Otani Takahito 大谷崇仁

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OTANI Takahito 大谷崇仁

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Researcher Number	80759738
Other IDs	https://orcid.org/0000-0003-2103-6873
Affiliation (Current)	2025: 福岡歯科大学, 口腔歯学部, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 福岡歯科大学, 口腔歯学部, 講師 2020: 福岡歯科大学, 口腔歯学部, 講師 2018 – 2019: 福岡歯科大学, 口腔歯学部, 助教 2016: 福岡歯科大学, 口腔歯学部, 助教 2015: 九州大学, 歯学研究科(研究院), 研究員
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Basic Section 57010:Oral biological science-related / Functional basic dentistry Except Principal Investigator Basic Section 57010:Oral biological science-related
Keywords	Principal Investigator 脂肪細胞 / オステオカルシン / 細胞死 / ネクロトーシス / 細胞骨格 / インテグリン / インスリン感受性 / シグナル伝達 / エピゲノム / 細胞接着 / 脂質代謝 … More Except Principal Investigator … More ケラチノサイト / リンパ節転移 / 細胞運動 / デスモソーム / Desmoglein-3 / Desmoglein-2 / Desmoglein-1 / E-cadherin / Lymph node metastasis / squamous cell carcinoma Less

Elucidation of the mechanism by which osteocalcin promotes insulin sensitivity in adipocytes via alteration of the response to the extracellular milieu.Principal Investigator
- Principal Investigator
  
  大谷崇仁
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Fukuoka Dental College
Study of the role of desmosome cadherin in cell motility and lymph node metastasis
- Principal Investigator
  
  稲井哲一朗
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57010:Oral biological science-related
- Research Institution
  Fukuoka Dental College
Elucidation of the mechanism of cell death of adipocytes induced by osteocalcinPrincipal Investigator
- Principal Investigator
  
  OTANI Takahito
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57010:Oral biological science-related
- Research Institution
  Fukuoka Dental College
Elucidation of the mechanism of inhibition of adiponectin expression in adipocytes induced by high-dose osteocalcinPrincipal Investigator
- Principal Investigator
  
  OTANI Takahito
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Functional basic dentistry
- Research Institution
  Fukuoka Dental College
  Kyushu University

All 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Adipocyte-specific GPRC6A ablation promotes diet-induced obesity by inhibiting lipolysis2021
- Author(s)
  Mukai Satoru、Mizokami Akiko、Otani Takahito、Sano Tomomi、Matsuda Miho、Chishaki Sakura、Gao Jing、Kawakubo-Yasukochi Tomoyo、Tang Ronghao、Kanematsu Takashi、Takeuchi Hiroshi、Jimi Eijiro、Hirata Masato
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 296 Pages: 100274-100274
- DOI
  10.1016/j.jbc.2021.100274
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09521, KAKENHI-PROJECT-19K10054, KAKENHI-PROJECT-20K09890, KAKENHI-PROJECT-20K18512, KAKENHI-PROJECT-20H03854, KAKENHI-PROJECT-17K11645, KAKENHI-PROJECT-17K19766, KAKENHI-PROJECT-18K17021, KAKENHI-PROJECT-18K17071, KAKENHI-PROJECT-19K10052, KAKENHI-PROJECT-20K21681
[Journal Article] The roles of osteocalcin in lipid metabolism in adipose tissue and liver2020
- Author(s)
  Otani Takahito、Mizokami Akiko、Kawakubo-Yasukochi Tomoyo、Takeuchi Hiroshi、Inai Tetsuichiro、Hirata Masato
- Journal Title
  
  Advances in Biological Regulation
  
  Volume: 78 Pages: 100752-100752
- DOI
  10.1016/j.jbior.2020.100752
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09521, KAKENHI-PROJECT-19K10052, KAKENHI-PROJECT-20H03854, KAKENHI-PROJECT-17K19766, KAKENHI-PROJECT-18K17021
[Journal Article] GLP-1 signaling is required for improvement of glucose tolerance by osteocalcin. J. Endocrinol.2020
- Author(s)
  Mizokami, A., Mukai, S., Gao, J., Kawakubo-Yasukochi, T., Otani, T., Takeuchi, H., Jimi, E., Hirata, M.
- Journal Title
  
  Journal of Endocrinology
  
  Volume: 244 Issue: 2 Pages: 285-296
- DOI
  10.1530/joe-19-0288
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11649, KAKENHI-PROJECT-18K09510, KAKENHI-PROJECT-18K09521, KAKENHI-PROJECT-19K10052, KAKENHI-PROJECT-19K10054, KAKENHI-PROJECT-17K19766, KAKENHI-PROJECT-18K17021, KAKENHI-PROJECT-17H01595, KAKENHI-PROJECT-16K11479
[Journal Article] Osteocalcin triggers Fas/FasL-mediated necroptosis in adipocytes regulated by the activation of p300.2018
- Author(s)
  Otani, T., Matsuda, M., Mizokami, A., Kitagawa, N., Takeuchi, H., Jimi, E.,Inai, T., and Hirata, M.
- Journal Title
  
  Cell Death Disease
  
  Volume: 9 Issue: 12 Pages: 1194-1210
- DOI
  10.1038/s41419-018-1257-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11645, KAKENHI-PROJECT-17K11649, KAKENHI-PROJECT-18K09510, KAKENHI-PROJECT-18K09521, KAKENHI-PROJECT-17K19766, KAKENHI-PROJECT-18K17021, KAKENHI-PROJECT-17H01595, KAKENHI-PROJECT-17H02111
[Presentation] デスモソーム蛋白desmoglein 3欠損がケラチノサイトに及ぼす影響の解析2022
- Author(s)
  小川修平、大谷崇仁、緒方佳代子、稲井哲一朗
- Organizer
  第６４回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-22K09921
[Presentation] 脂肪細胞の「数と質」を改善するオステオカルシン2020
- Author(s)
  大谷　崇仁
- Organizer
  第62回歯科基礎医学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K17021
[Presentation] 脂肪細胞を細胞死へと導く骨基質タンパクOsteocalcin2019
- Author(s)
  大谷　崇仁
- Organizer
  第61回歯科基礎医学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K17021
[Presentation] Necroptosis of Adipocytes Induced by Osteocalcin2019
- Author(s)
  Takahito Otani
- Organizer
  Kyudai Oral Bioscience & OBT Research Center Joint International Symposium 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K17021
[Presentation] オステオカルシンによる脂肪細胞のネクロトーシス2018
- Author(s)
  大谷崇仁
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K17021

1. 稲井哲一朗 (00264044)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 平木昭光 (60404034)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 吉本尚平 (70780188)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 緒方佳代子 (70830123)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 溝上顕子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 竹内弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 松田美穂

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Otani Takahito 大谷 崇仁

OTANI Takahito 大谷 崇仁

Research Projects

Research Products

Co-Researchers

Elucidation of the mechanism by which osteocalcin promotes insulin sensitivity in adipocytes via alteration of the response to the extracellular milieu.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of the role of desmosome cadherin in cell motility and lymph node metastasis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of cell death of adipocytes induced by osteocalcinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of inhibition of adiponectin expression in adipocytes induced by high-dose osteocalcinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Adipocyte-specific GPRC6A ablation promotes diet-induced obesity by inhibiting lipolysis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The roles of osteocalcin in lipid metabolism in adipose tissue and liver2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] GLP-1 signaling is required for improvement of glucose tolerance by osteocalcin. J. Endocrinol.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Osteocalcin triggers Fas/FasL-mediated necroptosis in adipocytes regulated by the activation of p300.2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] デスモソーム蛋白desmoglein 3欠損がケラチノサイトに及ぼす影響の解析2022

Author(s)

Organizer

Data Source

[Presentation] 脂肪細胞の「数と質」を改善するオステオカルシン2020

Author(s)

Organizer

Data Source

[Presentation] 脂肪細胞を細胞死へと導く骨基質タンパクOsteocalcin2019

Author(s)

Organizer

Data Source

[Presentation] Necroptosis of Adipocytes Induced by Osteocalcin2019

Author(s)

Organizer

Data Source

[Presentation] オステオカルシンによる脂肪細胞のネクロトーシス2018

Author(s)

Organizer

Data Source

Otani Takahito 大谷崇仁

OTANI Takahito 大谷崇仁