Takai Atsushi 高井淳

Researcher Number	80760587
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 助教
Affiliation (based on the past Project Information) *help	2025: 京都大学, 医学研究科, 助教 2019 – 2023: 京都大学, 医学研究科, 助教 2016 – 2019: 京都大学, 医学研究科, 特定助教 2015: 京都大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology
Keywords	Principal Investigator 肝細胞癌 / 肝癌 / DNA脱メチル化 / 脂肪肝炎 / オルガノイド培養 / ゲノム解析 / 全ゲノムシーケンス / 全ゲノム解析 / 肝癌抑制 / RNAiスクリーニング / PMPCB / EpCAM / 癌幹細胞

肝胆膵領域発癌過程においてIL-17-Regnase-1-NFKBIZ axisが果たす役割の解明Principal Investigator
- Principal Investigator
  
  高井淳
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyoto University
炎症性肝発癌過程におけるDNA脱メチル化酵素の機能的役割と分子機序の解明Principal Investigator
- Principal Investigator
  
  高井淳
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyoto University
The elucidation of the mechanism of multi-step hepatocarcinogenesis via whole genome sequence and organoid culture technologyPrincipal Investigator
- Principal Investigator
  
  Takai Atsushi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyoto University
Functional analysis of novel cancer-related gene of HCC identified by RNAi screening methodPrincipal Investigator
- Principal Investigator
  
  Takai Atsushi
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto University
RNAiスクリーニング法を用いた肝細胞癌における新規癌関連遺伝子の同定Principal Investigator
- Principal Investigator
  
  高井淳
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto University

All 2022 2021 2020 2019 2018 2017 2015

All Journal Article Presentation

[Journal Article] Genetic Landscape of Multistep Hepatocarcinogenesis2022
- Author(s)
  Takeda Haruhiko、Takai Atsushi、Eso Yuji、Takahashi Ken、Marusawa Hiroyuki、Seno Hiroshi
- Journal Title
  
  Cancers
  
  Volume: 14 Issue: 3 Pages: 568-568
- DOI
  10.3390/cancers14030568
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08443, KAKENHI-PROJECT-20H03659
[Journal Article] Risk factors and diagnostic biomarkers for nonalcoholic fatty liver disease-associated hepatocellular carcinoma: Current evidence and future perspectives2022
- Author(s)
  Ueno Masayuki、Takeda Haruhiko、Takai Atsushi、Seno Hiroshi
- Journal Title
  
  World Journal of Gastroenterology
  
  Volume: 28 Issue: 27 Pages: 3410-3421
- DOI
  10.3748/wjg.v28.i27.3410
- Data Source
  KAKENHI-PROJECT-22K07983
[Journal Article] Multiregional whole‐genome sequencing of hepatocellular carcinoma with nodule‐in‐nodule appearance reveals stepwise cancer evolution2020
- Author(s)
  Takeda Haruhiko、Takai Atsushi、Kumagai Ken、Iguchi Eriko、Arasawa Soichi、Eso Yuji、Shimizu Takahiro、Ueda Yoshihide、Taura Kojiro、Uemoto Shinji、Kita Ryuichi、Haga Hironori、Marusawa Hiroyuki、Fujimoto Akihiro、Seno Hiroshi
- Journal Title
  
  The Journal of Pathology
  
  Volume: 252 Issue: 4 Pages: 398-410
- DOI
  10.1002/path.5533
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08443, KAKENHI-PLANNED-18H05511, KAKENHI-PROJECT-19K17458
[Journal Article] Genome-Wide RNAi Screen Identifies PMPCB as a Therapeutic Vulnerability in EpCAM+ Hepatocellular Carcinoma2019
- Author(s)
  Atsushi Takai, Hien Dang, Naoki Oishi, Subreen Khatib, Sean P. Martin, Dana A. Dominguez, Ji Luo, Rachel Bagni, Xiaolin Wu, katie Powell, Qing-Hai Ye, Hu-Liang Jia, Lun-Xiu Qin, Jinqiu Chen, Gray A. Mitchell, Xiaoling Luo, Snorri S. Thorgeirsson, Xin Wei Wang
- Journal Title
  
  Cancer Research
  
  Volume: 79 Issue: 9 Pages: 2379-2391
- DOI
  10.1158/0008-5472.can-18-3015
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09357
[Journal Article] Combination of Mac-2 Binding Protein Glycosylation Isomer and Up-To-Seven Criteria as a Useful Predictor for Child-Pugh Grade Deterioration after Transarterial Chemoembolization for Hepatocellular Carcinoma2019
- Author(s)
  Eso Yuji、Takai Atsushi、Takahashi Ken、Ueda Yoshihide、Taura Kojiro、Marusawa Hiroyuki、Seno Hiroshi
- Journal Title
  
  Cancers
  
  Volume: 11 Issue: 3 Pages: 405-405
- DOI
  10.3390/cancers11030405
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09357, KAKENHI-PROJECT-17K15938
[Journal Article] Utility of ultrasound‐guided liver tumor biopsy for next‐generation sequencing‐based clinical sequencing2019
- Author(s)
  Eso Yuji、Kou Tadayuki、Nagai Hiroki、Kim Young Hak、Kanai Masashi、Matsumoto Shigemi、Mishima Masako、Arasawa Soichi、Iguchi Eriko、Nakamura Fumiyasu、Takeda Haruhiko、Takai Atsushi、Takahashi Ken、Ueda Yoshihide、Muto Manabu、Seno Hiroshi
- Journal Title
  
  Hepatology Research
  
  Volume: 印刷中 Issue: 5 Pages: 579-589
- DOI
  10.1111/hepr.13312
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09357, KAKENHI-PROJECT-17K15938, KAKENHI-PROJECT-19K17458
[Journal Article] Comprehensive analysis of genetic aberrations linked to tumorigenesis in regenerative nodules of liver cirrhosis2019
- Author(s)
  Kim Soo Ki、Takeda Haruhiko、Takai Atsushi、Matsumoto Tomonori、Kakiuchi Nobuyuki、Yokoyama Akira、Yoshida Kenichi、Kaido Toshimi、Uemoto Shinji、Minamiguchi Sachiko、Haga Hironori、Shiraishi Yuichi、Miyano Satoru、Seno Hiroshi、Ogawa Seishi、Marusawa Hiroyuki
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 印刷中 Issue: 7 Pages: 628-640
- DOI
  10.1007/s00535-019-01555-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09357, KAKENHI-PLANNED-15H05909, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-17H04158
[Journal Article] Ultrasound-guided microfoam sclerotherapy with polidocanol for symptomatic giant hepatic cyst: Initial experience2018
- Author(s)
  Eso Yuji、Furuta Akihiro、Takai Atsushi、Takahashi Ken、Ueda Yoshihide、Marusawa Hiroyuki、Seno Hiroshi
- Journal Title
  
  Hepatology Research
  
  Volume: 48 Issue: 12 Pages: 1055-1063
- DOI
  10.1111/hepr.13202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09357, KAKENHI-PROJECT-17K15938
[Journal Article] Genetic features of multicentric/multifocal intramucosal gastric carcinoma2018
- Author(s)
  Mizuguchi Aya、Takai Atsushi、Shimizu Takahiro、Matsumoto Tomonori、Kumagai Ken、Miyamoto Shin'ichi、Seno Hiroshi、Marusawa Hiroyuki
- Journal Title
  
  International Journal of Cancer
  
  Volume: 143 Issue: 8 Pages: 1923-1934
- DOI
  10.1002/ijc.31578
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09357
[Journal Article] Association of Mac-2-binding protein glycosylation isomer level with nutritional status in chronic liver disease2018
- Author(s)
  Eso Yuji、Takai Atsushi、Taura Kojiro、Takahashi Ken、Ueda Yoshihide、Marusawa Hiroyuki、Seno Hiroshi
- Journal Title
  
  Journal of Gastroenterology and Hepatology
  
  Volume: 印刷中 Issue: 9 Pages: 1649-1658
- DOI
  10.1111/jgh.14130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15938, KAKENHI-PROJECT-17H04157, KAKENHI-PROJECT-16K09357
[Journal Article] Proliferating EpCAM-Positive Ductal Cells in the Inflamed Liver Give Rise to Hepatocellular Carcinoma2017
- Author(s)
  Matsumoto Tomonori、Takai Atsushi、Eso Yuji、Kinoshita Kazuo、Manabe Toshiaki、Seno Hiroshi、Chiba Tsutomu、Marusawa Hiroyuki
- Journal Title
  
  Cancer Research
  
  Volume: 77 Issue: 22 Pages: 6131-6143
- DOI
  10.1158/0008-5472.can-17-1800
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09357, KAKENHI-PROJECT-17K15938, KAKENHI-PROJECT-17H04157, KAKENHI-PROJECT-17H04158, KAKENHI-PROJECT-16K15427
[Journal Article] Genetic basis of hepatitis virus-associated hepatocellular carcinoma: linkage between infection, inflammation, and tumorigenesis.2017
- Author(s)
  Takeda H, Takai A, Inuzuka T, Marusawa H.
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 52 Issue: 1 Pages: 26-38
- DOI
  10.1007/s00535-016-1273-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16J11897, KAKENHI-PROJECT-16K09357
[Journal Article] Oncogenic Activation of the RNA Binding Protein NELFE and MYC Signaling in Hepatocellular Carcinoma2017
- Author(s)
  Dang Hien、Takai Atsushi、Forgues Marshonna、Pomyen Yotsowat、Mou Haiwei、Xue Wen、Ray Debashish、Ha Kevin C.H.、Morris Quaid D.、Hughes Timothy R.、Wang Xin Wei
- Journal Title
  
  Cancer Cell
  
  Volume: 32 Issue: 1 Pages: 101-114.e8
- DOI
  10.1016/j.ccell.2017.06.002
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09357
[Journal Article] Evolution of multi-drug resistant HCV clones from pre-existing resistant-associated variants during direct-acting antiviral therapy determined by third-generation sequencing.2017
- Author(s)
  Takeda H, Ueda Y, Inuzuka T, Yamashita Y, Osaki Y, Nasu A, Umeda M, Takemura R, Seno H, Sekine A, Marusawa H.
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 45605-45605
- DOI
  10.1038/srep45605
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16J11897, KAKENHI-PROJECT-16K09357, KAKENHI-PROJECT-16H05496
[Presentation] 多段階発癌におけるミスマッチ修復異常関連体細胞変異シグネチャーの抽出2021
- Author(s)
  竹田治彦、高井淳、恵荘裕嗣、高橋健、田浦康二朗、波多野悦朗、喜多竜一、丸澤宏之、藤本明洋、妹尾浩
- Organizer
  第24回日本肝がん分子標的治療研究会
- Data Source
  KAKENHI-PROJECT-19K08443
[Presentation] 全ゲノムシーケンスを用いた多段階肝発癌過程の包括的解析2020
- Author(s)
  竹田治彦、高井淳、妹尾浩
- Organizer
  第56回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K08443
[Presentation] 全ゲノムシーケンス解析を用いた結節内結節型肝癌の病理像とゲノム異常の比較解析2019
- Author(s)
  竹田治彦、高井淳、妹尾浩．
- Organizer
  JDDW2019
- Data Source
  KAKENHI-PROJECT-19K08443
[Presentation] Sulfatase 2-TGFb1-SMADシグナル伝達によるPeriostinの誘導が肝細胞癌において血管新生に寄与する2018
- Author(s)
  井口恵里子、高井淳、上田佳秀、妹尾浩
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K09357
[Presentation] トランスクリプトーム解析を用いた肝硬変再生結節の発癌ポテンシャルの評価2018
- Author(s)
  竹田治彦、高井淳、金秀基、井口恵里子、荒澤荘一、熊谷健、恵荘裕嗣、清水孝洋、高橋健、上田佳秀、丸澤宏之、妹尾浩
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K09357
[Presentation] Identification of novel cancer driver genes in hepatocellular carcinoma cells by RNAi screening method2017
- Author(s)
  Takai Atsushi, Dang Hien, Oishi Naoki, Wang Xin Wei
- Organizer
  AACR Annual Meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09357
[Presentation] Genetic features of hepatocellular carcinoma arising after eradication of hepatitis C virus2017
- Author(s)
  Takeda Haruhiko, Takai Atsushi, Kim Soo Ki, Kakiuchi Nobuyuki, Seno Hiroshi, Ogawa Seishi, Marusawa Hiroyuki
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K09357
[Presentation] Characterization of hepatocellular carcinoma based on cellular origins2017
- Author(s)
  Takai Atsushi, Matsumoto Tomonori, Eso Yuji, Kinoshita Kazuo, Chiba Tsutomu, Seno Hiroshi, Marusawa Hiroyuki
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K09357
[Presentation] Identification of novel cancer driver genes in hepatocellular carcinoma cells by RNAi screening method2015
- Author(s)
  Atsushi Takai
- Organizer
  The 74th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Nagoya Congress Center
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15H06332

1. 恵荘裕嗣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takai Atsushi 高井 淳

Research Projects

Research Products

Co-Researchers

肝胆膵領域発癌過程においてIL-17-Regnase-1-NFKBIZ axisが果たす役割の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

炎症性肝発癌過程におけるDNA脱メチル化酵素の機能的役割と分子機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The elucidation of the mechanism of multi-step hepatocarcinogenesis via whole genome sequence and organoid culture technologyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis of novel cancer-related gene of HCC identified by RNAi screening methodPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

RNAiスクリーニング法を用いた肝細胞癌における新規癌関連遺伝子の同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Genetic Landscape of Multistep Hepatocarcinogenesis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Risk factors and diagnostic biomarkers for nonalcoholic fatty liver disease-associated hepatocellular carcinoma: Current evidence and future perspectives2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Multiregional whole‐genome sequencing of hepatocellular carcinoma with nodule‐in‐nodule appearance reveals stepwise cancer evolution2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genome-Wide RNAi Screen Identifies PMPCB as a Therapeutic Vulnerability in EpCAM+ Hepatocellular Carcinoma2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Combination of Mac-2 Binding Protein Glycosylation Isomer and Up-To-Seven Criteria as a Useful Predictor for Child-Pugh Grade Deterioration after Transarterial Chemoembolization for Hepatocellular Carcinoma2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Utility of ultrasound‐guided liver tumor biopsy for next‐generation sequencing‐based clinical sequencing2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comprehensive analysis of genetic aberrations linked to tumorigenesis in regenerative nodules of liver cirrhosis2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ultrasound-guided microfoam sclerotherapy with polidocanol for symptomatic giant hepatic cyst: Initial experience2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genetic features of multicentric/multifocal intramucosal gastric carcinoma2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of Mac-2-binding protein glycosylation isomer level with nutritional status in chronic liver disease2018

Takai Atsushi 高井淳