Kaneko Naoki 金子直樹

… Alternative Names

金子直樹カネコナオキ

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Researcher Number	80805284
Other IDs
Affiliation (Current)	2025: 九州大学, 歯学研究院, 助教
Affiliation (based on the past Project Information) *help	2021 – 2025: 九州大学, 歯学研究院, 助教 2017 – 2018: 九州大学, 大学病院, 医員
Review Section/Research Field	Principal Investigator Medium-sized Section 57:Oral science and related fields / Basic Section 57060:Surgical dentistry-related / Surgical dentistry Except Principal Investigator Basic Section 57060:Surgical dentistry-related / Basic Section 49020:Human pathology-related / Medium-sized Section 57:Oral science and related fields
Keywords	Principal Investigator COVID-19 / IgG4関連疾患 / 免疫複合体 / 自己抗原 / 形質細胞 / 腫瘍 / 自己免疫疾患 / 自己抗体 / 木村氏病 / B細胞 … More / 濾胞性T細胞 / COVID19 / IgG4 / クラススイッチ / IgG4-related disease / autoimmune disesase / double negative B cell / ダブルネガティブB細胞 / 細胞障害性CD4+ヘルパーT細胞 / DN B細胞 / CD4+CTLs / PAR / dNp63 / 上皮-間葉転換 / PAR2 / PAR1 / KLK6 / 上皮間葉転換 / 口腔扁平上皮癌 … More Except Principal Investigator 口腔扁平上皮癌 / シェーグレン症候群 / T細胞 / RANKL / 骨浸潤 / 骨吸収 / 難治性がん / 治療抵抗性 / 制御性T細胞 / 患者レジストリ / 自己抗原 / 特発性多中心性キャッスルマン病 / 疾患患者由来iPS細胞 / 唾液腺 / 免疫オルガノイド / 口腔癌 / 上皮-間葉転換 / ΔNp63 / 腫瘍微小環境 / 転移 / 浸潤 / PAR1 Less

Identification of molecular targets for the treatment of salivary gland diseases using immune organoid
- Principal Investigator
  
  美島健二
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Showa Medical University
特発性多中心性キャッスルマン病：病態解明に向けた分子基盤、病理および臨床の統合
- Principal Investigator
  
  佐藤康晴
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Okayama University
唾液腺組織由来自己抗原に着目したシェーグレン症候群の新たな治療戦略
- Principal Investigator
  
  森山雅文
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kyushu University
難治性癌の悪性形質獲得に関わる特異な制御性T細胞サブセットの同定とその活性化機構
- Principal Investigator
  
  川野真太郎
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kyushu University
口腔がん微小環境における骨吸収機序：Th17を介した破骨細胞活性化の研究
- Principal Investigator
  
  相川友直
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Hiroshima University
疾患特異的環境下における自己抗体産生B 細胞とその抗原の同定Principal Investigator
- Principal Investigator
  
  金子直樹
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Kyushu University
腫瘍微小環境におけるPAR1を介した口腔癌の高度悪性形質獲得機構の解明
- Principal Investigator
  
  川野真太郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kyushu University
The mechanisms of class switching in IgG4-related disease, Kimura's disease and COVID-19Principal Investigator
- Principal Investigator
  
  金子直樹
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kyushu University
Expansion of CD4+ cytotoxic T lymphocytes and IgD-CD27- double negative B cells in COVID-19 and autoimmune diseases including IgG4-related diseasePrincipal Investigator
- Principal Investigator
  
  金子直樹
- Project Period (FY)
  2021 – 2026
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Kyushu University
Differential roles of kallikrein-related peptidase 6 in malignant transformation and epithelial-mesenchymal transition of oral squamous cell carcinomaPrincipal Investigator
- Principal Investigator
  
  金子直樹
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Surgical dentistry
- Research Institution
  Kyushu University

All 2023 2022 2021 2018 2017

All Journal Article Presentation

[Journal Article] Expansion of CD4+ cytotoxic T lymphocytes with specific gene expression patterns may contribute to suppression of tumor immunity in oral squamous cell carcinoma: single-cell analysis and in vitro experiments2023
- Author(s)
  Chen Hu、Sameshima Junsei、Yokomizo Shiho、Sueyoshi Tomoki、Nagano Haruki、Miyahara Yuka、Sakamoto Taiki、Fujii Shinsuke、Kiyoshima Tamotsu、Guy Thomas、Nakamura Seiji、Moriyama Masafumi、Kaneko Naoki、Kawano Shintaro
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 14 Pages: 1305783-1305783
- DOI
  10.3389/fimmu.2023.1305783
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18401, KAKENHI-PROJECT-19K22723, KAKENHI-PROJECT-23KK0164, KAKENHI-PROJECT-22K10222, KAKENHI-PROJECT-20K10096, KAKENHI-PROJECT-23K27792
[Journal Article] Extrafollicular IgD?CD27?CXCR5?CD11c? DN3 B cells infiltrate inflamed tissues in autoimmune fibrosis and in severe COVID-192023
- Author(s)
  Allard-Chamard H、Kaneko N、Bertocchi A、Sun N、Boucau J、Kuo H、Farmer JR.、Perugino C、Mahajan VS.、Murphy SJ.H.、Premo K、Diefenbach T、Ghebremichael M、Yuen G、Kotta A、Akman Z、Lichterfeld M、Walker BD.、Yu XG.、Moriyama M、Maehara T、Nakamura S、Stone JH.、Padera RF.、Pillai S
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 6 Pages: 112630-112630
- DOI
  10.1016/j.celrep.2023.112630
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18401, KAKENHI-PROJECT-19K22723, KAKENHI-PROJECT-21K19607, KAKENHI-PROJECT-22K19631, KAKENHI-PROJECT-21KK0163, KAKENHI-PROJECT-23KK0164, KAKENHI-PROJECT-23K24548
[Journal Article] Orchestration of Immune Cells Contributes to Fibrosis in IgG4-Related Disease2022
- Author(s)
  Kaneko Naoki、Moriyama Masafumi、Maehara Takashi、Chen Hu、Miyahara Yuka、Nakamura Seiji
- Journal Title
  
  Immuno
  
  Volume: 2 Issue: 1 Pages: 170-184
- DOI
  10.3390/immuno2010013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00553, KAKENHI-PROJECT-18H03003, KAKENHI-PROJECT-21KK0163, KAKENHI-PROJECT-19K22723, KAKENHI-PROJECT-22K19631, KAKENHI-PROJECT-21H03141
[Journal Article] Cytotoxic CD8+ T cells may be drivers of tissue destruction in Sj?gren’s syndrome2022
- Author(s)
  Kaneko Naoki、Chen Hu、Perugino Cory A.、Maehara Takashi、Munemura Ryusuke、Yokomizo Shiho、Sameshima Junsei、Diefenbach Thomas J.、Premo Katherine R.、Chinju Akira、Miyahara Yuka、Sakamoto Mizuki、Moriyama Masafumi、Stone John H.、Nakamura Seiji、Pillai Shiv
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 15427-15427
- DOI
  10.1038/s41598-022-19397-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K17142, KAKENHI-PROJECT-21KK0163, KAKENHI-PROJECT-20H00553, KAKENHI-PROJECT-23K24548, KAKENHI-PROJECT-21H03141
[Journal Article] Significant association of increased PD-L1 and PD-1 expression with nodal metastasis and a poor prognosis in oral squamous cell carcinoma.2018
- Author(s)
  Maruse Y, Kawano S, Jinno T, Matsubara R, Goto Y, Kaneko N, Sakamoto T, Hashiguchi Y, Moriyama M, Toyoshima T, Kitamura R, Tanaka H, Oobu K, Kiyoshima T, Nakamura S.
- Journal Title
  
  International Journal of Oral and Maxillofacial Surgery
  
  Volume: － Issue: 7 Pages: 836-845
- DOI
  10.1016/j.ijom.2018.01.004
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11845, KAKENHI-PROJECT-17K17264, KAKENHI-PROJECT-17H06948, KAKENHI-PROJECT-16K21246
[Journal Article] Tumor-suppressive roles of ΔNp63β-miR-205 axis in epithelial-mesenchymal transition of oral squamous cell carcinoma via targeting ZEB1 and ZEB2.2017
- Author(s)
  Yuma Hashiguchi, Shintaro Kawano, Yuichi Goto, Kaori Yasuda, Naoki Kaneko, Taiki Sakamoto, Ryota Matsubara, Teppei Jinno, Yasuyuki Maruse, Hideaki Tanaka, Masahiko Morioka, Taichi Hattori, Shoichi Tanaka, Tamotsu Kiyoshima, Seiji Nakamura
- Journal Title
  
  Journal of Cellular Physiology
  
  Volume: － Issue: 10 Pages: 6565-6577
- DOI
  10.1002/jcp.26267
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11845, KAKENHI-PROJECT-16K21246, KAKENHI-PROJECT-17H06948, KAKENHI-PROJECT-16K20584, KAKENHI-PROJECT-18K17200
[Journal Article] Critical roles of Wnt5a-Ror2 signaling in aggressiveness of tongue squamous cell carcinoma and production of matrix metalloproteinase-2 via ΔNp63β-mediated epithelial-mesenchymal transition.2017
- Author(s)
  Taiki Sakamoto, Shintaro Kawano, Ryota Matsubara, Yuichi Goto, Teppei Jinno, Yasuyuki Maruse, Naoki Kaneko, Yuma Hashiguchi, Taichi Hattori, Shoichi Tanaka, Ryoji Kitamura, Tamotsu Kiyoshima, Seiji Nakamura
- Journal Title
  
  Oral Oncology
  
  Volume: 69 Pages: 15-25
- DOI
  10.1016/j.oraloncology.2017.03.019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11845, KAKENHI-PROJECT-16K21246, KAKENHI-PROJECT-17H06948, KAKENHI-PROJECT-16K20584
[Journal Article] Differential roles of kallikrein-related peptidase 6 in malignant transformation and ΔNp63β-mediated epithelial-mesenchymal transition of oral squamous cell carcinoma.2017
- Author(s)
  Naoki Kaneko, Shintaro Kawano, Kaori Yasuda, Yuma Hashiguchi, Taiki Sakamoto, Ryota Matsubara, Yuichi Goto, Teppei Jinno, Yasuyuki Maruse, Masahiko Morioka, Taichi Hattori, Shoichi Tanaka, Hideaki Tanaka, Ryoji Kitamura, Tamotsu Kiyoshima, Seiji Nakamura
- Journal Title
  
  Oral Oncology
  
  Volume: 75 Pages: 148-157
- DOI
  10.1016/j.oraloncology.2017.11.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11845, KAKENHI-PROJECT-16K21246, KAKENHI-PROJECT-17H06948, KAKENHI-PROJECT-16K20584
[Presentation] 病変局所に浸潤するダブルネガティブ3（DN3）B細胞はIgG4関連疾患の病態形成に関与する2023
- Author(s)
  金子直樹
- Organizer
  第68回公益社団法人日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-23K24548
[Presentation] 当科における口腔癌手術症例の再発リスクについての後ろ向き検討2023
- Author(s)
  濱田栄樹, 金子直樹, 樋渡萌美, 鮫島潤星, 末吉智貴, 長野晴紀, 坂本泰基, 前原隆, 大部一成, 川野真太郎
- Organizer
  第33回日本口腔内科学会学術大会
- Data Source
  KAKENHI-PROJECT-22K10222
[Presentation] 病変局所に浸潤するダブルネガティブ3（DN3）B細胞はIgG4関連疾患の病態形成に関与する2023
- Author(s)
  金子直樹
- Organizer
  第68回公益社団法人日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-21KK0163
[Presentation] Specific immune response in COVID-192021
- Author(s)
  金子直樹
- Organizer
  OBT International symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21KK0163
[Presentation] COVID-19における特異な免疫反応2021
- Author(s)
  金子直樹
- Organizer
  Research Salon
- Invited
- Data Source
  KAKENHI-PROJECT-21KK0163
[Presentation] 口腔扁平上皮癌におけるkallikrein-related peptidase 7の発現と機能に関する研究2017
- Author(s)
  金子直樹・川野真太郎・松原良太・後藤　雄一・神野哲平・丸瀬靖之・坂本泰基・橋口有真・服部多市・田中翔一・田中秀明・大部一成・中村誠司
- Organizer
  口腔扁平上皮癌におけるkallikrein-related peptidase 7の発現と機能に関する研究
- Data Source
  KAKENHI-PROJECT-17H06948
[Presentation] 下唇癌に対してadvancement flapにて再建を行った1例2017
- Author(s)
  金子直樹，川野真太郎，松原良太，服部多市，田中翔一，新井伸作，大部一成，中村誠司
- Organizer
  第36回日本口腔腫瘍学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-17H06948

1. 川野真太郎 (00398067)

# of Collaborated Projects: 5 results

# of Collaborated Products: 5 results
2. 森山雅文 (20452774)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
3. 林慶和 (00801078)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. 服部多市 (10897185)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 佐藤康晴 (00579831)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 石丸直澄 (60314879)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 中村誠司 (60189040)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. 金子一成 (00214453)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 美島健二 (50275343)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 細沼雅弘 (20836457)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 田中準一 (40710166)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 馬渕洋 (50424172)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 矢嶋宣幸 (70384360)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 大沼慎太郎 (81001196)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 錦織亜沙美 (20975362)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 細野祥之 (60820363)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 西村碧フィリーズ (80931568)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 前原隆 (10637333)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
19. 清島保 (20264054)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 相川友直 (00362674)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 宮川和晃 (50635381)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 宮原佑佳 (51003636)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 松原良太

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
24. 神野哲平

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
25. 坂本瑞樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kaneko Naoki 金子 直樹

金子 直樹 カネコ ナオキ

Research Projects

Research Products

Co-Researchers

Identification of molecular targets for the treatment of salivary gland diseases using immune organoid

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

特発性多中心性キャッスルマン病：病態解明に向けた分子基盤、病理および臨床の統合

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

唾液腺組織由来自己抗原に着目したシェーグレン症候群の新たな治療戦略

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

難治性癌の悪性形質獲得に関わる特異な制御性T細胞サブセットの同定とその活性化機構

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

口腔がん微小環境における骨吸収機序：Th17を介した破骨細胞活性化の研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

疾患特異的環境下における自己抗体産生B 細胞とその抗原の同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

腫瘍微小環境におけるPAR1を介した口腔癌の高度悪性形質獲得機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The mechanisms of class switching in IgG4-related disease, Kimura's disease and COVID-19Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Expansion of CD4+ cytotoxic T lymphocytes and IgD-CD27- double negative B cells in COVID-19 and autoimmune diseases including IgG4-related diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Differential roles of kallikrein-related peptidase 6 in malignant transformation and epithelial-mesenchymal transition of oral squamous cell carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Expansion of CD4+ cytotoxic T lymphocytes with specific gene expression patterns may contribute to suppression of tumor immunity in oral squamous cell carcinoma: single-cell analysis and in vitro experiments2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Extrafollicular IgD?CD27?CXCR5?CD11c? DN3 B cells infiltrate inflamed tissues in autoimmune fibrosis and in severe COVID-192023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Orchestration of Immune Cells Contributes to Fibrosis in IgG4-Related Disease2022

Author(s)

Journal Title

DOI

Data Source

Kaneko Naoki 金子直樹

金子直樹カネコナオキ