Ando Fumiaki 安藤史顕

Researcher Number	80804559
Other IDs
Affiliation (Current)	2025: 東京科学大学, 大学院医歯学総合研究科, 助教
Affiliation (based on the past Project Information) *help	2025: 東京科学大学, 大学院医歯学総合研究科, 助教 2023: 東京医科歯科大学, 大学院医歯学総合研究科, 助教 2022: 東京医科歯科大学, 東京医科歯科大学病院, 助教 2021: 東京医科歯科大学, 医学部附属病院, 助教 2019 – 2021: 東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座助教 2017 – 2018: 東京医科歯科大学, 医学部附属病院, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 52010:General internal medicine-related / Basic Section 53040:Nephrology-related / Basic Section 48030:Pharmacology-related / Kidney internal medicine Except Principal Investigator Basic Section 53040:Nephrology-related
Keywords	Principal Investigator AKAPs / AKAP / 肥満症 / AQP2 / AKAPs-PKA結合阻害 / PKA / 先天性腎性尿崩症 / Protein kinase A / 腎性尿崩症 / 血管透過性 … More / 水恒常性 / ZNF185 / LRBA / 抗肥満薬 / Protein Kinase A (PKA) / 褐色脂肪細胞 / Protein Kinase A / 結合阻害 / protein kinase A / 創薬 / 尿崩症 / 腎臓 / 医学 / 誘導体展開 / 低分子化合物 / AKAPs-PKA結合阻害剤 / AQP2水チャネル … More Except Principal Investigator タンパク質キナーゼA / タンパク質キナーゼAアンカータンパク質 / 水・尿素透過性 / 髄質内層集合管 / 先天性腎性尿崩症 / V2受容体 / 尿素透過性 / 水透過性 / 腎髄質内層集合尿細管 Less

LRBAを基軸とした新たな疾患概念の確立と治療法の開発Principal Investigator
- Principal Investigator
  
  安藤史顕
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Institute of Science Tokyo
Elucidation of pathology and drug development for PKA-related diseasesPrincipal Investigator
- Principal Investigator
  
  Ando Fumiaki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Tokyo Medical and Dental University
Development of AKAPs-PKA disruptors for the treatment of obesityPrincipal Investigator
- Principal Investigator
  
  Ando Fumiaki
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Tokyo Medical and Dental University
Studying the effects of activation of intracellular signaling on water and urea permeability in the inner medullary collecting duct
- Principal Investigator
  
  MORIMOTO TETSUJI
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
The application of AKAPs-PKA disruptors to the treatment of nephrogenic diabetes insipidusPrincipal Investigator
- Principal Investigator
  
  Ando Fumiaki
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Kidney internal medicine
- Research Institution
  Tokyo Medical and Dental University

All 2023 2022 2021 2020 2019 2018

All Journal Article Presentation Patent

[Journal Article] Identification of protein kinase A signalling molecules in renal collecting ducts2023
- Author(s)
  Ando Fumiaki、Hara Yu、Uchida Shinichi
- Journal Title
  
  The Journal of Physiology
  
  Volume: - Issue: 13 Pages: 3057-3067
- DOI
  10.1113/jp284178
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02933, KAKENHI-PROJECT-23K24346
[Journal Article] LRBA signalosomes activate vasopressin‐induced AQP2 trafficking at recycling endosomes2023
- Author(s)
  Yanagawa Hideki、Hara Yu、Ando Fumiaki、Suzuki Soichiro、Fujiki Tamami、Oikawa Daisuke、Yui Naofumi、Mandai Shintaro、Mori Yutaro、Susa Koichiro、Mori Takayasu、Sohara Eisei、Tokunaga Fuminori、Uchida Shinichi
- Journal Title
  
  The Journal of Physiology
  
  Volume: 601 Issue: 23 Pages: 5437-5451
- DOI
  10.1113/jp285188
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K18385, KAKENHI-PROJECT-21K06873, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-21H02688, KAKENHI-PROJECT-21H02933, KAKENHI-PROJECT-23K24346
[Journal Article] Mineralocorticoids induce polyuria by reducing apical aquaporin-2 expression of the kidney in partial vasopressin deficiency2023
- Author(s)
  Kurimoto Junki、Takagi Hiroshi、Miyata Takashi、Kawaguchi Yohei、Hodai Yuichi、Tsumura Tetsuro、Hagiwara Daisuke、Kobayashi Tomoko、Yasuda Yoshinori、Sugiyama Mariko、Onoue Takeshi、Iwama Shintaro、Suga Hidetaka、Banno Ryoichi、Katsuki Takeshi、Ando Fumiaki、Uchida Shinichi、Arima Hiroshi
- Journal Title
  
  Endocr J
  
  Volume: 70 Issue: 3 Pages: 295-304
- DOI
  10.1507/endocrj.EJ22-0339
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16339, KAKENHI-PROJECT-21K20930, KAKENHI-PROJECT-21H02933, KAKENHI-PROJECT-23K24346
[Journal Article] ZNF185 prevents stress fiber formation through the inhibition of RhoA in endothelial cells2023
- Author(s)
  Suzuki Soichiro、Ando Fumiaki、Kitagawa Sae、Hara Yu、Fujiki Tamami、Mandai Shintaro、Susa Koichiro、Mori Takayasu、Sohara Eisei、Rai Tatemitsu、Uchida Shinichi
- Journal Title
  
  Communications Biology
  
  Volume: 6 Issue: 1 Pages: 29-29
- DOI
  10.1038/s42003-023-04416-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08249, KAKENHI-PROJECT-21H02933, KAKENHI-PROJECT-23K24346
[Journal Article] LRBA is essential for urinary concentration and body water homeostasis2022
- Author(s)
  Hara Y, Ando F, Oikawa D, Ichimura K, Yanagawa H, Sakamaki Y, Nanamatsu A, Fujiki T, Mori S, Suzuki S, Yui N, Mandai S, Susa K, Mori T, Sohara E, Rai T, Takahashi M, Sasaki S, Kagechika H, Tokunaga F, Uchida S.
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119 Issue: 30
- DOI
  10.1073/pnas.2202125119
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06873, KAKENHI-PROJECT-21K08249, KAKENHI-PROJECT-22K18385, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-21H02688, KAKENHI-PROJECT-21H02933, KAKENHI-PROJECT-18K08233, KAKENHI-PUBLICLY-21H00291, KAKENHI-PROJECT-23K24346
[Journal Article] Vasopressin Induces Urinary Uromodulin Secretion By Activating PKA (Protein Kinase A)2021
- Author(s)
  Nanamatsu Azuma、Mori Takayasu、Ando Fumiaki、Furusho Taisuke、Mandai Shintaro、Susa Koichiro、Sohara Eisei、Rai Tatemitsu、Uchida Shinichi
- Journal Title
  
  Hypertension
  
  Volume: epub Issue: 6 Pages: 1953-1963
- DOI
  10.1161/hypertensionaha.121.17127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17733, KAKENHI-PROJECT-19H01049, KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-21H02933, KAKENHI-PROJECT-21K08249, KAKENHI-PROJECT-19H03672
[Journal Article] Activation of AQP2 water channels by protein kinase A: therapeutic strategies for congenital nephrogenic diabetes insipidus2021
- Author(s)
  Ando Fumiaki
- Journal Title
  
  Clinical and Experimental Nephrology
  
  Volume: 25 Issue: 10 Pages: 1051-1056
- DOI
  10.1007/s10157-021-02108-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02933
[Journal Article] 尿細管・間質疾患・尿路異常 AKAPに着眼したPKAシグナルの解析2021
- Author(s)
  安藤史顕
- Journal Title
  
  腎と透析
  
  Volume: 91 Pages: 863-867
- Data Source
  KAKENHI-PROJECT-21H02933
[Journal Article] 先天性腎性尿崩症2021
- Author(s)
  柳川英輝、安藤史顕
- Journal Title
  
  腎と透析
  
  Volume: 91 Pages: 119-123
- Data Source
  KAKENHI-PROJECT-21H02933
[Journal Article] 体液異常の病態と治療　細胞外液量が低下する病態と治療　多尿、尿崩症2021
- Author(s)
  原悠、安藤史顕、内田信一
- Journal Title
  
  腎と透析
  
  Volume: 90 Pages: 830-834
- Data Source
  KAKENHI-PROJECT-21H02933
[Journal Article] 【水電解質】先天性腎性尿崩症の治療薬開発の現状2020
- Author(s)
  安藤史顕, 内田信一
- Journal Title
  
  日本腎臓学会誌
  
  Volume: 62 Pages: 798-802
- Data Source
  KAKENHI-PROJECT-19K16501
[Journal Article] Tolvaptan activates the Nrf2/HO-1 antioxidant pathway through PERK phosphorylation2019
- Author(s)
  Fujiki Tamami、Ando Fumiaki、Murakami Kana、Isobe Kiyoshi、Mori Takayasu、Susa Koichiro、Nomura Naohiro、Sohara Eisei、Rai Tatemitsu、Uchida Shinichi
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 9245-9245
- DOI
  10.1038/s41598-019-45539-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16501, KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-19H03672, KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15970
[Journal Article] AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus2018
- Author(s)
  Ando Fumiaki、Mori Shuichi、Yui Naofumi、Morimoto Tetsuji、Nomura Naohiro、Sohara Eisei、Rai Tatemitsu、Sasaki Sei、Kondo Yoshiaki、Kagechika Hiroyuki、Uchida Shinichi
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 1411-1411
- DOI
  10.1038/s41467-018-03771-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-15K09286, KAKENHI-PROJECT-18K08233, KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15995, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-17H06656, KAKENHI-PROJECT-15K09301, KAKENHI-PROJECT-16K09642
[Journal Article] 新規先天性腎性尿崩症治療薬の開発2018
- Author(s)
  安藤　史顕
- Journal Title
  
  腎と透析
  
  Volume: 85 Pages: 105-109
- Data Source
  KAKENHI-PROJECT-17H06656
[Journal Article] Activation of AQP2 water channels without vasopressin: therapeutic strategies for congenital nephrogenic diabetes insipidus2018
- Author(s)
  Ando F, Uchida S
- Journal Title
  
  CLINICAL AND EXPERIMENTAL NEPHROLOGY
  
  Volume: 22 Issue: 3 Pages: 501-507
- DOI
  10.1007/s10157-018-1544-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-17H06656
[Patent] 化合物又はその塩、医薬、抗利尿薬及びプロテインキナ－ゼＡ活性化薬2020
- Inventor(s)
  内田　信一、影近　弘之、安藤　史顕、森　修一
- Industrial Property Rights Holder
  国立大学法人東京医科歯科大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-097124
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19K16501
[Presentation] 遺伝性尿細管機能異常症up to date 先天性腎性尿崩症2023
- Author(s)
  安藤　史顕、内田　信一
- Organizer
  第66回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02933
[Presentation] 水・電解質・骨ミネラル代謝の最新知見集合管におけるPKA研究の進展2023
- Author(s)
  安藤　史顕、内田　信一
- Organizer
  第66回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02933
[Presentation] AKAPーPKA結合は尿量調節の創薬標的として有望である2022
- Author(s)
  安藤史顕、内田信一
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21H02933
[Presentation] 尿濃縮のバゾプレシン応答性を制御するアンカータンパクの発見2022
- Author(s)
  安藤　史顕、内田　信一
- Organizer
  第65回日本腎臓学会学術総会シンポジウム
- Data Source
  KAKENHI-PROJECT-21H02933
[Presentation] Identification of therapeutic targets for congenital nephrogenic diabetes insipidus2022
- Author(s)
  Fumiaki Ando
- Organizer
  BENZON SYMPOSIUM No.66
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02933
[Presentation] AQP2水チャネルの制御メカニズムと治療標的としての有用性2021
- Author(s)
  安藤史顕
- Organizer
  第64回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02933
[Presentation] バソプレシンはPKA活性化を介してuromodulin尿中分泌を促進する2021
- Author(s)
  七松東、森崇寧、安藤史顕、古荘泰佑、萬代新太郎、須佐紘一郎、蘇原映誠、頼建光、内田信一
- Organizer
  第64回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02933
[Presentation] PKA活性化薬は白色脂肪のベージュ化を促進し、高脂肪食負荷マウスで体重増加を抑制する2021
- Author(s)
  藤木珠美、安藤史顕、萬代新太郎、須佐紘一郎、森崇寧、蘇原映誠、頼建光、内田信一
- Organizer
  第64回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02933
[Presentation] Identification of Therapeutic Targets for Congenital Nephrogenic Diabetes Insipidus2020
- Author(s)
  Ando F
- Organizer
  第63回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19K16501
[Presentation] Development of Novel Therapeutic Strategies for Congenital NDI and Other PKA-Related Diseases2020
- Author(s)
  Ando F, Uchida S
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K16501
[Presentation] 先天性腎性尿崩症の新規治療薬の開発2019
- Author(s)
  安藤史顕, 内田信一.
- Organizer
  第54回日本小児腎臓病学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K16501
[Presentation] 先天性腎性尿崩症の新規治療薬の開発2019
- Author(s)
  安藤史顕
- Organizer
  第29回バゾプレシン研究会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06656
[Presentation] Derivatives of FMP-API-1/27 Robustly Activate AQP2 Water Channels Independently of Vasopressin2019
- Author(s)
  Ando F, Yui N, Mandai S, Isobe K, Mori T, Susa K, Nomura N, Sohara E, Rai T, Uchida S.
- Organizer
  ASN Kidney Week 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16501
[Presentation] PKA活性化薬の開発と先天性腎性尿崩症治療への応用2019
- Author(s)
  安藤史顕, 磯部清志, 森崇寧, 須佐紘一郎, 野村尚弘, 蘇原映誠, 頼建光, 内田信一.
- Organizer
  第62回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19K16501
[Presentation] AQP2水チャネルの病態生理機能の解明と先天性腎性尿崩症の治療法開発2019
- Author(s)
  安藤史顕
- Organizer
  第30回日本医学会総会 2019中部
- Data Source
  KAKENHI-PROJECT-19K16501
[Presentation] 新規先天性腎性尿崩症治療薬の開発2018
- Author(s)
  安藤史顕
- Organizer
  第113期東京腎生理集談会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06656
[Presentation] AKAPs-PKA Disruptors Robustly Increase AQP2 Activity Independently of Vasopressin2018
- Author(s)
  Ando F, Yui N, Nomura N, Sohara E, Rai T, Sasaki S, Uchida S
- Organizer
  ASN Kidney Week 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06656
[Presentation] FMP-API-1はバゾプレシンに匹敵するAQP2水チャネル活性化作用を持つ―新規腎性尿崩症治療薬の開発―2018
- Author(s)
  安藤史顕, 油井直史, 森本哲司, 野村尚弘, 蘇原映誠, 頼建光, 佐々木成, 根東義明, 内田信一
- Organizer
  第61回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-17H06656
[Presentation] KAPs-PKA結合阻害剤はバゾプレシン非依存性に強力にAQP2水チャネルを活性化する2018
- Author(s)
  安藤史顕, 森修一, 油井直史, 森本哲司, 野村尚弘, 蘇原映誠, 頼建光, 佐々木成, 根東義明, 影近弘之, 内田信一
- Organizer
  第9回分子腎臓フォーラム
- Data Source
  KAKENHI-PROJECT-17H06656
[Presentation] 新規先天性腎性尿崩症治療薬の開発2018
- Author(s)
  安藤　史顕
- Organizer
  第113回東京腎生理集談会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06656

1. MORIMOTO TETSUJI (10344657)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 根東義明 (00221250)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. MORI shuichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 森崇寧

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. 佐々木成

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 内田信一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 及川大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. 徳永文稔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ando Fumiaki 安藤 史顕

Research Projects

Research Products

Co-Researchers

LRBAを基軸とした新たな疾患概念の確立と治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of pathology and drug development for PKA-related diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of AKAPs-PKA disruptors for the treatment of obesityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studying the effects of activation of intracellular signaling on water and urea permeability in the inner medullary collecting duct

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The application of AKAPs-PKA disruptors to the treatment of nephrogenic diabetes insipidusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Identification of protein kinase A signalling molecules in renal collecting ducts2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] LRBA signalosomes activate vasopressin‐induced AQP2 trafficking at recycling endosomes2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mineralocorticoids induce polyuria by reducing apical aquaporin-2 expression of the kidney in partial vasopressin deficiency2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] ZNF185 prevents stress fiber formation through the inhibition of RhoA in endothelial cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] LRBA is essential for urinary concentration and body water homeostasis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Vasopressin Induces Urinary Uromodulin Secretion By Activating PKA (Protein Kinase A)2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activation of AQP2 water channels by protein kinase A: therapeutic strategies for congenital nephrogenic diabetes insipidus2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 尿細管・間質疾患・尿路異常 AKAPに着眼したPKAシグナルの解析2021

Author(s)

Journal Title

Data Source

[Journal Article] 先天性腎性尿崩症2021

Author(s)

Journal Title

Data Source

[Journal Article] 体液異常の病態と治療 細胞外液量が低下する病態と治療 多尿、尿崩症2021

Ando Fumiaki 安藤史顕

[Journal Article] 体液異常の病態と治療　細胞外液量が低下する病態と治療　多尿、尿崩症2021

[Presentation] 水・電解質・骨ミネラル代謝の最新知見集合管におけるPKA研究の進展2023