NAGANUMA Fumito 長沼史登

Researcher Number	80780519
Other IDs
Affiliation (Current)	2025: 北海道大学, 医学研究院, 講師
Affiliation (based on the past Project Information) *help	2025: 北海道大学, 医学研究院, 講師 2023: 北海道大学, 医学研究院, 講師 2017 – 2023: 東北医科薬科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 46020:Anatomy and histopathology of nervous system-related / Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 46030:Function of nervous system-related / Neurochemistry/Neuropharmacology Except Principal Investigator Basic Section 55050:Anesthesiology-related
Keywords	Principal Investigator AAVベクター / アルツハイマー型認知症 / REM睡眠 / DREADDs / アミロイドβ / レム睡眠 / メラニン凝集ホルモン / アルツハイマー病 / in vivo カルシウムイメージング / オプトジェネティクス … More / ファイバーフォトメトリー / 光遺伝学的手法 / 睡眠覚醒 / 視床下部 / ニューロテンシン / 脳内微量注入法 / アデノ随伴ウイルス / 条件的遺伝子欠損法 / 脳内ヒスタミン / AAV / 条件的遺伝子欠損 / ヒスタミン … More Except Principal Investigator 神経イメージング / アストログリオーシス / ミスフォールディングタンパク質 / アルツハイマー病 / 高齢者 / 睡眠障害 / 全身麻酔薬 / 周術期認知機能障害 / 覚醒 / ヒスタミン神経系 / ニューロテンシン神経系 / 覚醒系神経回路 / ニューロテンシン / 吸入麻酔薬 Less

視床下部外側ニューロテンシン神経の覚醒制御神経回路の解明Principal Investigator
- Principal Investigator
  
  長沼史登
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46020:Anatomy and histopathology of nervous system-related
- Research Institution
  Hokkaido University
中枢神経系脆弱性と全身麻酔に関連した周術期認知機能障害の神経病理解析
- Principal Investigator
  
  中村正帆
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
REM睡眠による異常タンパク質の排出増加はアルツハイマー病を治療できるか？Principal Investigator
- Principal Investigator
  
  長沼史登
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Hokkaido University
  Tohoku Medical and Pharmaceutical University
Do neurotensin influence the effects of general anesthesia?
- Principal Investigator
  
  Nakamura Tadaho
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
Importance of lateral hypothalamic neurotensinergic neurons in wake maintenancePrincipal Investigator
- Principal Investigator
  
  Naganuma Fumito
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 46030:Function of nervous system-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
Functions of central histaminergic neurons in pathological modelPrincipal Investigator
- Principal Investigator
  
  NAGANUMA Fumito
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Tohoku Medical and Pharmaceutical University

All 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] In vivo [18F]THK-5351 imaging detected reactive astrogliosis in argyrophilic grain disease with comorbid pathology: A clinicopathological study2023
- Author(s)
  Ryota Kobayashi , Tadaho Nakamura, Fumito Naganuma, Ryuichi Harada, Daichi Morioka, Masafumi Kanoto, Shozo Furumoto, Yukitsuka Kudo, Takanobu Kabasawa, Koichi Otani, Mitsuru Futakuchi , Shinobu Kawakatsu, Nobuyuki Okamura
- Journal Title
  
  J Neuropathol Exp Neurol .
  
  Volume: - Issue: 5 Pages: 427-437
- DOI
  10.1093/jnen/nlad018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08043, KAKENHI-PROJECT-22K07373, KAKENHI-PROJECT-22K07552, KAKENHI-PROJECT-22KK0123, KAKENHI-PROJECT-18H02771, KAKENHI-PROJECT-20K07922, KAKENHI-PROJECT-20K09204, KAKENHI-PROJECT-19KK0212, KAKENHI-PROJECT-23K06646, KAKENHI-PROJECT-23K07129, KAKENHI-PROJECT-20K07619
[Journal Article] A Novel Near-Infrared Fluorescence Probe THK-565 Enables In Vivo Detection of Amyloid Deposits in Alzheimer’s Disease Mouse Model2023
- Author(s)
  Naganuma Fumito、Murata Daiki、Inoue Marie、Maehori Yuri、Harada Ryuichi、Furumoto Shozo、Kudo Yukitsuka、Nakamura Tadaho、Okamura Nobuyuki
- Journal Title
  
  Molecular Imaging and Biology
  
  Volume: 25 Issue: 6 Pages: 1115-1124
- DOI
  10.1007/s11307-023-01843-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22KK0123, KAKENHI-PROJECT-22K07373, KAKENHI-PROJECT-23K07069, KAKENHI-PROJECT-23K08342, KAKENHI-PROJECT-23K24070
[Journal Article] Organic Cation Transporters in Brain Histamine Clearance: Physiological and Psychiatric Implications2021
- Author(s)
  Naganuma Fumito、Yoshikawa Takeo
- Journal Title
  
  Handbook of Experimental Pharmacology
  
  Volume: 2021 Pages: 1-17
- DOI
  10.1007/164_2021_447
- ISBN
  9783030829834, 9783030829841
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16296
[Journal Article] Chemogenetic modulation of histaminergic neurons in the tuberomamillary nucleus alters territorial aggression and wakefulness2021
- Author(s)
  Naganuma Fumito、Nakamura Tadaho、Kuroyanagi Hiroshi、Tanaka Masato、Yoshikawa Takeo、Yanai Kazuhiko、Okamura Nobuyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 17935-17935
- DOI
  10.1038/s41598-021-95497-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06886, KAKENHI-PROJECT-20K09204
[Journal Article] Sleep-Wake Control by Melanin-Concentrating Hormone (MCH) Neurons: a Review of Recent Findings2020
- Author(s)
  Bandaru Sathyajit S.、Khanday Mudasir A.、Ibrahim Nazifa、Naganuma Fumito、Vetrivelan Ramalingam
- Journal Title
  
  Current Neurology and Neuroscience Reports
  
  Volume: 20 Issue: 12 Pages: 55-55
- DOI
  10.1007/s11910-020-01075-x
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16296
[Journal Article] Chronic brain histamine depletion in adult mice induced depression-like behaviours and impaired sleep-wake cycle2020
- Author(s)
  Yamada Yo、Yoshikawa Takeo、Naganuma Fumito、Kikkawa Takako、Osumi Noriko、Yanai Kazuhiko
- Journal Title
  
  Neuropharmacology
  
  Volume: 175 Pages: 108179-108179
- DOI
  10.1016/j.neuropharm.2020.108179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06886, KAKENHI-PROJECT-20K07237, KAKENHI-PROJECT-19K16296
[Journal Article] Histamine H1 receptor on astrocytes and neurons controls distinct aspects of mouse behaviour2019
- Author(s)
  Karpati Aniko、Yoshikawa Takeo、Naganuma Fumito、Matsuzawa Takuro、Kitano Haruna、Yamada Yo、Yokoyama Mariko、Futatsugi Akira、Mikoshiba Katsuhiko、Yanai Kazuhiko
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 16451-16451
- DOI
  10.1038/s41598-019-52623-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06886, KAKENHI-PROJECT-19K16296, KAKENHI-PROJECT-18J11446
[Journal Article] 2.Melanin-concentrating hormone neurons promote rapid eye movement sleep independent of glutamate release.2019
- Author(s)
  F Naganuma, SS Bandaru, G Absi, MJ Chee, R Vetrivelan.
- Journal Title
  
  Brain Struct Funct.
  
  Volume: 224 Issue: 1 Pages: 99-110
- DOI
  10.1007/s00429-018-1766-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K14965
[Presentation] 扁桃体中心核ニューロテンシン神経細胞のREM睡眠制御における細胞活性と神経投射について2023
- Author(s)
  若狭和彦、井上まり絵、杉山詩織、長沼史登、中村正帆、岡村信行
- Organizer
  第74回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-23K08342
[Presentation] 睡眠における扁桃体中心核ニューロテンシン神経細胞の役割について2023
- Author(s)
  中村正帆、長沼史登、吉川雄朗、岡村信行
- Organizer
  第7回黒潮カンファレンス
- Data Source
  KAKENHI-PROJECT-23K08342
[Presentation] ヒスタミン神経細胞の抑制はセボフルランの意識消失作用に影響するか2023
- Author(s)
  杉山詩織、若狭和彦、長沼史登、中村正帆、岡村信行
- Organizer
  第74回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-23K08342
[Presentation] ヒスタミン神経細胞特異的な活性化が攻撃行動と覚醒睡眠サイクルに及ぼす影響2022
- Author(s)
  中村正帆、長沼史登、黒柳浩志、田中聖人、吉川雄朗、谷内一彦、岡村信行
- Organizer
  第23回日本ヒスタミン学会
- Data Source
  KAKENHI-PROJECT-20K09204
[Presentation] 視床下部外側ニューロテンシン神経は睡眠覚醒サイクルに重要である2022
- Author(s)
  長沼史登 , 中村正帆 , ベトリベランラマリンガム , 吉川雄朗 , 岡村信行
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K09204
[Presentation] 扁桃体中心核ニューロテンシン神経細胞の睡眠覚醒サイクルにおける役割の検討2022
- Author(s)
  中村正帆 , 長沼史登 , 田中聖人 , 井上まり絵 , 直野留美 , 吉川雄朗 , 岡村信行
- Organizer
  第23回応用薬理シンポジウム
- Data Source
  KAKENHI-PROJECT-20K09204
[Presentation] 視床下部外側ニューロテンシン神経は睡眠覚醒サイクルに重要である2022
- Author(s)
  長沼史登, 中村正帆, Vetrivelan Ramalingam, 吉川雄朗, 岡村信行
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-22K07373
[Presentation] 吸入麻酔薬がニューロテンシン神経細胞の神経活動に及ぼす影響の検討2021
- Author(s)
  長沼史登、中村正帆、Vetrivelan Ramalignam、岡村信行
- Organizer
  第72回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-20K09204
[Presentation] ニューロテンシン神経細胞特異的活性化はセボフルラン麻酔からの覚醒を促進する。2020
- Author(s)
  中村正帆、長沼史登、岡村信行
- Organizer
  日本麻酔科学会第67回学術集会
- Data Source
  KAKENHI-PROJECT-20K09204
[Presentation] Deletion of brain histidine decarboxylase by adeno-associated virus induced anxiety-like behaviors in adult mice2019
- Author(s)
  Yo Yamada, Takeo Yoshikawa, Fumito Naganuma, Kazuhiko Yanai
- Organizer
  The 92nd Annual Meeting of the Japanese Pharmacological Society
- Data Source
  KAKENHI-PROJECT-17K14965
[Presentation] Role of Glutamate Produced by Melanin-Concentrating Hormone Neurons in Sleep-wake Regulation.2018
- Author(s)
  F Naganuma, SS Bandaru, G Absi, M Chee, R Vetrivelan.
- Organizer
  Society for Neuroscience2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K14965

1. Nakamura Tadaho (80734318)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
2. 吉川雄朗 (70506633)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
3. 原田龍一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 岡村信行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 古本祥三

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 原田愛子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NAGANUMA Fumito 長沼 史登

Research Projects

Research Products

Co-Researchers

視床下部外側ニューロテンシン神経の覚醒制御神経回路の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

中枢神経系脆弱性と全身麻酔に関連した周術期認知機能障害の神経病理解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

REM睡眠による異常タンパク質の排出増加はアルツハイマー病を治療できるか？Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Do neurotensin influence the effects of general anesthesia?

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Importance of lateral hypothalamic neurotensinergic neurons in wake maintenancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functions of central histaminergic neurons in pathological modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] In vivo [18F]THK-5351 imaging detected reactive astrogliosis in argyrophilic grain disease with comorbid pathology: A clinicopathological study2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Novel Near-Infrared Fluorescence Probe THK-565 Enables In Vivo Detection of Amyloid Deposits in Alzheimer’s Disease Mouse Model2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Organic Cation Transporters in Brain Histamine Clearance: Physiological and Psychiatric Implications2021

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Chemogenetic modulation of histaminergic neurons in the tuberomamillary nucleus alters territorial aggression and wakefulness2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sleep-Wake Control by Melanin-Concentrating Hormone (MCH) Neurons: a Review of Recent Findings2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chronic brain histamine depletion in adult mice induced depression-like behaviours and impaired sleep-wake cycle2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Histamine H1 receptor on astrocytes and neurons controls distinct aspects of mouse behaviour2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 2.Melanin-concentrating hormone neurons promote rapid eye movement sleep independent of glutamate release.2019

Author(s)

Journal Title

DOI

NAGANUMA Fumito 長沼史登