KATO HIDEAKI 加藤英明

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KATO Hideaki 加藤英明

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Researcher Number	80805961
Other IDs	https://orcid.org/0000-0002-1941-5535
Affiliation (Current)	2024: 東京大学, 先端科学技術研究センター, 教授
Affiliation (based on the past Project Information) *help	2024: 東京大学, 先端科学技術研究センター, 教授 2019 – 2023: 東京大学, 大学院総合文化研究科, 准教授
Review Section/Research Field	Principal Investigator Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Transformative Research Areas, Section (III) / Basic Section 43020:Structural biochemistry-related Except Principal Investigator Medium-sized Section 40:Forestry and forest products science, applied aquatic science, and related fields / Medium-sized Section 47:Pharmaceutical sciences and related fields / Transformative Research Areas, Section (III) / Biological Sciences
Keywords	Principal Investigator クライオ電子顕微鏡 / 膜タンパク質 / GPCR / 光受容体 / 構造生物学 / 光遺伝学 / ロドプシン / センサー / ツール開発 / タンパク質工学 … More / 神経調節因子 / ダイナミクス / 微生物型ロドプシン / 創薬 / アレスチン / Gタンパク質 / ニューロテンシン受容体 … More Except Principal Investigator 真核微生物 / 光受容 / 海洋微生物 / トランスクリプトーム / 光受容体 / ロドプシン / DREADD / G12 / GPCR / 死認識 / 社会性神経科学 / Ｘ線 / 蛋白質 / X線 / 電子顕微鏡 / 生物物理 Less

The analysis of structural dynamics of microbial rhodopsinsPrincipal Investigator
- Principal Investigator
  
  加藤英明
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  The University of Tokyo
Structural and functional analysis of novel transporter-type rhodopsinPrincipal Investigator
- Principal Investigator
  
  加藤英明
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  The University of Tokyo
The engineering of the novel imaging tools for neuromodulatorsPrincipal Investigator
- Principal Investigator
  
  加藤英明
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  The University of Tokyo
Neural representation of "Death" (general affairs)
- Principal Investigator
  
  奥山輝大
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  The University of Tokyo
Manipulation of G12/13 signaling and and drug development strategy
- Principal Investigator
  
  井上飛鳥
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Tohoku University
酵素型ロドプシン：光でON-OFFする酵素が描く新しい微生物の生き様
- Principal Investigator
  
  吉澤晋
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 40:Forestry and forest products science, applied aquatic science, and related fields
- Research Institution
  The University of Tokyo
Structural analysis of NTSR1-G-protein complexesPrincipal Investigator
- Principal Investigator
  
  KATO Hideaki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  The University of Tokyo
Molecular mechanism of membrane proteins regulated by physical stimuli
- Principal Investigator
  
  Nureki Osamu
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo

All 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation Book

[Book] 月刊「細胞」2021年 5月号 Gタンパク質共役型受容体（GPCR）の新展開2021
- Author(s)
  松井俊貴, 小柳淳暉, 加藤英明
- Total Pages
  4
- Publisher
  北隆館
- Data Source
  KAKENHI-PROJECT-19H03163
[Journal Article] Endogenous ligand recognition and structural transition of a human PTH receptor2022
- Author(s)
  Kobayashi Kazuhiro、Kawakami Kouki、Kusakizako Tsukasa、Miyauchi Hirotake、Tomita Atsuhiro、Kobayashi Kan、Shihoya Wataru、Yamashita Keitaro、Nishizawa Tomohiro、Kato Hideaki E.、Inoue Asuka、Nureki Osamu
- Journal Title
  
  Molecular Cell
  
  Volume: 82 Issue: 18 Pages: 3468-3483
- DOI
  10.1016/j.molcel.2022.07.003
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15072, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-20J21820, KAKENHI-PROJECT-20K15754, KAKENHI-PROJECT-21H05037
[Journal Article] Structural insights into the G protein selectivity revealed by the human EP3-Gi signaling complex2022
- Author(s)
  Ryoji Suno, Yukihiko Sugita, Kazushi Morimoto, Hiroko Takazaki, Hirokazu Tsujimoto, Mika Hirose, Chiyo Suno-Ikeda, Norimichi Nomura, Tomoya Hino, Asuka Inoue, Kenji Iwasaki, Takayuki Kato, So Iwata, Takuya Kobayashi
- Journal Title
  
  Cell Rep.
  
  Volume: 40(11) Issue: 11 Pages: 111323-111323
- DOI
  10.1016/j.celrep.2022.111323
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19360, KAKENHI-PLANNED-21H05112, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-19H03428, KAKENHI-PUBLICLY-22H04753
[Journal Article] Cryo-EM structure of the β3-adrenergic receptor reveals the molecular basis of subtype selectivity.2021
- Author(s)
  Nagiri, C., Kobayashi, K., Tomita, A., Kato, M., Kobayashi, K., Yamashita, K., Nishizawa, T., Inoue, A., Shihoya, W. and Nureki, O.
- Journal Title
  
  Mol. Cell
  
  Volume: 81 Issue: 15 Pages: 3205-3215
- DOI
  10.1016/j.molcel.2021.06.024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06294, KAKENHI-PUBLICLY-20H05437, KAKENHI-PROJECT-20J13299, KAKENHI-PROJECT-20K15728, KAKENHI-PROJECT-21H05037
[Journal Article] Structure of the neurotensin receptor 1 in complex with β-arrestin 12020
- Author(s)
  Huang Weijiao、Masureel Matthieu、Qu Qianhui、Janetzko John、Inoue Asuka、Kato Hideaki E.、Robertson Michael J.、Nguyen Khanh C.、Glenn Jeffrey S.、Skiniotis Georgios、Kobilka Brian K.
- Journal Title
  
  Nature
  
  Volume: 579 Issue: 7798 Pages: 303-308
- DOI
  10.1038/s41586-020-1953-1
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08264, KAKENHI-PROJECT-19H03163
[Journal Article] Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation2020
- Author(s)
  Nakamura Ryoki、Numata Tomohiro、Kasuya Go、Yokoyama Takeshi、Nishizawa Tomohiro、Kusakizako Tsukasa、Kato Takafumi、Hagino Tatsuya、Dohmae Naoshi、Inoue Masato、Watanabe Kengo、Ichijo Hidenori、Kikkawa Masahide、Shirouzu Mikako、Jentsch Thomas J.、Ishitani Ryuichiro、Okada Yasunobu、Nureki Osamu
- Journal Title
  
  Communications Biology
  
  Volume: 3 Issue: 1 Pages: 240-240
- DOI
  10.1038/s42003-020-0951-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03640, KAKENHI-PROJECT-20K15754, KAKENHI-PLANNED-16H06574, KAKENHI-PROJECT-18H03995, KAKENHI-PROJECT-18K06864, KAKENHI-PROJECT-19K23833, KAKENHI-PROJECT-16H06294
[Journal Article] Conformational transitions of a neurotensin receptor?1?Gi1?complex2019
- Author(s)
  Kato Hideaki E.、Zhang Yan、Hu Hongli、Suomivuori Carl-Mikael、Kadji Francois Marie Ngako、Aoki Junken、Krishna Kumar Kaavya、Fonseca Rasmus、Hilger Daniel、Huang Weijiao、Latorraca Naomi R.、Inoue Asuka、Dror Ron O.、Kobilka Brian K.、Skiniotis Georgios
- Journal Title
  
  Nature
  
  Volume: 572 Issue: 7767 Pages: 80-85
- DOI
  10.1038/s41586-019-1337-6
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03163, KAKENHI-PROJECT-17K08264
[Journal Article] Crystal structure of the Agrobacterium tumefaciens type VI effector-immunity complex.2018
- Author(s)
  Fukuhara S, Nakane T, Yamashita K, Ishii R, Ishitani R, Nureki O
- Journal Title
  
  Acta Crystallogr. F Struct. Biol. Commun.
  
  Volume: 74 Issue: 3 Pages: 810-816
- DOI
  10.1038/s41477-019-0367-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03640, KAKENHI-PROJECT-17J06203, KAKENHI-PROJECT-16H06294
[Journal Article] Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA62017
- Author(s)
  Taniguchi Reiya、Inoue Asuka、Sayama Misa、Uwamizu Akiharu、Yamashita Keitaro、Hirata Kunio、Yoshida Masahito、Tanaka Yoshiki、Kato Hideaki E.、Nakada-Nakura Yoshiko、Otani Yuko、Nishizawa Tomohiro、Doi Takayuki、Ohwada Tomohiko、Ishitani Ryuichiro、Aoki Junken、Nureki Osamu
- Journal Title
  
  Nature
  
  Volume: 548 Issue: 7667 Pages: 356-360
- DOI
  10.1038/nature23448
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08157, KAKENHI-PUBLICLY-16H00822, KAKENHI-PROJECT-17H03640, KAKENHI-PROJECT-16J07583, KAKENHI-PROJECT-16J08059, KAKENHI-PROJECT-16H06294, KAKENHI-PROJECT-17H05000
[Journal Article] Structural and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase.2016
- Author(s)
  Morita J, Kano K, Kato K, Takita H, Skagami H, Yamamoto Y, Mihara E, Ueda H, Sato T, Tokuyama H, Arai H, Asou H, Takagi J, Ishitani R, Nishimasu H, Nureki O, Aoki J
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Issue: 1 Pages: 20995-20995
- DOI
  10.1038/srep20995
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111006, KAKENHI-PROJECT-26253001, KAKENHI-PROJECT-15J08403, KAKENHI-PROJECT-25291011, KAKENHI-PROJECT-23227004, KAKENHI-PROJECT-26860004, KAKENHI-PROJECT-16H06294
[Journal Article] "Role of Asn112 in a light-driven sodium ion-pumping rhodopsin"2016
- Author(s)
  R. Abe-Yoshizumi, K. Inoue, H. E. Kato, O. Nureki, H. Kandori*
- Journal Title
  
  Biochemistry
  
  Volume: 55 Issue: 41 Pages: 5790-5797
- DOI
  10.1021/acs.biochem.6b00741
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-25104009, KAKENHI-PROJECT-15H02391, KAKENHI-PROJECT-14J40214, KAKENHI-PROJECT-26708001, KAKENHI-PROJECT-26620005, KAKENHI-PROJECT-16H06294
[Journal Article] Crystal structure of the plant receptor-like kinase TDR in complex with the TDIF peptide.2016
- Author(s)
  Morita, J., Kato, K., Nakane, T., Kondo, Y., Fukuda, H., Nishimasu, H., *Ishitani, R. and *Nureki, O.
- Journal Title
  
  Nat. Commun.
  
  Volume: 7 Issue: 1 Pages: 12383-12383
- DOI
  10.1038/ncomms12383
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01226, KAKENHI-PLANNED-15H05958, KAKENHI-PROJECT-25291011, KAKENHI-PROJECT-16H06294, KAKENHI-PROJECT-16H06377
[Journal Article] Crystal structures of the TRIC trimeric intracellular cation channel orthologues.2016
- Author(s)
  Kasuya G, Hiraizumi M, Maturana AD, Kumazaki K, Fujiwara Y, Liu K, Nakada-Nakura Y, Iwata S, Tsukada K, Komori T, Uemura S, Goto Y, Nakane T, Takemoto M, Kato HE, Yamashita K, Wada M, Ito K, Ishitani R, Hattori M, Nureki O.
- Journal Title
  
  Cell Res.
  
  Volume: 26 Issue: 12 Pages: 1288-1301
- DOI
  10.1038/cr.2016.140
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01389, KAKENHI-PROJECT-15J08129, KAKENHI-PROJECT-25291011, KAKENHI-PROJECT-26291030, KAKENHI-PROJECT-16K15180, KAKENHI-PROJECT-16H06294
[Journal Article] Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization.2016
- Author(s)
  Kato K, Satouh Y, Nishimasu H, Kurabayashi A, Morita J, Fujihara Y, Oji A, Ishitani R, Ikawa M, Nureki O.
- Journal Title
  
  Nature Communications
  
  Volume: 7 Issue: 1 Pages: 12198-12198
- DOI
  10.1038/ncomms12198
- NAID
  120006957420
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05573, KAKENHI-PROJECT-15J04519, KAKENHI-PROJECT-15J08403, KAKENHI-PROJECT-25291011, KAKENHI-PROJECT-16H06276, KAKENHI-ORGANIZER-25112001, KAKENHI-PROJECT-16H06294
[Presentation] CryoEM analysis of the GPCR neurotensin receptor 1 signaling complexes2020
- Author(s)
  加藤英明
- Organizer
  東京大学　医学部リサーチカンファ
- Invited
- Data Source
  KAKENHI-PROJECT-19H03163
[Presentation] CryoEM analysis of the GPCR neurotensin receptor 1 signaling complexes2020
- Author(s)
  加藤英明
- Organizer
  第93回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03163
[Presentation] Structural basis for the recognition of salient signals by GPCRs2020
- Author(s)
  Hideaki Kato
- Organizer
  第43回日本神経科学大会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03163
[Presentation] CryoEM analysis of the GPCR neurotensin receptor 1-G protein complex for the future engineering of biased allosteric modulator2020
- Author(s)
  加藤英明
- Organizer
  第418回 CBI学会講演会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03163
[Presentation] CryoEM analysis of the GPCR neurotensin receptor 1-G protein complex2019
- Author(s)
  Hideaki Kato
- Organizer
  The Joint Symposium on Fusion of Biomedical and Physical/ Informational Sciences in Neurobiology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03163
[Presentation] Structural and conformational transition in NTSR1-Gi1 protein complex2019
- Author(s)
  加藤英明
- Organizer
  名古屋工業大学セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19H03163
[Presentation] Structural and conformational transition in NTSR1-Gi1 protein complex2019
- Author(s)
  加藤英明
- Organizer
  第92回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03163
[Presentation] Structural and conformational transition in NTSR1-Gi1 protein complex2019
- Author(s)
  加藤英明
- Organizer
  第57回日本生物物理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03163
[Presentation] CryoEM analysis of the GPCR neurotensin receptor 1-G protein complex for the future engineering of biased allosteric modulator2019
- Author(s)
  Hideaki Kato
- Organizer
  AHeDD2019/IPAB2019 Joint Symposium
- Invited
- Data Source
  KAKENHI-PROJECT-19H03163
[Presentation] Structural and conformational transition in NTSR1-Gi1 protein complex2019
- Author(s)
  加藤英明
- Organizer
  東京大学第1292回生物科学セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19H03163
[Presentation] Structural and conformational transition in NTSR1-Gi1 protein complex2019
- Author(s)
  加藤英明
- Organizer
  金沢大学　NanoLSIセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19H03163

1. Nureki Osamu (10272460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 伊藤耕一 (10262073)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. MATURANA ANDRES (10452004)

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4. 石谷隆一郎 (90361568)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 井上圭一 (90467001)

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# of Collaborated Products: 1 results
6. 小林直也 (60781945)

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7. 奥山輝大 (80625955)

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8. 竹内春樹 (70548859)

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9. 三浦恭子 (80583062)

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10. 井上飛鳥 (50525813)

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11. 吉澤晋 (00553108)

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12. OTANI Yuko

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13. FUJIWARA Yuichiro

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14. FUJIHARA Yoshitaka

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15. 高木淳一

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16. 草木迫司

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17. 神取秀樹

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18. 近藤侑貴

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19. 小林拓也

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20. 寿野良二

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21. 井上明俊

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KATO HIDEAKI 加藤 英明

KATO Hideaki 加藤 英明

Research Projects

Research Products

Co-Researchers

The analysis of structural dynamics of microbial rhodopsinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural and functional analysis of novel transporter-type rhodopsinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The engineering of the novel imaging tools for neuromodulatorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Neural representation of "Death" (general affairs)

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Manipulation of G12/13 signaling and and drug development strategy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

酵素型ロドプシン：光でON-OFFする酵素が描く新しい微生物の生き様

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural analysis of NTSR1-G-protein complexesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanism of membrane proteins regulated by physical stimuli

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 月刊「細胞」2021年 5月号 Gタンパク質共役型受容体（GPCR）の新展開2021

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Endogenous ligand recognition and structural transition of a human PTH receptor2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural insights into the G protein selectivity revealed by the human EP3-Gi signaling complex2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cryo-EM structure of the β3-adrenergic receptor reveals the molecular basis of subtype selectivity.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structure of the neurotensin receptor 1 in complex with β-arrestin 12020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation2020

Author(s)

KATO HIDEAKI 加藤英明

KATO Hideaki 加藤英明