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Saito Masafumi  齋藤 雅史

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Masafumi Saito  齋藤 雅史

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Researcher Number 80826321
Other IDs
Affiliation (Current) 2025: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 免疫・微生物学, 助教
Affiliation (based on the past Project Information) *help 2023: 帝京大学, 医学部, 助教
2023: 帝京大学, 基礎医学, 助教
2021 – 2023: 神戸大学, 医学研究科, 助教
2020: 神戸大学, 医学研究科, 特命助教
2019: 神戸大学, 医学研究科, 学術研究員
Review Section/Research Field
Principal Investigator
Basic Section 55060:Emergency medicine-related
Except Principal Investigator
Basic Section 55020:Digestive surgery-related
Keywords
Principal Investigator
敗血症 / T細胞 / 精神障害 / 敗血症性脳症 / 神経新生 / IL-4 / CD4+T細胞 / ミクログリア / うつ / 不安様行動 … More / 脳内炎症 / 制御性T細胞 / リンパ球活性化因子 / 高齢者敗血症 / Interleukin-15 / リンパ球 / 長期予後 / 免疫抑制 / IL-15 / 高齢者 … More
Except Principal Investigator
空間的解析 / NKT細胞 / 免疫療法 / レジデントメモリーT細胞 / 肝転移 / 大腸癌 / 術前化学放射線療法 / イメージサイトメトリー / 細胞間相互作用 / CD8+T細胞 / レジデントメモリーCD8+T細胞 (TRM) / 化学放射線療法 / 直腸癌 / レジデントメモリーCD8+T細胞 / RNA解析 / 空間的情報 / 組織滞在型メモリーCD8+T細胞 / 人工知能イメージサイトメトリー / 免疫チェックポイント阻害剤 / 術前化学療法 / 食道癌 Less
  • Research Projects

    (6 results)
  • Research Products

    (17 results)
  • Co-Researchers

    (6 People)
  •  Spatial Analysis of Rectal Cancer after Preoperative Chemoradiotherapy to Explore Predictors of Treatment Response

    • Principal Investigator
      山下 公大
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Kobe University
  •  Establishment of novel precision immunotherapy for liver metastases of colorectal cancer

    • Principal Investigator
      裏川 直樹
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Kobe University
  •  Therapeutic strategies for sepsis-associated mental disorders focusing on T cells and neurogenesis in the brain.Principal Investigator

    • Principal Investigator
      齋藤 雅史
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55060:Emergency medicine-related
    • Research Institution
      Teikyo University
  •  Development of new preoperative therapy for esophageal cancer based on the dynamics of tumor-infiltrating lymphocytes

    • Principal Investigator
      押切 太郎
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Ehime University
      Kobe University
  •  Elucidation of pathogenesis of septic encephalopathy and associated psychiatric disorders and therapeutic strategies focusing on regulatory T cellsPrincipal Investigator

    • Principal Investigator
      Saito Masafumi
    • Project Period (FY)
      2021 – 2022
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 55060:Emergency medicine-related
    • Research Institution
      Kobe University
  •  Long-term immune evaluation and novel therapeutic strategy using lymphocyte activating factor in elderly with sepsisPrincipal Investigator

    • Principal Investigator
      Masafumi Saito
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 55060:Emergency medicine-related
    • Research Institution
      Kobe University

All 2023 2022 2021 2020 2019

All Journal Article Presentation

  • [Journal Article] Brain T cell ameliorates mental disorders in the mouse model of post-sepsis syndrome2022

    • Author(s)
      Saito Masafumi、Fujinami Yoshihisa、Ono Yuko、Yamashita Kimihiro、Inoue Shigeaki、Kotani Joji
    • Journal Title

      The Japanese Journal of SURGICAL METABOLISM and NUTRITION

      Volume: 56 Issue: 4 Pages: 155-159

    • DOI

      10.11638/jssmn.56.4_155

    • ISSN
      0389-5564, 2187-5154
    • Year and Date
      2022-08-15
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K16572
  • [Journal Article] Does Sepsis-Associated Encephalopathy Begin and End with T Cells?2021

    • Author(s)
      Masafumi Saito
    • Journal Title

      Journal of Mucosal Immunology Research

      Volume: 3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K16572
  • [Journal Article] IL-15 Improves Aging-Induced Persistent T Cell Exhaustion in Mouse Models of Repeated Sepsis2020

    • Author(s)
      Saito Masafumi、Inoue Shigeaki、Yamashita Kimihiro、Kakeji Yoshihiro、Fukumoto Takumi、Kotani Joji
    • Journal Title

      Shock

      Volume: 53 Issue: 2 Pages: 228-235

    • DOI

      10.1097/shk.0000000000001352

    • NAID

      120007002629

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K18323
  • [Journal Article] IL-15 improves aging-induced persistent T cell exhaustion in mouse models of repeated sepsis.2020

    • Author(s)
      Masafumi Saito, Shigeaki Inoue, Kimihiro Yamashita, Yoshihiro Kakeji, Takumi Fukumoto, and Joji Kotani
    • Journal Title

      SHOCK

      Volume: 53 Pages: 228-235

    • NAID

      120007002629

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K18323
  • [Presentation] 頸部リンパ節を除去した敗血症マウスでは、脳へのT細胞の浸潤が抑制され、敗血症に伴う精神障害の回復が遅れる2023

    • Author(s)
      齋藤雅史、大野雄康、中西信人、山下公大、小谷穣治
    • Organizer
      第28回 エンドトキシン・自然免疫研究会
    • Data Source
      KAKENHI-PROJECT-23K08459
  • [Presentation] 敗血症に伴う精神障害の回復にはCD4+T細胞が重要である2023

    • Author(s)
      齋藤雅史、大野雄康、山下公大、関恒慶、千原典夫、小谷穣治
    • Organizer
      第35回 日本神経免疫学会
    • Data Source
      KAKENHI-PROJECT-23K08459
  • [Presentation] CD4+ T細胞を欠失させた敗血症マウスでは、 ミクログリアの活性化と敗血症性脳症が遷延し、 不安様行動の回復が遅れる2022

    • Author(s)
      齋藤雅史、大野雄康、山下公大、小谷穣治
    • Organizer
      第27回 日本エンドトキシン・自然免疫研究会
    • Data Source
      KAKENHI-PROJECT-21K16572
  • [Presentation] 敗血症誘導後の脳内に増加したIL-17産生γδT細胞は、 いかにマウスの不安様行動を増悪させるのか?2022

    • Author(s)
      齋藤雅史、森山直紀、大野雄康、山下公大、小谷穣治
    • Organizer
      第27回 日本エンドトキシン・自然免疫研究会
    • Data Source
      KAKENHI-PROJECT-21K16572
  • [Presentation] Cervical lymph node-derived Treg attenuates anxiety-like behavior in the septic mice via alleviation of encephalopathy2022

    • Author(s)
      Masafumi Saito, Yuko Ono, Kimihiro Yamashita, Joji Kotani
    • Organizer
      Cell symposia: Neuro-immune Axis
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K16572
  • [Presentation] Cervical lymph node-derived CXCR3+ regulatory T cells alleviate anxiety-like behavior via attenuation of sepsis-associated encephalopathy in the septic mouse model2022

    • Author(s)
      Masafumi Saito, Yuko Ono, Kyosuke Agawa, Kimihiro Yamashita, Joji Kotani
    • Organizer
      第51回 日本免疫学会
    • Data Source
      KAKENHI-PROJECT-21K16572
  • [Presentation] CX3CR1high macrophage and Treg in the brain may help to improve anxiety-like behavior in septic mice2021

    • Author(s)
      齋藤雅史
    • Organizer
      International Endotoxin and Innate Immunity Society
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K16572
  • [Presentation] 敗血症モデルマウスにおいて、 脳内に浸潤したT細胞は敗血症性脳症とそれに伴う 不安様行動の回復を促進する2021

    • Author(s)
      齋藤雅史
    • Organizer
      外科代謝栄養学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K16572
  • [Presentation] 敗血症マウスの脳内に浸潤したT細胞は、敗血症性脳症を抑制し、精神障害の回復を促進する2021

    • Author(s)
      齋藤雅史
    • Organizer
      第35回 日本shock学会
    • Data Source
      KAKENHI-PROJECT-21K16572
  • [Presentation] 高齢マウス反復性敗血症モデルにおいて IL-15は遷延するT細胞疲弊を長期間改善する2019

    • Author(s)
      齋藤雅史、井上茂亮、安藤維洋、山田勇、前田裕二、小谷穣治
    • Organizer
      日本集中治療学会
    • Data Source
      KAKENHI-PROJECT-19K18323
  • [Presentation] 高齢マウス反復感染モデルにおける長期的な疲弊の機序解明とIL-15の効果2019

    • Author(s)
      齋藤雅史、井上茂亮、藤岡一路、小谷穣治
    • Organizer
      日本Shock学会
    • Data Source
      KAKENHI-PROJECT-19K18323
  • [Presentation] IL-15は、高齢マウス敗血症のT細胞疲弊と マクロファージ機能を改善し、 長期予後を改善する2019

    • Author(s)
      齋藤雅史、井上茂亮、山田勇、安藤維洋、山下公大、掛地吉弘、福本巧、小谷穣治
    • Organizer
      日本外科代謝栄養学会
    • Data Source
      KAKENHI-PROJECT-19K18323
  • [Presentation] Interleukin-15 improves aging-induced persistent T cell exhaustion in mouse models of repeated sepsis2019

    • Author(s)
      Masafumi Saito, Shigeaki Inoue, Joji Kotani
    • Organizer
      American shock society
    • Data Source
      KAKENHI-PROJECT-19K18323
  • 1.  掛地 吉弘 (80284488)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 2.  山下 公大 (80535427)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  高村 史記 (90528564)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  藤田 貢 (40609997)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  押切 太郎 (30771498)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  裏川 直樹 (20647763)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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