KIMURA Yasuaki 木村康明

… Alternative Names

Kimura Yasuaki 木村康明

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Researcher Number	80769977
Other IDs	https://orcid.org/0000-0002-3609-602X
Affiliation (Current)	2025: 名古屋大学, 理学研究科, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 名古屋大学, 理学研究科, 准教授 2020 – 2021: 名古屋大学, 理学研究科, 講師 2016 – 2019: 名古屋大学, 理学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 37030:Chemical biology-related / Medium-sized Section 37:Biomolecular chemistry and related fields / Biomolecular chemistry Except Principal Investigator Science and Engineering / Transition State Control
Keywords	Principal Investigator ポリメラーゼ / 核酸アナログ / 共有結合医薬 / 核酸医薬 / 細胞膜透過性 / mRNA / デリバリー法 / オリゴ核酸医薬 / siRNA / アンチセンス核酸 … More / デリバリー / ジスルフィド / リン酸化 / 活性化 / プロドラッグ / 抗HIV薬 / リン酸プロドラッグ / 阻害剤 / 不可逆阻害 / 選択性 / 標的選択性 / 核酸誘導体 / 抗ガン薬 / 抗ウイルス薬 / 標的選択制 / 薬学 / 化学合成法 / ｍRNA / 有機化学 / 化学合成 / ライゲーション / 核酸 / ホスホロチオエート / 核酸連結反応 / ケミカルライゲーション / DNA / RNA … More Except Principal Investigator 触媒 / 生体機能 / 機能性材料 / 元素効果 / 増幅 / 遷移状態 / センサー / 蛍光 / DNA / 鋳型反応 / RNA / RNAプローブ / 触媒回転数 / 核酸鋳型反応 / 蛍光プローブ / 核酸プローブ Less

Dynamic Element-Effect Design for Unconventional Molecular Functions
- Principal Investigator
  
  山口茂弘
- Project Period (FY)
  2022 – 2028
- Research Category
  
  Fund for the Promotion of Joint International Research (International Leading Research )
- Review Section
  
  Science and Engineering
- Research Institution
  Nagoya University
ジスルフィドを利用したオリゴ核酸デリバリー法の深化と技術拡張Principal Investigator
- Principal Investigator
  
  木村康明
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Nagoya University
Molecular design strategy to avoid side effects of covalent drugsPrincipal Investigator
- Principal Investigator
  
  Kimura Yasuaki
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  Nagoya University
Development of covalent drugs activatable by the target enzymesPrincipal Investigator
- Principal Investigator
  
  Kimura Yasuaki
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Nagoya University
Improvement of catalytic turnover based on transition state control of oligonucleotide template chemical reaction
- Principal Investigator
  
  Abe Hiroshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Transition State Control
- Research Institution
  Nagoya University
Development of Chemical Ligation Reaction of RNA for Chemical Synthesis of mRNAPrincipal Investigator
- Principal Investigator
  
  Kimura Yasuaki
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Nagoya University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation Book Patent

[Book] 中分子創薬に資するペプチド・核酸・糖鎖の合成技術　機能性核酸合成を指向した化学的核酸連結反応2018
- Author(s)
  木村康明、阿部洋
- Total Pages
  317
- Publisher
  シーエムシー出版
- ISBN
  9784781313207
- Data Source
  KAKENHI-PROJECT-16K21091
[Book] Biophilia 電子版 21　特集: 論理薬科学―創薬の基盤2017
- Author(s)
  阿部洋、木村康明
- Total Pages
  99
- Publisher
  アドスリー
- Data Source
  KAKENHI-PROJECT-16K21091
[Journal Article] Topological capture of mRNA for silencing gene expression2023
- Author(s)
  Lyu Fangjie、Tomita Takashi、Abe Naoko、Hiraoka Haruka、Hashiya Fumitaka、Nakashima Yuko、Kajihara Shiryu、Tomoike Fumiaki、Shu Zhaoma、Onizuka Kazumitsu、Kimura Yasuaki、Abe Hiroshi
- Journal Title
  
  Chemical Communications
  
  Volume: 59 Issue: 77 Pages: 11564-11567
- DOI
  10.1039/d2cc06189a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K19323, KAKENHI-PROJECT-23K23486
[Journal Article] Development of Fluorophosphoramidate as a Biocompatibly Transformable Functional Group and its Application as a Phosphate Prodrug for Nucleoside Analogs2022
- Author(s)
  Yoshida Yuki、Zheng Ti、Tanabe Wataru、Tomoike Fumiaki、Hashiya Fumitaka、Suzuki Tetsuro、Hirota Shuto、Saiki Yuriko、Horii Akira、Hirayama Akiyoshi、Soga Tomoyosi、Kimura Yasuaki、Abe Hiroshi
- Journal Title
  
  ChemMedChem
  
  Volume: 17 Issue: 17
- DOI
  10.1002/cmdc.202200188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21249
[Journal Article] A 2′-modified uridine analog, 2′-O-(methylthiomethoxy)methyl uridine, for siRNA applications2022
- Author(s)
  Fangjie Lyu, Seongjin An, Yoshiaki Kobayashi, Kohei Nomura, Rintaro Baba, Naoko Abe, Haruka Hiraoka, Fumitaka Hashiya, Zhaoma Shu, Kumiko Ui-Tei, Yasuaki Kimura, Hiroshi Abe
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 74 Pages: 128939-128939
- DOI
  10.1016/j.bmcl.2022.128939
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K14750, KAKENHI-PROJECT-21K20630, KAKENHI-PROJECT-21H02465, KAKENHI-PROJECT-23K23486
[Journal Article] Structure, Synthesis and Inhibition Mechanism of Nucleoside Analogues as HIV‐1 Reverse Transcriptase Inhibitors (NRTIs)2021
- Author(s)
  Yoshida Yuki、Honma Masakazu、Kimura Yasuaki、Abe Hiroshi
- Journal Title
  
  ChemMedChem
  
  Volume: 16 Issue: 5 Pages: 743-766
- DOI
  10.1002/cmdc.202000695
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21249
[Journal Article] Disulfide-Unit Conjugation Enables Ultrafast Cytosolic Internalization of Antisense DNA and siRNA2019
- Author(s)
  Shu Zhaoma、Tanaka Iku、Ota Azumi、Fushihara Daichi、Abe Naoko、Kawaguchi Saki、Nakamoto Kosuke、Tomoike Fumiaki、Tada Seiichi、Ito Yoshihiro、Kimura Yasuaki、Abe Hiroshi
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 印刷中 Issue: 20 Pages: 6611-6615
- DOI
  10.1002/anie.201900993
- NAID
  130007841763
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16KT0052, KAKENHI-PROJECT-17K15479, KAKENHI-PROJECT-18K14357, KAKENHI-PUBLICLY-18H04398
[Journal Article] A Covalent Inhibitor for Glutathione S‐Transferase Pi (GSTP1‐1) in Human Cells2019
- Author(s)
  Shishido Yuko、Tomoike Fumiaki、Kuwata Keiko、Fujikawa Haruka、Sekido Yoshitaka、Murakami‐Tonami Yuko、Kameda Tomoshi、Abe Naoko、Kimura Yasuaki、Shuto Satoshi、Abe Hiroshi
- Journal Title
  
  ChemBioChem
  
  Volume: 20 Issue: 7 Pages: 900-905
- DOI
  10.1002/cbic.201800671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14356, KAKENHI-PROJECT-17K15479, KAKENHI-PUBLICLY-18H04398, KAKENHI-PROJECT-19H01014, KAKENHI-PROJECT-18K06979, KAKENHI-PROJECT-15K08325
[Journal Article] Chemical Ligation Reactions of Oligonucleotides for Biological and Medicinal Applications2018
- Author(s)
  Abe Hiroshi、Kimura Yasuaki
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 66 Issue: 2 Pages: 117-122
- DOI
  10.1248/cpb.c17-00615
- NAID
  130006328058
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21091
[Journal Article] Chemical ligation of oligonucleotides using an electrophilic phosphorothioester2017
- Author(s)
  Maruyama Hideto、Oikawa Ryota、Hayakawa Mayu、Takamori Shono、Kimura Yasuaki、Abe Naoko、Tsuji Genichiro、Matsuda Akira、Shuto Satoshi、Ito Yoshihiro、Abe Hiroshi
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 45 Issue: 12 Pages: 7042-7048
- DOI
  10.1093/nar/gkx459
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21091, KAKENHI-PROJECT-16H02484
[Patent] プロドラッグ化合物2021
- Inventor(s)
  阿部洋　木村康明
- Industrial Property Rights Holder
  名古屋大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-013946
- Filing Date
  2021
- Acquisition Date
  2021
- Data Source
  KAKENHI-PROJECT-20K21249
[Patent] プロドラック化合物2021
- Inventor(s)
  阿部洋、木村康明
- Industrial Property Rights Holder
  阿部洋、木村康明
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-111420
- Filing Date
  2021
- Acquisition Date
  2021
- Data Source
  KAKENHI-PROJECT-20K21249
[Patent] β-MODIFIED PHOSPHORIC ACID COMPOUND PRECURSOR, β-MODIFIED PHOSPHORIC ACID COMPOUND, REACTION INHIBITOR, AND MEDICINE INCLUDING SAME, AND REACTION INHIBITION METHOD2019
- Inventor(s)
  阿部洋　木村康明
- Industrial Property Rights Holder
  阿部洋　木村康明
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Acquisition Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-18K14356
[Patent] β修飾リン酸化合物前駆体、β修飾リン酸化合物、反応阻害剤及びこれを含む医薬並びに反応阻害方法2018
- Inventor(s)
  阿部洋　木村康明
- Industrial Property Rights Holder
  阿部洋　木村康明
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-043329
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-18K14356
[Presentation] 核酸医薬への応用を志向した新規細胞膜透過性核酸の開発2024
- Author(s)
  横江隼人, Lyu Fangjie, 秤谷隼世, 平岡陽花, Li Zhenmin, 松原徳明, Soo Yonghao, 橋谷文貴, 阿部奈保子, Shu Zhaoma, 中本航介, 木村康明, 阿部洋
- Organizer
  日本薬学会第144年会（横浜）
- Data Source
  KAKENHI-PROJECT-23K23486
[Presentation] mRNAのトポロジカル捕捉による遺伝子発現抑制2023
- Author(s)
  木村康明, 富田貴志, Lyu Fangjie, 阿部奈保子, 平岡陽花, 橋谷文貴, 中嶋裕子, 梶原司琉, 友池史明, 鬼塚和光, 阿部洋
- Organizer
  第17回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-23K23486
[Presentation] Topological capture of mRNA for silencing gene expression2023
- Author(s)
  呂方杰, 富田貴志, 友池史明, 阿部奈保子, 鬼塚和光, 木村康明, 阿部洋
- Organizer
  日本核酸医薬学会第8回年会
- Data Source
  KAKENHI-PROJECT-23K23486
[Presentation] Topological Capture of mRNA for Silencing Gene Expression2023
- Author(s)
  Yasuaki Kimura, Takashi Tomita, Fangjie Lyu, Naoko Abe, Haruka Hiraoka, Fumitaka Hashiya, Yuko Nakashima, Shiryu Kajihara, Fumiaki Tomoike, Kazumitsu Onizuka, Hiroshi Abe
- Organizer
  ISNAC2023
- Data Source
  KAKENHI-PROJECT-23K23486
[Presentation] Development of new membrane permeable oligonucleotides for therapeutics2022
- Author(s)
  Lyu Fangjie, Hayase Hakariya, Haruka Hiraoka, Li Zhenmin, Noriaki Matsubara, Satoshi Uchida, Yasuaki Kimura, Hiroshi Abe
- Organizer
  第16回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-23K23486
[Presentation] フルオロリン酸アミデート基の開発と核酸アナログのプロドラッグへの応用2022
- Author(s)
  木村康明・吉田祐希・友池史明,・橋谷文貴・廣田嵩人・斎木由利子・堀井明・平山明由・曽我朋義・阿部洋
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K21249
[Presentation] 膜透過性核酸MPONの核移行によるエキソンスキッピングの促進2022
- Author(s)
  平岡陽花・Zhaoma Shu・Bao Tri Le・益田恵子・中本航介・林光太朗・阿部奈保子・木村康明・Rakesh N. Veedu・清水義宏・内田智士・阿部洋
- Organizer
  第16回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-23K23486
[Presentation] 1.アンチセンスDNAの送達プラットフォームとしての細胞膜透過性オリゴ核酸2022
- Author(s)
  秤谷隼世，Lyu Fangjie，Shu Zhaoma，Li Zhenmin，木村康明，阿部洋
- Organizer
  日本核酸医薬学会第7回年会
- Data Source
  KAKENHI-PROJECT-23K23486
[Presentation] フルオロリン酸アミデート基を用いた新規リン酸プロドラッグの開発2022
- Author(s)
  吉田祐希・Ti Zheng・田辺航・友池史明・橋谷文貴・廣田嵩人・齋木由利子・堀井明・木村康明・阿部洋
- Organizer
  日本化学会第102春季年会
- Data Source
  KAKENHI-PROJECT-20K21249
[Presentation] Tri-branched Disulfide Units Enables Efficient Intracellular Delivery of Antisense Oligonucleotides2022
- Author(s)
  Fangjie Lyu, Hayase Hakariya, Haruka Hiraoka, Zhenmin Li, Noriaki Matsubara, Satoshi Uchida, Yasuaki Kimura, Hiroshi Abe
- Organizer
  ISNAC2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23486
[Presentation] ジスルフィド結合を利用した細胞膜透過性オリゴ核酸の開発2022
- Author(s)
  松原徳明・平岡陽花・秤谷隼世・Li Zhenmin Li・Lyu Fangjie・内田智士・木村康明・阿部洋
- Organizer
  中部化学関係学協会支部連合秋季大会
- Data Source
  KAKENHI-PROJECT-23K23486
[Presentation] フルオロリン酸アミデート基を用いた新規リン酸プロドラッグの開発2021
- Author(s)
  吉田祐希・Zheng Ti・田辺航・友池史明・橋谷文貴・鈴木哲朗・廣田嵩人・齋木由利子・堀井明・平山明由・曽我朋義・木村康明・阿部洋
- Organizer
  第15回ケミカルバイオロジー学会
- Data Source
  KAKENHI-PROJECT-20K21249
[Presentation] 2'-β-プロパルギルセレノヌクレオシド用いた逆転写酵素不可逆阻害の機構解析2021
- Author(s)
  吉田祐希・新美結士・伏原大地・村瀬裕貴・木村康明・阿部洋
- Organizer
  第15回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-20K21249
[Presentation] フルオロリン酸アミデート基の開発と核酸アナログのプロドラッグへの応用2021
- Author(s)
  木村康明, 吉田祐希, 友池史明,, 橋谷文貴, 鈴木哲朗, 廣田嵩人, 齋木由利子, 堀井明, 平山明由, 曽我朋義, 阿部洋
- Organizer
  第15回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-20K21249
[Presentation] フルオロリン酸アミデート基の化学的性質の評価と医薬応用に向けた検討2020
- Author(s)
  木村康明・田辺航・Zheng Ti・吉田祐希・橋谷文貴・阿部洋
- Organizer
  第14回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-20K21249
[Presentation] 抗ウイルス性2′-β-セレン修飾ヌクレオシドアナログの開発2020
- Author(s)
  吉田祐希・新美結士・伏原大地・村瀬裕貴・木村康明・阿部洋
- Organizer
  第14回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-20K21249
[Presentation] Development of phosphorofluoridate prodrugs2020
- Author(s)
  吉田祐希, Zheng Ti, 伏原大地 , 新美結士, 中本航介, 橋谷文貴, 木村康明, 日吉貴子, 齋木由利子, 堀井明, 鈴木哲朗, 村上優子, 阿部洋
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K14356
[Presentation] Development of 2’-β Seleno Nucleoside Analogs as Irreversible Inhibitors for Viral Reverse Transcriptase2019
- Author(s)
  木村康明、丸山豪斗、笈川涼太、早川真由、吉永静也、辻厳一郎、阿部奈保子、木村康明、周東智、松田彰、南川典昭、阿部洋
- Organizer
  日本化学会　第99回年会
- Data Source
  KAKENHI-PROJECT-18K14356
[Presentation] Development of 2'-β-Thio or Seleno modified Nucleoside Analogs2019
- Author(s)
  Hirotaka Murase, Chang Jun Shi, Ti Zheng, Fumitaka Hashiya, Yasuaki Kimura, Hiroshi Abe
- Organizer
  International Symposium on Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14356
[Presentation] Synthesis of Anti-viral Selenium Modified Nucleoside Analogues2019
- Author(s)
  Daichi Fushihara, Yushi Nimi, Hideo Katakura, Tetsuro Suzuki, Tsutomu Murakami, Eichi Kodama, Yasuaki Kimura, Hiroshi Abe
- Organizer
  Commemorative International Symposium of the Japan Society of Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14356
[Presentation] 高分子核酸医薬の低分子化戦略：細胞内ビルドアップ法の開発2018
- Author(s)
  木村康明、丸山豪斗、笈川涼太、早川真由、吉永静也、辻厳一郎、阿部奈保子、周東智、松田彰、南川典昭、阿部洋
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K21091
[Presentation] Develpment of 2'-β-modified nucleosides for irreversible viral polymerase inhibitor2018
- Author(s)
  Yushi Niimi, Hideo Katakura, Tetsuro Suzuki, Akito Takato, Tsutomu Murakami, Yasuaki Kimura, Hiroshi Abe
- Organizer
  日本ウイルス学会　第６６回
- Data Source
  KAKENHI-PROJECT-18K14356
[Presentation] Chemical ligation reaction for oligonucleotides based on electrophilic phosphorothioester2018
- Author(s)
  Yasuaki Kimura、Hideto Maruyama、Ryota Oikawa、Mayu Hayakawa、Naoko Abe、Genichiro Tsuji、Akira Matsuda、Satoshi Shuto、Yoshihiro Ito、Hiroshi Abe
- Organizer
  255th ACS National Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21091
[Presentation] Development of 2’-β Seleno Nucleoside Analogs as Irreversible Inhibitors for Viral2018
- Author(s)
  Yasuaki Kimura, Yushi Niimi, Hideo Katakura, Fumiaki Tomoike, Tetsuro Suzuki, Tsutomu Murakami, Eiichi, Kodama, Hiroshi Abe
- Organizer
  The 45th International Symposium on Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14356
[Presentation] 抗ウイルス活性を指向した2’-β位修飾ヌクレオシドの合成と評価2018
- Author(s)
  新美結士, 片倉秀雄, 鈴木哲郎, 高田礼人, 村上努, 木村康明, 阿部洋
- Organizer
  日本ケミカルバイオロジー学会第13回年会
- Data Source
  KAKENHI-PROJECT-18K14356
[Presentation] Development of 2’-β Seleno Nucleoside Analogs as Irreversible Inhibitors for Viral Polymerases2018
- Author(s)
  Yasuaki Kimura, Yushi Niimi, Hideo Katakura, Tetsuro Suzuki, Tsutomu Murakami, Eiichi, Kodama, Hiroshi Abe
- Organizer
  日本ウイルス学会　第６６回
- Data Source
  KAKENHI-PROJECT-18K14356
[Presentation] 機能性核酸合成を志向した化学的核酸連結反応2017
- Author(s)
  笈川涼太、早川真由、丸山豪斗、阿部奈保子、木村康明、周東智、松田彰、南川典昭、阿部洋
- Organizer
  日本核酸医薬学会第3回年会
- Data Source
  KAKENHI-PROJECT-16K21091
[Presentation] 高分子核酸医薬の低分子戦略：細胞内ビルドアップ法の開発2017
- Author(s)
  木村康明、丸山豪斗、笈川涼太、早川真由、吉永静也、辻厳一郎、阿部奈保子、周東智、松田彰、南川典昭、阿部洋
- Organizer
  日本核酸医薬学会第3回年会
- Data Source
  KAKENHI-PROJECT-16K21091
[Presentation] 環境応答性環状オリゴ核酸による遺伝子発現制御2017
- Author(s)
  吉永静也、阿部奈保子、木村康明、友池史明、阿部洋
- Organizer
  第48回中化連秋季大会
- Data Source
  KAKENHI-PROJECT-16K21091
[Presentation] 機能性核酸合成を志向した化学的核酸連結反応2017
- Author(s)
  笈川涼太、早川真由、丸山豪斗、阿部奈保子、友池史明、木村康明、周東智、松田彰、南川典昭、阿部洋
- Organizer
  第48回中化連秋季大会
- Data Source
  KAKENHI-PROJECT-16K21091
[Presentation] 高分子核酸医薬の低分子戦略：細胞内ビルドアップ法の開発2017
- Author(s)
  木村康明、丸山豪斗、笈川涼太、早川真由、吉永静也、辻厳一郎、阿部奈保子、周東智、松田彰、南川典昭、阿部洋
- Organizer
  第35回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-16K21091
[Presentation] RNA Interference by Intracellar Buildup of siRNA2017
- Author(s)
  Yasuaki Kimura、Hideto Maruyama、Ryota Oikawa、Genichiro Tsuji、Shizuya Yoshinaga、Naoko Abe、Satoshi Shuto、Akira Matsuda、Yoshihiro Ito、Hiroshi Abe
- Organizer
  The 44th International Symposium on Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21091
[Presentation] 求電子的ホスホロチオエステルによる核酸の化学的連結反応2017
- Author(s)
  木村康明　丸山豪斗　笈川涼太　早川真由　阿部奈保子　松田彰　周東智　伊藤嘉浩　阿部洋
- Organizer
  日本化学会第97春季年会
- Place of Presentation
  慶応大学日吉キャンパス
- Year and Date
  2017-03-16
- Data Source
  KAKENHI-PROJECT-16K21091
[Presentation] 高分子核酸医薬の低分子戦略：細胞内ビルドアップ法の開発2017
- Author(s)
  木村康明、丸山豪斗、笈川涼太、早川真由、吉永静也、辻厳一郎、阿部奈保子、周東智、松田彰、南川典昭、阿部洋
- Organizer
  第11回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-16K21091
[Presentation] 高効率な核酸検出を可能にする核酸鋳型反応の開発2017
- Author(s)
  伊藤真央　柴田綾　阿部奈保子　木村康明　阿部洋
- Organizer
  日本薬学会
- Place of Presentation
  仙台
- Year and Date
  2017-03-26
- Data Source
  KAKENHI-PROJECT-16KT0052
[Presentation] 高分子核酸医薬の低分子戦略：細胞内ビルドアップ法の開発2017
- Author(s)
  木村康明、丸山豪斗、笈川涼太、早川真由、吉永静也、辻厳一郎、阿部奈保子、周東智、松田彰、南川典昭、阿部洋
- Organizer
  日本ケミカルバイオロジー学会　第12回年会
- Data Source
  KAKENHI-PROJECT-16K21091
[Presentation] Development of novel chemical ligation reaction for RNA strands2016
- Author(s)
  Ryota Oikawa, Hideto Maruyama, Mayu Hayakawa, Naoko Abe, Yasuaki Kimura, Hiroshi Abe
- Organizer
  The 43rd International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  熊本大学
- Year and Date
  2016-09-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21091
[Presentation] Chemical Ligation Reaction for RNA Strand2016
- Author(s)
  Yasuaki Kimura, Ryota Oikawa, Hideto Maruyama, Mayu Hayakawa, Naoko Abe, Hiroshi Abe
- Organizer
  RNA2016
- Place of Presentation
  京都国際会議場
- Year and Date
  2016-06-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21091
[Presentation] Chemical ligation of oligonucleotides using electrophilic phosphorothioester2016
- Author(s)
  木村康明　丸山豪斗　笈川涼太　早川真由　阿部奈保子　松田彰　周東智　伊藤嘉浩　阿部洋
- Organizer
  第10回バイオ関連化学シンポジウム
- Place of Presentation
  金沢石川県立音楽堂
- Year and Date
  2016-09-07
- Data Source
  KAKENHI-PROJECT-16K21091

1. Abe Hiroshi (80415067)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 村上努 (50336385)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 山口茂弘 (60260618)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 大井貴史 (80271708)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 斎藤進 (90273268)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 八木亜樹子 (20803282)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 松田亮太郎 (00402959)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 荘司長三 (90379587)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 柳井毅 (00462200)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 平岡陽花

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 鬼塚和光

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KIMURA Yasuaki 木村 康明

Kimura Yasuaki 木村 康明

Research Projects

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Dynamic Element-Effect Design for Unconventional Molecular Functions

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ジスルフィドを利用したオリゴ核酸デリバリー法の深化と技術拡張Principal Investigator

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Molecular design strategy to avoid side effects of covalent drugsPrincipal Investigator

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Development of covalent drugs activatable by the target enzymesPrincipal Investigator

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Improvement of catalytic turnover based on transition state control of oligonucleotide template chemical reaction

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Development of Chemical Ligation Reaction of RNA for Chemical Synthesis of mRNAPrincipal Investigator

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[Book] 中分子創薬に資するペプチド・核酸・糖鎖の合成技術 機能性核酸合成を指向した化学的核酸連結反応2018

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[Book] Biophilia 電子版 21 特集: 論理薬科学―創薬の基盤2017

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[Journal Article] Topological capture of mRNA for silencing gene expression2023

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[Journal Article] Development of Fluorophosphoramidate as a Biocompatibly Transformable Functional Group and its Application as a Phosphate Prodrug for Nucleoside Analogs2022

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[Journal Article] A 2′-modified uridine analog, 2′-O-(methylthiomethoxy)methyl uridine, for siRNA applications2022

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[Journal Article] Structure, Synthesis and Inhibition Mechanism of Nucleoside Analogues as HIV‐1 Reverse Transcriptase Inhibitors (NRTIs)2021

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[Journal Article] Disulfide-Unit Conjugation Enables Ultrafast Cytosolic Internalization of Antisense DNA and siRNA2019

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NAID

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[Journal Article] A Covalent Inhibitor for Glutathione S‐Transferase Pi (GSTP1‐1) in Human Cells2019

Author(s)

KIMURA Yasuaki 木村康明

Kimura Yasuaki 木村康明

[Book] 中分子創薬に資するペプチド・核酸・糖鎖の合成技術　機能性核酸合成を指向した化学的核酸連結反応2018

[Book] Biophilia 電子版 21　特集: 論理薬科学―創薬の基盤2017