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Mishima Yuta  三嶋 雄太

Researcher Number 80770263
Other IDs
  • ORCIDhttps://orcid.org/0000-0003-4945-7346
Affiliation (Current) 2025: 筑波大学, 医学医療系, 助教
Affiliation (based on the past Project Information) *help 2020 – 2023: 筑波大学, 医学医療系, 助教
2016 – 2019: 京都大学, iPS細胞研究所, 特定研究員
2017 – 2018: 京都大学, iPS細胞研究所, 特別研究員(PD)
2016: 京都大学, IPS細胞研究所, 特別研究員(PD)
Review Section/Research Field
Principal Investigator
Tumor therapeutics / Basic Section 90110:Biomedical engineering-related / Basic Section 50020:Tumor diagnostics and therapeutics-related
Except Principal Investigator
Biomedical engineering/Biomaterial science and engineering / Basic Section 90110:Biomedical engineering-related
Keywords
Principal Investigator
iPS細胞 / 遺伝子治療 / Cancer Immunotherapy / 再生医療 / CAR-T細胞 / AI画像解析 / マイクロ流体デバイス / TCR / CAR / CD8T細胞 … More / TCR-T療法 / CAR-T療法 / CTL / 腫瘍免疫 / 免疫治療 / Tancer-on-a-chip / CAR-T cell / ユニバーサルiPS細胞 / 免疫細胞 / 血管内皮細胞 / Cancer-on-a-chip / MPS / immunotherapy / Microdevice / CAR-T therapy / iPS cell / Immunotherapy / がん免疫 / Tumor-on-a-chip / 再生T細胞 / がん免疫細胞療法 / 免疫細胞分化 / CAT-T細胞治療 / IPS細胞 / がん免疫治療 … More
Except Principal Investigator
免疫学 / 再生医学 / organ-on-a-chip / iPS細胞 / 癌 / がんオルガノイド / がん免疫 / がん評価モデル / マイクロ・ナノデバイス / マイクロデバイス / 3次元培養 / 血管 / マイクロ流体デバイス / Organ-on-a-chip / 3次元培養 / 組織培養 / がんモデル / がんの評価モデル / がん免疫細胞療法 / 3次元培養法 / バイオテクノロジー / システムオンチップ / 生体模倣 / T細胞 / 胸腺 Less
  • Research Projects

    (6 results)
  • Research Products

    (30 results)
  • Co-Researchers

    (6 People)
  •  Development and demonstration of a patient tissue-derived 3D tumor-on-a-chip for evaluation of T cell function in cancer immunotherapyPrincipal Investigator

    • Principal Investigator
      三嶋 雄太
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 90110:Biomedical engineering-related
    • Research Institution
      University of Tsukuba
  •  Development of the killing function of iPSC derived CAR-T cell for solid tumor.Principal Investigator

    • Principal Investigator
      Mishima Yuta
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      University of Tsukuba
  •  Development of a 3D tumor-on-a-chip platform for cancer immunotherapy

    • Principal Investigator
      鳥澤 勇介
    • Project Period (FY)
      2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 90110:Biomedical engineering-related
    • Research Institution
      Kyoto University
  •  Development of patient-derived cancer on-a-chip devices for cancer immunotherapy

    • Principal Investigator
      Torisawa Yu-suke
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biomedical engineering/Biomaterial science and engineering
    • Research Institution
      Kyoto University
  •  Development of a microfluidic device to mimic the function of the thymus for immunotherapy

    • Principal Investigator
      Torisawa Yu-suke
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Biomedical engineering/Biomaterial science and engineering
    • Research Institution
      Kyoto University
  •  iPS細胞由来再生T細胞とがん特異抗原レセプター遺伝子導入による免疫療法の開発Principal Investigator

    • Principal Investigator
      三嶋 雄太
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for JSPS Fellows
    • Research Field
      Tumor therapeutics
    • Research Institution
      Kyoto University

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Book Patent

  • [Book] 生物の科学 遺伝2017

    • Author(s)
      三嶋雄太、金子新
    • Total Pages
      104
    • Publisher
      株式会社エヌ・ディー・エス
    • ISBN
      9784860434878
    • Data Source
      KAKENHI-PROJECT-16J09729
  • [Journal Article] がん免疫細胞療法のT細胞評価を可能とするチップ技術の開発2023

    • Author(s)
      三嶋雄太
    • Journal Title

      真の実臨床応用をめざした再生医療2023

      Volume: 41巻2号 Pages: 94-100

    • Data Source
      KAKENHI-PROJECT-20K16439
  • [Journal Article] がん免疫細胞療法のT細胞評価を可能とするチップ技術の開発2023

    • Author(s)
      三嶋雄太
    • Journal Title

      真の実臨床応用をめざした再生医療2023

      Volume: 41巻2号 Pages: 94-100

    • Data Source
      KAKENHI-PROJECT-22K12778
  • [Journal Article] iPS細胞を用いた3次元がんチップの開発2022

    • Author(s)
      三嶋雄太
    • Journal Title

      Medical Science Digest

      Volume: 48巻13号 Pages: 51-53

    • Data Source
      KAKENHI-PROJECT-20K16439
  • [Journal Article] iPS細胞を用いた3次元がんチップの開発2022

    • Author(s)
      三嶋雄太
    • Journal Title

      Medical Science Digest

      Volume: 48巻13号 Pages: 51-53

    • Data Source
      KAKENHI-PROJECT-22K12778
  • [Journal Article] Suppression of multiple anti‐apoptotic BCL2 family proteins recapitulates the effects of JAK2 inhibitors in JAK2V617F driven myeloproliferative neoplasms2021

    • Author(s)
      Takei Hisashi、Coelho‐Silva Juan Luiz、Tavares Leal Cristina、Queiroz Arantes Rocha Adriana、Mantello Bianco Thiago、Welner Robert S.、Mishima Yuta、Kobayashi Ikei S.、Mullally Ann、Lima Keli、Machado‐Neto Joao Agostinho、Kobayashi Susumu S.、Lobo de Figueiredo‐Pontes Lorena
    • Journal Title

      Cancer Science

      Volume: 113 Issue: 2 Pages: 597-608

    • DOI

      10.1111/cas.15210

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K16439
  • [Journal Article] A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy2021

    • Author(s)
      Iriguchi Shoichi、Yasui Yutaka、Kawai Yohei、Arima Suguru、Kunitomo Mihoko、Sato Takayuki、Ueda Tatsuki、Minagawa Atsutaka、Mishima Yuta、Yanagawa Nariaki、Baba Yuji、Miyake Yasuyuki、Nakayama Kazuhide、Takiguchi Maiko、Shinohara Tokuyuki、Nakatsura Tetsuya、Yasukawa Masaki、Kassai Yoshiaki、Hayashi Akira、Kaneko Shin
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 430-430

    • DOI

      10.1038/s41467-020-20658-3

    • NAID

      120006954089

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K16439, KAKENHI-PROJECT-18H02839, KAKENHI-PROJECT-19K16688, KAKENHI-PROJECT-18H02641
  • [Journal Article] Generation of GM-CSF-producing antigen-presenting cells that induce a cytotoxic T cell-mediated antitumor response.2020

    • Author(s)
      Mashima H, Zhang R, Kobayashi T, Hagiya Y, Tsukamoto H, Liu T, Iwama T, Yamamoto M, Lin C, Nakatsuka R, Mishima Y, Watanabe N, Yamada T, Senju S, Kaneko S, Idiris A, Nakatsura T, Ohdan H, Uemura Y.
    • Journal Title

      Oncoimmunology

      Volume: 9(1) Issue: 1 Pages: 1814620-1814620

    • DOI

      10.1080/2162402x.2020.1814620

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K09186, KAKENHI-PROJECT-20K16439, KAKENHI-PROJECT-18K07325
  • [Journal Article] Developing thymus-on-a-chip and cancer-on-a-chip for cancer immunotherapy2019

    • Author(s)
      Torisawa Y, Mishima Y, Kaneko S
    • Journal Title

      Impact

      Volume: 2019 Issue: 2 Pages: 33-35

    • DOI

      10.21820/23987073.2019.2.33

    • Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H02082, KAKENHI-PROJECT-16J09729
  • [Patent] Hematopoietic progenitor cell marker2018

    • Inventor(s)
      金子新、入口翔一、三嶋雄太、葛西義明、林哲、有馬寿来留
    • Industrial Property Rights Holder
      金子新、入口翔一、三嶋雄太、葛西義明、林哲、有馬寿来留
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Overseas
    • Data Source
      KAKENHI-PROJECT-16J09729
  • [Patent] 造血前駆細胞マーカー2017

    • Inventor(s)
      金子新、入口翔一、三嶋雄太、葛西義明、林哲、有馬寿来留
    • Industrial Property Rights Holder
      国立大学法人京都大学、武田薬品工業株式会社
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Data Source
      KAKENHI-PROJECT-16J09729
  • [Presentation] Modeling of Tumor-on-a-Chip using HLA edited iPS cell-derived vascular endothelial cells for cancer immune cell therapy2021

    • Author(s)
      ○Yuta Mishima, Shin Kaneko and Yu-suke Torisawa
    • Organizer
      第80回 日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-20K16439
  • [Presentation] がん免疫細胞療法の評価を目的としてiPS細胞由来血管内皮細胞を用いたTumor-on-a-Chipの開発2021

    • Author(s)
      ○三嶋 雄太、早稲田 真澄、高久保 瞳、森 千寿、佐野 絵美、王 博、上田 樹、金子 新、鳥澤 勇介
    • Organizer
      第20回 日本再生医療学会総会
    • Data Source
      KAKENHI-PROJECT-20K16439
  • [Presentation] 免疫細胞療法の評価を目的としてiPS細胞由来血管内皮細胞を用いた Tumor-on-a-Chipの開発2020

    • Author(s)
      三嶋雄太
    • Organizer
      患者由来がんモデル講演会 2020
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H04502
  • [Presentation] MODELING CANCER IMMUNOTHERAPY IN A PERFUSABLE 3D VASCULARIZED TUMOR-ON-A-CHIP USING HLA-KO UNIVERSAL HUMAN IPSC-DERIVED ENDOTHELIAL CELLS2020

    • Author(s)
      ○Yuta Mishima, Masazumi Waseda, Hitomi Takakubo, Chihiro Mori, Emi Sano, Wang Bo, Tatsuki Ueda, Shoichi Iriguchi, Yuka Ozaki, Shin Kaneko, Yu-suke Torisawa
    • Organizer
      ISSCR 2020 Virtual
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K16439
  • [Presentation] MODELING CANCER IMMUNOTHERAPY IN A PERFUSABLE 3D VASCULARIZED TUMOR-ON-A-CHIP USING HLA-KO UNIVERSAL HUMAN IPSC-DERIVED ENDOTHELIAL CELLS2020

    • Author(s)
      Yuta Mishima, Masazumi Waseda, Hitomi Takakubo, Chihiro Mori, Emi Sano, Wang Bo, Tatsuki Ueda, Shoichi Iriguchi, Yuka Ozaki, Shin Kaneko and Yu-suke Torisawa
    • Organizer
      2020 International Society of Stem Cell Research Annual meeting,
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H04502
  • [Presentation] Engineering of Perfusable 3D Vascularized Tumor-on-a-Chip Using hiPSC-derived Endothelial cells.2019

    • Author(s)
      三嶋雄太、早稲田真澄、高久保瞳、王博、佐野絵美、森千尋、金子新、鳥澤勇介
    • Organizer
      第18回 日本再生医療学会総会
    • Data Source
      KAKENHI-PROJECT-16J09729
  • [Presentation] iPS細胞とレギュラトリーサイエンス2019

    • Author(s)
      三嶋雄太
    • Organizer
      順天堂大学医療の経済学 第10回授業
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H02082
  • [Presentation] Engineering of Perfusable 3D Vascularized Tumor-on-a-Chip Using hiPSC-derived Endothelial cells2019

    • Author(s)
      三嶋雄太、早稲田真澄、高久保瞳、王博、佐野絵美、森千尋、金子新、鳥澤勇介
    • Organizer
      第18回日本再生医療学会総会
    • Data Source
      KAKENHI-PROJECT-17H02082
  • [Presentation] Microfluidic Tissue Engineering of a 3D Vascularized Tissue-on-a-Chip using Human iPSC-derived Cells to Study Cancer Immunotherapy2018

    • Author(s)
      Yu-suke Torisawa, Yuta Mishima, Emi Sano, Masazumi Waseda, Hitomi Takakubo, Chihiro Mori, Shoichi Iriguchi, Shin Kaneko
    • Organizer
      5th Tissue Engineering and Regenerative Medicine International Society World Congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K12874
  • [Presentation] Microfluidic Tissue Engineering of a 3D Vascularized Tissue-on-a-Chip using Human iPSC-derived Cells to Study Cancer Immunotherapy.2018

    • Author(s)
      Yu-suke Torisawa, Yuta Mishima, Emi Sano, Masazumi Waseda, Hitomi Takakubo, Chihiro Mori, Shoichi Iriguchi, Shin Kaneko.
    • Organizer
      5th TERMIS World Congress, Tissue Engineering and Regenerative Medicine International Society
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16J09729
  • [Presentation] Microfluidic Tissue Engineering of a 3D Vascularized Tissue-on-a-Chip using Human iPSC-derived Cells to Study Cancer Immunotherapy2018

    • Author(s)
      Yu-suke Torisawa, Yuta Mishima, Emi Sano, Masazumi Waseda, Hitomi Takakubo, Chihiro Mori, Shoichi Iriguchi, Shin Kaneko
    • Organizer
      5th Tissue Engineering and Regenerative Medicine International Society World Congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H02082
  • [Presentation] Development of a 3D vascularized cancer-on-a-chip platform using hiPSC-derived endothelial cells2018

    • Author(s)
      Torisawa Y, Mishima Y, Sano E, Mori C, Takakubo H, Kaneko S
    • Organizer
      EMBS Micro and Nanotechnology in Medicine Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H02082
  • [Presentation] Engineering of a 3D Vascularized Tissue-on-a-Chip using Human iPSC-derived Cells2018

    • Author(s)
      Torisawa Y, Mishima Y, Sano E, Takakubo H, Mori C, Kaneko S
    • Organizer
      22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H02082
  • [Presentation] Characterization of human iPSC-derived CD8αβ positive T cells with tumor-specific cytotoxicity.2018

    • Author(s)
      Takayuki Sato,Atsutaka,Minagawa,Shoichi Iriguchi,Yohei Kawai,Yutaka Yasui,Yuta Mishima,Mihoko Kunitomo,Tokuyuki Shinohara,Kazuhide Nakayama,Masashi Yamada,Suguru Arima,Maiko Takiguchi,Yuumi Okuzono,Toshiaki Yoshikawa,Toshihiro Suzuki,Tetsuya Nakatsura,Masaaki Yasukawa,Yoshiaki Kassai,Akira Hayashi,Shin Kaneko
    • Organizer
      第22回日本がん免疫学会総会
    • Data Source
      KAKENHI-PROJECT-16J09729
  • [Presentation] Generation and characterization of hPSC-derived CD8αβ positive T cells with tumor-specific cytotoxicity for "off the shelf" cancer immunotherapy.2018

    • Author(s)
      Yoshiaki Kassai,Atsutaka Minagawa,Shoichi Iriguchi,Yohei Kawai,Yutaka Yasui,Yuta Mishima,Mihoko Kunitomo,Tokuyuki Shinohara,Takayuki Sato,Kazuhide Nakayama,Masashi Yamada,Suguru Arima,Maiko Takiguchi,Yuumi Okuzono,Toshiaki Yoshikawa,Toshihiro Suzuki,Tetsuya Nakatsura,Masaki Yasukawa,Akira Hayashi,Shin Kaneko
    • Organizer
      ISSCR 2018 Annual Meeting, International Society for Stem Cell Research
    • Data Source
      KAKENHI-PROJECT-16J09729
  • [Presentation] Microfluidic Tissue Engineering of a 3D Vascularized Tissue-on-a-Chip using Human iPSC-derived Cells to Study Cancer Immunotherapy2018

    • Author(s)
      Torisawa Y, Mishima Y, Sano E, Waseda M, Takakubo H, Mori C, Iriguchi S, Kaneko S
    • Organizer
      5th Tissue Engineering and Regenerative Medicine International Society World Congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H02082
  • [Presentation] MICROFLUIDIC TISSUE ENGINEERING OF PERFUSABLE 3D VASCULAR NETWORKS ON A CHIP USING HUMAN IPS CELLS2017

    • Author(s)
      Yuta Mishima, Masazumi Waseda, Emi Sano, Shoichi Iriguchi, Yutaka Yasui, Shin Kaneko, Yu-suke Torisawa
    • Organizer
      International Society for Stem Cell Research 2017 Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K12874
  • [Presentation] MICROFLUIDIC TISSUE ENGINEERING OF PERFUSABLE 3D VASCULAR NETWORKS ON A CHIP USING HUMAN IPS CELLS2017

    • Author(s)
      Yuta Mishima, Masazumi Waseda, Emi Sano, Shoichi Iriguchi, Yutaka Yasui, Shin Kaneko, Yu-suke Torisawa
    • Organizer
      International Society for Stem Cell Research 2017 Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H02082
  • [Presentation] MICROFLUIDIC TISSUE ENGINEERING OF PERFUSABLE 3D VASCULAR NETWORKS ON A CHIP USING HUMAN IPS CELLS.2017

    • Author(s)
      三嶋雄太
    • Organizer
      ISSCR(国際幹細胞学会)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16J09729
  • 1.  Torisawa Yu-suke (10767354)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 10 results
  • 2.  金子 新 (40361331)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 10 results
  • 3.  井上 匡美 (10379232)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  高山 浩一 (50274444)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  植村 靖史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  張 エイ
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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