Kubota Shigehisa 窪田成寿

Researcher Number	80759118
Other IDs
Affiliation (Current)	2025: 滋賀医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2020 – 2024: 滋賀医科大学, 医学部, 助教 2018 – 2019: 滋賀医科大学, 医学部, 医員 2017: 滋賀医科大学, 医学部, 非常勤講師
Review Section/Research Field	Principal Investigator Basic Section 56030:Urology-related / Urology Except Principal Investigator Basic Section 56030:Urology-related
Keywords	Principal Investigator γ-グルタミルシクロトランスフェラーゼ / 腎細胞がん / GGCT / 腎がん / がん増殖関連たんぱく / がん増殖関連タンパク / 新規治療標的 / 腎癌 / がん増殖関連蛋白 / 増殖抑制機構 … More / 細胞周期関連遺伝子 / 癌関連タンパク / 抗腫瘍メカニズム / メタボローム解析 / トランスクリプトーム解析 / γ-グルタミルシクロトランスフェラーぜ … More Except Principal Investigator γ-グルタミルシクロトランスフェラーゼ / siRNA / ドラッグデリバリーシステム / ホーミングペプチド / 前立腺癌 / 癌 / 悪液質 / 癌悪液質 / 抗がん治療 / γーグルタミルシクロトランスフェラーゼ / がん / 抗癌療法 / グルタチオン Less

腫瘍特異的ホーミングペプチド結合核酸によるGGCT標的抗癌治療の開発
- Principal Investigator
  
  影山進
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Shiga University of Medical Science
脳内炎症に着目した泌尿器癌悪液質の新規診断・治療法の開発
- Principal Investigator
  
  沖中勇輝
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Shiga University of Medical Science
Comprehensive analysis of glutathione-related molecular changes induced by inhibition of GGCT
- Principal Investigator
  
  Kageyama Susumu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Shiga University of Medical Science
Development of a novel treatment for renal cancer targeting the cancer proliferation-related protein GGCTPrincipal Investigator
- Principal Investigator
  
  Kubota Shigehisa
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Shiga University of Medical Science
Elucidation of the mechanism of antitumor effect in inhibition of GGCT expression using integrated omics analysisPrincipal Investigator
- Principal Investigator
  
  Kubota Shigehisa
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Shiga University of Medical Science

All 2024 2023 2022 2021 2019

All Journal Article Presentation

[Journal Article] Spinal Transection Switches the Effect of Metabotropic Glutamate Receptor Subtype 7 from the Facilitation to Inhibition of Ejaculation2023
- Author(s)
  Masugi-Tokita Miwako、Kubota Shigehisa、Kobayashi Kenichi、Yoshida Tetsuya、Kageyama Susumu、Sakamoto Hirotaka、Kawauchi Akihiro
- Journal Title
  
  Neuroscience
  
  Volume: 509 Pages: 10-19
- DOI
  10.1016/j.neuroscience.2022.11.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K09342, KAKENHI-PROJECT-21K09420, KAKENHI-PROJECT-22K19332, KAKENHI-PROJECT-23K23919
[Journal Article] Prognostic nutritional index of early post?pembrolizumab therapy predicts long?term survival in patients with advanced urothelial carcinoma2022
- Author(s)
  Kageyama Susumu、Yoshida Tetsuya、Kobayashi Kenichi、Wada Akinori、Nagasawa Masayuki、Kubota Shigehisa、Kusaba Takuto、Jo Fumiyasu、Nakagawa Shota、Johnin Kazuyoshi、Narita Mitsuhiro、Kawauchi Akihiro
- Journal Title
  
  Oncology Letters
  
  Volume: 25 Issue: 2 Pages: 49-49
- DOI
  10.3892/ol.2022.13635
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09342
[Journal Article] Androgen receptor axis?targeted agents are not superior to conventional hormonal therapy for treatment of metastatic prostate cancer2022
- Author(s)
  Wada Akinori、Narita Mitsuhiro、Nagasawa Masayuki、Kusaba Takuto、Kubota Shigehisa、Yoshida Tetsuya、Johnin Kazuyoshi、Kawauchi Akihiro、Kageyama Susumu
- Journal Title
  
  Oncology Letters
  
  Volume: 24 Issue: 4 Pages: 333-333
- DOI
  10.3892/ol.2022.13453
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09342, KAKENHI-PROJECT-20K09524
[Journal Article] Single short retention instillation of pirarubicin prevents intravesical recurrence of low-risk non muscle invasive bladder cancer2021
- Author(s)
  Susumu Kageyama, koki Maeda, Shigehisa Kubota, Tetsuya Yoshida, Takashi Osafune, Yutaka Arai, Hiroki Soga, Zenkai Nishikawa, Yuji Sano, Keita Takimoto, Chul Jang Kim, Tokuhiro Chano, Akihiro Kawauchi
- Journal Title
  
  in vivo
  
  Volume: 35 Issue: 2 Pages: 1141-1145
- DOI
  10.21873/invivo.12360
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09687, KAKENHI-PROJECT-18K09192, KAKENHI-PROJECT-19K07413, KAKENHI-PROJECT-21K09342
[Journal Article] γ-Glutamylcyclotransferase, a novel regulator of HIF-1α expression, triggers aerobic glycolysis2021
- Author(s)
  Taniguchi Keiko、Kageyama Susumu、Moyama Chiami、Ando Shota、Ii Hiromi、Ashihara Eishi、Horinaka Mano、Sakai Toshiyuki、Kubota Shigehisa、Kawauchi Akihiro、Nakata Susumu
- Journal Title
  
  Cancer Gene Therapy
  
  Volume: - Issue: 1 Pages: 37-48
- DOI
  10.1038/s41417-020-00287-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07623, KAKENHI-PROJECT-20K23233, KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06398, KAKENHI-PROJECT-19H01079, KAKENHI-PROJECT-19H03889, KAKENHI-PROJECT-19K22773, KAKENHI-PROJECT-21K09342
[Journal Article] Pro-GA, a Novel Inhibitor of γ-Glutamylcyclotransferase, Suppresses Human Bladder Cancer Cell Growth2019
- Author(s)
  HANADA EIKI、KAGEYAMA SUSUMU、MURAI RYOSUKE、KUBOTA SHIGEHISA、II HIROMI、NAKATA SUSUMU、KITA HIROKO、KAWAUCHI AKIHIRO、CHANO TOKUHIRO
- Journal Title
  
  Anticancer Research
  
  Volume: 39 Issue: 4 Pages: 1893-1898
- DOI
  10.21873/anticanres.13297
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09192, KAKENHI-PROJECT-19K07413, KAKENHI-PROJECT-17K11131
[Presentation] 癌悪液質モデルマウスにおける脳内の変化について2024
- Author(s)
  沖中勇輝、片岡洋祐、西田将成、城文泰、草場拓人、窪田成寿、和田晃典、小林憲市、吉田哲也、上仁数義、影山進
- Organizer
  第59回京阪泌尿器腫瘍セミナー
- Data Source
  KAKENHI-PROJECT-22K09445
[Presentation] メタボローム解析を用いた泌尿器癌関連疲労バイオマーカーの探索2023
- Author(s)
  沖中勇輝、片岡洋祐、草場拓人、窪田成寿、永澤誠之、和田晃典、小林憲市、吉田哲也、影山進、河内明宏
- Organizer
  第32回泌尿器科分子・細胞研究会
- Data Source
  KAKENHI-PROJECT-22K09445
[Presentation] メタボローム解析を用いた泌尿器癌関連疲労バイオマーカーの探索2023
- Author(s)
  沖中勇輝，片岡洋祐，草場拓人，窪田成寿，永澤誠之，和田晃典，小林憲市，吉田哲也，影山進，河内明宏
- Organizer
  第32回泌尿器科分子・細胞研究会
- Data Source
  KAKENHI-PROJECT-21K09342
[Presentation] オミックス解析に基づくGGCT発現阻害による抗腫瘍メカニズムの解明と膀胱癌治療への応用2021
- Author(s)
  窪田成寿、礒野高敬, 吉田哲也, 影山進, 成田充弘, 河内明宏
- Organizer
  第109回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-21K09342
[Presentation] GGCTを治療標的とした尿路上皮癌治療の基礎的検討2019
- Author(s)
  影山進, 窪田成寿, 村井亮介, 吉田哲也, 成田充弘, 茶野徳宏, 河内明宏
- Organizer
  日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-17K11131

1. Kageyama Susumu (50378452)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
2. 吉田哲也 (60510310)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
3. 河内明宏 (90240952)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
4. 草場拓人 (90847211)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. 礒野高敬 (20176259)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 富田圭司 (30640148)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 茶野徳宏 (40346028)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 沖中勇輝 (90780718)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. 永澤誠之 (30750525)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 寺島智也 (40378485)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 小林憲市 (40727434)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 和田晃典 (90750539)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 金哲将

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 飯居宏美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 中田晋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 村井亮介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kubota Shigehisa 窪田 成寿

Research Projects

Research Products

Co-Researchers

腫瘍特異的ホーミングペプチド結合核酸によるGGCT標的抗癌治療の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

脳内炎症に着目した泌尿器癌悪液質の新規診断・治療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Comprehensive analysis of glutathione-related molecular changes induced by inhibition of GGCT

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a novel treatment for renal cancer targeting the cancer proliferation-related protein GGCTPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of antitumor effect in inhibition of GGCT expression using integrated omics analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Spinal Transection Switches the Effect of Metabotropic Glutamate Receptor Subtype 7 from the Facilitation to Inhibition of Ejaculation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prognostic nutritional index of early post?pembrolizumab therapy predicts long?term survival in patients with advanced urothelial carcinoma2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Androgen receptor axis?targeted agents are not superior to conventional hormonal therapy for treatment of metastatic prostate cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Single short retention instillation of pirarubicin prevents intravesical recurrence of low-risk non muscle invasive bladder cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] γ-Glutamylcyclotransferase, a novel regulator of HIF-1α expression, triggers aerobic glycolysis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pro-GA, a Novel Inhibitor of γ-Glutamylcyclotransferase, Suppresses Human Bladder Cancer Cell Growth2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] 癌悪液質モデルマウスにおける脳内の変化について2024

Author(s)

Organizer

Data Source

[Presentation] メタボローム解析を用いた泌尿器癌関連疲労バイオマーカーの探索2023

Author(s)

Organizer

Data Source

[Presentation] メタボローム解析を用いた泌尿器癌関連疲労バイオマーカーの探索2023

Author(s)

Organizer

Data Source

[Presentation] オミックス解析に基づくGGCT発現阻害による抗腫瘍メカニズムの解明と膀胱癌治療への応用2021

Author(s)

Organizer

Data Source

Kubota Shigehisa 窪田成寿