OKIHARA HIDEMASA 沖原秀政

… Alternative Names

OKIHARA Hidemasa 沖原秀政

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Researcher Number	80754960
Other IDs
Affiliation (Current)	2025: 東京科学大学, その他の部局等, 非常勤講師
Affiliation (based on the past Project Information) *help	2025: 東京科学大学, 大学院医歯学総合研究科, 非常勤講師 2022 – 2023: 東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 2021: 東京医科歯科大学, 東京医科歯科大学病院, 特任助教 2019 – 2020: 東京医科歯科大学, 歯学部附属病院, 特任助教 2014 – 2018: 東京医科歯科大学, 歯学部附属病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 57070:Developmental dentistry-related / Orthodontics/Pediatric dentistry Except Principal Investigator Orthodontics/Pediatric dentistry / Orthodontic/Pediatric dentistry
Keywords	Principal Investigator Wnt 3a / 咀嚼刺激低下 / 記憶・学習機能障害 / 学習機能 / 記憶機能 / 海馬 / Wnt signal　pathway / DKK-1 / Wnt signaling pathway / Wnt signal pathway … More / 鼻呼吸障害 / 記憶・学習機能 / 記憶学習機能 / 歯学 / CaMKⅡα / CaMKIIa … More Except Principal Investigator 鼻呼吸障害 / 鼻閉 / 電気生理 / 舌 / 体性感覚 / 舌機能 / 開口反射 / 筋線維 / 成長期 / 大脳皮質一次運動野 / Trk-B / 記憶・学習 / Trk B / BDNF / 記憶学習障害 / ストレス / 海馬 / 記憶学習機能 / 咀嚼運動 / 感覚受容器 / 反射 / 電気生理学 / 口呼吸 / 酸素飽和度 Less

成長期咀嚼刺激回復による記憶学習機能の最適時期と神経カスケードメカニズムの解明Principal Investigator
- Principal Investigator
  
  沖原秀政
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57070:Developmental dentistry-related
- Research Institution
  Institute of Science Tokyo
海馬における記憶・学習機能の評価による、成長期咀嚼刺激回復の生物学的意義の検証Principal Investigator
- Principal Investigator
  
  沖原秀政
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57070:Developmental dentistry-related
- Research Institution
  Tokyo Medical and Dental University
Biological significance of hippocampal Wnt signaling pathway modulation and improvement of nasal breathing disordersPrincipal Investigator
- Principal Investigator
  
  Okihara Hidemasa
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57070:Developmental dentistry-related
- Research Institution
  Tokyo Medical and Dental University
Influence of breathing style change on hippocampal BDNF/TrkB signaling regulation
- Principal Investigator
  
  YABUSHITA Tadachika
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthodontics/Pediatric dentistry
- Research Institution
  Tokyo Medical and Dental University
Mechanism by which masticatry dysfunction induces hippocampal Wnt signal and CaMKIIa disorderPrincipal Investigator
- Principal Investigator
  
  Okihara Hidemasa
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Orthodontics/Pediatric dentistry
- Research Institution
  Tokyo Medical and Dental University
Comprehensive analysis of peripheral-central coupling on modulation of tongue motion control mechanism with nasal respiratory disorder during growth periods
- Principal Investigator
  
  KOKAI Satoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthodontics/Pediatric dentistry
- Research Institution
  Tokyo Medical and Dental University
Reorganization of the neural circuits of oral somatosensory system with respiratory disturbance.
- Principal Investigator
  
  KOKAI SATOSHI
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthodontic/Pediatric dentistry
- Research Institution
  Tokyo Medical and Dental University

All 2023 2022 2021 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Pre-Adolescent Diet Normalization Restores Cognitive Function in Young Mice2023
- Author(s)
  Sun Wenqian、Okihara Hidemasa、Ogawa Takuya、Ishidori Hideyuki、Misawa Eri、Kato Chiho、Ono Takashi
- Journal Title
  
  Journal of Clinical Medicine
  
  Volume: 12 Issue: 11 Pages: 3642-3642
- DOI
  10.3390/jcm12113642
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K21056, KAKENHI-PROJECT-22K10262, KAKENHI-PROJECT-22K10265
[Journal Article] Reduced mastication during growth inhibits cognitive function by affecting trigeminal ganglia and modulating Wnt signaling pathway and ARHGAP33 molecular transmission2023
- Author(s)
  Misawa-Omori Eri、Okihara Hidemasa、Ogawa Takuya、Abe Yasunori、Kato Chiho、Ishidori Hideyuki、Fujita Akiyo、Kokai Satoshi、Ono Takashi
- Journal Title
  
  Neuropeptides
  
  Volume: 102 Pages: 102370-102370
- DOI
  10.1016/j.npep.2023.102370
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K21056, KAKENHI-PROJECT-22K10265
[Journal Article] Nasal obstruction during the growth period modulates the Wnt/β‐catenin pathway and brain‐derived neurotrophic factor production in association with tyrosine kinase receptor B mRNA reduction in mouse hippocampus2021
- Author(s)
  Ishidori Hideyuki、Okihara Hidemasa、Ogawa Takuya、Abe Yasunori、Kato Chiho、Aung Phyo Thura、Fujita Akiyo、Kokai Satoshi、Ono Takashi
- Journal Title
  
  European Journal of Neuroscience
  
  Volume: 55 Issue: 1 Pages: 5-17
- DOI
  10.1111/ejn.15547
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K17244, KAKENHI-PROJECT-19K19260, KAKENHI-PROJECT-19K10377, KAKENHI-PROJECT-19K19286
[Journal Article] Nasal obstruction during adolescence induces memory/learning impairments associated with BDNF/TrkB signaling pathway hypofunction and high corticosterone levels2018
- Author(s)
  Ogawa Takuya、Okihara Hidemasa、Kokai Satoshi、Abe Yasunori、Karin Harumi Uchima Koecklin、Makiguchi Mio、Kato Chiho、Yabushita Tadachika、Michikawa Makoto、Ono Takashi
- Journal Title
  
  Journal of Neuroscience Research
  
  Volume: 96 Issue: 6 Pages: 1056-1065
- DOI
  10.1002/jnr.24216
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K11338, KAKENHI-PROJECT-15K11339, KAKENHI-PROJECT-15K15712, KAKENHI-PROJECT-16H05559, KAKENHI-PROJECT-15K20581
[Journal Article] Unilateral nasal obstruction affects motor representation development within the face primary motor cortex in growing rats.2017
- Author(s)
  Abe Y, Kato C, Uchima Koecklin KH, Okihara H, Ishida T, Fujita K, Yabushita T, Kokai S, Ono T.
- Journal Title
  
  J Appl Physiol
  
  Volume: 印刷中 Issue: 6 Pages: 1494-1503
- DOI
  10.1152/japplphysiol.01130.2016
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K11338, KAKENHI-PROJECT-15K11339, KAKENHI-PROJECT-15K20581
[Journal Article] Effects of increased occlusal vertical dimension on the jaw-opening reflex in adult rats.2016
- Author(s)
  Makiguchi M, Funaki Y, Kato C, Okihara H, Ishida T, Yabushita T, Kokai S, Ono T.
- Journal Title
  
  Arch Oral Biol.
  
  Volume: 72 Pages: 39-46
- DOI
  10.1016/j.archoralbio.2016.08.009
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K11338, KAKENHI-PROJECT-15K11339
[Journal Article] Liquid diet induces memory impairment accompanied by a decreased number of hippocampal neurons in mice.2014
- Author(s)
  Okihara H, Ito J, Kokai S, Ishida T, Hiranuma M, Kato C, Yabushita T, Ishida K, Ono T, Michikawa M.
- Journal Title
  
  J Neurosci Res.
  
  Volume: 92 Issue: 8 Pages: 1010-7
- DOI
  10.1002/jnr.23383
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24593081, KAKENHI-PROJECT-24792279, KAKENHI-PROJECT-25461375, KAKENHI-PROJECT-26350610
[Presentation] 成長期咀嚼刺激低下は三叉神経節、Wntシグナル経路およびARHGAP33の分子伝達に影響を与え認知機能を抑制する2023
- Author(s)
  三澤(大森)英里、加藤千帆、沖原秀政、小川卓也、小海暁、石通秀行、藤田秋世、小野卓史
- Organizer
  第88回口腔病学会
- Data Source
  KAKENHI-PROJECT-22K10265
[Presentation] 成長期における粉末飼料飼育から固形飼料飼育への変化が海馬における記憶・学習機能の回復に与える影響2022
- Author(s)
  孫文倩、沖原秀政、小川卓也、石通秀行、三澤英里、加藤千帆、小野卓史
- Organizer
  第81回日本矯正歯科学会学術大会＆第9回日韓ジョイントシンポジウム
- Data Source
  KAKENHI-PROJECT-22K10265
[Presentation] 成長期咀嚼刺激低下はWnt signaling pathwayおよびARHGAP33の分子伝達を変調する2021
- Author(s)
  三澤英里、沖原秀政、小川卓也、小海暁、阿部泰典、加藤千帆、石通秀行、藤田秋世、谷川萌、小野卓史
- Organizer
  第80回　日本矯正歯科学会学術大会in横浜
- Data Source
  KAKENHI-PROJECT-18K17244
[Presentation] マウス成長期鼻呼吸障害は海馬におけるWnt signaling pathwayに変調をもたらす2019
- Author(s)
  石通秀行、沖原秀政、小川卓也、小海暁、阿部泰典、加藤千帆、Phyo Thu RhaAung、藤田秋世、小野卓史
- Organizer
  第78回日本矯正歯科学会
- Data Source
  KAKENHI-PROJECT-18K17244
[Presentation] 成長期鼻呼吸障害に伴う記憶・学習機能および海馬組織の変化に関する多角的解析2017
- Author(s)
  小川卓也, 沖原秀政, 小海暁, 阿部泰典, Uchima Koecklin Karin Harumi , 牧口実央, 加藤千帆, 藪下忠親, 道川誠, 小野卓史
- Organizer
  第76回日本矯正歯科学会大会
- Data Source
  KAKENHI-PROJECT-15K11338
[Presentation] Nasal obstruction induces memory and learning impairment and decreases the number of hippocampal neurons in growing mice2017
- Author(s)
  Takuya Ogawa, Hidemasa Okihara, Satoshi Kokai, Makoto Michikawa, Takashi Ono
- Organizer
  93th congress of the European Orthodontic Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K11339
[Presentation] 成長期鼻呼吸障害に伴う記憶・学習機能および海馬組織の変化に関する多角的解析2017
- Author(s)
  小川卓也、沖原秀政、小海暁、阿部泰典、Uchima Koecklin Karin Harumi、牧口実央、加藤千帆、藪下忠親、道川誠、小野卓史
- Organizer
  第76回日本矯正歯科学会学術大会
- Data Source
  KAKENHI-PROJECT-15K11339
[Presentation] Nasal obstruction induces memory and learning impairment and decreases the number of hippocampal neurons in growing mice.2017
- Author(s)
  Ogawa T, Okihara H, Kokai S, Michikawa M, Ono T
- Organizer
  The 93rd congress of the European Orthodontic Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K11338
[Presentation] 成長期における鼻呼吸障害はラット大脳皮質一次運動野顔面領域の発達に影響を与える2016
- Author(s)
  阿部泰典, 加藤千帆, Uchima Koecklin KH, 沖原秀政, 石田宝義, 藪下忠親, 小海暁, 小野卓史
- Organizer
  第75回日本矯正歯科学会大会
- Place of Presentation
  アスティ徳島（徳島）
- Year and Date
  2016-11-08
- Data Source
  KAKENHI-PROJECT-15K11338
[Presentation] Force changes of the tongue-protruding muscles after nasal obstruction during the growth period in rats.2016
- Author(s)
  Uchima Koecklin KH, Kato C, Kataguchi T, Okihara H, Ishida T, Fujita K, Yabushita T, Kokai S, Ono T
- Organizer
  第75回日本矯正歯科学会大会
- Place of Presentation
  アスティ徳島（徳島）
- Year and Date
  2016-11-08
- Data Source
  KAKENHI-PROJECT-15K11338
[Presentation] 成長期ラットにおける大脳皮質一次運動野顎顔面領域の機能局在の発達2015
- Author(s)
  阿部泰典, 加藤千帆, 舟木幸葉, 沖原秀政, 藤田紘一, 石田宝義, 藪下忠親, 小海暁, 小野卓史
- Organizer
  第74回日本矯正歯科学会大会学術大会
- Place of Presentation
  福岡国際会議場・マリンメッセ（福岡）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K11338
[Presentation] 成獣ラットにおける開口反射は咬合高径増加に対して長期的に順応する2015
- Author(s)
  牧口実央, 舟木幸葉, 沖原秀政, 加藤千帆, 石田宝義, 藤田紘一, 藪下忠親, 小海暁, 小野卓史
- Organizer
  第74回日本矯正歯科学会大会学術大会
- Place of Presentation
  福岡国際会議場・マリンメッセ（福岡）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K11338
[Presentation] 成長期における咀嚼刺激低下は海馬BDNF/TrkB signalingの低下に起因した記憶・学習機能障害を呈する2015
- Author(s)
  沖原秀政, 伊藤仁一, 小海暁, 石田宝義, 平沼摩耶, 加藤千帆, 藪下忠親, 道川誠, 小野卓史
- Organizer
  第74回東京矯正歯科学会
- Place of Presentation
  ベルサール新宿グランド（東京）
- Year and Date
  2015-07-16
- Data Source
  KAKENHI-PROJECT-15K11339
[Presentation] 成長期における咀嚼刺激低下は海馬BDNF/TrkB signalingの低下に起因した記憶・学習機能障害を呈する2015
- Author(s)
  沖原秀政, 伊藤仁一, 小海暁, 石田宝義, 平沼摩耶, 加藤千帆, 藪下忠親, 道川誠, 小野卓史
- Organizer
  第74回東京矯正歯科学会
- Place of Presentation
  ベルサール新宿グランド（東京）
- Year and Date
  2015-07-16
- Data Source
  KAKENHI-PROJECT-15K11338
[Presentation] Association between the decrease of masticatory function and synaptic plasticity.2013
- Author(s)
  Okihara H, Ito J, Kokai S, Ishida T, Hiranuma M, Kato C, Yabushita T, Ishida K, Michikawa M, Ono T
- Organizer
  2nd Meeting of the International Association of Dental Research-Asia Pacific Region
- Place of Presentation
  Bangkok, Thailand
- Data Source
  KAKENHI-PROJECT-24593081
[Presentation] 成長期における咀嚼環境の変化が記憶・学習機能に与える影響2013
- Author(s)
  沖原秀政, 小海暁, 石田宝義, 加藤千帆, 平沼摩耶, 藪下忠親, 石田和人, 道川誠, 小野卓史
- Organizer
  第72回　日本矯正歯科学会学術大会
- Place of Presentation
  松本・キッセイ文化ホール
- Data Source
  KAKENHI-PROJECT-24593081
[Presentation] Association between the masticatory dysfunction and memory function2013
- Author(s)
  Hidemasa Okihara, Jinichi Ito, Satoshi Kokai, Takayoshi Ishida, Maya Hiranuma, Chiho Kato, Tadachika Yabushita, Kazuto Ishida, Makoto Michikawa, Takashi ONO.
- Organizer
  2nd Meeting of the International Association for Dental Research - Asia Pacific Region
- Place of Presentation
  Bangkok, Thailand
- Data Source
  KAKENHI-PROJECT-24593081
[Presentation] Development of the motor representation within the face primary motor cortex in growing rats
- Author(s)
  Yasunori Abe, Chiho Kato, Yukiha Funaki, Hidemasa Okihara, Kouichi Fujita, Takayoshi Ishida, Tadachika Yabushita, Satoshi Kokai and Takashi Ono
- Organizer
  Vietnam Dental Conference
- Place of Presentation
  Ho Chi Minh, Vietnam
- Year and Date
  2015-04-12 – 2015-04-13
- Data Source
  KAKENHI-PROJECT-24593081

1. KOKAI SATOSHI (50431937)

# of Collaborated Projects: 4 results

# of Collaborated Products: 19 results
2. ONO Takashi (30221857)

# of Collaborated Projects: 4 results

# of Collaborated Products: 20 results
3. KATO Chiho (80706987)

# of Collaborated Projects: 3 results

# of Collaborated Products: 16 results
4. YONEMITSU Ikuo (00431940)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. YABUSHITA Tadachika (40420260)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 渡一平 (10431941)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. HIRANUMA Maya

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. FUNAKI Yukiha

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. MICHIKAWA Makoto

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. MAKIGUCHI Mio

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. ABE Yasunori

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. OGAWA Takuya

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. Uchima Koecklin Karin Harumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 石通秀行

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

OKIHARA HIDEMASA 沖原 秀政

OKIHARA Hidemasa 沖原 秀政

Research Projects

Research Products

Co-Researchers

成長期咀嚼刺激回復による記憶学習機能の最適時期と神経カスケードメカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

海馬における記憶・学習機能の評価による、成長期咀嚼刺激回復の生物学的意義の検証Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Biological significance of hippocampal Wnt signaling pathway modulation and improvement of nasal breathing disordersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Influence of breathing style change on hippocampal BDNF/TrkB signaling regulation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism by which masticatry dysfunction induces hippocampal Wnt signal and CaMKIIa disorderPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Comprehensive analysis of peripheral-central coupling on modulation of tongue motion control mechanism with nasal respiratory disorder during growth periods

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Reorganization of the neural circuits of oral somatosensory system with respiratory disturbance.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Pre-Adolescent Diet Normalization Restores Cognitive Function in Young Mice2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Reduced mastication during growth inhibits cognitive function by affecting trigeminal ganglia and modulating Wnt signaling pathway and ARHGAP33 molecular transmission2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nasal obstruction during the growth period modulates the Wnt/β‐catenin pathway and brain‐derived neurotrophic factor production in association with tyrosine kinase receptor B mRNA reduction in mouse hippocampus2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nasal obstruction during adolescence induces memory/learning impairments associated with BDNF/TrkB signaling pathway hypofunction and high corticosterone levels2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Unilateral nasal obstruction affects motor representation development within the face primary motor cortex in growing rats.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of increased occlusal vertical dimension on the jaw-opening reflex in adult rats.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Liquid diet induces memory impairment accompanied by a decreased number of hippocampal neurons in mice.2014

Author(s)

Journal Title

OKIHARA HIDEMASA 沖原秀政

OKIHARA Hidemasa 沖原秀政

[Presentation] 成長期における鼻呼吸障害はラット大脳皮質一次運動野顔面領域の発達に影響を与える2016