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Saeki Noritaka  佐伯 法学

… Alternative Names

SAEKI NORITAKA  佐伯 法学

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Researcher Number 80791607
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-2520-8292
Affiliation (Current) 2025: 愛媛大学, 先端研究院先端研究高度支援室, 准教授
Affiliation (based on the past Project Information) *help 2021 – 2024: 愛媛大学, 学術支援センター, 講師
2017 – 2020: 愛媛大学, 学術支援センター, 助教
Review Section/Research Field
Principal Investigator
Basic Section 42030:Animal life science-related / Integrative animal science
Except Principal Investigator
Basic Section 64010:Environmental load and risk assessment-related
Keywords
Principal Investigator
関節リウマチ / マクロファージ / 関節炎 / 性差 / エストロゲン受容体 / 滑膜マクロファージ / 自己免疫疾患 / Uhrf1 / エピジェネティクス / 滑膜線維芽細胞 … More / 臓器連関 / 性ホルモン / 組織マクロファージ / scRNA-seq / Apoptosis / CCL20 / DNAメチル化 / UHRF1 / シグナル伝達 / 細胞・組織 / 炎症性サイトカイン … More
Except Principal Investigator
リスク評価 / 神経毒性 / 環境汚染物質 / iPS細胞 / 鯨類 Less
  • Research Projects

    (5 results)
  • Research Products

    (41 results)
  • Co-Researchers

    (9 People)
  •  エストロゲンを基軸とした臓器連関による関節リウマチ病態の性差構築機構の解明Principal Investigator

    • Principal Investigator
      佐伯 法学
    • Project Period (FY)
      2024 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 42030:Animal life science-related
    • Research Institution
      Ehime University
  •  Establishment of cetacean iPS cells and application to neurotoxicity assays of environmental pollutants

    • Principal Investigator
      落合 真理
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 64010:Environmental load and risk assessment-related
    • Research Institution
      Ehime University
  •  Investigation of sexual dimorphism of rheumatoid arthritis focusing on synovial macrophages.Principal Investigator

    • Principal Investigator
      Saeki Noritaka
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 42030:Animal life science-related
    • Research Institution
      Ehime University
  •  Investigation of proinflammatory regulation via epigenetics in synoviocytes.Principal Investigator

    • Principal Investigator
      Saeki Noritaka
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 42030:Animal life science-related
    • Research Institution
      Ehime University
  •  Investigation of physiological functions of epigenetic regulator Uhrf1 in rheumatoid arthritisPrincipal Investigator

    • Principal Investigator
      SAEKI NORITAKA
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Integrative animal science
    • Research Institution
      Ehime University

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation Book

  • [Book] Rheumatoid Arthritis: Methods and Protocols2024

    • Author(s)
      Noritaka Saeki (共著)
    • Total Pages
      365
    • Publisher
      Humana
    • ISBN
      1071636812
    • Data Source
      KAKENHI-PROJECT-21K05974
  • [Journal Article] Bub1 suppresses inflammatory arthritis?associated bone loss in mice through inhibition of TNFα?mediated osteoclastogenesis2024

    • Author(s)
      Yoshida Shuhei、Ikedo Aoi、Yanagihara Yuta、Sakaue Tomohisa、Saeki Noritaka、Imai Yuuki
    • Journal Title

      Journal of Bone and Mineral Research

      Volume: 39 Issue: 3 Pages: 341-356

    • DOI

      10.1093/jbmr/zjae015

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K05974
  • [Journal Article] LIM1 contributes to the malignant potential of endometrial cancer2023

    • Author(s)
      Kato Hiroaki、Saeki Noritaka、Imai Matome、Onji Hiroshi、Yano Akiko、Yoshida Shuhei、Sakaue Tomohisa、Fujioka Toru、Sugiyama Takashi、Imai Yuuki
    • Journal Title

      Frontiers in Oncology

      Volume: 13

    • DOI

      10.3389/fonc.2023.1082441

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K05974, KAKENHI-PROJECT-21K09373
  • [Journal Article] Crosstalk between synovial macrophages and fibroblasts in rheumatoid arthritis.2023

    • Author(s)
      Noritaka Saeki, Yuuki Imai
    • Journal Title

      Histology and histopathology

      Volume: 38 Pages: 1231-1238

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K05974
  • [Journal Article] Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue2023

    • Author(s)
      Saeki Noritaka、Imai Yuuki
    • Journal Title

      Journal of Visualized Experiments

      Volume: - Issue: 192

    • DOI

      10.3791/65196

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K05974, KAKENHI-PROJECT-23K24462
  • [Journal Article] Epigenetic regulator UHRF1 orchestrates proinflammatory gene expression in rheumatoid arthritis in a suppressive manner2022

    • Author(s)
      Saeki Noritaka、Inoue Kazuki、Ideta-Otsuka Maky、Watamori Kunihiko、Mizuki Shinichi、Takenaka Katsuto、Igarashi Katsuhide、Miura Hiromasa、Takeda Shu、Imai Yuuki
    • Journal Title

      Journal of Clinical Investigation

      Volume: 132 Issue: 11

    • DOI

      10.1172/jci150533

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K05974, KAKENHI-PROJECT-21H02949, KAKENHI-PROJECT-23K24462, KAKENHI-PROJECT-21H03604
  • [Journal Article] DNA maintenance methylation enzyme Dnmt1 in satellite cells is essential for muscle regeneration2021

    • Author(s)
      Iio Hiroyuki、Kikugawa Tadahiko、Sawada Yuichiro、Sakai Hiroshi、Yoshida Shuhei、Yanagihara Yuta、Ikedo Aoi、Saeki Noritaka、Fukada So-ichiro、Saika Takashi、Imai Yuuki
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 534 Pages: 79-85

    • DOI

      10.1016/j.bbrc.2020.11.116

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H03786, KAKENHI-PROJECT-19K16015, KAKENHI-PROJECT-19K19947
  • [Journal Article] Myofiber androgen receptor increases muscle strength mediated by a skeletal muscle splicing variant of Mylk42021

    • Author(s)
      Iori Sakakibara, Yuta Yanagihara, Koichi Himori, Takashi Yamada, Hiroshi Sakai, Yuichiro Sawada, Hirotaka Takahashi, Noritaka Saeki, Hiroyuki Hirakawa, Atsushi Yokoyama, So-Ichiro Fukada, Tatsuya Sawasaki, Yuuki Imai
    • Journal Title

      iScience

      Volume: 24 Issue: 4 Pages: 102303-102303

    • DOI

      10.1016/j.isci.2021.102303

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20J01754, KAKENHI-PROJECT-19K19947, KAKENHI-PUBLICLY-21H00287, KAKENHI-PROJECT-20K06611, KAKENHI-PROJECT-21K05974, KAKENHI-PROJECT-21K11439, KAKENHI-PROJECT-21K19230, KAKENHI-PROJECT-21K19723, KAKENHI-PROJECT-21K17568, KAKENHI-PROJECT-23K21587
  • [Journal Article] Reprogramming of synovial macrophage metabolism by synovial fibroblasts under inflammatory conditions2020

    • Author(s)
      Saeki Noritaka、Imai Yuuki
    • Journal Title

      Cell Communication and Signaling

      Volume: 18 Issue: 1 Pages: 188-188

    • DOI

      10.1186/s12964-020-00678-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H03786, KAKENHI-PROJECT-19K16015
  • [Journal Article] GPRC5A facilitates cell proliferation through cell cycle regulation and correlates with bone metastasis in prostate cancer2020

    • Author(s)
      Sawada Y, Kikugawa T, Iio H, Sakakibara I, Yoshida S, Ikedo A, Yanagihara Y, Saeki N, Gyorffy B, Kishida T, Okubo Y, Nakamura Y, Miyagi Y, Saika T, Imai Y.
    • Journal Title

      International Journal of Cancer

      Volume: 146 Issue: 5 Pages: 1369-1382

    • DOI

      10.1002/ijc.32554

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K09168, KAKENHI-PROJECT-19K16015, KAKENHI-PROJECT-19H03786, KAKENHI-PROJECT-16H06277
  • [Journal Article] Zscan10 Suppresses Osteoclast Differentiation by Regulating Expression of Haptoglobin.2019

    • Author(s)
      Yanagihara Y, Inoue K, Saeki N, Sawada Y, Yoshida S, Lee JW, Iimura T and Imai Y.
    • Journal Title

      Bone

      Volume: 122 Pages: 93-100

    • DOI

      10.1016/j.bone.2019.02.011

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K19728, KAKENHI-PROJECT-17K17929, KAKENHI-PROJECT-18K19649, KAKENHI-PROJECT-18H02983, KAKENHI-PROJECT-19H03786
  • [Journal Article] The E3 ubiquitin ligase MIB2 enhances inflammation by degrading the deubiquitinating enzyme CYLD2019

    • Author(s)
      Uematsu Atsushi、Kido Kohki、Takahashi Hirotaka、Takahashi Chikako、Yanagihara Yuta、Saeki Noritaka、Yoshida Shuhei、Maekawa Masashi、Honda Mamoru、Kai Tsutomu、Shimizu Kouhei、Higashiyama Shigeki、Imai Yuuki、Tokunaga Fuminori、Sawasaki Tatsuya
    • Journal Title

      Journal of Biological Chemistry

      Volume: 294 Issue: 38 Pages: 14135-14148

    • DOI

      10.1074/jbc.ra119.010119

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K22541, KAKENHI-PROJECT-19K16015, KAKENHI-PLANNED-16H06575, KAKENHI-PLANNED-16H06579, KAKENHI-PUBLICLY-19H05292, KAKENHI-PROJECT-18H02619, KAKENHI-PROJECT-19H03218, KAKENHI-PROJECT-19H03786, KAKENHI-PROJECT-17K07261
  • [Presentation] 関節リウマチ病態の滑膜恒常性維持に寄与するエピジェネティック制御因子UHRF12024

    • Author(s)
      佐伯法学, 井上和樹, 大塚まき, 渡森一光, 水木伸一, 竹中克斗, 五十嵐勝秀, 三浦裕正, 竹田秀, 今井祐記
    • Organizer
      第36回日本軟骨代謝学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K05974
  • [Presentation] 関節リウマチ病態を網羅的に制御するDNAメチル化因子UHRF12023

    • Author(s)
      佐伯法学, 井上和樹, 大塚まき, 渡森一光, 水木伸一, 竹中克斗, 五十嵐勝秀, 三浦裕正, 竹田秀, 今井祐記
    • Organizer
      第41回日本骨代謝学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K05974
  • [Presentation] ERα signaling in synovial macrophage promotes inflammatory arthritis via excessive metabolic flux2023

    • Author(s)
      Noritaka Saeki, Yuuki Imai
    • Organizer
      第 21 回松山国際学術シンポジウム
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K05974
  • [Presentation] 滑膜マクロファージのERαシグナルは細胞内代謝を制御し関節炎病態を悪化する2023

    • Author(s)
      佐伯法学, 今井祐記
    • Organizer
      第8回日本骨免疫学会
    • Data Source
      KAKENHI-PROJECT-21K05974
  • [Presentation] 滑膜マクロファージにおけるERαシグナルは細胞内代謝を介して関節炎病態を増悪する2023

    • Author(s)
      佐伯法学, 今井祐記
    • Organizer
      第41回日本骨代謝学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K05974
  • [Presentation] 関節リウマチ病態に寄与するエピジェネティック制御因子の同定と新規治療標的としての可能性2023

    • Author(s)
      佐伯法学
    • Organizer
      PRiME・PROS 第10回学術シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K05974
  • [Presentation] 滑膜マクロファージのERαシグナルは細胞内代謝制御を介して関節炎病態を悪化する2023

    • Author(s)
      佐伯法学, 今井祐記
    • Organizer
      第13回 Orthopedic Research Club
    • Data Source
      KAKENHI-PROJECT-21K05974
  • [Presentation] ERα signaling in resident synovial macrophages promotes inflammatory arthritis via the activation of cellular metabolism2023

    • Author(s)
      Noritaka Saeki, Yuuki Imai
    • Organizer
      The American Society for Bone and Mineral Research 2023 Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K05974
  • [Presentation] Stabilization of UHRF1 in synovial fibroblasts is a novel therapeutic strategy for rheumatoid arthritis.2022

    • Author(s)
      Noritaka Saeki, Kazuki Inoue, Maky Ideta-Otsuka, Kunihiko Watamori, Shinichi Mizuki, Katsuto Takenaka, Katsuhide Igarashi, Hiromasa Miura, Yuuki Imai
    • Organizer
      European Calcified Tissue Society (ECTS) Congress 2022
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K05974
  • [Presentation] Estrogen receptor-alpha promotes activation of synovium-resident macrophages in arthritis model mice.2022

    • Author(s)
      佐伯法学, 今井祐記
    • Organizer
      プロテイン・アイランド2022国際シンポジウム
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K05974
  • [Presentation] 関節炎モデルマウスにおけるマクロファージの ERα 機能解析2022

    • Author(s)
      佐伯法学, 今井祐記
    • Organizer
      第7回日本骨免疫学会
    • Data Source
      KAKENHI-PROJECT-21K05974
  • [Presentation] 滑膜線維芽細胞に発現するUHRF1はDNAメチル化を介して関節リウマチの多様な増悪因子を抑制する2022

    • Author(s)
      佐伯 法学, 井上 和樹, 大塚 まき, 渡森 一光, 水木 伸一, 竹中 克斗, 五十嵐勝秀, 三浦 裕正, 今井 祐記
    • Organizer
      第40回日本骨代謝学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K05974
  • [Presentation] Stabilization of UHRF1 in synovial fibroblasts is a novel therapeutic strategy for rheumatoid arthritis.2021

    • Author(s)
      Noritaka Saeki, Kazuki Inoue, Maky Ideta-Otsuka, Watamori Kunihiko, Shinichi Mizuki, Katsuto Takenaka, Katsuhide Igarashi, Hiromasa Miura, Yuuki Imai
    • Organizer
      The American Society for Bone and Mineral Research 2021 Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K05974
  • [Presentation] UHRF1は関節リウマチの多様な増悪因子を抑制する2021

    • Author(s)
      佐伯法学, 井上和樹, 大塚まき, 渡森一光, 水木伸一, 竹中克斗, 五十嵐勝秀, 三浦裕正, 今井祐記
    • Organizer
      第6回日本骨免疫学会
    • Data Source
      KAKENHI-PROJECT-21K05974
  • [Presentation] エピジェネティック制御因子UHRF1は関節リウマチの多様な増悪因子を抑制する2021

    • Author(s)
      佐伯 法学, 井上 和樹, 大塚 まき, 渡森 一光, 水木 伸一, 竹中 克斗, 五十嵐勝秀, 三浦 裕正, 今井 祐記
    • Organizer
      第39回 日本骨代謝学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K05974
  • [Presentation] DNA メチル化制御分子 UHRF1 は関節リウマチの病態増悪を抑制する2020

    • Author(s)
      佐伯法学, 井上和樹, 大塚まき, 渡森一光, 水木伸一, 竹中克斗, 五十嵐勝秀, 三浦裕正, 今井祐記
    • Organizer
      第38回日本骨代謝学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K16015
  • [Presentation] Epigenetic regulator UHRF1 orchestrates expressions of cytokine-related genes in rheumatoid arthritis.2019

    • Author(s)
      Noritaka Saeki, Kazuki Inoue, Maky Ideta-Otsuka, Watamori Kunihiko, Shinichi Mizuki, Katsuto Takenaka, Katsuhide Igarashi, Hiromasa Miura, Yuuki Imai
    • Organizer
      29th Australian and New Zealand Bone and Mineral Society Annual Scientific Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K16015
  • [Presentation] エピジェネティック制御因子Uhrf1はサイトカイン関連遺伝子発現を抑制し関節リウマチ病態を制御する2019

    • Author(s)
      佐伯法学, 井上和樹, 渡森一光, 水木伸一, 竹中克斗, 三浦裕正, 今井祐記
    • Organizer
      第5回日本骨免疫学会
    • Data Source
      KAKENHI-PROJECT-19K16015
  • [Presentation] Epigenetic regulator Uhrf1 suppresses progression of arthritis in CAIA mouse model2019

    • Author(s)
      Noritaka Saeki, Kazuki Inoue, Yuuki Imai
    • Organizer
      International Federation of Musculoskeletal Research Societies 3rd Herbert Fleisch Workshop
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K17929
  • [Presentation] エピジェネティック制御因子Uhrf1は関節リウマチにおける増悪因子発現を制御する2019

    • Author(s)
      佐伯法学, 井上和樹, 渡森一光, 水木伸一, 竹中克斗, 三浦裕正, 今井祐記
    • Organizer
      第37回日本骨代謝学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K16015
  • [Presentation] Epigenetic regulator, Uhrf1, positively controls skeletal muscle differentiation2018

    • Author(s)
      Yuichiro Sawada, Tadahiko Kikugawa, Iori Sakakibara, Yusuke Ono, Yuta Yanagihara, Noritaka Saeki, Hiroyuki Iio, Takashi Saika, Yuuki Imai
    • Organizer
      The American Society for Bone and Mineral Research 2018 Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K17929
  • [Presentation] Zscan10 Suppresses Osteoclast Differentiation through Expression of Haptoglobin.2018

    • Author(s)
      Yuta Yanagihara, Kazuki Inoue, Noritaka Saeki, Yuichiro Sawada, Jiwon Lee, Tadahiro Iimura, Yuuki Imai
    • Organizer
      The American Society for Bone and Mineral Research 2018 Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K17929
  • [Presentation] Zscan10はHaptoglobinの転写を介して破骨細胞分化を負に制御する2018

    • Author(s)
      柳原裕太,井上和樹,佐伯法学,沢田雄一郎,李智媛,飯村忠浩,今井祐記
    • Organizer
      第36回日本骨代謝学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K17929
  • [Presentation] エピジェネティック制御因子Uhrf1は関節炎病態の抑制に働く2018

    • Author(s)
      佐伯法学,今井祐記,井上和樹
    • Organizer
      第36回日本骨代謝学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K17929
  • [Presentation] エピゲノム制御因子Uhrf1は筋分化を正に制御する2018

    • Author(s)
      沢田雄一郎,榊原伊織,柳原裕太,佐伯法学,菊川忠彦,雑賀隆史,小野悠介,今井祐記
    • Organizer
      第36回日本骨代謝学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K17929
  • [Presentation] Zscan10 Suppresses Osteoclast Differentiation by Regulating Expression of Haptoglobin2018

    • Author(s)
      Yuta Yanagihara, Kazuki Inoue, Noritaka Saeki, Yuichiro Sawada, Jiwon Lee, Tadahiro Iimura, Yuuki Imai
    • Organizer
      第15回Bone Biology Forum
    • Data Source
      KAKENHI-PROJECT-17K17929
  • [Presentation] Epigenetic regulator Uhrf1 suppresses progression of arthritis in CAIA mice model2018

    • Author(s)
      Noritaka Saeki, Kazuki Inoue, Yuuki Imai
    • Organizer
      プロテイン・アイランド松山2018国際シンポジウム
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K17929
  • [Presentation] エピゲノム制御因子Uhrf1は筋分化を正に制御する2018

    • Author(s)
      沢田雄一郎, 菊川忠彦, 飯尾浩之, 酒井大史, 榊原伊織, 小野悠介, 柳原裕太, 佐伯法学, 雑賀隆史, 今井祐記
    • Organizer
      第6回若手による骨格筋細胞研究会
    • Data Source
      KAKENHI-PROJECT-17K17929
  • [Presentation] Zscan10 Suppresses Osteoclast Differentiation by Regulating Expression of Haptoglobin2018

    • Author(s)
      Yuta Yanagihara, Kazuki Inoue, Noritaka Saeki, Yuichiro Sawada, Jiwon Lee, Tadahiro Iimura, Yuuki Imai
    • Organizer
      プロテイン・アイランド2018国際シンポジウム
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K17929
  • 1.  今井 祐記 (10423873)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 14 results
  • 2.  落合 真理 (70612662)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  岩田 久人 (10271652)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  Yanagihara Yuta
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  Iimura Tadahiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  Lee Jiwon
    # of Collaborated Projects: 0 results
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  • 7.  雑賀 隆史
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    # of Collaborated Products: 1 results
  • 8.  菊川 忠彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  徳永 文稔
    # of Collaborated Projects: 0 results
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