Mishima Yuta 三嶋雄太

Researcher Number	80770263
Other IDs	https://orcid.org/0000-0003-4945-7346
Affiliation (Current)	2025: 筑波大学, 医学医療系, 助教
Affiliation (based on the past Project Information) *help	2020 – 2023: 筑波大学, 医学医療系, 助教 2016 – 2019: 京都大学, iPS細胞研究所, 特定研究員 2017 – 2018: 京都大学, iPS細胞研究所, 特別研究員(PD) 2016: 京都大学, IPS細胞研究所, 特別研究員(PD)
Review Section/Research Field	Principal Investigator Tumor therapeutics / Basic Section 90110:Biomedical engineering-related / Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Biomedical engineering/Biomaterial science and engineering / Basic Section 90110:Biomedical engineering-related
Keywords	Principal Investigator iPS細胞 / 遺伝子治療 / Cancer Immunotherapy / 再生医療 / CAR-T細胞 / AI画像解析 / マイクロ流体デバイス / TCR / CAR / CD8T細胞 … More / TCR-T療法 / CAR-T療法 / CTL / 腫瘍免疫 / 免疫治療 / Tancer-on-a-chip / CAR-T cell / ユニバーサルiPS細胞 / 免疫細胞 / 血管内皮細胞 / Cancer-on-a-chip / MPS / immunotherapy / Microdevice / CAR-T therapy / iPS cell / Immunotherapy / がん免疫 / Tumor-on-a-chip / 再生T細胞 / がん免疫細胞療法 / 免疫細胞分化 / CAT-T細胞治療 / IPS細胞 / がん免疫治療 … More Except Principal Investigator 免疫学 / 再生医学 / organ-on-a-chip / iPS細胞 / 癌 / がんオルガノイド / がん免疫 / がん評価モデル / マイクロ・ナノデバイス / マイクロデバイス / 3次元培養 / 血管 / マイクロ流体デバイス / Organ-on-a-chip / ３次元培養 / 組織培養 / がんモデル / がんの評価モデル / がん免疫細胞療法 / 3次元培養法 / バイオテクノロジー / システムオンチップ / 生体模倣 / T細胞 / 胸腺 Less

Development and demonstration of a patient tissue-derived 3D tumor-on-a-chip for evaluation of T cell function in cancer immunotherapyPrincipal Investigator
- Principal Investigator
  
  三嶋雄太
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  University of Tsukuba
Development of the killing function of iPSC derived CAR-T cell for solid tumor.Principal Investigator
- Principal Investigator
  
  Mishima Yuta
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  University of Tsukuba
Development of a 3D tumor-on-a-chip platform for cancer immunotherapy
- Principal Investigator
  
  鳥澤勇介
- Project Period (FY)
  2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Kyoto University
Development of patient-derived cancer on-a-chip devices for cancer immunotherapy
- Principal Investigator
  
  Torisawa Yu-suke
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Kyoto University
Development of a microfluidic device to mimic the function of the thymus for immunotherapy
- Principal Investigator
  
  Torisawa Yu-suke
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Kyoto University
ｉＰＳ細胞由来再生Ｔ細胞とがん特異抗原レセプター遺伝子導入による免疫療法の開発Principal Investigator
- Principal Investigator
  
  三嶋雄太
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Research Field
  
  Tumor therapeutics
- Research Institution
  Kyoto University

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Book Patent

[Book] 生物の科学　遺伝2017
- Author(s)
  三嶋雄太、金子新
- Total Pages
  104
- Publisher
  株式会社エヌ・ディー・エス
- ISBN
  9784860434878
- Data Source
  KAKENHI-PROJECT-16J09729
[Journal Article] がん免疫細胞療法のT細胞評価を可能とするチップ技術の開発2023
- Author(s)
  三嶋雄太
- Journal Title
  
  真の実臨床応用をめざした再生医療2023
  
  Volume: 41巻2号 Pages: 94-100
- Data Source
  KAKENHI-PROJECT-20K16439
[Journal Article] がん免疫細胞療法のT細胞評価を可能とするチップ技術の開発2023
- Author(s)
  三嶋雄太
- Journal Title
  
  真の実臨床応用をめざした再生医療2023
  
  Volume: 41巻2号 Pages: 94-100
- Data Source
  KAKENHI-PROJECT-22K12778
[Journal Article] iPS細胞を用いた３次元がんチップの開発2022
- Author(s)
  三嶋雄太
- Journal Title
  
  Medical Science Digest
  
  Volume: 48巻13号 Pages: 51-53
- Data Source
  KAKENHI-PROJECT-20K16439
[Journal Article] iPS細胞を用いた３次元がんチップの開発2022
- Author(s)
  三嶋雄太
- Journal Title
  
  Medical Science Digest
  
  Volume: 48巻13号 Pages: 51-53
- Data Source
  KAKENHI-PROJECT-22K12778
[Journal Article] Suppression of multiple anti‐apoptotic BCL2 family proteins recapitulates the effects of JAK2 inhibitors in JAK2V617F driven myeloproliferative neoplasms2021
- Author(s)
  Takei Hisashi、Coelho‐Silva Juan Luiz、Tavares Leal Cristina、Queiroz Arantes Rocha Adriana、Mantello Bianco Thiago、Welner Robert S.、Mishima Yuta、Kobayashi Ikei S.、Mullally Ann、Lima Keli、Machado‐Neto Joao Agostinho、Kobayashi Susumu S.、Lobo de Figueiredo‐Pontes Lorena
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 2 Pages: 597-608
- DOI
  10.1111/cas.15210
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16439
[Journal Article] A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy2021
- Author(s)
  Iriguchi Shoichi、Yasui Yutaka、Kawai Yohei、Arima Suguru、Kunitomo Mihoko、Sato Takayuki、Ueda Tatsuki、Minagawa Atsutaka、Mishima Yuta、Yanagawa Nariaki、Baba Yuji、Miyake Yasuyuki、Nakayama Kazuhide、Takiguchi Maiko、Shinohara Tokuyuki、Nakatsura Tetsuya、Yasukawa Masaki、Kassai Yoshiaki、Hayashi Akira、Kaneko Shin
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 430-430
- DOI
  10.1038/s41467-020-20658-3
- NAID
  120006954089
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16439, KAKENHI-PROJECT-18H02839, KAKENHI-PROJECT-19K16688, KAKENHI-PROJECT-18H02641
[Journal Article] Generation of GM-CSF-producing antigen-presenting cells that induce a cytotoxic T cell-mediated antitumor response.2020
- Author(s)
  Mashima H, Zhang R, Kobayashi T, Hagiya Y, Tsukamoto H, Liu T, Iwama T, Yamamoto M, Lin C, Nakatsuka R, Mishima Y, Watanabe N, Yamada T, Senju S, Kaneko S, Idiris A, Nakatsura T, Ohdan H, Uemura Y.
- Journal Title
  
  Oncoimmunology
  
  Volume: 9(1) Issue: 1 Pages: 1814620-1814620
- DOI
  10.1080/2162402x.2020.1814620
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09186, KAKENHI-PROJECT-20K16439, KAKENHI-PROJECT-18K07325
[Journal Article] Developing thymus-on-a-chip and cancer-on-a-chip for cancer immunotherapy2019
- Author(s)
  Torisawa Y, Mishima Y, Kaneko S
- Journal Title
  
  Impact
  
  Volume: 2019 Issue: 2 Pages: 33-35
- DOI
  10.21820/23987073.2019.2.33
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02082, KAKENHI-PROJECT-16J09729
[Patent] Hematopoietic progenitor cell marker2018
- Inventor(s)
  金子新、入口翔一、三嶋雄太、葛西義明、林哲、有馬寿来留
- Industrial Property Rights Holder
  金子新、入口翔一、三嶋雄太、葛西義明、林哲、有馬寿来留
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-16J09729
[Patent] 造血前駆細胞マーカー2017
- Inventor(s)
  金子新、入口翔一、三嶋雄太、葛西義明、林哲、有馬寿来留
- Industrial Property Rights Holder
  国立大学法人京都大学、武田薬品工業株式会社
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16J09729
[Presentation] Modeling of Tumor-on-a-Chip using HLA edited iPS cell-derived vascular endothelial cells for cancer immune cell therapy2021
- Author(s)
  ○Yuta Mishima, Shin Kaneko and Yu-suke Torisawa
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K16439
[Presentation] がん免疫細胞療法の評価を目的としてiPS細胞由来血管内皮細胞を用いたTumor-on-a-Chipの開発2021
- Author(s)
  ○三嶋雄太、早稲田真澄、高久保瞳、森千寿、佐野絵美、王博、上田樹、金子新、鳥澤勇介
- Organizer
  第20回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-20K16439
[Presentation] 免疫細胞療法の評価を目的としてiPS細胞由来血管内皮細胞を用いた Tumor-on-a-Chipの開発2020
- Author(s)
  三嶋雄太
- Organizer
  患者由来がんモデル講演会 2020
- Invited
- Data Source
  KAKENHI-PROJECT-20H04502
[Presentation] MODELING CANCER IMMUNOTHERAPY IN A PERFUSABLE 3D VASCULARIZED TUMOR-ON-A-CHIP USING HLA-KO UNIVERSAL HUMAN IPSC-DERIVED ENDOTHELIAL CELLS2020
- Author(s)
  ○Yuta Mishima, Masazumi Waseda, Hitomi Takakubo, Chihiro Mori, Emi Sano, Wang Bo, Tatsuki Ueda, Shoichi Iriguchi, Yuka Ozaki, Shin Kaneko, Yu-suke Torisawa
- Organizer
  ISSCR 2020 Virtual
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16439
[Presentation] MODELING CANCER IMMUNOTHERAPY IN A PERFUSABLE 3D VASCULARIZED TUMOR-ON-A-CHIP USING HLA-KO UNIVERSAL HUMAN IPSC-DERIVED ENDOTHELIAL CELLS2020
- Author(s)
  Yuta Mishima, Masazumi Waseda, Hitomi Takakubo, Chihiro Mori, Emi Sano, Wang Bo, Tatsuki Ueda, Shoichi Iriguchi, Yuka Ozaki, Shin Kaneko and Yu-suke Torisawa
- Organizer
  2020 International Society of Stem Cell Research Annual meeting,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H04502
[Presentation] Engineering of Perfusable 3D Vascularized Tumor-on-a-Chip Using hiPSC-derived Endothelial cells.2019
- Author(s)
  三嶋雄太、早稲田真澄、高久保瞳、王博、佐野絵美、森千尋、金子新、鳥澤勇介
- Organizer
  第18回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-16J09729
[Presentation] iPS細胞とレギュラトリーサイエンス2019
- Author(s)
  三嶋雄太
- Organizer
  順天堂大学医療の経済学第10回授業
- Invited
- Data Source
  KAKENHI-PROJECT-17H02082
[Presentation] Engineering of Perfusable 3D Vascularized Tumor-on-a-Chip Using hiPSC-derived Endothelial cells2019
- Author(s)
  三嶋雄太、早稲田真澄、高久保瞳、王博、佐野絵美、森千尋、金子新、鳥澤勇介
- Organizer
  第18回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-17H02082
[Presentation] Microfluidic Tissue Engineering of a 3D Vascularized Tissue-on-a-Chip using Human iPSC-derived Cells to Study Cancer Immunotherapy2018
- Author(s)
  Yu-suke Torisawa, Yuta Mishima, Emi Sano, Masazumi Waseda, Hitomi Takakubo, Chihiro Mori, Shoichi Iriguchi, Shin Kaneko
- Organizer
  5th Tissue Engineering and Regenerative Medicine International Society World Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K12874
[Presentation] Microfluidic Tissue Engineering of a 3D Vascularized Tissue-on-a-Chip using Human iPSC-derived Cells to Study Cancer Immunotherapy.2018
- Author(s)
  Yu-suke Torisawa, Yuta Mishima, Emi Sano, Masazumi Waseda, Hitomi Takakubo, Chihiro Mori, Shoichi Iriguchi, Shin Kaneko.
- Organizer
  5th TERMIS World Congress, Tissue Engineering and Regenerative Medicine International Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16J09729
[Presentation] Microfluidic Tissue Engineering of a 3D Vascularized Tissue-on-a-Chip using Human iPSC-derived Cells to Study Cancer Immunotherapy2018
- Author(s)
  Yu-suke Torisawa, Yuta Mishima, Emi Sano, Masazumi Waseda, Hitomi Takakubo, Chihiro Mori, Shoichi Iriguchi, Shin Kaneko
- Organizer
  5th Tissue Engineering and Regenerative Medicine International Society World Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02082
[Presentation] Development of a 3D vascularized cancer-on-a-chip platform using hiPSC-derived endothelial cells2018
- Author(s)
  Torisawa Y, Mishima Y, Sano E, Mori C, Takakubo H, Kaneko S
- Organizer
  EMBS Micro and Nanotechnology in Medicine Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02082
[Presentation] Engineering of a 3D Vascularized Tissue-on-a-Chip using Human iPSC-derived Cells2018
- Author(s)
  Torisawa Y, Mishima Y, Sano E, Takakubo H, Mori C, Kaneko S
- Organizer
  22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02082
[Presentation] Characterization of human iPSC-derived CD8αβ positive T cells with tumor-specific cytotoxicity.2018
- Author(s)
  Takayuki Sato,Atsutaka,Minagawa,Shoichi Iriguchi,Yohei Kawai,Yutaka Yasui,Yuta Mishima,Mihoko Kunitomo,Tokuyuki Shinohara,Kazuhide Nakayama,Masashi Yamada,Suguru Arima,Maiko Takiguchi,Yuumi Okuzono,Toshiaki Yoshikawa,Toshihiro Suzuki,Tetsuya Nakatsura,Masaaki Yasukawa,Yoshiaki Kassai,Akira Hayashi,Shin Kaneko
- Organizer
  第22回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-16J09729
[Presentation] Generation and characterization of hPSC-derived CD8αβ positive T cells with tumor-specific cytotoxicity for "off the shelf" cancer immunotherapy.2018
- Author(s)
  Yoshiaki Kassai,Atsutaka Minagawa,Shoichi Iriguchi,Yohei Kawai,Yutaka Yasui,Yuta Mishima,Mihoko Kunitomo,Tokuyuki Shinohara,Takayuki Sato,Kazuhide Nakayama,Masashi Yamada,Suguru Arima,Maiko Takiguchi,Yuumi Okuzono,Toshiaki Yoshikawa,Toshihiro Suzuki,Tetsuya Nakatsura,Masaki Yasukawa,Akira Hayashi,Shin Kaneko
- Organizer
  ISSCR 2018 Annual Meeting, International Society for Stem Cell Research
- Data Source
  KAKENHI-PROJECT-16J09729
[Presentation] Microfluidic Tissue Engineering of a 3D Vascularized Tissue-on-a-Chip using Human iPSC-derived Cells to Study Cancer Immunotherapy2018
- Author(s)
  Torisawa Y, Mishima Y, Sano E, Waseda M, Takakubo H, Mori C, Iriguchi S, Kaneko S
- Organizer
  5th Tissue Engineering and Regenerative Medicine International Society World Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02082
[Presentation] MICROFLUIDIC TISSUE ENGINEERING OF PERFUSABLE 3D VASCULAR NETWORKS ON A CHIP USING HUMAN IPS CELLS2017
- Author(s)
  Yuta Mishima, Masazumi Waseda, Emi Sano, Shoichi Iriguchi, Yutaka Yasui, Shin Kaneko, Yu-suke Torisawa
- Organizer
  International Society for Stem Cell Research 2017 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K12874
[Presentation] MICROFLUIDIC TISSUE ENGINEERING OF PERFUSABLE 3D VASCULAR NETWORKS ON A CHIP USING HUMAN IPS CELLS2017
- Author(s)
  Yuta Mishima, Masazumi Waseda, Emi Sano, Shoichi Iriguchi, Yutaka Yasui, Shin Kaneko, Yu-suke Torisawa
- Organizer
  International Society for Stem Cell Research 2017 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02082
[Presentation] MICROFLUIDIC TISSUE ENGINEERING OF PERFUSABLE 3D VASCULAR NETWORKS ON A CHIP USING HUMAN IPS CELLS.2017
- Author(s)
  三嶋雄太
- Organizer
  ISSCR（国際幹細胞学会）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16J09729

1. Torisawa Yu-suke (10767354)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
2. 金子新 (40361331)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
3. 井上匡美 (10379232)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 高山浩一 (50274444)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 植村靖史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 張エイ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Mishima Yuta 三嶋 雄太

Research Projects

Research Products

Co-Researchers

Development and demonstration of a patient tissue-derived 3D tumor-on-a-chip for evaluation of T cell function in cancer immunotherapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of the killing function of iPSC derived CAR-T cell for solid tumor.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a 3D tumor-on-a-chip platform for cancer immunotherapy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of patient-derived cancer on-a-chip devices for cancer immunotherapy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a microfluidic device to mimic the function of the thymus for immunotherapy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ｉＰＳ細胞由来再生Ｔ細胞とがん特異抗原レセプター遺伝子導入による免疫療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 生物の科学 遺伝2017

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] がん免疫細胞療法のT細胞評価を可能とするチップ技術の開発2023

Author(s)

Journal Title

Data Source

[Journal Article] がん免疫細胞療法のT細胞評価を可能とするチップ技術の開発2023

Author(s)

Journal Title

Data Source

[Journal Article] iPS細胞を用いた３次元がんチップの開発2022

Author(s)

Journal Title

Data Source

[Journal Article] iPS細胞を用いた３次元がんチップの開発2022

Author(s)

Journal Title

Data Source

[Journal Article] Suppression of multiple anti‐apoptotic BCL2 family proteins recapitulates the effects of JAK2 inhibitors in JAK2V617F driven myeloproliferative neoplasms2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Generation of GM-CSF-producing antigen-presenting cells that induce a cytotoxic T cell-mediated antitumor response.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Developing thymus-on-a-chip and cancer-on-a-chip for cancer immunotherapy2019

Author(s)

Mishima Yuta 三嶋雄太

[Book] 生物の科学　遺伝2017