Isobe Kiyoshi 磯部清志

Researcher Number	80804591
Other IDs
Affiliation (based on the past Project Information) *help	2020 – 2021: 東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 2018 – 2019: 東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座助教
Review Section/Research Field	Principal Investigator Basic Section 53040:Nephrology-related
Keywords	Principal Investigator リン酸化プロテオミクス / 塩分感受性高血圧 / メタボリックシンドローム / WNK4 / Proteomics / WNK1 / WNKキナーゼ / 高血圧 / ミオシン軽鎖キナーゼ / アクアポリン２ … More / WNK / SILAC / ３T3-L1 / WNK４ / C/EBPα / PPARγ / 3T3-L1 / 脂肪分化 Less

Development of new antihypertensive drug by comprehensive analysis of WNK signalPrincipal Investigator
- Principal Investigator
  
  ISOBE KIYOSHI
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Tokyo Medical and Dental University
New drug development for metabolic syndrome via WNK4 singnaling analysisPrincipal Investigator
- Principal Investigator
  
  Isobe Kiyoshi
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Tokyo Medical and Dental University

All 2021 2020 2019 2018

All Journal Article

[Journal Article] Structural Development of Salicylanilide‐Based SPAK Inhibitors as Candidate Antihypertensive Agents2021
- Author(s)
  Fujii Shinya、Kikuchi Eriko、Suzuyama Honoka、Watanabe Yuko、Ishigami‐Yuasa Mari、Masuno Hiroyuki、Mori Takayasu、Isobe Kiyoshi、Uchida Shinichi、Kagechika Hiroyuki
- Journal Title
  
  ChemMedChem
  
  Volume: 16 Issue: 18 Pages: 2817-2822
- DOI
  10.1002/cmdc.202100273
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22486, KAKENHI-PROJECT-20K17244, KAKENHI-PROJECT-17H03997
[Journal Article] Structural development of N-(4-phenoxyphenyl)benzamide derivatives as novel SPAK inhibitors blocking WNK kinase signaling2020
- Author(s)
  Fujii Shinya、Kikuchi Eriko、Watanabe Yuko、Suzuyama Honoka、Ishigami-Yuasa Mari、Mori Takayasu、Isobe Kiyoshi、Uchida Shinichi、Kagechika Hiroyuki
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 30 Issue: 17 Pages: 127408-127408
- DOI
  10.1016/j.bmcl.2020.127408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22486, KAKENHI-PROJECT-20K17244, KAKENHI-PROJECT-17H03997
[Journal Article] CRISPR-Cas9/phosphoproteomics identifies multiple noncanonical targets of myosin light chain kinase2020
- Author(s)
  Isobe Kiyoshi、Raghuram Viswanathan、Krishnan Laya、Chou Chung-Lin、Yang Chin-Rang、Knepper Mark A.
- Journal Title
  
  American Journal of Physiology-Renal Physiology
  
  Volume: 318 Issue: 3 Pages: F600-F616
- DOI
  10.1152/ajprenal.00431.2019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15970
[Journal Article] Sodium-calcium exchanger 1 is the key molecule for urinary potassium excretion against acute hyperkalemia2020
- Author(s)
  Shoda W, Nomura N, Ando F, Tagashira H, Iwamoto T, Ohta A, Isobe K, Mori T, Susa K, Sohara E, Rai T, Uchida S.
- Journal Title
  
  PLoS One.
  
  Volume: 15(6) Issue: 6 Pages: 0235360-0235360
- DOI
  10.1371/journal.pone.0235360
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16509, KAKENHI-PROJECT-20K17244, KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-19H03672, KAKENHI-PROJECT-19K23982
[Journal Article] Nationwide in-hospital mortality following major fractures among hemodialysis patients and the general population: An observational cohort study2020
- Author(s)
  Mandai Shintaro、Sato Hidehiko、Iimori Soichiro、Naito Shotaro、Tanaka Haruna、Ando Fumiaki、Susa Koichiro、Isobe Kiyoshi、Mori Takayasu、Nomura Naohiro、Sohara Eisei、Okado Tomokazu、Uchida Shinichi、Fushimi Kiyohide、Rai Tatemitsu
- Journal Title
  
  Bone
  
  Volume: 130 Pages: 115122-115122
- DOI
  10.1016/j.bone.2019.115122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-19H03672, KAKENHI-PROJECT-18K15970
[Journal Article] Renal TNFα activates the WNK phosphorylation cascade and contributes to salt-sensitive hypertension in chronic kidney disease2020
- Author(s)
  Furusho T, Sohara E, Mandai S, Kikuchi H, Takahashi N, Fujimaru T, Hashimoto H, Arai Y, Ando F, Zeniya M, Mori T, Susa K, Isobe K, Nomura N, Yamamoto K, Okado T, Rai T, Uchida S
- Journal Title
  
  Kidney International
  
  Volume: 97 Issue: 4 Pages: 713-727
- DOI
  10.1016/j.kint.2019.11.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15970, KAKENHI-PROJECT-18K15995, KAKENHI-PROJECT-19K21299, KAKENHI-PROJECT-20K17244, KAKENHI-PROJECT-20K17276, KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-19H03672
[Journal Article] Failure to sense energy depletion may be a novel therapeutic target in chronic kidney disease2019
- Author(s)
  Kikuchi H, Sasaki E, Nomura N, Mori T, Minamishima YA, Yoshizaki Y, Takahashi N, Furusho T, Arai Y, Mandai S, Yamashita T, Ando F, Maejima Y, Isobe K, Okado T, Rai T, Uchida S, Sohara E
- Journal Title
  
  Kidney international
  
  Volume: 95 Issue: 1 Pages: 123-137
- DOI
  10.1016/j.kint.2018.08.030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15995, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-16K09642, KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-18K15970, KAKENHI-PROJECT-16H04723
[Journal Article] Tacrolimus ameliorates the phenotypes of type 4 Bartter syndrome model mice through activation of sodium?potassium?2 chloride cotransporter and sodium?chloride cotransporter2019
- Author(s)
  Matsuura Yoshiaki、Nomura Naohiro、Shoda Wakana、Mori Takayasu、Isobe Kiyoshi、Susa Koichiro、Ando Fumiaki、Sohara Eisei、Rai Tatemitsu、Uchida Shinichi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 517 Issue: 2 Pages: 364-368
- DOI
  10.1016/j.bbrc.2019.07.086
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-19H03672, KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15970, KAKENHI-PROJECT-18K15995
[Journal Article] Tolvaptan activates the Nrf2/HO-1 antioxidant pathway through PERK phosphorylation2019
- Author(s)
  Fujiki Tamami、Ando Fumiaki、Murakami Kana、Isobe Kiyoshi、Mori Takayasu、Susa Koichiro、Nomura Naohiro、Sohara Eisei、Rai Tatemitsu、Uchida Shinichi
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 9245-9245
- DOI
  10.1038/s41598-019-45539-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16501, KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-19H03672, KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15970
[Journal Article] Decreased KLHL3 expression is involved in the pathogenesis of pseudohypoaldosteronism type II caused by cullin 3 mutation in vivo2018
- Author(s)
  Yoshida S, Araki Y, Mori T, Sasaki E, Kasagi Y, Isobe K, Susa K, Inoue Y, Bomont P, Okado T, Rai T, Uchida S, Sohara E
- Journal Title
  
  Clinical and experimental nephrology
  
  Volume: 22 Issue: 6 Pages: 1251-1257
- DOI
  10.1007/s10157-018-1593-z
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15970, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-16K09642
[Journal Article] Metformin increases urinary sodium excretion by reducing phosphorylation of the sodium-chloride cotransporter2018
- Author(s)
  Hashimoto Hiroko、Nomura Naohiro、Shoda Wakana、Isobe Kiyoshi、Kikuchi Hiroaki、Yamamoto Kouhei、Fujimaru Takuya、Ando Fumiaki、Mori Takayasu、Okado Tomokazu、Rai Tatemitsu、Uchida Shinichi、Sohara Eisei
- Journal Title
  
  Metabolism
  
  Volume: 85 Pages: 23-31
- DOI
  10.1016/j.metabol.2018.02.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09642, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-16K15467, KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15970, KAKENHI-PROJECT-18K15995, KAKENHI-PROJECT-16H05314

1. 内田信一

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
2. 藤井晋也

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 頼建光

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
4. 田頭秀章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 安藤史顕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Isobe Kiyoshi 磯部 清志

Research Projects

Research Products

Co-Researchers

Development of new antihypertensive drug by comprehensive analysis of WNK signalPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

New drug development for metabolic syndrome via WNK4 singnaling analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Structural Development of Salicylanilide‐Based SPAK Inhibitors as Candidate Antihypertensive Agents2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural development of N-(4-phenoxyphenyl)benzamide derivatives as novel SPAK inhibitors blocking WNK kinase signaling2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CRISPR-Cas9/phosphoproteomics identifies multiple noncanonical targets of myosin light chain kinase2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sodium-calcium exchanger 1 is the key molecule for urinary potassium excretion against acute hyperkalemia2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nationwide in-hospital mortality following major fractures among hemodialysis patients and the general population: An observational cohort study2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Renal TNFα activates the WNK phosphorylation cascade and contributes to salt-sensitive hypertension in chronic kidney disease2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Failure to sense energy depletion may be a novel therapeutic target in chronic kidney disease2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tacrolimus ameliorates the phenotypes of type 4 Bartter syndrome model mice through activation of sodium?potassium?2 chloride cotransporter and sodium?chloride cotransporter2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tolvaptan activates the Nrf2/HO-1 antioxidant pathway through PERK phosphorylation2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Decreased KLHL3 expression is involved in the pathogenesis of pseudohypoaldosteronism type II caused by cullin 3 mutation in vivo2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Metformin increases urinary sodium excretion by reducing phosphorylation of the sodium-chloride cotransporter2018

Author(s)

Journal Title

DOI

Data Source

Isobe Kiyoshi 磯部清志