Saito Rie 齋藤理恵

Researcher Number	80829078
Other IDs	https://orcid.org/0000-0001-7294-5183
Affiliation (Current)	2025: 新潟大学, 脳研究所, 助教
Affiliation (based on the past Project Information) *help	2018 – 2024: 新潟大学, 脳研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related / 0902:General internal medicine and related fields Except Principal Investigator Medium-sized Section 52:General internal medicine and related fields / Medium-sized Section 51:Brain sciences and related fields
Keywords	Principal Investigator 脳小血管病 / 3D神経病理 / CARASIL / CADASIL / 3D neuropathology / 白質変性 / 認知症 / 脳アミロイドアンギオパチー / フレイル / 3D病理 … More / 3D神経病理学 / 白質脳症 / 血管性認知症 / もやもや病 / アミロイドアンギオパチー / HTRA1 / Small vessel disease / Aged brain / Smooth muscle cells / CAA / HTRA1-SVD / 組織透明化 / 3Dイメージング / 診断基準 / ３D神経病理 / 遺伝性脳小血管病 / Binswanger病 / vascular dementia / vessel twisting / leukoencephalopathy / small vessel disease / 3D蛍光イメージング / 血管走行パターン / 血管変性 / 脳血管性認知症 … More Except Principal Investigator 透明化 / 一細胞解析 / 一細胞オミックス / 細胞外マトリックス / 加齢 / 脳小血管 / 脳小血管病 / デジタル / 組織病理 / デジタル画像 / 神経病理学 / 脳病変 / ３次元イメージング / ヒト脳組織 Less

Understanding Human 3D Cerebral Vascular Network Frailty in Small Vessel Disease (SVD)Principal Investigator
- Principal Investigator
  
  齋藤理恵
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Niigata University
Identification of cell groups that perturb the extracellular matrix of cerebral small vessel disease and deciphering their regulatory mechanisms.
- Principal Investigator
  
  小野寺理
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Niigata University
Cerebral microangiopathy: To clarify the pathologic basis and pathomechanismPrincipal Investigator
- Principal Investigator
  
  Saito Rie
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Niigata University
Digital 3D Neuropathology: Methodological Platform Creation
- Principal Investigator
  
  Kakita Akiyoshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 51:Brain sciences and related fields
- Research Institution
  Niigata University
Vascular dementia: for establishing clinicopathologic diagnostic criteria for small vessel diseasePrincipal Investigator
- Principal Investigator
  
  Saito Rie
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0902:General internal medicine and related fields
- Research Institution
  Niigata University

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation Book

[Book] 非腫瘍性疾患病理アトラス中枢神経「CARASIL」2024
- Author(s)
  齋藤理恵
- Total Pages
  291
- Publisher
  文光堂
- ISBN
  9784830604942
- Data Source
  KAKENHI-PROJECT-20K16595
[Journal Article] Inherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humans2024
- Author(s)
  Joe A. Holley, Shoichiro Ando, Samuel D. Chauvin, Atsushi Sugie, Rie Saito, Yuya Hatano, Sho Kitahara, Shin Koide, Akiyoshi Kakita, Osamu Onodera, Taisuke Kato, Jonathan J. Miner
- Journal Title
  
  Nature Communications
  
  Volume: -
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16595
[Journal Article] An autopsied patient with palatal tremor and fatal bilateral vocal cord abduction paralysis associated with bilateral cerebellar dentate nucleus infarction2023
- Author(s)
  Sato Tomoe、Saito Rie、Sainouchi Makoto、Mezaki Naomi、Miura Takeshi、Mashima Takuya、Kakita Akiyoshi
- Journal Title
  
  Rinsho Shinkeigaku
  
  Volume: 63 Issue: 9 Pages: 572-576
- DOI
  10.5692/clinicalneurol.cn-001859
- ISSN
  0009-918X, 1882-0654
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-20K16595
[Journal Article] 臨床医のための神経病理再入門：CARASIL2022
- Author(s)
  齋藤理恵　小野寺理　柿田明美
- Journal Title
  
  Clinical Neurosceience
  
  Volume: 40
- Data Source
  KAKENHI-PROJECT-20K16595
[Journal Article] 脳小血管病の病理2022
- Author(s)
  齋藤理恵　柿田明美
- Journal Title
  
  脳神経内科
  
  Volume: -
- Data Source
  KAKENHI-PROJECT-20K16595
[Journal Article] Long Spinal Cord Lesions Caused by Venous Congestive Myelopathy Associated with Intravascular Large B-cell Lymphoma: A Case Report2021
- Author(s)
  Takeshi Miura, Shoji Saito, Rie Saito
- Journal Title
  
  Internal Medicine
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16595
[Journal Article] Genetic variations and neuropathologic features of patients with PARK2.2021
- Author(s)
  Seike N, Yokoseki A, Takeuchi R, Saito K, Miyahara H, Miyashita A, Ikeda T, Aida I, Nakajima T, Kanazawa M, Wakabayashi M, Toyoshima Y, Takahashi H, Matumoro R, Toda T, Onodera O, Ishikawa A, Ikeuchi T, Kakita A.
- Journal Title
  
  Mov Disord
  
  Volume: 36 Issue: 7 Pages: 1634-1643
- DOI
  10.1002/mds.28521
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K20468, KAKENHI-PROJECT-19H01061
[Journal Article] The diagnosis and management of monogenic cerebral small vessel diseases: Practical guideline by European Academy of Neurology.2020
- Author(s)
  Saito R, Lioutas VA
- Journal Title
  
  Eur J Neurol.
  
  Volume: - Issue: 7 Pages: 1097-1098
- DOI
  10.1111/ene.14222
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21314, KAKENHI-PROJECT-20K16595
[Journal Article] Oculopharyngodistal myopathy with coexisting histology of systemic neuronal intranuclear inclusion disease: Clinicopathologic features of an autopsied patient harboring CGG repeat expansions in LRP122020
- Author(s)
  Rie Saito, Hiroshi Shimizu, Takeshi Miura, Norikazu Hara, Naomi Mezaki, Yo Higuchi, Akinori Miyashita, Izumi Kawachi, Kazuhiro Sanpei, Yoshiaki Honma, Osamu Onodera, Takeshi Ikeuchi, Akiyoshi Kakita
- Journal Title
  
  Acta Neuropathologica Communications
  
  Volume: 8 Issue: 1 Pages: 75-75
- DOI
  10.1186/s40478-020-00945-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07841, KAKENHI-PROJECT-20K20468
[Journal Article] Versatile whole-organ/body staining and imaging based on electrolyte-gel properties of biological tissues2020
- Author(s)
  Susaki Etsuo A.、Shimizu Chika、Kuno Akihiro、Tainaka Kazuki、Li Xiang、Shibayama Mitsuhiro、Ueda Hiroki R. et al.
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 1982-1982
- DOI
  10.1038/s41467-020-15906-5
- NAID
  120006956725
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02277, KAKENHI-PROJECT-18H02548, KAKENHI-PROJECT-19H03542, KAKENHI-PROJECT-20K20468, KAKENHI-PROJECT-20K20589, KAKENHI-PROJECT-20K21246, KAKENHI-PLANNED-17H06328, KAKENHI-PUBLICLY-20H04700, KAKENHI-PROJECT-18H05270, KAKENHI-PROJECT-19H01061, KAKENHI-PROJECT-18H02105, KAKENHI-PROJECT-18H02540, KAKENHI-PROJECT-19H03413, KAKENHI-PROJECT-19J13188
[Journal Article] Novel CHP1 mutation in autosomal-recessive cerebellar ataxia: autopsy features of two siblings2020
- Author(s)
  Saito Rie、Hara Norikazu、Tada Mari、Honma Yoshiaki、Miyashita Akinori、Onodera Osamu、Ikeuchi Takeshi、Kakita Akiyoshi
- Journal Title
  
  Acta Neuropathologica Communications
  
  Volume: 8 Issue: 1 Pages: 134-134
- DOI
  10.1186/s40478-020-01008-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07972, KAKENHI-PROJECT-20K20468
[Journal Article] Rapid chemical clearing of white matter in the post-mortem human brain by 1,2-hexanediol delipidation.2019
- Author(s)
  Inoue M, Saito R, Kakita A, Tainaka K.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 29 Issue: 15 Pages: 1886-1890
- DOI
  10.1016/j.bmcl.2019.05.049
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-18H04543, KAKENHI-PROJECT-19H01061, KAKENHI-PROJECT-18H02105, KAKENHI-PROJECT-18H02540, KAKENHI-PROJECT-20K20468, KAKENHI-PROJECT-18K19373, KAKENHI-PROJECT-19K21314
[Journal Article] Rapid clearing of white matter in post-mortem human brain by 1,2-hexanediol delipidation2019
- Author(s)
  Inoue Masafumi, Rie Saito, Kakita Akiyoshi, Tainaka Kazuki
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters in press
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K21314
[Journal Article] Retinal Vasculopathy With Cerebral Leukodystrophy: Clinicopathologic Features of an Autopsied Patient With a Heterozygous TREX 1 Mutation2018
- Author(s)
  Saito Rie、Nozaki Hiroaki、Kato Taisuke、Toyoshima Yasuko、Tanaka Hajime、Tsubata Yutaka、Morioka Tetsuo、Horikawa Yoh、Oyanagi Kiyomitsu、Morita Takashi、Onodera Osamu、Kakita Akiyoshi
- Journal Title
  
  Journal of Neuropathology & Experimental Neurology
  
  Volume: 78 Issue: 2 Pages: 181-186
- DOI
  10.1093/jnen/nly115
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26117006, KAKENHI-PROJECT-19K21314, KAKENHI-PROJECT-19K07820
[Presentation] 脳小血管ワールド　脳小血管保護による攻めの脳神経内科へ　病理からみた脳小血管病2023
- Author(s)
  齋藤理恵
- Organizer
  神経学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-20K16595
[Presentation] Fibulin5 immunoprofiles in terms of diagnosis of HTRA1-related small vessel disease2022
- Author(s)
  Rie Saito, Taisuke Kato, Osamu Onodera, Akiyoshi Kakita
- Organizer
  The 63nd annual meeting of the Japanese Society of Neurology
- Data Source
  KAKENHI-PROJECT-20K16595
[Presentation] SYNE1 ataxia: Clinicopathologic features of an autopsied patient with a compound heterozygous SYNE1 mutation.2021
- Author(s)
  Saito R, Tada M, Hara N, Wakabayashi M, Miyashita A, Onodera O, Ikeuchi T, Kakita A.
- Organizer
  第62回日本神経病理学会
- Data Source
  KAKENHI-PROJECT-20K20468
[Presentation] Cerebral small vessel diseases: vascular and white matter degeneration revealed by 3D histopathologic evaluation2021
- Author(s)
  Rie Saito, Kazuki Tainaka, Akiyoshi Kakita
- Organizer
  第62回神経病理学会総会
- Data Source
  KAKENHI-PROJECT-20K16595
[Presentation] Small vessel diseases: 3D characteristics of the vasculature and white matter.2021
- Author(s)
  Saito R, Tainaka K, Onodera O, Kakita A.
- Organizer
  AOCN-NPSICON 2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20468
[Presentation] white matter degeneration revealed by 3D histopathologic evaluation2021
- Author(s)
  Rie Saito, Kazuki Tainaka, Osamu Onodera, Akiyoshi Kakita
- Organizer
  The 62nd annual meeting of the Japanese Society of Neurology
- Data Source
  KAKENHI-PROJECT-20K16595
[Presentation] Cerebral small vessel diseases: vascular and white matter degeneration revealed by 3D histopathologic evaluation2021
- Author(s)
  Rie Saito, Kazuki Tainaka, Akiyoshi Kakita
- Organizer
  Asian Oceanian Congress of Neuropathology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16595
[Presentation] Cerebral small vessel diseases: vascular and white matter degeneration revealed by 3D histopathologic evaluation2021
- Author(s)
  Rie Saito, Kazuki Tainaka, Akiyoshi Kakita
- Organizer
  American Association of Neuropathologists
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16595
[Presentation] Cerebral small vessel disease: white matter degeneration revealed by 3D histopathologic evaluation2021
- Author(s)
  Rie Saito, Kazuki Tainaka, Osamu Onodera, Akiyoshi Kakita
- Organizer
  The 62nd annual meeting of the Japanese Society of Neuropathology
- Data Source
  KAKENHI-PROJECT-20K16595
[Presentation] Cerebral small vessel diseases: white matter degeneration revealed by 3D histopathologic evaluation2021
- Author(s)
  Rie Saito, Kazuki Tainaka, Akiyoshi Kakita
- Organizer
  97th American Association of Neuropathologists
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16595
[Presentation] 3D histopathologic analysis of degenerative vasculature and white matter in small-vessel diseases2021
- Author(s)
  Rie Saito, Akiyoshi Kakita
- Organizer
  生理研-霊長研-脳研合同シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-20K16595
[Presentation] 2D and 3D histopathologic features of degenerative white matter of cerebral small vessel diseases.2021
- Author(s)
  Saito R, Nozaki H, Tainaka K, Uemura M, Suzuki M, Tanaka M, Hasegawa A, Abe T, Sato A, Hashidate H, Igarashi S, Koike R, Onodera O, Kakita A.
- Organizer
  第62回日本神経学会
- Data Source
  KAKENHI-PROJECT-20K20468
[Presentation] 3D pathology of cerebral amyloid antipathy based on tissue clearing technique.2020
- Author(s)
  Inoue M, Saito R, Kakita A, Tainaka K.
- Organizer
  第61回日本神経病理学会
- Data Source
  KAKENHI-PROJECT-20K20468
[Presentation] Small vessel characteristics of autopsied patients with CADASIL and those heterozygous for HTRA1 mutations: 3D analysis using the CUBIC tissue clearing technique2019
- Author(s)
  Rie Saito, Kazuki Tainaka, Akiyoshi Kakita
- Organizer
  Amercan Academy of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21314
[Presentation] ３D神経病理学に向けたホールマウント染色手法の開発.2019
- Author(s)
  田井中一樹、齋藤理恵、井上雅文、柿田明美.
- Organizer
  日本神経病理学会
- Data Source
  KAKENHI-PROJECT-20K20468
[Presentation] CADASILとCARASILヘテロ接合体患者の剖検脳における小血管の特徴：CUBIC組織透明化手法を用いた3D解析．2019
- Author(s)
  齋藤理恵、田井中一貴、柿田明美.
- Organizer
  日本神経病理学会
- Data Source
  KAKENHI-PROJECT-20K20468
[Presentation] CADASILとCARASILヘテロ接合体患者の剖検脳における小血管の特徴：CUBIC組織透明化手法を用いた3D解析2019
- Author(s)
  齋藤理恵，井上雅文，野崎洋明，田井中一貴，柿田明美
- Organizer
  神経病理学会学術総会
- Data Source
  KAKENHI-PROJECT-19K21314
[Presentation] 孤発性脳小血管病とCADASIL：剖検脳の白質変性に関する組織像の定量的解析2019
- Author(s)
  齋藤理恵，鈴木正博，田中政春，野崎洋明，小野寺理，柿田明美
- Organizer
  神経病理学会学術総会
- Data Source
  KAKENHI-PROJECT-19K21314
[Presentation] 3D analysis of small vessels of patients with CADASIL and those heterozygous for HTRA1 mutations.2019
- Author(s)
  Saito R, Tainaka K, Kakita A.
- Organizer
  日本神経学会
- Data Source
  KAKENHI-PROJECT-20K20468
[Presentation] Small vessel characteristics of autopsied patients with CADASIL and heterozygous HTRA1 mutations: 3D analysis using tissue clearing technique CUBIC.2019
- Author(s)
  Saito R, Tainaka K, Kakita A.
- Organizer
  American Association of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20468
[Presentation] Astrocytic features in white matter of patients with CADASIL and Binswanger's disease2018
- Author(s)
  齋藤理恵，他田真理，柿田明美ら
- Organizer
  第59回神経学会総会
- Data Source
  KAKENHI-PROJECT-19K21314
[Presentation] CADASIL and CARASIL2018
- Author(s)
  Rie Saito, Akiyoshi Kakita
- Organizer
  19th International Congress of Neuropathology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21314

1. Kakita Akiyoshi (80281012)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
2. 北浦弘樹 (80401769)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 田井中一貴 (80506113)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
4. 小野寺理 (20303167)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 加藤泰介 (30598496)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 塚田啓道 (40794087)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 清水宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 柴山充弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. Li Xiang

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 池内健

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 他田真理

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Saito Rie 齋藤 理恵

Research Projects

Research Products

Co-Researchers

Understanding Human 3D Cerebral Vascular Network Frailty in Small Vessel Disease (SVD)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of cell groups that perturb the extracellular matrix of cerebral small vessel disease and deciphering their regulatory mechanisms.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Cerebral microangiopathy: To clarify the pathologic basis and pathomechanismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Digital 3D Neuropathology: Methodological Platform Creation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Vascular dementia: for establishing clinicopathologic diagnostic criteria for small vessel diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 非腫瘍性疾患病理アトラス 中枢神経「CARASIL」2024

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Inherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humans2024

Author(s)

Journal Title

Data Source

[Journal Article] An autopsied patient with palatal tremor and fatal bilateral vocal cord abduction paralysis associated with bilateral cerebellar dentate nucleus infarction2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] 臨床医のための神経病理再入門：CARASIL2022

Author(s)

Journal Title

Data Source

[Journal Article] 脳小血管病の病理2022

Author(s)

Journal Title

Data Source

[Journal Article] Long Spinal Cord Lesions Caused by Venous Congestive Myelopathy Associated with Intravascular Large B-cell Lymphoma: A Case Report2021

Author(s)

Journal Title

Data Source

[Journal Article] Genetic variations and neuropathologic features of patients with PARK2.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The diagnosis and management of monogenic cerebral small vessel diseases: Practical guideline by European Academy of Neurology.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Oculopharyngodistal myopathy with coexisting histology of systemic neuronal intranuclear inclusion disease: Clinicopathologic features of an autopsied patient harboring CGG repeat expansions in LRP122020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Versatile whole-organ/body staining and imaging based on electrolyte-gel properties of biological tissues2020

Author(s)

Saito Rie 齋藤理恵

[Book] 非腫瘍性疾患病理アトラス中枢神経「CARASIL」2024

[Presentation] 脳小血管ワールド　脳小血管保護による攻めの脳神経内科へ　病理からみた脳小血管病2023