Hayashi Tsuyoshi 林豪士

Researcher Number	80824648
Other IDs
Affiliation (Current)	2025: 国立感染症研究所, ウイルス第二部, 主任研究官
Affiliation (based on the past Project Information) *help	2020 – 2023: 国立感染症研究所, ウイルス第二部, 主任研究官
Review Section/Research Field	Principal Investigator Medium-sized Section 58:Society medicine, nursing, and related fields / Basic Section 49060:Virology-related Except Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Medium-sized Section 22:Civil engineering and related fields
Keywords	Principal Investigator 腸管オルガノイド / ヒトノロウイルス / ノロウイルス / RNAseq / インターフェロン / siRNA / 抗ウイルス活性 / CRISPR-Cas9 / 自然免疫 / 宿主因子 … More Except Principal Investigator … More FlipGFP / 阻害剤 / プロテアーゼ / SARS-CoV-2 / 起源解析 / リスク管理 / 水道水 / 糞便汚染 / 水環境 / 水道 / ウイルス指標 / 感染性評価 / PCR / リスク評価 / 指標微生物 / 微生物起源解析 / 下水疫学 / ウイルス Less

感染効率と汎用性の高いfirst classのヒトノロウイルス培養細胞系の樹立Principal Investigator
- Principal Investigator
  
  林豪士
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  National Institute of Infectious Diseases
Screening of SARS-CoV-2 protease inhibitors using FlipGFP reporter system
- Principal Investigator
  
  染谷雄一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  National Institute of Infectious Diseases
Studies on host factors involved in human norovirus infection using human intestinal organoidPrincipal Investigator
- Principal Investigator
  
  Hayashi Tsuyoshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  National Institute of Infectious Diseases
Comprehensive utilization of innovative virus indicators for microbial water safety
- Principal Investigator
  
  KATAYAMA HIROYUKI
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 22:Civil engineering and related fields
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] Inhibitory effects of senkyuchachosan on SARS-CoV-2 papain-like protease activity in vitro2024
- Author(s)
  Kiba Yuka、Tanikawa Takashi、Hayashi Tsuyoshi、Yokogawa Takami、Sano Aiko、Suzuki Ryuichiro、Kitamura Masashi
- Journal Title
  
  Journal of Natural Medicines
  
  Volume: - Issue: 3 Pages: 784-791
- DOI
  10.1007/s11418-024-01788-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K14372, KAKENHI-PROJECT-22K06625
[Journal Article] Human norovirus cultivation systems and their use in antiviral research2024
- Author(s)
  Hayashi Tsuyoshi、Kobayashi Sakura、Hirano Junki、Murakami Kosuke
- Journal Title
  
  Journal of Virology
  
  Volume: 98 Issue: 4
- DOI
  10.1128/jvi.01663-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K18381, KAKENHI-PROJECT-22K15479, KAKENHI-PROJECT-23K21380
[Journal Article] 生薬成分によるFurin cleavage site（FCS）開裂抑制およびSARS-CoV-2感染抑制効果2022
- Author(s)
  北村雅史，谷川尚，林豪士
- Journal Title
  
  月刊「細胞」
  
  Volume: 54 Pages: 33-35
- Data Source
  KAKENHI-PROJECT-22K06625
[Journal Article] CRISPR-Cas9-Based Technology for Studying Enteric Virus Infection2022
- Author(s)
  Hirano Junki、Murakami Kosuke、Hayashi Tsuyoshi
- Journal Title
  
  Frontiers in Genome Editing
  
  Volume: 4 Pages: 888878-888878
- DOI
  10.3389/fgeed.2022.888878
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07520
[Journal Article] Dasabuvir Inhibits Human Norovirus Infection in Human Intestinal Enteroids2021
- Author(s)
  Hayashi Tsuyoshi、Murakami Kosuke、Hirano Junki、Fujii Yoshiki、Yamaoka Yoko、Ohashi Hirofumi、Watashi Koichi、Estes Mary K.、Muramatsu Masamichi
- Journal Title
  
  mSphere
  
  Volume: 6 Issue: 6
- DOI
  10.1128/msphere.00623-21
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07520, KAKENHI-PROJECT-20K16267
[Presentation] ヒトノロウイルス感染を制御する宿主因子の探索研究2023
- Author(s)
  林豪士、村上耕介、小林さくら、上野小百合、松田麻未、鈴木亮介、村松正道
- Organizer
  第8回デザイン生命工学研究会
- Data Source
  KAKENHI-PROJECT-20K07520
[Presentation] Flip-GFPレポーターシステムを用いたエンテロウイルスプロテアーゼの性状解析2023
- Author(s)
  平野順紀, 林豪士，染谷雄一, 岡田和真, 上村健太朗, 小野慎子, 田鍬修平, 松浦善治
- Organizer
  第70回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-22K06625
[Presentation] ウイルスプロテアーゼをターゲットとした創薬探索研究2023
- Author(s)
  林豪士，平野順紀, 村上耕介, 谷川尚, 北村雅史, 染谷雄一
- Organizer
  第9回デザイン生命工学研究会
- Data Source
  KAKENHI-PROJECT-22K06625
[Presentation] ヒト腸管オルガノイドを用いた下痢症ウイルス研究の展開状況2022
- Author(s)
  林豪士
- Organizer
  ウイルス性下痢症研究会第33回学術集会
- Data Source
  KAKENHI-PROJECT-20K07520
[Presentation] ヒトノロウイルス感染に対する宿主自然免疫応答の解析2022
- Author(s)
  林豪士, 村上耕介, 平野順紀, 松田麻未, 鈴木亮介, 村松正道
- Organizer
  第69回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07520
[Presentation] 腸管オルガノイド培養系を利用した新規抗ヒトノロウイルス阻害剤の探索2022
- Author(s)
  林豪士、村上耕介、藤井克樹
- Organizer
  第63回日本臨床ウイルス学会
- Data Source
  KAKENHI-PROJECT-20K07520
[Presentation] 腸管オルガノイド培養系を用いたヒトノロウイルス感染に対する宿主免疫機構の解析.2022
- Author(s)
  林豪士，村上耕介, 平野順紀, 松田麻未, 鈴木亮介, 村松正道.
- Organizer
  第7回デザイン生命工学研究会
- Data Source
  KAKENHI-PROJECT-20K07520
[Presentation] Screening of an antiviral compound library identifies dasabuvir as a novel anti-human norovirus inhibitor.2021
- Author(s)
  林豪士, 村上耕介, 平野順紀, 藤井克樹, 山岡曜子, 大橋啓史, 渡士幸一, Mary K. Estes, 村松正道.
- Organizer
  第68回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07520

1. KATAYAMA HIROYUKI (00302779)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 原本英司 (00401141)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 端昭彦 (70726306)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 三浦尚之 (70770014)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 鳥居将太郎 (30939476)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 染谷雄一 (50283809)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 平野順紀 (50899101)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 村上耕介 (60586973)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 北村雅史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hayashi Tsuyoshi 林 豪士

Research Projects

Research Products

Co-Researchers

感染効率と汎用性の高いfirst classのヒトノロウイルス培養細胞系の樹立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Screening of SARS-CoV-2 protease inhibitors using FlipGFP reporter system

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studies on host factors involved in human norovirus infection using human intestinal organoidPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Comprehensive utilization of innovative virus indicators for microbial water safety

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Inhibitory effects of senkyuchachosan on SARS-CoV-2 papain-like protease activity in vitro2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Human norovirus cultivation systems and their use in antiviral research2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 生薬成分によるFurin cleavage site（FCS）開裂抑制およびSARS-CoV-2感染抑制効果2022

Author(s)

Journal Title

Data Source

[Journal Article] CRISPR-Cas9-Based Technology for Studying Enteric Virus Infection2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dasabuvir Inhibits Human Norovirus Infection in Human Intestinal Enteroids2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] ヒトノロウイルス感染を制御する宿主因子の探索研究2023

Author(s)

Organizer

Data Source

[Presentation] Flip-GFPレポーターシステムを用いたエンテロウイルスプロテアーゼの性状解析2023

Author(s)

Organizer

Data Source

[Presentation] ウイルスプロテアーゼをターゲットとした創薬探索研究2023

Author(s)

Organizer

Data Source

[Presentation] ヒト腸管オルガノイドを用いた下痢症ウイルス研究の展開状況2022

Author(s)

Organizer

Data Source

[Presentation] ヒトノロウイルス感染に対する宿主自然免疫応答の解析2022

Author(s)

Organizer

Data Source

[Presentation] 腸管オルガノイド培養系を利用した新規抗ヒトノロウイルス阻害剤の探索2022

Author(s)

Organizer

Data Source

[Presentation] 腸管オルガノイド培養系を用いたヒトノロウイルス感染に対する宿主免疫機構の解析.2022

Author(s)

Organizer

Data Source

Hayashi Tsuyoshi 林豪士