OSHIMA JUNKO ＯＳＨＩＭＡＪＵＮＫＯ

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OSHIMA JYUNKO OSHIMA JUNKO

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Researcher Number	80792275
Other IDs
Affiliation (Current)	2025: 千葉大学, 大学院医学研究院, 特任教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 千葉大学, 大学院医学研究院, 特任教授 2017 – 2019: 千葉大学, 大学院医学研究院, 特任教授
Review Section/Research Field	Principal Investigator Basic Section 52010:General internal medicine-related / General medical chemistry Except Principal Investigator Basic Section 54040:Metabolism and endocrinology-related
Keywords	Principal Investigator 老化 / 核とシグナル / 早老症国際コンソーシアム / 核とミトコンドリアシグナル / 早老症原因遺伝子 / ワーナー症候群 / 早老症 / 内科 / ゲノム / 遺伝学 … More Except Principal Investigator … More lncRNA / 血管内皮 / IncRNA / 細胞老化 / 加齢性疾患 / 脂肪細胞 / 転写因子p53 / 細胞老化IncRNA Less

Fundamental research of nuclear and mitochondrial interacting signals for accelerated aging by applying premature aging disease model.Principal Investigator
- Principal Investigator
  
  OSHIMA JUNKO
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Chiba University
Roles of p53-dependent long non-coding RNAs in adipose tissues and blood vessels
- Principal Investigator
  
  Hashimoto Naoko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Chiba University
Discovery of novel progeroid syndrome loci and contribution to normative agingPrincipal Investigator
- Principal Investigator
  
  OSHIMA JYUNKO
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Chiba University

All 2024 2023 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Maternal histone methyltransferases antagonistically regulate monoallelic expression in<i>C. elegans</i>2024
- Author(s)
  Sands Bryan、Yun Soo R.、Oshima Junko、Mendenhall Alexander R.
- Journal Title
  
  elegans. bioRxiv.
  
  Volume: 25
- DOI
  10.1101/2024.01.22.576748
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27500
[Journal Article] In Memory of George M. Martin2023
- Author(s)
  Rabinovitch Peter S、Disteche Christine、Kaeberlein Matt、Martin Kelsey C、Monnat Raymond J、Oshima Junko、Promislow Daniel
- Journal Title
  
  The Journals of Gerontology: Series A
  
  Volume: 78 Issue: 4 Pages: 619-620
- DOI
  10.1093/gerona/glac257
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27500
[Journal Article] Woodhouse?Sakati syndrome in an Indian patient with a novel pathogenic variant2023
- Author(s)
  Amalnath S. Deepak、Jothivanan、Oshima Junko、Buchan Jillian G.、Paolucci Sarah
- Journal Title
  
  American Journal of Medical Genetics Part A
  
  Volume: 194 Issue: 1 Pages: 100-102
- DOI
  10.1002/ajmg.a.63405
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27500
[Journal Article] Renal dysfunction, malignant neoplasms, atherosclerotic cardiovascular diseases, and sarcopenia as key outcomes observed in a three-year follow-up study using the Werner Syndrome Registry2023
- Author(s)
  Y Maeda, M Koshizaka, M Shoji, H Kaneko, H Kato, Y Maezawa, J Kawashima, K Yoshinaga, M Ishikawa, A Sekiguchi, S Motegi, H Nakagami, Y Yamada, S Tsukamoto, A Taniguchi, K Sugimoto, Y Takami,Y Shoda, K Hashimoto, T Yoshimura, A Kogure, D Suzuki, N Okubo, T Yoshida, K Watanabe, K Kuzuya, M, M Takemoto, J Oshima, K Yokote
- Journal Title
  
  Aging
  
  Volume: 15 Issue: 9 Pages: 3273-3294
- DOI
  10.18632/aging.204681
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27500
[Journal Article] Insights into aging from progeroid syndrome epigenetics2023
- Author(s)
  Bejaoui Yosra、Oshima Junko、Hajj Nady El
- Journal Title
  
  Aging
  
  Volume: 15
- DOI
  10.18632/aging.204977
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27500
[Journal Article] Key elements of cellular senescence involve transcriptional repression of mitotic and DNA repair genes through the p53-p16/RB-E2F-DREAM complex2023
- Author(s)
  Kandhaya-Pillai Renuka、Miro-Mur Francesc、Alijotas-Reig Jaume、Tchkonia Tamar、Schwartz Simo、Kirkland James L.、Oshima Junko
- Journal Title
  
  Aging
  
  Volume: 15 Issue: 10 Pages: 4012-4034
- DOI
  10.18632/aging.204743
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27500
[Journal Article] Accelerated epigenetic aging and DNA methylation alterations in Berardinelli?Seip congenital lipodystrophy2023
- Author(s)
  Qannan Abeer、Bejaoui Yosra、Izadi Mahmoud、Yousri Noha A、Razzaq Aleem、Christiansen Colette、Martin George M、Bell Jordana T、Horvath Steve、Oshima Junko、Megarbane Andre、Ericsson Johan、Pourkarimi Ehsan、El Hajj Nady
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 32 Issue: 11 Pages: 1826-1835
- DOI
  10.1093/hmg/ddad016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27500
[Journal Article] Caspase 5 depletion is linked to hyper-inflammatory response and progeroid syndrome2023
- Author(s)
  Hisama Fuki M.、Pillai Renuka Kandhaya、Sidorova Julia、Patterson Karynne、Gokingco Carolina、Yacobi-Bach Michal、Oshima Junko
- Journal Title
  
  GeroScience
  
  Volume: 46 Issue: 2 Pages: 2771-2775
- DOI
  10.1007/s11357-023-00907-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27500
[Journal Article] Martin1GM. Cell to cell variations in gene expression are differentially modulated by knockdowns of diverse genetic loci: implications for the pathobiology of aging.2020
- Author(s)
  Zhang J, Burnaevskiy N, Annis J, Han W, Hou D, Ladd P, Lee L, Mendenhall AR, Oshima J,
- Journal Title
  
  J Gerontol A Biol Sci Med Sci
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04037
[Journal Article] Inactivating mutations in exonuclease and polymerase domains in DNA polymerase delta alter sensitivities to inhibitors of dNTP synthesis.2020
- Author(s)
  .Zhang J, Hou D, Annis J, Sargolzaeiaval F, Appelbaum J, Takahashi E, Martin GM, Herr A, Oshima J.
- Journal Title
  
  DNA Cell Biol.
  
  Volume: 39 Issue: 1 Pages: 50-56
- DOI
  10.1089/dna.2019.5125
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04037
[Journal Article] Epigenetic signatures of Werner syndrome occur early in life and are distinct from normal epigenetic aging processes2019
- Author(s)
  14.Maierhofer M, Flunkert J, Oshima J, Martin GM, Poot M, Nanda I, Dittrich M, Müller T4, Haaf T.
- Journal Title
  
  Aging Cell
  
  Volume: 18 Issue: 5
- DOI
  10.1111/acel.12995
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04037
[Journal Article] Characteristic Clinical Features of Werner Syndrome with a Novel Compound Heterozygous WRN Mutation c.1720+1G>A Plus c.3139-1G>C2019
- Author(s)
  Matsumoto Namiko、Ohta Yasuyuki、Deguchi Kentaro、Kishida Masayuki、Sato Kota、Shang Jingwei、Takemoto Mami、Hishikawa Nozomi、Yamashita Toru、Watanabe Aki、Yokote Koutaro、Takemoto Minoru、Oshima Junko、Abe Koji
- Journal Title
  
  Intern. Med.
  
  Volume: 58 Issue: 7 Pages: 1033-1036
- DOI
  10.2169/internalmedicine.1816-18
- NAID
  130007622212
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2019-04-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04037
[Journal Article] Precision Medicine and Progress in the Treatment of Hutchinson-Gilford Progeria Syndrome.2018
- Author(s)
  Hisama FM, Oshima J.
- Journal Title
  
  JAMA
  
  Volume: 319 Issue: 16 Pages: 1663-1664
- DOI
  10.1001/jama.2018.2199
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04037
[Journal Article] Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies.2018
- Author(s)
  Horvath S, Oshima J, Martin GM, Lu AT, Quach A, Cohen H, Felton S, Matsuyama M, Lowe D, Kabacik S, Wilson JG, Reiner AP, Maierhofer A, Flunkert J, Aviv A, Hou L, Baccarelli AA, Li Y, Stewart JD, Whitsel EA, Ferrucci L, Matsuyama S, Raj K.
- Journal Title
  
  Aging (Albany NY)
  
  Volume: 10 Issue: 7 Pages: 1758-1775
- DOI
  10.18632/aging.101508
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04037
[Journal Article] RECQ helicase disease and related progeroid syndromes: RECQ2018 meeting2018
- Author(s)
  Oshima J, Kato H, Maezawa Y, Yokote K
- Journal Title
  
  Mech Ageing Dev
  
  Volume: 173 Pages: 80-83
- DOI
  10.1016/j.mad.2018.05.002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09292, KAKENHI-PROJECT-17H01558, KAKENHI-PROJECT-17H04037, KAKENHI-PROJECT-16K09341
[Journal Article] CTC1 mutations in a Brazilian family with progeroid features and recurrent bone fractures2018
- Author(s)
  6.Sargolzaeiaval F, Zhang J, Schleit J, Lessel D, Kubisch C, Precioso DR, Sillence D, Hisama FM, Dorschner M, Martin GM, Oshima J.
- Journal Title
  
  Molecular Genetics & Genomic Medicine
  
  Volume: 6 Issue: 6 Pages: 1148-1156
- DOI
  10.1002/mgg3.495
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04037
[Journal Article] Biallelic WRN Mutations in Newly Identified Japanese Werner Syndrome Patients2018
- Author(s)
  Maezawa Y, Kato H, Takemoto M, Watanabe A, Koshizaka M, Ishikawa T, Sargolzaeiaval F, Kuzuya M, Wakabayashi H, Kusaka T, Yokote K, Oshima J
- Journal Title
  
  Mol Syndromol
  
  Volume: 9 Issue: 4 Pages: 214-218
- DOI
  10.1159/000489055
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09292, KAKENHI-PROJECT-17K09687, KAKENHI-PROJECT-17H01558, KAKENHI-PROJECT-17H04037, KAKENHI-PROJECT-16K09229, KAKENHI-PROJECT-16K09341, KAKENHI-PROJECT-16K19530
[Journal Article] High incidence ofBSCL2intragenic recombinational mutation in Peruvian type 2 Berardinelli-Seip syndrome2017
- Author(s)
  Purizaca-Rosillo Nelson、Mori Takayasu、Benites-Condor Yamali、Hisama Fuki M.、Martin George M.、Oshima Junko
- Journal Title
  
  American Journal of Medical Genetics Part A
  
  Volume: 173 Issue: 2 Pages: 471-478
- DOI
  10.1002/ajmg.a.38053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04037
[Journal Article] ERCC4 variants identified in a cohort of patients with segmental progeroid syndromes2017
- Author(s)
  Mori Takayasu、Yousefzadeh Matthew J.、Faridounnia Maryam、Chong Jessica X.、Hisama Fuki M.、Hudgins Louanne、Mercado Gabriela、Wade Erin A.、Barghouthy Amira S.、Lee Lin、Martin George M.、Nickerson Deborah A.、Bamshad Michael J.、Niedernhofer Laura J.、Oshima Junko
- Journal Title
  
  Human Mutation
  
  Volume: 39 Issue: 2 Pages: 255-265
- DOI
  10.1002/humu.23367
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04037, KAKENHI-PROJECT-17H06657
[Presentation] “Genetics of Aging: Molecular Mechanisms of Progeroid Syndromes2019
- Author(s)
  Oshima Junko
- Organizer
  Leading Seminar, Chiba University
- Invited
- Data Source
  KAKENHI-PROJECT-17H04037
[Presentation] Genetics of Aging: Molecular Mechanisms of Progeroid Syndromes2019
- Author(s)
  Oshima Junko
- Organizer
  Seminars in Medical Sciences Series
- Invited
- Data Source
  KAKENHI-PROJECT-17H04037
[Presentation] International Registry of Werner Syndrome: Search for progeroid syndrome mutations and mechanisms2018
- Author(s)
  Junko Oshima
- Organizer
  The International Meeting on RECQ Helicases and Related Diseases 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04037

1. 田中知明 (50447299)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. Hashimoto Naoko (10724875)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 横手幸太郎 (20312944)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 前澤善朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. 竹本稔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OSHIMA JUNKO ＯＳＨＩＭＡ ＪＵＮＫＯ

OSHIMA JYUNKO OSHIMA JUNKO

Research Projects

Research Products

Co-Researchers

Fundamental research of nuclear and mitochondrial interacting signals for accelerated aging by applying premature aging disease model.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Roles of p53-dependent long non-coding RNAs in adipose tissues and blood vessels

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Discovery of novel progeroid syndrome loci and contribution to normative agingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Maternal histone methyltransferases antagonistically regulate monoallelic expression in<i>C. elegans</i>2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In Memory of George M. Martin2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Woodhouse?Sakati syndrome in an Indian patient with a novel pathogenic variant2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Renal dysfunction, malignant neoplasms, atherosclerotic cardiovascular diseases, and sarcopenia as key outcomes observed in a three-year follow-up study using the Werner Syndrome Registry2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Insights into aging from progeroid syndrome epigenetics2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Key elements of cellular senescence involve transcriptional repression of mitotic and DNA repair genes through the p53-p16/RB-E2F-DREAM complex2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Accelerated epigenetic aging and DNA methylation alterations in Berardinelli?Seip congenital lipodystrophy2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Caspase 5 depletion is linked to hyper-inflammatory response and progeroid syndrome2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Martin1GM. Cell to cell variations in gene expression are differentially modulated by knockdowns of diverse genetic loci: implications for the pathobiology of aging.2020

Author(s)

Journal Title

Data Source

[Journal Article] Inactivating mutations in exonuclease and polymerase domains in DNA polymerase delta alter sensitivities to inhibitors of dNTP synthesis.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Epigenetic signatures of Werner syndrome occur early in life and are distinct from normal epigenetic aging processes2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Characteristic Clinical Features of Werner Syndrome with a Novel Compound Heterozygous WRN Mutation c.1720+1G&gt;A Plus c.3139-1G&gt;C2019

Author(s)

Journal Title

OSHIMA JUNKO ＯＳＨＩＭＡＪＵＮＫＯ

[Journal Article] Characteristic Clinical Features of Werner Syndrome with a Novel Compound Heterozygous WRN Mutation c.1720+1G>A Plus c.3139-1G>C2019