Isoda Takeshi 磯田健志

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ISODA TAKESHI 磯田健志

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Researcher Number	80815225
Other IDs
Affiliation (Current)	2025: 東京科学大学, 大学院医歯学総合研究科, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 東京医科歯科大学, 大学院医歯学総合研究科, 講師 2018 – 2021: 東京医科歯科大学, 医学部附属病院, 助教 2020: 東京医科歯科大学, 医学部附属病院, 講師
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
Keywords	Principal Investigator メチル化 / ThymoD / 免疫不全症 / 非コードRNA / 白血病 / エピジェネティクス / ゲノムの３次元構造 / ゲノムの3次元構造 / 転写 / R-loop … More / エンハンサー / 運命決定 / T細胞分化 / 非ホジキンリンパ腫 / 急性リンパ性白血病 / エンハンサー活性制御 … More Except Principal Investigator エピジェネティクス / 免疫学的記憶 / B細胞 / 原発性免疫不全症 / 抗体産生不全症 / がん化 / 転写制御 / 白血病 / 転写因子 / 胸腺 / T細胞分化 / 非コードRNA Less

非コードRNA転写による脱メチル化制御とスーパーエンハンサー活性化機構の解明Principal Investigator
- Principal Investigator
  
  磯田健志
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Tokyo Medical and Dental University
Elucidation of human Immunological memory through the analysis of primary antibody deficiency
- Principal Investigator
  
  今井耕輔
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  National Defense Medical College
Mechanistic Insights into Non-Coding RNA Transcription and Super-Enhancer Activation via Control Region MutationsPrincipal Investigator
- Principal Investigator
  
  Isoda Takeshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Tokyo Medical and Dental University
Roles of a non-coding RNA that regulates normal and neoplastic T cell development
- Principal Investigator
  
  Ikawa Tomokatsu
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Tokyo University of Science
Investigation for control of enhancer activity by non-coding RNA transcription and mechanism of developing primary immunodeficiency and oncogenesis under the disrupted non-coding transcription.Principal Investigator
- Principal Investigator
  
  ISODA TAKESHI
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Tokyo Medical and Dental University

All 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Myeloid/natural killer (NK) cell precursor acute leukemia as a distinct leukemia type2023
- Author(s)
  Nishimura Akira、Yokoyama Kazuaki、Naruto Takuya、...、Ishida Yasushi、Takita Junko、Ishikawa Fumihiko、Goto Hiroaki、Morio Tomohiro、Mizutani Shuki、Tojo Arinobu、Takagi Masatoshi
- Journal Title
  
  Science Advances
  
  Volume: 9 Issue: 50 Pages: 50-50
- DOI
  10.1126/sciadv.adj4407
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18264, KAKENHI-PROJECT-21K08419, KAKENHI-PROJECT-21H02878
[Journal Article] Case report: Optimized ruxolitinib-based therapy in an infant with familial hemophagocytic lymphohistiocytosis type 32022
- Author(s)
  Niizato Daiki、Isoda Takeshi、Mitsuiki Noriko、Kaneko Shuya、Tomomasa Dan、Kamiya Takahiro、Takagi Masatoshi、Imai Kohsuke、Kajiwara Michiko、Shimizu Masaki、Morio Tomohiro、Kanegane Hirokazu
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 13 Pages: 977463-977463
- DOI
  10.3389/fimmu.2022.977463
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02878
[Journal Article] Identification of Germline Non-coding Deletions in XIAP Gene Causing XIAP Deficiency Reveals a Key Promoter Sequence2022
- Author(s)
  Sbihi Zineb、Tanita Kay、Bachelet Camille、Bole Christine、Jabot-Hanin Fabienne、…Isoda Takeshi（24人中20番目）、…、Kanegane Hirokazu、Latour Sylvain
- Journal Title
  
  Journal of Clinical Immunology
  
  Volume: 42 Issue: 3 Pages: 559-571
- DOI
  10.1007/s10875-021-01188-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02878, KAKENHI-PROJECT-20J10721, KAKENHI-PROJECT-20K08152, KAKENHI-PROJECT-22K07887
[Journal Article] Novel variants for Glanzmann thrombasthenia manifesting with purpura at birth2022
- Author(s)
  Eguchi Shiori、Isoda Takeshi、Yamaguchi Asuka、Takagi Masatoshi
- Journal Title
  
  Pediatrics International
  
  Volume: 64 Issue: 1
- DOI
  10.1111/ped.15149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02878
[Journal Article] Successful ruxolitinib administration for a patient with steroid‐refractory idiopathic pneumonia syndrome following hematopoietic stem cell transplantation: A case report and literature review2021
- Author(s)
  Tomomasa Dan、Isoda Takeshi、Mitsuiki Noriko、Yamashita Motoi、Morishita Aoi、Tomoda Takahiro、Okano Tsubasa、Endo Akifumi、Kamiya Takahiro、Yanagimachi Masakatsu、Imai Kohsuke、Kanegane Hirokazu、Takagi Masatoshi、Morio Tomohiro
- Journal Title
  
  Clinical Case Reports
  
  Volume: 9 Issue: 12 Pages: 1-9
- DOI
  10.1002/ccr3.5242
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02878, KAKENHI-PROJECT-20K16437
[Journal Article] Cytomegalovirus Laryngitis in Primary Combined Immunodeficiency Diseases2020
- Author(s)
  Inoue Maiko、Isoda Takeshi、Yamashita Motoi、Tomoda Takahiro、Inoue Kento、Okano Tsubasa、Ohkawa Teppei、Endo Akifumi、Mitsuiki Noriko、Kamiya Takahiro、Yanagimachi Masakatsu、Yamamoto Kouhei、Inaba Yuichiro、Sasaki Toru、Takagi Masatoshi、Kanegane Hirokazu、Imai Kohsuke、Morio Tomohiro
- Journal Title
  
  Journal of Clinical Immunology
  
  Volume: 41 Issue: 1 Pages: 243-247
- DOI
  10.1007/s10875-020-00873-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17460, KAKENHI-PROJECT-18K07814, KAKENHI-PROJECT-18K15661
[Journal Article] Upon Microbial Challenge, Human Neutrophils Undergo Rapid Changes in Nuclear Architecture and Chromatin Folding to Orchestrate an Immediate Inflammatory Gene Program2020
- Author(s)
  Matthew Denholtz, Yina Zhu, Zhaoren He, Hanbin Lu, Takeshi Isoda, Simon Dohrmann, Victor Nizet, Cornelis Murre
- Journal Title
  
  Genes and Development
  
  Volume: 34 Issue: 3-4 Pages: 149-165
- DOI
  10.1101/gad.333708.119
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15661
[Journal Article] Noncoding RNA transcription at enhancers and genome folding in cancer2019
- Author(s)
  Takeshi Isoda, Tomohiro Morio, Masatoshi Takagi
- Journal Title
  
  Cancer Science
  
  Volume: 110 Issue: 8 Pages: 2328-2336
- DOI
  10.1111/cas.14107
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15661
[Presentation] Non-coding RNA transcription and super-enhancer activation facilitate 3D genome structure2023
- Author(s)
  1.Akira Nishimura, Makiko Sasaki, Riski Muhaimin, Yukie Tanaka, Tomohiro Morio, Masatoshi Takagi, Takeshi Isoda
- Organizer
  The 14th International Workshop on Advanced Genomics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02878
[Presentation] 非コードRNA転写とスーパーエンハンサー活性化によるゲノムの3次元構造維持機構2022
- Author(s)
  4.西村聡、佐々木麻起子、高木正稔、磯田健志
- Organizer
  第81回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-21H02878
[Presentation] ロングリードシークエンサーを用いた先天性免疫不全症・白血病発症機構の解明2021
- Author(s)
  磯田健志
- Organizer
  令和３年度川野小児医学奨学財団助成研究成果発表会
- Data Source
  KAKENHI-PROJECT-21H02878
[Presentation] 非コードRNA転写異常を背景とした免疫不全、発がんの病態探索2020
- Author(s)
  磯田健志、森尾友宏
- Organizer
  第48回日本臨床免疫学会総会　シンポジウム3　病態探索に挑む
- Invited
- Data Source
  KAKENHI-PROJECT-18K15661
[Presentation] 非コードRNA転写による核内局在転換はT細胞への系列決定を誘導しT細胞系腫瘍の抑制に関与する2020
- Author(s)
  Isoda T, Nishimura A, Morio T, Takagi M
- Organizer
  第 62 回日本小児血液・がん学会学術集会　シンポジウム 4 血液基礎、核ダイナミクスから non-mRNA による細胞制御
- Invited
- Data Source
  KAKENHI-PROJECT-18K15661
[Presentation] BTK転写調節の異常によるX連鎖無ガンマグロブリン血症の3家系2019
- Author(s)
  石橋佑脩、岡野翼、谷田けい、磯田健志、小林法元、藤原享志、座波清誉、野々山恵章、今井耕輔、森尾友宏、金兼弘和
- Organizer
  第2回日本免疫不全・自己炎症学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K15661
[Presentation] ThymoD modulates nuclear architecture to specify T-cell fate and blocks T-cell malignancies2018
- Author(s)
  Takeshi Isoda, Akira Nishimura, Satoshi Miyamoto, Tomohiro Morio, Masatoshi Takagi, Cornelis Murre
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15661
[Presentation] Non-Coding RNA ThymoD Transcription Modulates Nuclear Architecture to Orchestrate T-Cell Fate and Block T-Cell Malignancies2018
- Author(s)
  T.Isoda, A.Nishimura,S.Miyamoto,T.Morio,M.Takagi, C. Murre
- Organizer
  50th SIOP
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15661
[Presentation] Non-coding RNA transcription modulates nuclear architecture to specify T-cell fate and blocks T-cell malignancies2018
- Author(s)
  磯田健志、高木正稔
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K15661
[Presentation] Non-coding RNA ThymoD transcription modulates nuclear architecture to specify T-cell fate and inhibits T-cell malignancies2018
- Author(s)
  磯田健志
- Organizer
  第47回日本免疫学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K15661
[Presentation] 非コードRNA転写によるエンハンサー、プロモーターの相互作用の誘導が、T細胞の運命決定を指揮する2018
- Author(s)
  磯田健志
- Organizer
  第28回京都T細胞カンファレンス学術集会
- Data Source
  KAKENHI-PROJECT-18K15661

1. 高木正稔 (10406267)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. Ikawa Tomokatsu (60450392)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 高野淳一朗 (00852162)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 森尾友宏 (30239628)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. 今井耕輔 (90332626)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 森谷邦彦 (40646999)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 遠藤明史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 滝田順子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Isoda Takeshi 磯田 健志

ISODA TAKESHI 磯田 健志

Research Projects

Research Products

Co-Researchers

非コードRNA転写による脱メチル化制御とスーパーエンハンサー活性化機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of human Immunological memory through the analysis of primary antibody deficiency

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanistic Insights into Non-Coding RNA Transcription and Super-Enhancer Activation via Control Region MutationsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Roles of a non-coding RNA that regulates normal and neoplastic T cell development

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation for control of enhancer activity by non-coding RNA transcription and mechanism of developing primary immunodeficiency and oncogenesis under the disrupted non-coding transcription.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Myeloid/natural killer (NK) cell precursor acute leukemia as a distinct leukemia type2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Case report: Optimized ruxolitinib-based therapy in an infant with familial hemophagocytic lymphohistiocytosis type 32022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of Germline Non-coding Deletions in XIAP Gene Causing XIAP Deficiency Reveals a Key Promoter Sequence2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel variants for Glanzmann thrombasthenia manifesting with purpura at birth2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Successful ruxolitinib administration for a patient with steroid‐refractory idiopathic pneumonia syndrome following hematopoietic stem cell transplantation: A case report and literature review2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cytomegalovirus Laryngitis in Primary Combined Immunodeficiency Diseases2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Upon Microbial Challenge, Human Neutrophils Undergo Rapid Changes in Nuclear Architecture and Chromatin Folding to Orchestrate an Immediate Inflammatory Gene Program2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Noncoding RNA transcription at enhancers and genome folding in cancer2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] Non-coding RNA transcription and super-enhancer activation facilitate 3D genome structure2023

Author(s)

Organizer

Data Source

[Presentation] 非コードRNA転写とスーパーエンハンサー活性化によるゲノムの3次元構造維持機構2022

Isoda Takeshi 磯田健志

ISODA TAKESHI 磯田健志