro、Sanada Hajime、Suzuki Kazuyuki、Takeji Akari、Zoshima Takeshi、Hara Satoshi、Ito Kiyoaki、Fujii Hiroshi、Yamada Kazunori、Kawano Mitsuhiro
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 13341-13341
- DOI
  10.1038/s41598-021-92814-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09083, KAKENHI-PROJECT-17K09999, KAKENHI-PROJECT-18K08236, KAKENHI-PROJECT-21K08473, KAKENHI-PROJECT-19K17904
[Journal Article] Tertiary lymphoid tissue in early‐stage IgG4-related tubulointerstitial nephritis incidentally detected with a tumor lesion of the ureteropelvic junction: a case report2021
- Author(s)
  Miyanaga Tatsuhito、Mizuguchi Keishi、Hara Satoshi、Zoshima Takeshi、Inoue Dai、Nishioka Ryo、Mizushima Ichiro、Ito Kiyoaki、Fuji Hiroshi、Yamada Kazunori、Sato Yuki、Yanagita Motoko、Kawano Mitsuhiro
- Journal Title
  
  BMC Nephrology
  
  Volume: 22 Issue: 1 Pages: 34-34
- DOI
  10.1186/s12882-021-02240-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08236, KAKENHI-PROJECT-20K08129, KAKENHI-PROJECT-19K17904, KAKENHI-PROJECT-20K16849, KAKENHI-PROJECT-17K09999, KAKENHI-PROJECT-21K08483
[Journal Article] Different factors underlie recurrent and de novo organ involvement in immunoglobulin G4-related disease.2020
- Author(s)
  Mizushima I, Tsuge S, Fujisawa Y, Hara S, Suzuki F, Ito K, Fujii H, Yamada K, Kawano M.
- Journal Title
  
  Rheumatology (Oxford).
  
  Volume: 59 Pages: 513-518
- DOI
  10.1093/rheumatology/kez321
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09083, KAKENHI-PROJECT-18K08236, KAKENHI-PROJECT-19K17904, KAKENHI-PROJECT-16K19597, KAKENHI-PROJECT-17K09999
[Journal Article] Hypocomplementemia is related to elevated serum levels of IgG subclasses other than IgG4 in IgG4-related kidney disease.2020
- Author(s)
  Fujisawa Y, Mizushima I, Yamada K, Yamamoto M, Saeki T, Matsui S, Tsuge S, Hara S, Ito K, Fujii H, Takahashi H, Nomura H, Kawa S, Kawano M.
- Journal Title
  
  Mod Rheumatol.
  
  Volume: 13 Issue: 1 Pages: 1-8
- DOI
  10.1080/14397595.2019.1709942
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09083, KAKENHI-PROJECT-17K09999, KAKENHI-PROJECT-19K17904, KAKENHI-PROJECT-16K19597, KAKENHI-PROJECT-18K08236, KAKENHI-PROJECT-19K08645
[Journal Article] A Case Report of Crystalline Light Chain Inclusion-Associated Kidney Disease Affecting Podocytes but Without Fanconi Syndrome: A Clonal Analysis of Pathological Monoclonal Light Chain.2019
- Author(s)
  20.Ito K*, Hara S*, Yamada K, Zoshima T, Mizushima I, Fujii H, Miyazaki R, Kawai Y, Yachie A, Nagata M, Izui S, Yamagichi M, Kawano M.(*equally contribution)
- Journal Title
  
  Medicine
  
  Volume: 98 Issue: 5 Pages: e13915-e13915
- DOI
  10.1097/md.0000000000013915
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19485
[Journal Article] Clinical and Pathological Characteristics of IgG4-Related Periaortitis/Periarteritis and Retroperitoneal Fibrosis Diagnosed Based on Experts’ Diagnosis2019
- Author(s)
  Mizushima Ichiro、Kasashima Satomi、Fujinaga Yasunari、Notohara Kenji、Saeki Takako、Zen Yoh、Inoue Dai、Yamamoto Motohisa、Kasashima Fuminari、Matsumoto Yasushi、Amiya Eisuke、Sato Yasuharu、Yamada Kazunori、Domoto Yukako、Kawa Shigeyuki、Kawano Mitsuhiro、Ishizaka Nobukazu
- Journal Title
  
  Ann Vasc Dis
  
  Volume: 12 Issue: 4 Pages: 460-472
- DOI
  10.3400/avd.oa.19-00085
- NAID
  130007772896
- ISSN
  1881-641X, 1881-6428
- Year and Date
  2019-12-25
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09999, KAKENHI-PROJECT-19K17904, KAKENHI-PROJECT-17K08717, KAKENHI-PROJECT-16K19597
[Journal Article] New clues to the nature of immunoglobulin G4-related disease: a retrospective Japanese multicenter study of baseline clinical features of 334 cases.2017
- Author(s)
  Yamada K, Yamamoto M, Saeki T, Mizushima I, Matsui S, Fujisawa Y, Hara S, Takahashi H, Nomura H, Kawa S, Kawano M.
- Journal Title
  
  Arthritis Res Ther
  
  Volume: 19 Issue: 1 Pages: 262-271
- DOI
  10.1186/s13075-017-1467-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09999, KAKENHI-PROJECT-16K19597, KAKENHI-PROJECT-15K09045
[Presentation] IgG4関連腎臓病における三次リンパ組織の形成は疾患活動性と相関する2023
- Author(s)
  眞田創, 原怜史, 藤澤雄平, 蔵島乾, 伊藤清亮, 水島伊知郎, 荒木英雄, 中島昭勝, 川野充弘
- Organizer
  第67回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-23K07907
[Presentation] 後腹膜線維症/大動脈周囲炎様の画像所見を呈したIgG4関連疾患Mimicker症例の検討2023
- Author(s)
  宮永達人, 水島伊知郎, 朝倉啓太, 干場涼平, 眞田創, 髙橋芳徳, 柘植俊介, 西岡亮, 蔵島乾, 原怜史, 伊藤清亮, 川野充弘
- Organizer
  第67回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-23K07907
[Presentation] IgG4関連後腹膜線維症と画像上鑑別が困難であった悪性リンパ腫の2例2023
- Author(s)
  森杏里, 赤松洋光, 笠原菜摘, 齋藤寛晃, 坂田玲, 眞田創, 高橋芳徳, 柘植俊介, 西岡亮, 蔵島乾, 原怜史, 伊藤清亮, 水島伊知郎, 川野充弘
- Organizer
  第31回日本シェーグレン症候群学会
- Data Source
  KAKENHI-PROJECT-23K07907
[Presentation] COVID-19流行下の模擬患者非接触型・半遠隔評価方式Post-CC OSCEの信頼性評価2021
- Author(s)
  原　怜史、玉井利克、杉森公一、倉知　慎、三原　弘、山本靖彦、太田邦雄、野村英樹
- Organizer
  第53回日本医学教育学会
- Data Source
  KAKENHI-PROJECT-18K09969
[Presentation] 一般化可能性理論を用いた3年間の診療参加型臨床実習後OSCEの信頼性評価2020
- Author(s)
  原怜史, 玉井利克, 太田邦雄, 山本靖彦, 野村英樹
- Organizer
  第52回日本医学教育学会大会
- Data Source
  KAKENHI-PROJECT-18K09969
[Presentation] 一般化可能性理論を用いた2年間の臨床実習後OSCEの信頼性の評価2019
- Author(s)
  原怜史、玉井利克、太田邦雄、山本靖彦、野村英樹
- Organizer
  第51回日本医学教育学会大会
- Data Source
  KAKENHI-PROJECT-18K09969
[Presentation] 一般化可能性理論を用いた臨床実習後OSCEの信頼性の検討2018
- Author(s)
  原怜史、玉井利克、太田邦雄、野村英樹
- Organizer
  日本医学教育学会
- Data Source
  KAKENHI-PROJECT-18K09969
[Presentation] Serum IgG4 levels at diagnosis can predict the outcomes of untreated patients with IgG4-related disease: a Japanese single-center retrospective study.2018
- Author(s)
  Mizushima I,Suzuki N,Yoshida M,Takeji A,Matsunaga T,Zoshima T,Hara S,Ito K,Fujii H,Yamada K, Kawano M
- Organizer
  Annual European Congress of Rheumatology Jun. 13-16, 2018 (Amsterdam,Netherlands)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09999
[Presentation] IgG4関連尿細管間質性腎炎におけるステロイド治療開始前の腎機能低下速度の検討2018
- Author(s)
  川野　充弘，水島　伊知郎，谷口　義典，佐伯　敬子，中島　衡，原　怜史，松永　貴弘，藤井　博，山田　和徳
- Organizer
  第62回日本リウマチ学会総会・学術集会　Apr.26-28,2018（東京）
- Data Source
  KAKENHI-PROJECT-17K09999
[Presentation] Clinical Impact of Peritubular Capillaritis on Renal Prognosis in ANCA-Associated Glomerulonephritis2017
- Author(s)
  1.Satoshi Hara, Fae Suzuki, Ichiro Mizushima, Kiyoaki Ito, Hiroshi Fujii, Kazunori Yamada, Mitsuhiro Kawano
- Organizer
  Kidney Week 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09999
[Presentation] IgG4関連疾患の既存病変再燃、新規病変出現に関与する因子の差異2017
- Author(s)
  水島伊知郎、柘植俊介、藤澤雄平、原怜史、鈴木華恵、伊藤清亮、會津元彦、藤井博、山田和徳、川野充弘
- Organizer
  第61回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-17K09999
[Presentation] 低補体血症を合併したIgG4関連腎臓病についての臨床的検討2017
- Author(s)
  藤澤雄平、水島伊知郎、柘植俊介、原怜史、鈴木華恵、伊藤清亮、會津元彦、藤井博、山田和徳、川野充弘
- Organizer
  第61回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-17K09999

1. 伊藤清亮 (10467110)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
2. 川野充弘 (20361983)

# of Collaborated Projects: 3 results

# of Collaborated Products: 14 results
3. 水島伊知郎 (50645124)

# of Collaborated Projects: 3 results

# of Collaborated Products: 15 results
4. YAMADA Kazunori (90397224)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
5. Hideki Nomura (80313667)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. 塚正彦 (00272956)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 太田邦雄 (00303280)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. 玉井利克 (40782082)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. 原重雄 (10590648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. HARA Akinori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 藤井博

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
12. 中村裕之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 辻口博聖

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 原丈介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hara Satoshi 原 怜史

Research Projects

Research Products

Co-Researchers

Targeting galectin-8 in glomerular endothelial cells as a novel mechanism for progression of glomerulosclerosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

補体経路に着目したIgG4関連腎臓病の病態解析と特異的治療開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

モデルマウスを用いたIgG4関連疾患における喫煙の影響の解明と疾病予防的指針の確立

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

免疫グロブリン軽鎖による腎障害の病態解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Targeting integrins as a novel mechanism for progression of glomerulosclerosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study on improving reliability of objective structured clinical examination after clinical clerkship in a medical school

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The Role of Innate Immunity in IgG4-Related Diseases and the Search for Novel Therapeutic Targets

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The analysis of pathogensis and therapy deveolpment of kidney involvement of monoclonal kappa chain-induced crystal-storing histiocytosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Pediatric IgG4-related disease: a descriptive review.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High serum IgA levels in patients with IgG4-related disease are associated with mild inflammation, sufficient disease-specific features, and favourable responses to treatments.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Solitary recurrence of IgG4-related giant coronary aneurysm: Case report and review of the literature focusing on treatment strategies and complications.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of gut microbiome on serum IgG4 levels in the general population: Shika-machi super preventive health examination results2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clues to mortality trends and their related factors in IgG4-related disease: A Japanese single-centre retrospective study2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Serum IgG4 levels at diagnosis can predict unfavorable outcomes of untreated patients with IgG4-related disease2021

Author(s)

Journal Title

Hara Satoshi 原怜史