Unregistered Unregistered 冨樫敬太

… Alternative Names

Keita Togashi 冨樫敬太

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Researcher Number	80810796
Other IDs
Affiliation (Current)	2025: 山形大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2023: 山形大学, 医学部, 助教 2022: 山形大学, 医学部, 医員 2021: 山形大学, 医学部, 病院助教 2019 – 2020: 山形大学, 医学部, 医員
Review Section/Research Field	Principal Investigator Basic Section 56060:Ophthalmology-related
Keywords	Principal Investigator p53 / MDM4 / CEP1347 / PKC / ぶどう膜悪性黒色腫 / アンメット・メディカル・ニーズ / 新規治療薬開発 / 眼科悪性腫瘍 / 細胞死 / 増殖抑制 / 細胞増殖抑制能 / CEP-1347 / 網膜芽細胞腫

Development of a novel therapeutic drug targeting both MDM4 and PKC, critical points in uveal malignant melanomaPrincipal Investigator
- Principal Investigator
  
  冨樫敬太
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Yamagata University
Establishment of a novel treatment for uveal melanoma based on p53 pathway activationPrincipal Investigator
- Principal Investigator
  
  Togashi Keita
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Yamagata University
Clarification of mechanisms for inhibition of retinoblastoma growth by CEP-1347Principal Investigator
- Principal Investigator
  
  Keita Togashi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Yamagata University

All 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Givinostat Inhibition of Sp1-dependent MGMT Expression Sensitizes Glioma Stem Cells to Temozolomide.2023
- Author(s)
  Nakagawa-Saito Y, Mitobe Y, Togashi K, Suzuki S, Sugai A, Kitanaka C, Okada M.
- Journal Title
  
  Anticancer Res.
  
  Volume: 3 Issue: 3 Pages: 1131-1138
- DOI
  10.21873/anticanres.16258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07631, KAKENHI-PROJECT-22K09202, KAKENHI-PROJECT-21K16867, KAKENHI-PROJECT-19K09449, KAKENHI-PROJECT-21H03040
[Journal Article] Domatinostat Targets the FOXM1?Survivin Axis to Reduce the Viability of Ovarian Cancer Cells Alone and in Combination with Chemotherapeutic Agents2023
- Author(s)
  Nakagawa-Saito Yurika、Mitobe Yuta、Suzuki Shuhei、Togashi Keita、Sugai Asuka、Kitanaka Chifumi、Okada Masashi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 13 Pages: 10817-10817
- DOI
  10.3390/ijms241310817
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09202, KAKENHI-PROJECT-23K06689, KAKENHI-PROJECT-23K08492, KAKENHI-PROJECT-23K09020, KAKENHI-PROJECT-20K07631, KAKENHI-PROJECT-21K16867
[Journal Article] The Novel MDM4 Inhibitor CEP-1347 Activates the p53 Pathway and Blocks Malignant Meningioma Growth In Vitro and In Vivo2023
- Author(s)
  Mitobe Yuta、Suzuki Shuhei、Nakagawa-Saito Yurika、Togashi Keita、Sugai Asuka、Sonoda Yukihiko、Kitanaka Chifumi、Okada Masashi
- Journal Title
  
  Biomedicines
  
  Volume: 11 Issue: 7 Pages: 1967-1967
- DOI
  10.3390/biomedicines11071967
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09202, KAKENHI-PROJECT-22K09250, KAKENHI-PROJECT-23K06689, KAKENHI-PROJECT-23K08492, KAKENHI-PROJECT-20K07631, KAKENHI-PROJECT-21K16867
[Journal Article] CEP-1347 Dually Targets MDM4 and PKC to Activate p53 and Inhibit the Growth of Uveal Melanoma Cells2023
- Author(s)
  Togashi Keita、Suzuki Shuhei、Mitobe Yuta、Nakagawa-Saito Yurika、Sugai Asuka、Takenouchi Senri、Sugimoto Masahiko、Kitanaka Chifumi、Okada Masashi
- Journal Title
  
  Cancers
  
  Volume: 16 Issue: 1 Pages: 118-118
- DOI
  10.3390/cancers16010118
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09202, KAKENHI-PROJECT-23K06689, KAKENHI-PROJECT-23K08492, KAKENHI-PROJECT-23K09020, KAKENHI-PROJECT-20K07631, KAKENHI-PROJECT-21K16867
[Journal Article] Antagonizing MDM2 Overexpression Induced by MDM4 Inhibitor CEP-1347 Effectively Reactivates Wild-Type p53 in Malignant Brain Tumor Cells2023
- Author(s)
  Mitobe Yuta、Suzuki Shuhei、Nakagawa-Saito Yurika、Togashi Keita、Sugai Asuka、Sonoda Yukihiko、Kitanaka Chifumi、Okada Masashi
- Journal Title
  
  Cancers
  
  Volume: 15 Issue: 17 Pages: 4326-4326
- DOI
  10.3390/cancers15174326
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09202, KAKENHI-PROJECT-22K09250, KAKENHI-PROJECT-23K06689, KAKENHI-PROJECT-23K08492, KAKENHI-PROJECT-23K09020, KAKENHI-PROJECT-20K07631, KAKENHI-PROJECT-21K16867, KAKENHI-PROJECT-21H03040
[Journal Article] HDAC Class I Inhibitor Domatinostat Preferentially Targets Glioma Stem Cells over Their Differentiated Progeny2022
- Author(s)
  Nakagawa-Saito Yurika、Saitoh Shinichi、Mitobe Yuta、Sugai Asuka、Togashi Keita、Suzuki Shuhei、Kitanaka Chifumi、Okada Masashi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 15 Pages: 8084-8084
- DOI
  10.3390/ijms23158084
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07631, KAKENHI-PROJECT-22K09250, KAKENHI-PROJECT-21K16867, KAKENHI-PROJECT-21H03040, KAKENHI-PROJECT-19K09449
[Journal Article] CEP-1347 Targets MDM4 Protein Expression to Activate p53 and Inhibit the Growth of Glioma Cells.2022
- Author(s)
  Mitobe Y, Nakagawa-Saito Y, Togashi K, Suzuki S, Sugai A, Matsuda KI, Sonoda Y, Kitanaka C, Okada M.
- Journal Title
  
  Anticancer Res.
  
  Volume: 10 Issue: 10 Pages: 4727-4733
- DOI
  10.21873/anticanres.15977
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07631, KAKENHI-PROJECT-22K09202, KAKENHI-PROJECT-22K09250, KAKENHI-PROJECT-21K16867, KAKENHI-PROJECT-21H03040, KAKENHI-PROJECT-19K09449
[Journal Article] Inhibition of the Phospholipase Cε-c-Jun N-Terminal Kinase Axis Suppresses Glioma Stem Cell Properties2022
- Author(s)
  Okada Masashi、Nakagawa-Saito Yurika、Mitobe Yuta、Sugai Asuka、Togashi Keita、Suzuki Shuhei、Kitanaka Chifumi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 15 Pages: 8785-8785
- DOI
  10.3390/ijms23158785
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07631, KAKENHI-PROJECT-22K09202, KAKENHI-PROJECT-22K09250, KAKENHI-PROJECT-21K16867, KAKENHI-PROJECT-21H03040, KAKENHI-PROJECT-19K09449
[Journal Article] Gemcitabine Cooperates with Everolimus to Inhibit the Growth of and Sensitize Malignant Meningioma Cells to Apoptosis Induced by Navitoclax, an Inhibitor of Anti-Apoptotic BCL-2 Family Proteins2022
- Author(s)
  Yamamoto Masahiro、Suzuki Shuhei、Togashi Keita、Sugai Asuka、Okada Masashi、Kitanaka Chifumi
- Journal Title
  
  Cancers
  
  Volume: 14 Issue: 7 Pages: 1706-1706
- DOI
  10.3390/cancers14071706
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18870, KAKENHI-PROJECT-21K16867, KAKENHI-PROJECT-22K09250, KAKENHI-PROJECT-19K09449
[Journal Article] Targeting Folate Metabolism Is Selectively Cytotoxic to Glioma Stem Cells and Effectively Cooperates with Differentiation Therapy to Eliminate Tumor-Initiating Cells in Glioma Xenografts2021
- Author(s)
  Okada Masashi、Suzuki Shuhei、Togashi Keita、Sugai Asuka、Yamamoto Masahiro、Kitanaka Chifumi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 21 Pages: 11633-11633
- DOI
  10.3390/ijms222111633
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18870, KAKENHI-PROJECT-21H03040, KAKENHI-PROJECT-20K07631, KAKENHI-PROJECT-21K16867
[Journal Article] Gemcitabine radiosensitization primes irradiated malignant meningioma cells for senolytic elimination by navitoclax2021
- Author(s)
  Yamamoto Masahiro、Sanomachi Tomomi、Suzuki Shuhei、Togashi Keita、Sugai Asuka、Seino Shizuka、Sato Atsushi、Okada Masashi、Kitanaka Chifumi
- Journal Title
  
  Neuro-Oncology Advances
  
  Volume: 3 Issue: 1 Pages: 1-11
- DOI
  10.1093/noajnl/vdab148
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18870, KAKENHI-PROJECT-20K17949, KAKENHI-PROJECT-20K07631, KAKENHI-PROJECT-21K16867
[Journal Article] Metastatic Orbital Tumor From Breast Ductal Carcinoma With Neuroendocrine Differentiation Initially Presenting as Ocular Symptoms: A Case Report and Literature Review2021
- Author(s)
  Togashi Keita、Nishitsuka Koichi、Hayashi Shion、Namba Hiroyuki、Goto Sakiko、Takeda Yusuke、Suzuki Shuhei、Kato Tomoya、Yamada Yuki、Konno Eriko、Yoshioka Takashi、Yamakawa Mitsunori、Sonoda Yukihiko、Suzuki Tamio、Yamashita Hidetoshi
- Journal Title
  
  Frontiers in Endocrinology
  
  Volume: 12
- DOI
  10.3389/fendo.2021.625663
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18870
[Journal Article] Inhibition of the Lipid Droplet-Peroxisome Proliferator-Activated Receptor α Axis Suppresses Cancer Stem Cell Properties.2021
- Author(s)
  Kuramoto K, Yamamoto M, Suzuki S, Togashi K, Sanomachi T, Kitanaka C, Okada M.
- Journal Title
  
  Genes (Basel)
  
  Volume: 12(1) Issue: 1 Pages: 99-99
- DOI
  10.3390/genes12010099
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07631, KAKENHI-PROJECT-19K18870
[Journal Article] Lurasidone Sensitizes Cancer Cells to Osimertinib by Inducing Autophagy and Reduction of Survivin2021
- Author(s)
  SUZUKI SHUHEI、YAMAMOTO MASAHIRO、SANOMACHI TOMOMI、TOGASHI KEITA、SEINO SHIZUKA、SUGAI ASUKA、YOSHIOKA TAKASHI、OKADA MASASHI、KITANAKA CHIFUMI
- Journal Title
  
  Anticancer Research
  
  Volume: 41 Issue: 9 Pages: 4321-4331
- DOI
  10.21873/anticanres.15237
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K18870, KAKENHI-PROJECT-19K09449, KAKENHI-PROJECT-20K07631, KAKENHI-PROJECT-21K16867
[Journal Article] Dexamethasone Sensitizes Cancer Stem Cells to Gemcitabine and 5-Fluorouracil by Increasing Reactive Oxygen Species Production through NRF2 Reduction2021
- Author(s)
  Suzuki Shuhei、Yamamoto Masahiro、Sanomachi Tomomi、Togashi Keita、Sugai Asuka、Seino Shizuka、Yoshioka Takashi、Okada Masashi、Kitanaka Chifumi
- Journal Title
  
  Life
  
  Volume: 11 Issue: 9 Pages: 885-885
- DOI
  10.3390/life11090885
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18870, KAKENHI-PROJECT-20K07631, KAKENHI-PROJECT-21K16867
[Journal Article] Roles for hENT1 and dCK in gemcitabine sensitivity and malignancy of meningioma2021
- Author(s)
  Yamamoto Masahiro、Sanomachi Tomomi、Suzuki Shuhei、Uchida Hiroyuki、Yonezawa Hajime、Higa Nayuta、Takajo Tomoko、Yamada Yuki、Sugai Asuka、Togashi Keita、Seino Shizuka、Okada Masashi、Sonoda Yukihiko、Hirano Hirofumi、Yoshimoto Koji、Kitanaka Chifumi
- Journal Title
  
  Neuro-Oncology
  
  Volume: XX Issue: 6 Pages: 1-10
- DOI
  10.1093/neuonc/noab015
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17949, KAKENHI-PROJECT-18K16550, KAKENHI-PROJECT-19K18870, KAKENHI-PROJECT-20K07631
[Journal Article] Therapeutic targeting of pancreatic cancer stem cells by dexamethasone modulation of the MKP-1?JNK axis2020
- Author(s)
  Suzuki Shuhei、Okada Masashi、Sanomachi Tomomi、Togashi Keita、Seino Shizuka、Sato Atsushi、Yamamoto Masahiro、Kitanaka Chifumi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 295 Issue: 52 Pages: 18328-18342
- DOI
  10.1074/jbc.ra120.015223
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09449, KAKENHI-PROJECT-20K07631, KAKENHI-PROJECT-19K18870
[Journal Article] Inhibition of Retinoblastoma Cell Growth by CEP1347 Through Activation of the P53 Pathway.2020
- Author(s)
  Togashi K, Okada M, Suzuki S, Sanomachi T, Seino S, Yamamoto M, Yamashita H, Kitanaka C.
- Journal Title
  
  Anticancer Res.
  
  Volume: 40(9) Issue: 9 Pages: 4961-4968
- DOI
  10.21873/anticanres.14499
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07631, KAKENHI-PROJECT-19K18870
[Journal Article] Verteporfin inhibits oxidative phosphorylation and induces cell death specifically in glioma stem cells2020
- Author(s)
  Kuramoto Kenta、Yamamoto Masahiro、Suzuki Shuhei、Sanomachi Tomomi、Togashi Keita、Seino Shizuka、Kitanaka Chifumi、Okada Masashi
- Journal Title
  
  The FEBS Journal
  
  Volume: Epub ahead of print Issue: 10 Pages: 2023-2036
- DOI
  10.1111/febs.15187
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02908, KAKENHI-PROJECT-20K07631, KAKENHI-PROJECT-19K18870
[Journal Article] Spironolactone, a Classic Potassium-Sparing Diuretic, Reduces Survivin Expression and Chemosensitizes Cancer Cells to Non-DNA-Damaging Anticancer Drugs2019
- Author(s)
  Sanomachi T, Togashi K et al.
- Journal Title
  
  Cancers (Basel)
  
  Volume: 11 Pages: 1550-1566
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K18870
[Journal Article] Brexpiprazole Reduces Survivin and Reverses EGFR Tyrosine Kinase Inhibitor Resistance in Lung and Pancreatic Cancer2019
- Author(s)
  Sanomachi T, Togashi K et al.
- Journal Title
  
  Anticancer Res
  
  Volume: 39 Pages: 4817-4828
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K18870
[Journal Article] Brexpiprazole, a Serotonin-Dopamine Activity Modulator, Can Sensitize Glioma Stem Cells to Osimertinib, a Third-Generation EGFR-TKI, via Survivin Reduction2019
- Author(s)
  Suzuki S, Togashi K et al.
- Journal Title
  
  Cancers (Basel)
  
  Volume: 11 Pages: 947-959
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K18870
[Journal Article] In vitro and in vivo anti-tumor effects of brexpiprazole, a newly-developed serotonin-dopamine activity modulator with an improved safety profile2019
- Author(s)
  Suzuki S, Togashi K et al.
- Journal Title
  
  Oncotarget
  
  Volume: 10 Pages: 3547-3558
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K18870
[Presentation] 脂漏性角化症を契機に発見された早期眼瞼印鑑細胞癌の1例2023
- Author(s)
  冨樫敬太, 樺澤崇允, 赤羽梢, 安達功武, 金子優, 高村浩 , 海野裕一郎 , 二口充, 杦本昌彦
- Organizer
  第77回日本臨床眼科学会
- Data Source
  KAKENHI-PROJECT-21K16867
[Presentation] 脂漏性角化症を契機に発見された早期眼瞼印鑑細胞癌の1例2023
- Author(s)
  冨樫敬太, 樺澤崇允, 赤羽梢, 安達功武, 金子優, 高村浩 , 海野裕一郎 , 二口充, 杦本昌彦
- Organizer
  第77回日本臨床眼科学会
- Data Source
  KAKENHI-PROJECT-23K09020
[Presentation] 眼球摘出に至った脈絡膜悪性黒色腫症例の腫瘍検体の初代培養による細胞株樹立の試み2020
- Author(s)
  冨樫敬太, 林思音, 岡田雅司, 大江倫太郎, 髙村浩, 今野伸弥 , 難波広幸, 赤羽梢, 西塚弘一, 山川光徳, 北中千史, 山下英俊
- Organizer
  第124回日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-19K18870
[Presentation] 眼球突出を契機として原発巣が判明した神経内分泌型乳管癌の眼窩転移の1例2019
- Author(s)
  冨樫敬太, 林思音, 後藤早紀子, 武田祐介, 鈴木修平, 加藤智也, 山田裕樹, 紺野恵理子, 吉岡孝志, 山川光徳, 園田順彦, 鈴木民夫, 西塚弘一, 山下英俊
- Organizer
  第137回山形眼科研究会
- Data Source
  KAKENHI-PROJECT-19K18870

1. OKADA Masashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
2. 鈴木修平

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
3. 北中千史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 佐野町友美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Unregistered Unregistered 冨樫 敬太

Keita Togashi 冨樫 敬太

Research Projects

Research Products

Co-Researchers

Development of a novel therapeutic drug targeting both MDM4 and PKC, critical points in uveal malignant melanomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of a novel treatment for uveal melanoma based on p53 pathway activationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clarification of mechanisms for inhibition of retinoblastoma growth by CEP-1347Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Givinostat Inhibition of Sp1-dependent MGMT Expression Sensitizes Glioma Stem Cells to Temozolomide.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Domatinostat Targets the FOXM1?Survivin Axis to Reduce the Viability of Ovarian Cancer Cells Alone and in Combination with Chemotherapeutic Agents2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Novel MDM4 Inhibitor CEP-1347 Activates the p53 Pathway and Blocks Malignant Meningioma Growth In Vitro and In Vivo2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CEP-1347 Dually Targets MDM4 and PKC to Activate p53 and Inhibit the Growth of Uveal Melanoma Cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antagonizing MDM2 Overexpression Induced by MDM4 Inhibitor CEP-1347 Effectively Reactivates Wild-Type p53 in Malignant Brain Tumor Cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HDAC Class I Inhibitor Domatinostat Preferentially Targets Glioma Stem Cells over Their Differentiated Progeny2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CEP-1347 Targets MDM4 Protein Expression to Activate p53 and Inhibit the Growth of Glioma Cells.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of the Phospholipase Cε-c-Jun N-Terminal Kinase Axis Suppresses Glioma Stem Cell Properties2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gemcitabine Cooperates with Everolimus to Inhibit the Growth of and Sensitize Malignant Meningioma Cells to Apoptosis Induced by Navitoclax, an Inhibitor of Anti-Apoptotic BCL-2 Family Proteins2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Targeting Folate Metabolism Is Selectively Cytotoxic to Glioma Stem Cells and Effectively Cooperates with Differentiation Therapy to Eliminate Tumor-Initiating Cells in Glioma Xenografts2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gemcitabine radiosensitization primes irradiated malignant meningioma cells for senolytic elimination by navitoclax2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Metastatic Orbital Tumor From Breast Ductal Carcinoma With Neuroendocrine Differentiation Initially Presenting as Ocular Symptoms: A Case Report and Literature Review2021

Author(s)

Unregistered Unregistered 冨樫敬太

Keita Togashi 冨樫敬太