KAZUHIRO KOBUKE 小武家和博

Researcher Number	80805648
Other IDs
Affiliation (based on the past Project Information) *help	2018 – 2023: 広島大学, 医系科学研究科(医), 寄附講座助教 2018: 広島大学, 医歯薬保健学研究科(医), 寄附講座助教 2017: 広島大学, 病院(医), 医科診療医
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / Basic Section 54040:Metabolism and endocrinology-related / Endocrinology
Keywords	Principal Investigator 原発性アルドステロン症 / アルドステロン産生腺腫 / 二次性高血圧 / アルドステロン / 体細胞遺伝子変異 / ナトリウムイオンチャネル / 細胞増殖 / 動脈硬化症 / 副腎皮質腫瘍 / アルドステロン産生腫瘍 … More / 二次性高血圧症 / 副腎 / 高血圧症 / NADPH / 腫瘍形成 / メタボローム / DNAメチル化 / 内分泌性高血圧 / 内科 / 循環器・高血圧 / 副腎腫瘍 / エピゲノム調節 Less

小胞体ストレス応答を介したアルドステロン産生線種の発症および腫瘍増殖機構の解明Principal Investigator
- Principal Investigator
  
  小武家和博
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Hiroshima University
Mechanisms of Cell proliferation and tumorigenesis in ATP1A1 gene mutated adrenal cellsPrincipal Investigator
- Principal Investigator
  
  Kobuke Kazuhiro
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Hiroshima University
Exploratory research of treatment target or marker for aldosterone producing adenoma by using of metabolome analysisPrincipal Investigator
- Principal Investigator
  
  Kobuke Kazuhiro
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Hiroshima University
Discovery of aldosterone synthesis mechanisms and drug target via epigenomic regulationPrincipal Investigator
- Principal Investigator
  
  KAZUHIRO KOBUKE
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Endocrinology
- Research Institution
  Hiroshima University

All 2022 2021 2018

All Journal Article Presentation

[Journal Article] Hypomethylation associated vitamin D receptor expression in ATP1A1 mutant aldosterone-producing adenoma2022
- Author(s)
  Nanao Yuta、Oki Kenji、Kobuke Kazuhiro、Itcho Kiyotaka、Baba Ryuta、Kodama Takaya、Otagaki Yu、Okada Akira、Yoshii Yoko、Nagano Gaku、Ohno Haruya、Arihiro Koji、Gomez-Sanchez Celso E.、Hattori Noboru、Yoneda Masayasu
- Journal Title
  
  Molecular and Cellular Endocrinology
  
  Volume: 548 Pages: 111613-111613
- DOI
  10.1016/j.mce.2022.111613
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17964, KAKENHI-PROJECT-22K16415, KAKENHI-PROJECT-21K08557, KAKENHI-PROJECT-21K16058
[Journal Article] ATP1A1 Mutant in Aldosterone-Producing Adenoma Leads to Cell Proliferation2021
- Author(s)
  Kobuke Kazuhiro、Oki Kenji、Gomez-Sanchez Celso E.、Gomez-Sanchez Elise P.、Itcho Kiyotaka、Ohno Haruya、Nagano Gaku、Yoshii Yoko、Baba Ryuta、Kodama Takaya、Arihiro Koji、Hattori Noboru、Yoneda Masayasu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 20 Pages: 10981-10981
- DOI
  10.3390/ijms222010981
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17964, KAKENHI-PROJECT-19K17972, KAKENHI-PROJECT-21K08557, KAKENHI-PROJECT-21K16058
[Journal Article] Aberrant G protein-receptor expression is associated with DNA methylation in aldosterone-producing adenoma2018
- Author(s)
  Itcho K, Oki K, Kobuke K, Yoshii Y, Ohno H, Yoneda M, Hattori N.
- Journal Title
  
  Mol Cell Endocrinol
  
  Volume: 461 Pages: 100-104
- DOI
  10.1016/j.mce.2017.08.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09883, KAKENHI-PROJECT-17K16166, KAKENHI-PROJECT-17H06894
[Journal Article] Purkinje Cell Protein 4 Expression Is Associated With DNA Methylation Status in Aldosterone-Producing Adenoma.2018
- Author(s)
  Kobuke K, Oki K, Gomez-Sanchez CE, Ohno H, Itcho K, Yoshii Y, Yoneda M, Hattori N.
- Journal Title
  
  J Clin Endocrinol Metab
  
  Volume: 103 Issue: 3 Pages: 965-971
- DOI
  10.1210/jc.2017-01996
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09883, KAKENHI-PROJECT-17K16166, KAKENHI-PROJECT-17H06894
[Presentation] ATP1A1 変異アルドステロン産生腫瘍において VDR は低メチル化し細胞増殖に関与する2022
- Author(s)
  七尾裕太、沖健司、小武家和博、一町澄宜、馬場隆太、児玉尭也、大田垣裕、岡田晃、長野学、大野晴也、米田真康
- Organizer
  第95回　日本内分泌学会総会
- Data Source
  KAKENHI-PROJECT-21K16058
[Presentation] The regulation of PCP4 transcription via DNA methylation in aldosterone-producing adenoma2018
- Author(s)
  Kiyotaka Itcho, Kenji Oki, Celso E, Gomez-Sanchez, Kazuhiro Kobuke, Yoko Yoshii, Haruya Ohno, Masayasu Yoneda
- Organizer
  42nd Meeting of the International Aldosterone Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06894

1. 沖健司 (30638995)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. Itcho Kiyotaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results

KAZUHIRO KOBUKE 小武家 和博

Research Projects

Research Products

Co-Researchers

小胞体ストレス応答を介したアルドステロン産生線種の発症および腫瘍増殖機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanisms of Cell proliferation and tumorigenesis in ATP1A1 gene mutated adrenal cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploratory research of treatment target or marker for aldosterone producing adenoma by using of metabolome analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Discovery of aldosterone synthesis mechanisms and drug target via epigenomic regulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Hypomethylation associated vitamin D receptor expression in ATP1A1 mutant aldosterone-producing adenoma2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ATP1A1 Mutant in Aldosterone-Producing Adenoma Leads to Cell Proliferation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Aberrant G protein-receptor expression is associated with DNA methylation in aldosterone-producing adenoma2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Purkinje Cell Protein 4 Expression Is Associated With DNA Methylation Status in Aldosterone-Producing Adenoma.2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] ATP1A1 変異アルドステロン産生腫瘍において VDR は低メチル化し細胞増殖に関与する2022

Author(s)

Organizer

Data Source

[Presentation] The regulation of PCP4 transcription via DNA methylation in aldosterone-producing adenoma2018

Author(s)

Organizer

Data Source

KAZUHIRO KOBUKE 小武家和博