Ohnuma Takehiro 大沼毅紘

Researcher Number	80793116
Other IDs
Affiliation (based on the past Project Information) *help	2017 – 2020: 山梨大学, 大学院総合研究部, 助教
Review Section/Research Field	Principal Investigator Basic Section 53050:Dermatology-related / Dermatology
Keywords	Principal Investigator メラノーマ / 免疫チェックポイント阻害剤 / 腫瘍浸潤リンパ球 / MHC class I消失 / 治療抵抗性 / 抗PD-1抗体 / 免疫チェックポイント / 獲得耐性 / 治療抵抗性因子 / TIL / 再発 / B2M

Analysis of the mechanism of acquired resistance for T cell based immunotherapyPrincipal Investigator
- Principal Investigator
  
  Onuma Takehiro
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  University of Yamanashi
Identification of molecules that mediate acquired resistance for anti-PD-1 therapyPrincipal Investigator
- Principal Investigator
  
  Ohnuma Takehiro
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  University of Yamanashi

All 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Heterogeneity in congenital melanocytic nevi contributes to multicentric melanomagenesis2020
- Author(s)
  Honobe Akiko、Sakai Kazuko、Togashi Yosuke、Ohnuma Takehiro、Kawamura Tatsuyoshi、Nishio Kazuto、Inozume Takashi
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: 100 Issue: 3 Pages: 217-219
- DOI
  10.1016/j.jdermsci.2020.09.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08744, KAKENHI-PROJECT-20H03694, KAKENHI-PROJECT-19K22574, KAKENHI-PROJECT-19K17794
[Journal Article] Analysis of the tumor reactivity of tumor-infiltrating lymphocytes in a metastatic melanoma lesion that lost MHC class I expression after anti-PD-1 therapy.2019
- Author(s)
  Inozume T, Yaguchi T, Ariyasu R, Togashi Y, Ohnuma T, Honobe A, Nishikawa H, Kawakami Y, Kawamura T.
- Journal Title
  
  J Invest Dermatol.
  
  Volume: 印刷中 Issue: 7 Pages: 30023-5
- DOI
  10.1016/j.jid.2019.01.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08309, KAKENHI-PROJECT-26221005, KAKENHI-PROJECT-16K10148, KAKENHI-PROJECT-17K16335, KAKENHI-PROJECT-17K18388, KAKENHI-PROJECT-17H06162, KAKENHI-PROJECT-19K08744, KAKENHI-PROJECT-19K17794
[Journal Article] Case of metastatic uveal melanoma in which an antitumor effect appeared after ipilimumab discontinuation due to autoimmune hypophysitis2017
- Author(s)
  Ohnuma Takehiro, Takashi Inozume et al
- Journal Title
  
  Journal of Dermatology
  
  Volume: 44 Issue: 11 Pages: 1325-1326
- DOI
  10.1111/1346-8138.13692
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16335
[Presentation] Heterogeneity in congenital melanocytic nevi contributes to muliticentric melanomagenesis2021
- Author(s)
  Takashi Inozume, Akiko Honobe, Kazuko Sakai, Yosuke Togashi, Takehiro Ohnuma, Tatsuyoshi Kawamura, Kazuto Nishio
- Organizer
  第18回日本臨床腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-19K17794
[Presentation] TIGIT/CD155 axis mediates resistance to immunotherapies in inflamed tumors2021
- Author(s)
  Shusuke Kawashima, Takashi Inozume, Masahito Kawazu, Etsuko Tanji, Akiko Honobe, Takehiro Ohnuma, Tatsuyoshi Kawamura, Hiroyuki Matsue, Yosuke Togashi
- Organizer
  第18回日本臨床腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-19K17794
[Presentation] Identification and characterization of tumor-infiltrating lymphocytes that may mediate anti-tumor response by nivolumab2019
- Author(s)
  Takashi Inozume, Ryo Ariyasu, Yosuke Togashi, Tomonori Yaguchi, Takehiro Ohnuma, Hiroyoshi Nishikawa, Yutaka Kawakami, Tatsuyoshi Kawamura
- Organizer
  The 44 the annual meeting of Japanese Society for Investigative Dermatology
- Data Source
  KAKENHI-PROJECT-19K17794
[Presentation] 抗PD-1抗体が著効した進行期メラノーマにおけるTILの機能解析2019
- Author(s)
  猪爪隆史, 冨樫庸介, 有安亮, 谷口智憲, 大沼毅紘, 河上裕,　西川博嘉
- Organizer
  第23回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-19K17794
[Presentation] Analysis of the tumor reactivity of tumor-infiltrating lymphocytes in a metastatic melanoma lesion that lost MHC class I expression after anti-PD-1 therapy2019
- Author(s)
  Takashi Inozume, Tomonori Yaguchi, Ryo Ariyasu, Yosuke Togashi, Takehiro Ohnuma, Akiko Honobe, Hiroyoshi Nishikawa, Yutaka Kawakami, Tatsuyoshi Kawamura
- Organizer
  The 77 the annual meeting of Society for Investigative Dermatology
- Data Source
  KAKENHI-PROJECT-19K17794
[Presentation] 抗PD-1抗体により長期安定後に悪化した病巣のメラノーマ細胞とTILの解析2018
- Author(s)
  猪爪隆史、谷口智憲、大沼毅紘、河上裕、川村龍吉
- Organizer
  第２２回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-17K16335
[Presentation] イピリムマブ投与後に生じた自己免疫性下垂体炎の1例2017
- Author(s)
  大沼毅紘、猪爪隆史ら
- Organizer
  第６９回日本皮膚科学会西部支部学術大会
- Data Source
  KAKENHI-PROJECT-17K16335

1. INOZUME takashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
2. YAGUCHI Tomonori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 河上裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohnuma Takehiro 大沼 毅紘

Research Projects

Research Products

Co-Researchers

Analysis of the mechanism of acquired resistance for T cell based immunotherapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of molecules that mediate acquired resistance for anti-PD-1 therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Heterogeneity in congenital melanocytic nevi contributes to multicentric melanomagenesis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Analysis of the tumor reactivity of tumor-infiltrating lymphocytes in a metastatic melanoma lesion that lost MHC class I expression after anti-PD-1 therapy.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Case of metastatic uveal melanoma in which an antitumor effect appeared after ipilimumab discontinuation due to autoimmune hypophysitis2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] Heterogeneity in congenital melanocytic nevi contributes to muliticentric melanomagenesis2021

Author(s)

Organizer

Data Source

[Presentation] TIGIT/CD155 axis mediates resistance to immunotherapies in inflamed tumors2021

Author(s)

Organizer

Data Source

[Presentation] Identification and characterization of tumor-infiltrating lymphocytes that may mediate anti-tumor response by nivolumab2019

Author(s)

Organizer

Data Source

[Presentation] 抗PD-1抗体が著効した進行期メラノーマ におけるTILの機能解析2019

Author(s)

Organizer

Data Source

[Presentation] Analysis of the tumor reactivity of tumor-infiltrating lymphocytes in a metastatic melanoma lesion that lost MHC class I expression after anti-PD-1 therapy2019

Author(s)

Organizer

Data Source

[Presentation] 抗PD-1抗体により長期安定後に悪化した病巣のメラノーマ細胞とTILの解析2018

Author(s)

Organizer

Data Source

[Presentation] イピリムマブ投与後に生じた自己免疫性下垂体炎の1例2017

Author(s)

Organizer

Data Source

Ohnuma Takehiro 大沼毅紘

[Presentation] 抗PD-1抗体が著効した進行期メラノーマにおけるTILの機能解析2019