Yang Ximeng 楊熙蒙

Researcher Number	80818922
Other IDs
Affiliation (Current)	2025: 富山大学, 学術研究部薬学・和漢系, 助教
Affiliation (based on the past Project Information) *help	2020 – 2024: 富山大学, 学術研究部薬学・和漢系, 助教 2019: 富山大学, 学術研究部薬学・和漢系, 特命助教
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 46030:Function of nervous system-related Except Principal Investigator Basic Section 47050:Environmental and natural pharmaceutical resources-related
Keywords	Principal Investigator 軸索再伸長 / アルツハイマー病 / 神経薬理学 / 神経科学 / diosgenin / Galectin-1 / SPARC / Diosgenin / 記憶回復 Except Principal Investigator Acteoside … More / アクテオシド / ニクジュヨウ / 植物性医薬品 / 軸索修復 / 頚椎症性脊髄症 Less

アルツハイマー病の根本的治療戦略の確立：神経回路の“正確な修復”からのアプローチPrincipal Investigator
- Principal Investigator
  
  楊熙蒙
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  University of Toyama
頚椎症性脊髄症の機能を軸索修復により根本的に回復する新しい植物性医薬品の開発
- Principal Investigator
  
  東田千尋
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  University of Toyama
Development of therapeutic strategy for Alzheimer's disease based on axonal regeneration in the brainPrincipal Investigator
- Principal Investigator
  
  Yang Ximeng
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 46030:Function of nervous system-related
- Research Institution
  University of Toyama

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation Patent

[Journal Article] Diosgenin restores memory function via SPARC-driven axonal growth from the hippocampus to the PFC in Alzheimer’s disease model mice2023
- Author(s)
  Yang Ximeng、Tohda Chihiro
- Journal Title
  
  Molecular Psychiatry
  
  Volume: - Issue: 6 Pages: 2398-2411
- DOI
  10.1038/s41380-023-02052-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16288
[Journal Article] Memory enhancement effect of saponins from Eleutherococcus senticosus leaves and blood-brain barrier-permeated saponins profiling using a pseudotargeted monitoring strategy.2022
- Author(s)
  Huang Y. H., Ding W. L., Li X. T., Cai M. T., Li H. L., Yang Z.Y., Piao X. H., Zhu S., Tohda C., Komatsu K., Wang S. M., Ge Y. W.
- Journal Title
  
  Food Funct.
  
  Volume: 13 Issue: 6 Pages: 3603-3620
- DOI
  10.1039/d1fo03078g
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06716, KAKENHI-PROJECT-23K24039
[Journal Article] Axonal Regeneration Mediated by a Novel Axonal Guidance Pair, Galectin-1 and Secernin-12022
- Author(s)
  Yang Ximeng、Tohda Chihiro
- Journal Title
  
  Molecular Neurobiology
  
  Volume: 60 Issue: 3 Pages: 1250-1266
- DOI
  10.1007/s12035-022-03125-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16288, KAKENHI-PROJECT-23K24039
[Patent] 軸索伸展剤2020
- Inventor(s)
  東田千尋、楊熙蒙
- Industrial Property Rights Holder
  東田千尋、楊熙蒙
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Acquisition Date
  2020
- Data Source
  KAKENHI-PROJECT-19K16288
[Presentation] SPARCはアルツハイマー病モデルマウス脳内で軸索を正しく再伸長させ記憶障害を回復する2024
- Author(s)
  楊熙蒙、東田千尋
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-19K16288
[Presentation] Diosgeninによる脳での軸索再伸長と記憶回復にはGalectin-1の増加が関与する2023
- Author(s)
  楊熙蒙、東田千尋
- Organizer
  第40回和漢医薬学会学術大会
- Data Source
  KAKENHI-PROJECT-19K16288
[Presentation] Galectin-1-elicited axonal regeneration in the brains and memory recovery effects in Alzheimer’s disease model mice.2023
- Author(s)
  Yang Ximeng, Tohda Chihiro
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K16288
[Presentation] Galectin-1 contributes to axonal regeneration in the brain and memory recovery in Alzheimer’s disease model mice2023
- Author(s)
  楊熙蒙、東田千尋
- Organizer
  第66回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-19K16288
[Presentation] Long-distance axonal regeneration in the brain recovers memory deficits in a mouse model of Alzheimer’s disease.2023
- Author(s)
  Yang Ximeng, Tohda Chihiro
- Organizer
  17th Meeting of the Asian-Pacific Society for Neurochemistry (APSN2023)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16288
[Presentation] DiosgeninによるGalectin-1の増加は、アルツハイマー病モデルマウスにおいて脳での軸索再伸長と記憶回復を引き起こす2023
- Author(s)
  楊熙蒙、東田千尋
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-19K16288
[Presentation] Diosgeninが脳での軸索再伸長と記憶回復を引き起こす分子メカニズムの解明2022
- Author(s)
  楊熙蒙、東田千尋
- Organizer
  第45回日本神経科学大会・第65回日本神経化学会大会・第32回日本神経回路学会大会合同学会 (NEURO2022)
- Data Source
  KAKENHI-PROJECT-19K16288
[Presentation] Matureニューロンの軸索伸長活性がdiosgeninによって高まる分子機構の解明2022
- Author(s)
  楊熙蒙、東田千尋
- Organizer
  第39回和漢医薬学会学術大会
- Data Source
  KAKENHI-PROJECT-19K16288
[Presentation] Diosgenin promotes long-distance axonal regeneration in the brain and recovers memory deficits in a mouse model of Alzheimer’s disease.2022
- Author(s)
  Yang X, Tohda C
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K16288
[Presentation] 頚椎症性脊髄症に対するニクジュヨウエキスの効果．2022
- Author(s)
  須山真聡、楊熙蒙、東田千尋．
- Organizer
  Neuro2022
- Data Source
  KAKENHI-PROJECT-23K24039
[Presentation] Diosgeninがアルツハイマー病モデルマウスの脳内で軸索を再伸長させる分子メカニズムの解明2022
- Author(s)
  楊熙蒙，東田千尋
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K16288
[Presentation] Identification of molecular mechanisms for accurate axonal regeneration in Alzheimer’s disease model mouse brains2022
- Author(s)
  Yang Ximeng、Tohda Chihiro
- Organizer
  Society for Neuroscience 52th annual meeting (Neuroscience 2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16288
[Presentation] Clarification of molecular mechanisms for axonal regeneration in the brains of Alzheimer’s disease model mouse2022
- Author(s)
  Yang Ximeng、Tohda Chihiro
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K16288
[Presentation] 食薬区分を生かした和漢薬からの創薬研究．2022
- Author(s)
  東田千尋、楊熙蒙、稲田祐奈．
- Organizer
  第96回日本薬理学会年会　日本農芸化学会共催シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-23K24039
[Presentation] What factors contribute to diosgenin-induced memory recovery?2022
- Author(s)
  Nagata Tomoya、Yang Ximeng、Tohda Chihiro
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K16288
[Presentation] Diosgenin is a candidate drug for stimulating axonal regeneration in the brain and recovering memory deficits in Alzheimer’s disease.2021
- Author(s)
  Yang X, Tohda C
- Organizer
  第16回国際医薬伝統シンポジウム2021
- Invited
- Data Source
  KAKENHI-PROJECT-19K16288
[Presentation] Diosgeninはアルツハイマー病モデルマウスの脳内において軸索を再伸長させ記憶障害を改善する2021
- Author(s)
  楊熙蒙、東田千尋
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K16288
[Presentation] Diosgenin-rich yam extract enhances cognitive function: a placebo-controlled, randomized, double-blind, crossover study of healthy adults.2021
- Author(s)
  Tohda C, Inada Y, Yang X
- Organizer
  第64回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-19K16288
[Presentation] Diosgeninによるアルツハイマー病脳内での軸索修復作用と臨床研究への展開2021
- Author(s)
  東田千尋，楊熙蒙，稲田祐奈
- Organizer
  第94回日本生化学大会シンポジウム「健康長寿社会に向けた和漢薬研究の新展開」
- Invited
- Data Source
  KAKENHI-PROJECT-19K16288
[Presentation] Diosgenin含有山薬エキスによる認知機能向上作用：マウスおよび健常人での検討2021
- Author(s)
  東田千尋，楊熙蒙，稲田祐奈
- Organizer
  日本生薬学会第67回年会
- Data Source
  KAKENHI-PROJECT-19K16288
[Presentation] Molecular mechanisms for long-distance axonal regeneration in the brain of Alzheimer’s disease model mouse.2021
- Author(s)
  Yang X, Tohda C
- Organizer
  第64回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-19K16288
[Presentation] Diosgeninによって軸索が再伸長し記憶が改善する分子メカニズムの解明2021
- Author(s)
  楊熙蒙、東田千尋
- Organizer
  第2回和漢医薬学会若手研究者フォーラム
- Data Source
  KAKENHI-PROJECT-19K16288
[Presentation] Diosgeninはアルツハイマー病の脳内において軸索を正しく再伸長させる2020
- Author(s)
  楊熙蒙、東田千尋
- Organizer
  第37回和漢医薬学会学術大会
- Data Source
  KAKENHI-PROJECT-19K16288
[Presentation] アミロイドβによる軸索変性に着目したアルツハイマー病予防・治療法の開発2020
- Author(s)
  久保山友晴、楊熙蒙、東田千尋
- Organizer
  第37回和漢医薬学会学術大会
- Data Source
  KAKENHI-PROJECT-19K16288
[Presentation] Clarification of the mechanisms for diosgenin-induced accurate axonal regrowth in the brain of a mouse model of Alzheimer’s disease.2020
- Author(s)
  Yang X., Tohda C.
- Organizer
  第63回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-19K16288
[Presentation] 山薬エキスによる記憶亢進作用の検討2019
- Author(s)
  楊熙蒙, 東田千尋
- Organizer
  第36回和漢医薬学会学術大会
- Data Source
  KAKENHI-PROJECT-19K16288
[Presentation] Diosgenin improves memory deficits in a mouse model of Alzheimer’s disease by promoting axonal regrowth in the brain.2019
- Author(s)
  Yang X., Tohda C.
- Organizer
  Society for Neuroscience 49th annual meeting (Neuroscience 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16288
[Presentation] Diosgenin promotes proper axonal regrowth in the brain and recovers memory deficits in a mouse model of Alzheimer’s disease.2019
- Author(s)
  Yang X., Tohda C.
- Organizer
  Toyama Forum for Academic Summit on “Dynamic Brain”
- Data Source
  KAKENHI-PROJECT-19K16288
[Presentation] 和漢薬成分diosgeninの基礎研究により見出されたアルツハイマー病の根本的治療への展望2019
- Author(s)
  楊熙蒙
- Organizer
  第36回和漢医薬学会学術大会若手シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19K16288
[Presentation] Diosgenin elicits axonal regrowth in the brain and improves memory deficits in a mouse model of Alzheimer’s disease.2019
- Author(s)
  Yang X., Tohda C.
- Organizer
  第42回日本神経科学大会・第62回日本神経化学会大会合同学会 (NEURO2019)
- Data Source
  KAKENHI-PROJECT-19K16288

1. 東田千尋 (10272931)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 川口善治 (00262527)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 稲田祐奈 (40835154)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 箭原康人 (60456390)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 朱しゅう

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yang Ximeng 楊 熙蒙

Research Projects

Research Products

Co-Researchers

アルツハイマー病の根本的治療戦略の確立：神経回路の“正確な修復”からのアプローチPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

頚椎症性脊髄症の機能を軸索修復により根本的に回復する新しい植物性医薬品の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of therapeutic strategy for Alzheimer's disease based on axonal regeneration in the brainPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Diosgenin restores memory function via SPARC-driven axonal growth from the hippocampus to the PFC in Alzheimer’s disease model mice2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Memory enhancement effect of saponins from Eleutherococcus senticosus leaves and blood-brain barrier-permeated saponins profiling using a pseudotargeted monitoring strategy.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Axonal Regeneration Mediated by a Novel Axonal Guidance Pair, Galectin-1 and Secernin-12022

Author(s)

Journal Title

DOI

Data Source

[Patent] 軸索伸展剤2020

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Acquisition Date

Data Source

[Presentation] SPARCはアルツハイマー病モデルマウス脳内で軸索を正しく再伸長させ記憶障害を回復する2024

Author(s)

Organizer

Data Source

[Presentation] Diosgeninによる脳での軸索再伸長と記憶回復にはGalectin-1の増加が関与する2023

Author(s)

Organizer

Data Source

[Presentation] Galectin-1-elicited axonal regeneration in the brains and memory recovery effects in Alzheimer’s disease model mice.2023

Author(s)

Organizer

Data Source

[Presentation] Galectin-1 contributes to axonal regeneration in the brain and memory recovery in Alzheimer’s disease model mice2023

Author(s)

Organizer

Data Source

[Presentation] Long-distance axonal regeneration in the brain recovers memory deficits in a mouse model of Alzheimer’s disease.2023

Author(s)

Organizer

Data Source

[Presentation] DiosgeninによるGalectin-1の増加は、アルツハイマー病モデルマウスにおいて脳での軸索再伸長と記憶回復を引き起こす2023

Author(s)

Organizer

Data Source

[Presentation] Diosgeninが脳での軸索再伸長と記憶回復を引き起こす分子メカニズムの解明2022

Author(s)

Organizer

Data Source

[Presentation] Matureニューロンの軸索伸長活性がdiosgeninによって高まる分子機構の解明2022

Author(s)

Organizer

Data Source

[Presentation] Diosgenin promotes long-distance axonal regeneration in the brain and recovers memory deficits in a mouse model of Alzheimer’s disease.2022

Author(s)

Organizer

Data Source

Yang Ximeng 楊熙蒙