Nishikawa Yoshihiro 西川義浩

Researcher Number	80802785
Other IDs	https://orcid.org/0000-0002-1113-6937
Affiliation (Current)	2025: 京都大学, 医学研究科, 特定助教
Affiliation (based on the past Project Information) *help	2023 – 2024: 京都大学, 医学研究科, 特定助教 2021 – 2022: 神戸大学, 医学研究科, 特別研究員(PD) 2020 – 2021: 神戸大学, 科学技術イノベーション研究科, 特別研究員(PD) 2017 – 2019: 京都大学, 医学研究科, 医員
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Basic Section 53010:Gastroenterology-related / Basic Section 53010:Gastroenterology-related / Gastroenterology
Keywords	Principal Investigator 膵癌 / ELF3 / Hes1 / 発癌 / 胆嚢 / 胆道癌 / 胆嚢癌

慢性炎症を背景とした胆嚢癌の発癌メカニズムの解明Principal Investigator
- Principal Investigator
  
  西川義浩
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyoto University
Elucidation of the carcinogenic mechanisms of bile duct cancer focusing on genetic mutations based on the site of occurrence.Principal Investigator
- Principal Investigator
  
  Nishikawa Yoshihiro
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kyoto University
  Kobe University
次世代マウスモデルおよび患者由来オルガノイドを用いた膵癌の新規治療標的の探索Principal Investigator
- Principal Investigator
  
  西川義浩
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kobe University
The role of ELF3 in homeostasis and tumorigenesis of pancreasPrincipal Investigator
- Principal Investigator
  
  Nishikawa Yoshihiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kobe University
  Kyoto University
The role of Hes1 in pancreatic tumorigenesisPrincipal Investigator
- Principal Investigator
  
  Nishikawa Yoshihiro
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto University

All 2023 2022 2021 2019 2018 2017

All Journal Article Presentation

[Journal Article] ELF3 suppresses gallbladder cancer development through downregulation of the EREG/EGFR/mTOR complex 1 signalling pathway.2023
- Author(s)
  Nakamura T, Nishikawa Y, Shiokawa M, Takeda H, Yokode M, Matsumoto S, Muramoto Y, Ota S, Yoshida H, Okada H, Kuwada T, Marui S, Matsumori T, Maruno T, Uza N, Kodama Y, Hatano E, Seno H.
- Journal Title
  
  J Pathol
  
  Volume: 261 Issue: 1 Pages: 28-42
- DOI
  10.1002/path.6144
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19480, KAKENHI-PROJECT-22K15528, KAKENHI-PROJECT-23K27582
[Journal Article] Context-Dependent Roles of Hes1 in the Adult Pancreas and Pancreatic Tumor Formation.2022
- Author(s)
  Marui S, Nishikawa Y, Shiokawa M, Yokode M, Matsumoto S, Muramoto Y, Ota S, Nakamura T, Yoshida H, Okada H, Kuwada T, Matsumori T, Kuriyama K, Fukuda A, Saur D, Aoi T, Uza N, Kodama Y, Chiba T, Seno H.
- Journal Title
  
  Gastroenterology.
  
  Volume: 163 Issue: 6 Pages: 1613-1629
- DOI
  10.1053/j.gastro.2022.08.048
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19480, KAKENHI-PROJECT-19H03639, KAKENHI-PROJECT-20H03659, KAKENHI-PROJECT-20J01362
[Journal Article] Hes1 plays an essential role in Kras-driven pancreatic tumorigenesis2019
- Author(s)
  Nishikawa Y、Kodama Y、Shiokawa M、Matsumori T、Marui S、Kuriyama K、Kuwada T、Sogabe Y、Kakiuchi N、Tomono T、Mima A、Morita T、Ueda T、Tsuda M、Yamauchi Y、Sakuma Y、Ota Y、Maruno T、Uza N、Uesugi M、Kageyama R、Chiba T、Seno H
- Journal Title
  
  Oncogene
  
  Volume: in press Issue: 22 Pages: 4283-4296
- DOI
  10.1038/s41388-019-0718-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06480, KAKENHI-PROJECT-17H06803, KAKENHI-PROJECT-16K09395, KAKENHI-PROJECT-19K22619, KAKENHI-PROJECT-17H04157, KAKENHI-PROJECT-19J01318, KAKENHI-PROJECT-18K16149, KAKENHI-PLANNED-17H06408, KAKENHI-PROJECT-26220206
[Journal Article] Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone.2018
- Author(s)
  Perron A, Nishikawa Y, Iwata J, Shimojo H, Takaya J, Kobayashi K, Imayoshi I, Mbenza NM, Takenoya M, Kageyama R, Kodama Y, Uesugi M.
- Journal Title
  
  J Biol Chem.
  
  Volume: 印刷中 Issue: 21 Pages: 8285-8294
- DOI
  10.1074/jbc.ra118.002316
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09395, KAKENHI-PROJECT-17K19197, KAKENHI-PLANNED-17H06408, KAKENHI-PROJECT-17H06803, KAKENHI-PROJECT-26220206
[Presentation] ELF3 SUPPRESSES GALLBLADDER CANCER DEVELOPMENT THROUGH DOWNREGURATION OF EREG/EGFR/MTOR COMPLEX 1 SIGNALING PATHWAY2023
- Author(s)
  NAKAMURA T, NISHIKAWA Y, SHIOKAWA M, UZA N, SENO H.
- Organizer
  Digestive Disease Week 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15528
[Presentation] ELF3はERBB/MTORC1 signaling cascadeを制御することで胆嚢癌の進展を抑制する2022
- Author(s)
  中村武晴, 西川義浩, 塩川雅広, 宇座徳光, 妹尾浩
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K15528
[Presentation] Hes1は膵腫瘍の状況に応じて異なる役割を果たす2022
- Author(s)
  西川義浩, 塩川雅広, 中村武晴, 岡田浩和, 宇座徳光, 児玉裕三, 妹尾浩
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20J01362
[Presentation] 膵癌の進展におけるHes1の果たす役割について2021
- Author(s)
  丸井彩子、西川義浩、塩川雅広
- Organizer
  日本消化器関連学会週間
- Data Source
  KAKENHI-PROJECT-20J01362
[Presentation] Hes1 plays an essential role in the initiation of pancreatic cancer formation by regulating acinar-ductal reprogramming2018
- Author(s)
  Yoshihiro Nishikawa, Yuzo Kodama, Hirokazu Okada, Takeshi Kuwada, Saiko Marui, Toshihiro Morita, Tomoaki Matsumori, Teruko Tomono, Yuki Yamauchi, Masahiro Shiokawa, Norimitsu Uza, Hiroshi Seno
- Organizer
  Digestive Disease Week
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06803
[Presentation] Hes1 KOは膵癌マウスモデルにおいて膵発癌を抑制する2017
- Author(s)
  西川義浩、児玉裕三、桒田威、丸井彩子、曽我部裕子、森田敏広、垣内伸之、美馬淳志、松森友昭、友野輝子、上田樹、津田喬之、山内雄揮、佐久間洋二朗、栗山勝利、丸野貴久、塩川雅広、宇座徳光、妹尾浩
- Organizer
  第48回　日本膵臓病学会　大会
- Data Source
  KAKENHI-PROJECT-17H06803
[Presentation] 膵癌形成におけるHes1の機能解析2017
- Author(s)
  Yoshihiro Nishikawa, Yuzo Kodama, Hiroshi Seno
- Organizer
  第78回　日本癌学会　学術総会
- Data Source
  KAKENHI-PROJECT-17H06803

1. 垣内伸之 (90839721)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. KODAMA Yuzo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 妹尾浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 影山龍一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nishikawa Yoshihiro 西川 義浩

Research Projects

Research Products

Co-Researchers

慢性炎症を背景とした胆嚢癌の発癌メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the carcinogenic mechanisms of bile duct cancer focusing on genetic mutations based on the site of occurrence.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

次世代マウスモデルおよび患者由来オルガノイドを用いた膵癌の新規治療標的の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of ELF3 in homeostasis and tumorigenesis of pancreasPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of Hes1 in pancreatic tumorigenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] ELF3 suppresses gallbladder cancer development through downregulation of the EREG/EGFR/mTOR complex 1 signalling pathway.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Context-Dependent Roles of Hes1 in the Adult Pancreas and Pancreatic Tumor Formation.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hes1 plays an essential role in Kras-driven pancreatic tumorigenesis2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone.2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] ELF3 SUPPRESSES GALLBLADDER CANCER DEVELOPMENT THROUGH DOWNREGURATION OF EREG/EGFR/MTOR COMPLEX 1 SIGNALING PATHWAY2023

Author(s)

Organizer

Data Source

[Presentation] ELF3はERBB/MTORC1 signaling cascadeを制御することで胆嚢癌の進展を抑制する2022

Author(s)

Organizer

Data Source

[Presentation] Hes1は膵腫瘍の状況に応じて異なる役割を果たす2022

Author(s)

Organizer

Data Source

[Presentation] 膵癌の進展におけるHes1の果たす役割について2021

Author(s)

Organizer

Data Source

[Presentation] Hes1 plays an essential role in the initiation of pancreatic cancer formation by regulating acinar-ductal reprogramming2018

Author(s)

Organizer

Data Source

[Presentation] Hes1 KOは膵癌マウスモデルにおいて膵発癌を抑制する2017

Author(s)

Organizer

Data Source

[Presentation] 膵癌形成におけるHes1の機能解析2017

Author(s)

Nishikawa Yoshihiro 西川義浩