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Kobayashi Hotaka  小林 穂高

ORCIDConnect your ORCID iD *help
Researcher Number 80802975
Other IDs
Affiliation (Current) 2025: 徳島大学, 先端酵素学研究所, 准教授
2025: 東京大学, 定量生命科学研究所, 客員准教授
Affiliation (based on the past Project Information) *help 2025: 徳島大学, 先端酵素学研究所, 准教授
2023 – 2024: 東京大学, 定量生命科学研究所, 客員准教授
2018: 東京大学, 定量生命科学研究所, 博士研究員
2017: 東京大学, 分子細胞生物学研究所, 助教
Review Section/Research Field
Principal Investigator
Transformative Research Areas, Section (III) / Basic Section 43010:Molecular biology-related / Cell biology
Keywords
Principal Investigator
細胞内1分子イメージング / mRNA / 翻訳 / microRNA / 時空間動態 / 局所翻訳 / アクチン / 細胞伸長 / タンパク質 / 蛋白質 … More / 反応場 / イメージング / poly(A)鎖 / VCP / オートファジー / ユビキチン / Argonaute Less
  • Research Projects

    (6 results)
  • Research Products

    (11 results)
  • Co-Researchers

    (4 People)
  •  Translation and Reaction Sites: Toward Understanding Protein SocietyArea Organizer

    • Area Organizer
      小林 穂高
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Transformative Research Areas (B)
  •  翻訳と反応場から考える蛋白質の新しい社会像の領域推進Principal Investigator

    • Principal Investigator
      小林 穂高
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Transformative Research Areas (B)
    • Review Section
      Transformative Research Areas, Section (III)
    • Research Institution
      The University of Tokushima
  •  細胞伸長部位を「反応場」とするアクチン局所翻訳の実証と開拓Principal Investigator

    • Principal Investigator
      小林 穂高
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Transformative Research Areas (B)
    • Review Section
      Transformative Research Areas, Section (III)
    • Research Institution
      The University of Tokushima
  •  microRNAの時空間動態を細胞内1分子イメージングで解き明かすPrincipal Investigator

    • Principal Investigator
      小林 穂高
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 43010:Molecular biology-related
    • Research Institution
      The University of Tokushima
  •  高時空間解像度イメージングという視点から翻訳の典型的・非典型的な制御機構に迫るPrincipal Investigator

    • Principal Investigator
      小林 穂高
    • Project Period (FY)
      2023 – 2024
    • Research Category
      Grant-in-Aid for Transformative Research Areas (A)
    • Review Section
      Transformative Research Areas, Section (III)
    • Research Institution
      The University of Tokyo
  •  Dissecting the mechanism for autophagic degradation of empty ArgonautePrincipal Investigator

    • Principal Investigator
      Kobayashi Hotaka
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Cell biology
    • Research Institution
      The University of Tokyo

All 2023 2019 2018 2017

All Journal Article Presentation

  • [Journal Article] Single-molecule Analysis of miRNA Function2023

    • Author(s)
      Neina Motoki, Yukihide Tomari, Hotaka Kobayashi
    • Journal Title

      Seibutsu Butsuri

      Volume: 63 Issue: 3 Pages: 160-162

    • DOI

      10.2142/biophys.63.160

    • ISSN
      0582-4052, 1347-4219
    • Language
      Japanese
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-23H04251
  • [Journal Article] Iruka Eliminates Dysfunctional Argonaute by Selective Ubiquitination of Its Empty State2019

    • Author(s)
      Kobayashi Hotaka, Shoji Keisuke, Kiyokawa Kaori, Negishi Lumi, Tomari Yukihide
    • Journal Title

      Molecular Cell

      Volume: 73 Issue: 1 Pages: 119-129

    • DOI

      10.1016/j.molcel.2018.10.033

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-26113007, KAKENHI-PROJECT-17H06616, KAKENHI-PROJECT-18H05271
  • [Presentation] Imaging translation at different mRNA ages2023

    • Author(s)
      Neina Motoki, Yukihide Tomari, Hotaka Kobayashi
    • Organizer
      第24回 日本RNA学会年会
    • Data Source
      KAKENHI-PUBLICLY-23H04251
  • [Presentation] 蛋白質合成の制御過程を細胞内1分子イメージングで見る2023

    • Author(s)
      小林 穂高
    • Organizer
      第23回 日本蛋白質科学会年会
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-23H04251
  • [Presentation] ストレス応答を支えるmicroRNA-その背後にある不思議な現象を複合的なオミクス解析から紐解く-2023

    • Author(s)
      小林 穂高
    • Organizer
      第17回 日本臨床ストレス応答学会大会
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-23H04251
  • [Presentation] ncRNAが機能する様子をこの目で見てみたい2023

    • Author(s)
      小林 穂高
    • Organizer
      第63回 生物物理若手の会 夏の学校
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-23H04251
  • [Presentation] Iruka ensures the quality of Argonaute by selective ubiquitination of its empty state2018

    • Author(s)
      Kobayashi H, Shoji K, Negishi L, Tomari Y
    • Organizer
      13th Microsymposium on Small RNA Biology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H06616
  • [Presentation] Iruka ensures the quality of Argonaute by selective ubiquitination of its empty state2018

    • Author(s)
      Kobayashi H
    • Organizer
      13th Microsymposium on Small RNA Biology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H06616
  • [Presentation] Iruka directs selective ubiquitination of empty Argonaute for successful miRNA-mediated silencing2018

    • Author(s)
      小林 穂高、庄司 佳祐、根岸 瑠美、泊 幸秀
    • Organizer
      第18回 東京大学生命科学シンポジウム
    • Data Source
      KAKENHI-PROJECT-17H06616
  • [Presentation] Iruka mediates selective degradation of miRNA-unloaded Argonaute2017

    • Author(s)
      Kobayashi H, Negishi L, Tomari Y
    • Organizer
      The 43rd Naito Conference on “Noncoding RNA:Biology, Chemistry, & Diseases”
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H06616
  • [Presentation] IrukaはmicroRNA非結合型Argonauteを選択的にユビキチン化する2017

    • Author(s)
      小林穂高、根岸瑠美、泊幸秀
    • Organizer
      第19回日本RNA学会年会
    • Data Source
      KAKENHI-PROJECT-17H06616
  • 1.  七野 悠一 (40748365)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  柏木 一宏 (60732980)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  松尾 芳隆 (00725252)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  TOMARI Yukihide
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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