Okabe Atsushi 岡部篤史

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OKABE Atsushi 岡部篤史

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Researcher Number	80778118
Other IDs	https://orcid.org/0000-0001-7748-6078
Affiliation (Current)	2025: 千葉大学, 健康疾患オミクスセンター, 特任准教授
Affiliation (based on the past Project Information) *help	2023 – 2025: 千葉大学, 健康疾患オミクスセンター, 特任准教授 2019 – 2023: 千葉大学, 大学院医学研究院, 助教 2019: 千葉大学, 医学(系)研究科(研究院), 助教 2015: 千葉大学, 医学研究院, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 43050:Genome biology-related Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 47050:Environmental and natural pharmaceutical resources-related / Digestive surgery
Keywords	Principal Investigator 胃癌 / クロマチン構造 / Epstein-Barrウイルス / Chromatin structure / エピゲノム / Epstein-Barr Virus / Epigenetics / Heterochromatin / Epstein-Barr vius / 発癌 … More / Gastric cancer / Histone modification / Epigenome / EBV … More Except Principal Investigator エピゲノム / ヒストン修飾 / 転写因子 / 肝芽腫 / HDAC / 抗癌小分子化合物 / 抗がん作用 / Motif解析 / H3K27ac / c-Myc / トランスクリプトーム / 白血病細胞株 / 天然化合物 / transcriptome / Cinobufagin / 生薬 / 抗癌 / 白血病 / 和漢薬 Less

ウイルスタンパク質EBNA1によるヘテロクロマチン異常活性化機構の解明Principal Investigator
- Principal Investigator
  
  岡部篤史
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  Chiba University
網羅的エピゲノム解析とゲノム編集技術を用いた肝芽腫の新規治療候補遺伝子の同定
- Principal Investigator
  
  工藤渉
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Chiba University
癌ウイルスによるクロマチン構造破綻が誘導する新規発癌機構の解明Principal Investigator
- Principal Investigator
  
  岡部篤史
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  Chiba University
胃癌におけるクロマチン構造異常による癌化機構の解明Principal Investigator
- Principal Investigator
  
  岡部篤史
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  Chiba University
Searching for novel anticancer epigenetic drugs from Kampo medicines followed by elucidation of the mechanism through transcriptomic analyses.
- Principal Investigator
  
  Hirasaki Yoshiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Chiba University
Analysis of epigenetic aberrations induced by oncovirus infectionPrincipal Investigator
- Principal Investigator
  
  Okabe Atsushi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  Chiba University
Analysis on alterated chromatin status of viral genome in the host cells.
- Principal Investigator
  
  Kaneda Atsushi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Chiba University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Aberrant Upregulation of RUNX3 Activates Developmental Genes to Drive Metastasis in Gastric Cancer2024
- Author(s)
  Suda Kazuto、Okabe Atsushi、Matsuo Junichi、Chuang Linda Shyue Huey、Li Ying、Jangphattananont Nawaphat、Mon Naing Naing、Myint Khine Nyein、Yamamura Akihiro、So Jimmy Bok-Yan、Voon Dominic Chih-Cheng、Yang Henry、Yeoh Khay Guan、Kaneda Atsushi、Ito Yoshiaki
- Journal Title
  
  Cancer Research Communications
  
  Volume: 4 Issue: 2 Pages: 279-292
- DOI
  10.1158/2767-9764.crc-22-0165
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0415, KAKENHI-PROJECT-22K19553, KAKENHI-PROJECT-23K23859
[Journal Article] Enhancer infestation drives tumorigenic activation of inactive B compartment in Epstein-Barr virus-positive nasopharyngeal carcinoma2024
- Author(s)
  Mizokami Harue、Okabe Atsushi、Choudhary Ruchi、Mima Masato、Saeda Kenta、Fukuyo Masaki、Rahmutulla Bahityar、Seki Motoaki、Goh Boon-Cher、Kondo Satoru、Dochi Hirotomo、Moriyama-Kita Makiko、Misawa Kiyoshi、Hanazawa Toyoyuki、Tan Patrick、Yoshizaki Tomokazu、Fullwood Melissa Jane、Kaneda Atsushi
- Journal Title
  
  eBioMedicine
  
  Volume: 102 Pages: 105057-105057
- DOI
  10.1016/j.ebiom.2024.105057
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0415, KAKENHI-PROJECT-22K07164, KAKENHI-PROJECT-21K07934, KAKENHI-PROJECT-22K19553, KAKENHI-PROJECT-23K23859
[Journal Article] Chromatin activation with H3K36me2 and compartment shift in metastatic castration-resistant prostate cancer2024
- Author(s)
  Kanaoka Sanji、Okabe Atsushi、Kanesaka Manato、Rahmutulla Bahityar、Fukuyo Masaki、Seki Motoaki、Hoshii Takayuki、Sato Hiroaki、Imamura Yusuke、Sakamoto Shinichi、Ichikawa Tomohiko、Kaneda Atsushi
- Journal Title
  
  Cancer Letters
  
  Volume: 588 Pages: 216815-216815
- DOI
  10.1016/j.canlet.2024.216815
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K15757, KAKENHI-PROJECT-19KK0415, KAKENHI-PROJECT-22K07164, KAKENHI-PROJECT-22K19553, KAKENHI-PROJECT-21K16727, KAKENHI-PROJECT-23K23859
[Journal Article] Tumorigenic activation around <scp>HPV</scp> integrated sites in head and neck squamous cell carcinoma2023
- Author(s)
  Mima Masato、Okabe Atsushi、Hoshii Takayuki、Nakagawa Takuya、Kurokawa Tomoya、Kondo Satoru、Mizokami Harue、Fukuyo Masaki、Fujiki Ryoji、Rahmutulla Bahityar、Yoshizaki Tomokazu、Hanazawa Toyoyuki、Misawa Kiyoshi、Kaneda Atsushi
- Journal Title
  
  International Journal of Cancer
  
  Volume: 152 Issue: 9 Pages: 1847-1862
- DOI
  10.1002/ijc.34439
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07164, KAKENHI-PROJECT-22K19553, KAKENHI-PROJECT-19KK0415, KAKENHI-PROJECT-20K18271, KAKENHI-PROJECT-23K23859, KAKENHI-PROJECT-20K09689, KAKENHI-PROJECT-21K19557, KAKENHI-PROJECT-23K27744
[Journal Article] The Link of mRNA and rRNA Transcription by PUF60/FIR through TFIIH/P62 as a Novel Therapeutic Target for Cancer2023
- Author(s)
  Kitamura Kouichi、Hoshino Tyuji、Okabe Atsushi、Fukuyo Masaki、Rahmutulla Bahityar、Tanaka Nobuko、Kobayashi Sohei、Tanaka Tomoaki、Shida Takashi、Ueda Mashiro、Minamoto Toshinari、Matsubara Hisahiro、Kaneda Atsushi、Ishii Hideshi、Matsushita Kazuyuki
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 24 Pages: 17341-17341
- DOI
  10.3390/ijms242417341
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K17429, KAKENHI-PROJECT-21K15599, KAKENHI-PROJECT-19KK0415, KAKENHI-PROJECT-22K07164, KAKENHI-PROJECT-23K06618, KAKENHI-PROJECT-23K06712, KAKENHI-PROJECT-20K07336, KAKENHI-PROJECT-21K19526, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-20H00541, KAKENHI-PROJECT-23K23859
[Journal Article] Comprehensive molecular phenotyping of<i>ARID1A</i>-deficient gastric cancer reveals pervasive epigenomic reprogramming and therapeutic opportunities2023
- Author(s)
  Xu Chang、Huang Kie Kyon、Law Jia Hao、Chua Joy Shijia、Sheng Taotao、Flores Natasha M、Pizzi Melissa Pool、Okabe Atsushi、Kaneda Atsushi、Prabhakar Shyam、Mazur Pawel Karol、Ajani Jaffer A、Yeoh Khay Guan、So Jimmy Bok-Yan、Tan Patrick
- Journal Title
  
  Gut
  
  Volume: 0 Issue: 9 Pages: 1-13
- DOI
  10.1136/gutjnl-2022-328332
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0415, KAKENHI-PROJECT-23K23859
[Journal Article] Hi-C analysis to identify genome-wide chromatin structural aberration in cancer.2023
- Author(s)
  Okabe A, Kaneda A.
- Journal Title
  
  Methods Mol Biol
  
  Volume: 2519 Pages: 127-140
- DOI
  10.1007/978-1-0716-2433-3_15
- ISBN
  9781071624326, 9781071624333
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19553, KAKENHI-PROJECT-19KK0415, KAKENHI-PROJECT-23K23859
[Journal Article] Oncofetal protein IGF2BP1 regulates IQGAP3 expression to maintain stem cell potential in cancer2022
- Author(s)
  Myint Khine、Chuang Linda Shyue Huey、Teh Yu Xuan、Mawan Nur Astiana、Shi Edward Jizhong、Mok Michelle Meng Huang、Nuttonmanit Napat、Matsuo Junichi、Li Ying、Yang Henry、Okabe Atsushi、Kaneda Atsushi、Osato Motomi、So Jimmy Bok-Yan、Yong Wei Peng、Tan Patrick、Yeoh Khay Guan、Ito Yoshiaki
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 10 Pages: 105194-105194
- DOI
  10.1016/j.isci.2022.105194
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0415, KAKENHI-PROJECT-19K07668, KAKENHI-PROJECT-23K23859, KAKENHI-PROJECT-23K24165
[Journal Article] ARID1A loss-of-function induces CpG island methylator phenotype2022
- Author(s)
  Yamada Harumi、Takeshima Hideyuki、Fujiki Ryoji、Yamashita Satoshi、Sekine Shigeki、Ando Takayuki、Hattori Naoko、Okabe Atsushi、Yoshikawa Takaki、Obama Kazutaka、Katai Hitoshi、Kaneda Atsushi、Ushijima Toshikazu
- Journal Title
  
  Cancer Letters
  
  Volume: 532 Pages: 215587-215587
- DOI
  10.1016/j.canlet.2022.215587
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08456, KAKENHI-PROJECT-19H03726, KAKENHI-PROJECT-19KK0415, KAKENHI-PROJECT-21K15525
[Journal Article] 胃癌とエピジェネティクス異常2022
- Author(s)
  岡部篤史、金田篤志
- Journal Title
  
  病理と臨床
  
  Volume: 40 Pages: 19-25
- Data Source
  KAKENHI-PROJECT-19KK0415
[Journal Article] 胃癌とエピジェネティクス異常2022
- Author(s)
  岡部篤史、金田篤志
- Journal Title
  
  病理と臨床
  
  Volume: 40 Pages: 116-122
- Data Source
  KAKENHI-PROJECT-23K23859
[Journal Article] [Chiba Medical Society Young Investigator Award Minireview] Epigenetic contribution to tumorigenesis of host cells by Epstein-Barr virus infection2022
- Author(s)
  Fujii T, Okabe A, Kaneda A
- Journal Title
  
  Chiba medical journal
  
  Volume: 98E Issue: 1 Pages: 1-7
- DOI
  10.20776/S03035476-98E-1-P1
- NAID
  120007193772
- URL
  https://opac.ll.chiba-u.jp/da/curator/900120227/
- Year and Date
  2022-02-10
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21625, KAKENHI-PROJECT-22K19553, KAKENHI-PROJECT-19KK0415, KAKENHI-PROJECT-23K23859
[Journal Article] Repression of DERL3 via DNA methylation by Epstein-Barr virus latent membrane protein 1 in nasopharyngeal carcinoma2022
- Author(s)
  Kondo S, Okabe A, Nakagawa T, Matsusaka K, Fukuyo M, Rahmutulla B, Dochi H, Mizokami H, Kitagawa Y, Kurokawa T, Mima M, Endo K, Sugimoto H, Wakisaka N, Misawa K, Yoshizaki T, Kaneda A.
- Journal Title
  
  Biochimica et Biophysica Acta - Molecular Basis of Disease
  
  Volume: 1869(2) Issue: 2 Pages: 166598-166598
- DOI
  10.1016/j.bbadis.2022.166598
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09689, KAKENHI-PROJECT-21K09627, KAKENHI-PROJECT-22K06936, KAKENHI-PROJECT-22K07164, KAKENHI-PROJECT-20K21648, KAKENHI-PROJECT-22K19553, KAKENHI-PROJECT-19KK0415, KAKENHI-PROJECT-23K21477, KAKENHI-PROJECT-23K23859
[Journal Article] Cinobufagin inhibits proliferation of acute myeloid leukaemia cells by repressing c-Myc pathway-associated genes2022
- Author(s)
  Hirasaki Yoshiro、Okabe Atsushi、Fukuyo Masaki、Rahmutulla Bahityar、Mano Yasunobu、Seki Motoaki、Hoshii Takayuki、Namiki Takao、Kaneda Atsushi
- Journal Title
  
  Chemico-Biological Interactions
  
  Volume: 360 Pages: 109936-109936
- DOI
  10.1016/j.cbi.2022.109936
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07934, KAKENHI-PROJECT-22K07164, KAKENHI-PROJECT-19KK0415, KAKENHI-PROJECT-20K07096, KAKENHI-PROJECT-23K23859
[Journal Article] Chromatin Rewiring by Mismatch Repair Protein MSH2 Alters Cell Adhesion Pathways and Sensitivity to BET Inhibition in Gastric Cancer2022
- Author(s)
  Nargund Amrita M.、Xu Chang、Mandoli Amit、Okabe Atsushi、Fullwood Melissa J.、Teh Bin Tean、Bi Xuezhi、Kaneda Atsushi、Li Shang、Tan Patrick
- Journal Title
  
  Cancer Research
  
  Volume: 82 Issue: 14 Pages: 2538-2551
- DOI
  10.1158/0008-5472.can-21-2072
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0415, KAKENHI-PROJECT-23K23859
[Journal Article] An integrative transcriptional logic model of hepatic insulin resistance2021
- Author(s)
  Kitamoto Takumi、Kuo Taiyi、Okabe Atsushi、Kaneda Atsushi、Accili Domenico
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 118 Issue: 45
- DOI
  10.1073/pnas.2102222118
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0415
[Journal Article] TET1 upregulation drives cancer cell growth through aberrant enhancer hydroxymethylation of HMGA2 in hepatocellular carcinoma.2021
- Author(s)
  Shirai K, Nagae G, Seki M, Kudo Y, Kamio A, Hayashi A, Okabe A, Ota S, Tsutsumi S, Fujita T, Yamamoto S, Nakaki R, Kanki Y, Osawa T, Midorikawa Y, Tateishi K, Ichinose M, Aburatani H.
- Journal Title
  
  Cancer Sci.
  
  Volume: 112 Issue: 7 Pages: 2855-2869
- DOI
  10.1111/cas.14897
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-19H05744, KAKENHI-PUBLICLY-20H04834, KAKENHI-PROJECT-19H01031, KAKENHI-PROJECT-19H03496, KAKENHI-PROJECT-20H03432, KAKENHI-PROJECT-21K07934, KAKENHI-PROJECT-21K19399, KAKENHI-PROJECT-19KK0415, KAKENHI-PROJECT-23K21431
[Journal Article] Activation of EHF via STAT3 phosphorylation by LMP2A in Epstein‐Barr virus‐positive gastric cancer2021
- Author(s)
  Li Wenzhe、Okabe Atsushi、Usui Genki、Fukuyo Masaki、Matsusaka Keisuke、Rahmutulla Bahityar、Mano Yasunobu、Hoshii Takayuki、Funata Sayaka、Hiura Nobuhiro、Fukayama Masashi、Tan Patrick、Ushiku Tetsuo、Kaneda Atsushi
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 8 Pages: 3349-3362
- DOI
  10.1111/cas.14978
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07457, KAKENHI-PROJECT-19K16707, KAKENHI-PROJECT-19H03726, KAKENHI-PROJECT-19KK0415, KAKENHI-PROJECT-19H03690
[Journal Article] Transcriptional dysregulation by aberrant enhancer activation and rewiring in cancer2021
- Author(s)
  Okabe Atsushi、Kaneda Atsushi
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 6 Pages: 2081-2088
- DOI
  10.1111/cas.14884
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03726, KAKENHI-PROJECT-19KK0415
[Journal Article] Cross-species chromatin interactions drive transcriptional rewiring in Epstein-Barr virus-positive gastric adenocarcinoma2020
- Author(s)
  Okabe Atsushi, Huang Kie Kyon, Matsusaka Keisuke, Fukuyo Masaki, Xing Manjie, Ong Xuewen, Hoshii Takayuki, Usui Genki, Seki Motoaki, Mano Yasunobu, Rahmutulla Bahityar, Kanda Teru, Suzuki Takayoshi, Rha Sun Young, Ushiku Tetsuo, Fukayama Masashi, Tan Patrick, Kaneda Atsushi
- Journal Title
  
  Nature Genetics
  
  Volume: 52 Issue: 9 Pages: 919-930
- DOI
  10.1038/s41588-020-0665-7
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07457, KAKENHI-PROJECT-19K09184, KAKENHI-PROJECT-19K16707, KAKENHI-PROJECT-19KK0415, KAKENHI-PROJECT-19H01079, KAKENHI-PROJECT-19H03690, KAKENHI-PROJECT-19H03726, KAKENHI-PROJECT-18J00861, KAKENHI-PROJECT-18K06983, KAKENHI-PROJECT-19K22399, KAKENHI-PROJECT-19K16101
[Journal Article] Epstein‐Barr virus positive gastric cancer involves enhancer activation through ATF32020
- Author(s)
  Asakawa Yuta、Okabe Atsushi、Fukuyo Masaki、Li Wenzhe、Ikeda Eriko、Mano Yasunobu、Funata Sayaka、Namba Hiroe、Fujii Takahiro、Kita Kazuko、Matsusaka Keisuke、Kaneda Atsushi
- Journal Title
  
  Cancer Science
  
  Volume: 00 Issue: 5 Pages: 1-11
- DOI
  10.1111/cas.14370
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16707, KAKENHI-PROJECT-19H03726, KAKENHI-PROJECT-18J00861, KAKENHI-PROJECT-19K07457, KAKENHI-PROJECT-19KK0415, KAKENHI-PROJECT-19K16101
[Presentation] Chromatin structural alteration induced by oncovirus infection aberrantly activate transcriptional regulation2023
- Author(s)
  Atsushi Okabe, Takahiro Fujii, Harue Mizokami, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla, Patrick Tan, Hironori Yoshiyama, Atsushi Kaneda
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19KK0415
[Presentation] Chromatin structural aberrations induced by oncovirus infection2023
- Author(s)
  岡部篤史
- Organizer
  第82回日本癌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-19KK0415
[Presentation] 統合解析による肝芽腫の生存・増殖に重要な転写因子の同定2023
- Author(s)
  工藤渉, 星居孝之, 関元昭, 岡部篤史, 福世真樹,バハテヤリラヒムトラ, 菱木知郎,金田篤志
- Organizer
  第65回日本小児血液・がん学会
- Data Source
  KAKENHI-PROJECT-23K07245
[Presentation] The virus-host genomic interactions drive heterochromatin disruption and oncogenic activation of enhancers2023
- Author(s)
  Atsushi Okabe, Takahiro Fujii, Harue Mizokami, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla, Patrick Tan, Hironori Yoshiyama, Atsushi Kaneda
- Organizer
  第16回エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-19KK0415
[Presentation] 癌ウイルス感染が誘導するクロマチン構造異常2023
- Author(s)
  岡部篤史, 藤井貴大、溝上晴恵、松坂恵介、福世真樹、Bhityar Rahmutulla、Patrick Tan、金田篤志
- Organizer
  第34回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-19KK0415
[Presentation] The virus-host genomic interactions drive heterochromatin disruption and oncogenic activation of enhancers2023
- Author(s)
  Atsushi Okabe, Takahiro Fujii, Harue Mizokami, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla, Patrick Tan, Hironori Yoshiyama, Atsushi Kaneda
- Organizer
  第16回エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-23K23859
[Presentation] Identifying key transcription factors to survival and growth in hepatoblastoma by integrated analysis2023
- Author(s)
  工藤渉, 星居孝之, 関元昭, 岡部篤史, 福世真樹,バハテヤリラヒムトラ, 菱木知郎,金田篤志
- Organizer
  第82回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-23K07245
[Presentation] Chromatin structural aberrations induced by oncovirus infection2023
- Author(s)
  岡部篤史
- Organizer
  第82回日本癌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-23K23859
[Presentation] 癌ウイルス感染が誘導するクロマチン構造異常2023
- Author(s)
  岡部篤史, 藤井貴大、溝上晴恵、松坂恵介、福世真樹、Bhityar Rahmutulla、Patrick Tan、金田篤志
- Organizer
  第34回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-23K23859
[Presentation] Chromatin structural alteration induced by oncovirus infection aberrantly activate transcriptional regulation2023
- Author(s)
  Atsushi Okabe, Takahiro Fujii, Harue Mizokami, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla, Patrick Tan, Hironori Yoshiyama, Atsushi Kaneda
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K23859
[Presentation] Analysis of chromatin structural aberrations induced by oncovirus infection2022
- Author(s)
  Atsushi Okabe, Takahiro Fujii, Masaki Fukuyo, Bahityar Rahmutulla, Hironori Yoshiyama, Patrick Tan, Atsushi Kaneda
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K23859
[Presentation] Oncovirus infection induces 3D chromatin structural aberrations2022
- Author(s)
  Atsushi Okabe
- Organizer
  第45回分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-23K23859
[Presentation] Analysis of chromatin structural aberrations in Epstein-Barr virus (+) Burkitt lymphoma2022
- Author(s)
  Atsushi Okabe, Takahiro Fujii, Masaki Fukuyo, Bahityar Rahmutulla, Hironori Yoshiyama,　Patrick Tan, Atsushi Kaneda
- Organizer
  20th International Symposium on Epstein-Barr virus and Associated Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23859
[Presentation] Analysis of chromatin structural aberrations in Epstein-Barr virus (+) Burkitt lymphoma2022
- Author(s)
  Atsushi Okabe, Takahiro Fjii, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla, Patrick Tan, Atsushi Kaneda
- Organizer
  第15回日本エピジェネティクス研究会
- Data Source
  KAKENHI-PROJECT-23K23859
[Presentation] Analysis of chromatin structural aberrations in Epstein-Barr virus (+) Burkitt lymphoma2022
- Author(s)
  Atsushi Okabe, Takahiro Fjii, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla, Patrick Tan, Atsushi Kaneda
- Organizer
  第15回日本エピジェネティクス研究会
- Data Source
  KAKENHI-PROJECT-19KK0415
[Presentation] Analysis of chromatin structural aberrations induced by oncovirus infection2022
- Author(s)
  Atsushi Okabe, Takahiro Fujii, Masaki Fukuyo, Bahityar Rahmutulla, Hironori Yoshiyama, Patrick Tan, Atsushi Kaneda
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19KK0415
[Presentation] Oncovirus infection induces 3D chromatin structural aberrations2022
- Author(s)
  Atsushi Okabe
- Organizer
  第45回分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19KK0415
[Presentation] Analysis of chromatin structural aberrations in Epstein-Barr virus (+) Burkitt lymphoma2022
- Author(s)
  Atsushi Okabe, Takahiro Fujii, Masaki Fukuyo, Bahityar Rahmutulla, Hironori Yoshiyama,　Patrick Tan, Atsushi Kaneda
- Organizer
  20th International Symposium on Epstein-Barr virus and Associated Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0415
[Presentation] Heterochromatin disruption and chromatin structural rewiring induced by Epstein-Barr virus infection in gastric adenocarcinoma2021
- Author(s)
  Atsushi Okabe, Kie Kyon Huang, Keisuke Matsusaka, Masaki Fukuyo, Takayuki Hoshii, Bahityar Rahmutulla, Genki Usui, Teru Kanda, Tetsuo Ushiku, Masashi Fukayama, Patrick Tan, Atsushi Kaneda
- Organizer
  19th International Symposium on Epstein-Barr Virus and associated diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0415
[Presentation] ウイルスがもたらすヘテロクロマチン破綻と新たなエピジェネティック発癌機構「エンハンサー侵襲」の発見2021
- Author(s)
  岡部篤史、Kie Kyon Huang、松坂恵介、福世真樹、星居孝之、臼井源紀、関元昭、眞野恭伸、Bahityar Rahmutulla、神田輝、鈴木孝禎、牛久哲男、深山正久、Patrick Tan、金田篤志
- Organizer
  第14回日本エピジェネティクス研究会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19KK0415
[Presentation] Heterochromatin rewiring by oncovirus infection through the novel mechanism ”enhancer infestation” in gastric adenocarcinoma2021
- Author(s)
  Atsushi Okabe, Kie Kyon Huang, Keisuke Matsusaka, Masaki Fukuyo, Takayuki Hoshii, Genki Usui, Motoaki Seki, Yasunobu Mano, Bahityar Rahmutulla, Teru Kanda, Takayoshi Suzuki, Tetsuo Ushiku, Masashi Fukayama, Patrick Tan, Atsushi Kaneda
- Organizer
  第80回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-19KK0415
[Presentation] Chromatin structural alteration induced by oncovirus infection aberrantly activate transcriptional regulation2021
- Author(s)
  Atsushi Okabe, Kie Kyon Huang, Keisuke Matsusaka, Masaki Fukuyo, Takayuki Hoshii, Bahityar Rahmutulla, Genki Usui, Teru Kanda, Tetsuo Ushiku, Masashi Fukayama, Patrick Tan, Atsushi Kaneda
- Organizer
  第44回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19KK0415
[Presentation] CHROMATIN REWIRING BY ONCOVIRUS INFECTION THROUGH THE NOVEL MECHANISM ”ENHANCER INFESTATION” IN GASTRIC ADENOCARCINOMA2021
- Author(s)
  Atsushi Okabe, Kie Kyon Huang, Keisuke Matsusaka, Masaki Fukuyo, Takayuki Hoshii, Bahityar Rahmutulla, Manjie Xing, Xuewen Ong, Patrick Tan, Atsushi Kaneda
- Organizer
  15th Asian Epigenomics Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16101
[Presentation] Tissue-wide analysis of chromatin structural aberrations induced by oncovirus infection2021
- Author(s)
  Atsushi Okabe, Takahiro Fjii, Harue Mizokami, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla, Patrick Tan, Atsushi Kaneda
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19KK0415
[Presentation] CHROMATIN REWIRING BY ONCOVIRUS INFECTION THROUGH THE NOVEL MECHANISM ”ENHANCER INFESTATION” IN GASTRIC ADENOCARCINOMA2021
- Author(s)
  Atsushi Okabe, Kie Kyon Huang, Keisuke Matsusaka, Masaki Fukuyo, Takayuki Hoshii, Bahityar Rahmutulla, Manjie Xing, Xuewen Ong, Patrick Tan, Atsushi Kaneda
- Organizer
  15th Asian Epigenomics Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0415
[Presentation] ウイルスがもたらすヘテロクロマチン破綻と新たなエピジェネティック発癌機構「エンハンサー侵襲」の発見2021
- Author(s)
  岡部篤史、Kie Kyon Huang、松坂恵介、福世真樹、星居孝之、臼井源紀、関元昭、眞野恭伸、Bahityar Rahmutulla、神田輝、鈴木孝禎、牛久哲男、深山正久、Patrick Tan、金田篤志
- Organizer
  第14回日本エピジェネティクス研究会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K16101
[Presentation] Heterochromatin disruption and chromatin structural rewiring in gastric adenocarcinoma infected by Epstein-Barr virus2020
- Author(s)
  Atsushi Okabe, Kie Kyon Huang, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla, Patrick Tan, Atsushi Kaneda
- Organizer
  Cold Spring Harbor Meeting Epigenetics and Chromatin
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16101
[Presentation] (イ)Heterochromatin reprogramming and chromatin structural rewiring induced by oncovirus infection in gastric adenocarcinoma2020
- Author(s)
  (エ)Atsushi Okabe, Kie Kyon Huang, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla, Takayuki Hoshii, Patrick Tan, Atsushi Kaneda
- Organizer
  第31回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-19K16101
[Presentation] Heterochromatin disruption and chromatin structural rewiring in gastric adenocarcinoma infected by Epstein-Barr virus2020
- Author(s)
  Atsushi Okabe, Kie Kyon Huang, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla, Patrick Tan, Atsushi Kaneda
- Organizer
  Cold Spring Harbor Meeting Epigenetics and Chromatin
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0415
[Presentation] (イ)Heterochromatin reprogramming and chromatin structural rewiring induced by oncovirus infection in gastric adenocarcinoma2020
- Author(s)
  (エ)Atsushi Okabe, Kie Kyon Huang, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla, Takayuki Hoshii, Patrick Tan, Atsushi Kaneda
- Organizer
  第31回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-19KK0415
[Presentation] Chromatin Structural Aberrations due to oncovirus infection activate neighboring oncogenes through enhancer activation2020
- Author(s)
  Atsushi Okabe, Kie Kyon Huang, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla, Patrick Tan, Atsushi Kaneda
- Organizer
  第79回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-19KK0415
[Presentation] Chromatin Structural Aberrations due to oncovirus infection activate neighboring oncogenes through enhancer activation2020
- Author(s)
  Atsushi Okabe, Kie Kyon Huang, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla, Patrick Tan, Atsushi Kaneda
- Organizer
  第79回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-19K16101
[Presentation] Heterochromatin reprogramming induced by Epstein-Barr virus infection induces oncogenic activation through aberrant enhancer activation2019
- Author(s)
  Atsushi Okabe, Keisuke Matsusaka, Masaki Fukuyo, Hiroe Namba, Sayaka Funata, Atsushi Kaneda
- Organizer
  第13回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-19K16101
[Presentation] 癌ウイルス感染がもたらすヘテロクロマチンリプログラミングによる癌遺伝子の活性化2019
- Author(s)
  Atsushi Okabe, Kie Kyon Huang, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla, Patrick Tan, Atsushi Kaneda
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K16101
[Presentation] EBV infection induces domain structural changes which lead to oncogenic activation2019
- Author(s)
  Atsushi Okabe, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla, Patrick Tan, Atsushi Kaneda
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K16101

1. Kaneda Atsushi (10313024)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
2. MATSUSAKA Keisuke (40610150)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. FUNATA Sayaka (80756081)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Hirasaki Yoshiro (40436374)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 福世真樹 (40639085)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 関元昭 (70714278)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 川島祐介 (30588124)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 神田輝 (50333472)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 工藤渉 (10928047)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 菱木知郎 (00375776)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. 星居孝之 (20464042)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. 田中知明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 山田晴美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 油谷浩幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 金坂学斗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 三澤清

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Okabe Atsushi 岡部 篤史

OKABE Atsushi 岡部 篤史

Research Projects

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ウイルスタンパク質EBNA1によるヘテロクロマチン異常活性化機構の解明Principal Investigator

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網羅的エピゲノム解析とゲノム編集技術を用いた肝芽腫の新規治療候補遺伝子の同定

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癌ウイルスによるクロマチン構造破綻が誘導する新規発癌機構の解明Principal Investigator

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胃癌におけるクロマチン構造異常による癌化機構の解明Principal Investigator

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Searching for novel anticancer epigenetic drugs from Kampo medicines followed by elucidation of the mechanism through transcriptomic analyses.

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Analysis of epigenetic aberrations induced by oncovirus infectionPrincipal Investigator

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Analysis on alterated chromatin status of viral genome in the host cells.

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[Journal Article] Aberrant Upregulation of RUNX3 Activates Developmental Genes to Drive Metastasis in Gastric Cancer2024

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[Journal Article] Enhancer infestation drives tumorigenic activation of inactive B compartment in Epstein-Barr virus-positive nasopharyngeal carcinoma2024

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[Journal Article] Chromatin activation with H3K36me2 and compartment shift in metastatic castration-resistant prostate cancer2024

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[Journal Article] Tumorigenic activation around <scp>HPV</scp> integrated sites in head and neck squamous cell carcinoma2023

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[Journal Article] The Link of mRNA and rRNA Transcription by PUF60/FIR through TFIIH/P62 as a Novel Therapeutic Target for Cancer2023

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[Journal Article] Comprehensive molecular phenotyping of<i>ARID1A</i>-deficient gastric cancer reveals pervasive epigenomic reprogramming and therapeutic opportunities2023

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[Journal Article] Hi-C analysis to identify genome-wide chromatin structural aberration in cancer.2023

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Okabe Atsushi 岡部篤史

OKABE Atsushi 岡部篤史