Kashima Yukie 鹿島幸恵

Researcher Number	80831883
Other IDs	https://orcid.org/0000-0002-2240-5418
Affiliation (Current)	2024: 東京大学, 大学院新領域創成科学研究科, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2022: 東京大学, 大学院新領域創成科学研究科, 特任助教 2019 – 2020: 国立研究開発法人国立がん研究センター, 先端医療開発センター, 研究員
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Medium-sized Section 50:Oncology and related fields / Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator ロングリード / MinION / がん薬剤 / scRNA-seq / RNA-seq / 一細胞解析 / 薬剤耐性 / オシメルチニブ / EGFR-TKI / がん不均一性 / シングルセル解析 … More Except Principal Investigator … More 家族性乳がん・卵巣がん / 新規生殖細胞突然変異 / BRCA2 / 新規併用療法の開発戦略 / オミックス統合解析 / DNA損傷反応 / CDC7阻害剤TAK-931 / マルチオミックス解析 / 併用療法戦略 / がん治療薬 / 複製ストレス / TAK-931 / CDC7阻害剤 / 薬効・薬理研究 / バイオマーカー / トランスクリプトーム解析 / 橋渡し研究 / Drug Discovery / 低分子阻害剤 / CDC7キナーゼ / DNA複製ストレス Less

Combination treatment with CDC7 inhibitor and DNA damage agents enhances antiproliferative activity in multiple preclinical models
- Principal Investigator
  
  Akihiro Ohashi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Cancer Center Japan
A novel germline mutation in the non-coding region of BRCA2 is associated with hereditary breast cancer
- Principal Investigator
  
  大橋紹宏
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  National Cancer Center Japan
Single-cell analyses reveal diverse mechanisms of resistance to EGFR-TKI in lung cancerPrincipal Investigator
- Principal Investigator
  
  Kashima Yukie
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  The University of Tokyo
  National Cancer Center Japan

All 2021 2019

All Journal Article Presentation

[Journal Article] Single-Cell Analyses Reveal Diverse Mechanisms of Resistance to EGFR Tyrosine Kinase Inhibitors in Lung Cancer2021
- Author(s)
  Kashima Yukie、Shibahara Daisuke、Suzuki Ayako、Muto Kyoko、Kobayashi Ikei S.、Plotnick David、Udagawa Hibiki、Izumi Hiroki、Shibata Yuji、Tanaka Kosuke、Fujii Masanori、Ohashi Akihiro、Seki Masahide、Goto Koichi、Tsuchihara Katsuya、Suzuki Yutaka、Kobayashi Susumu S.
- Journal Title
  
  Cancer Research
  
  Volume: 81 Issue: 18 Pages: 4835-4848
- DOI
  10.1158/0008-5472.can-20-2811
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16879, KAKENHI-PROJECT-20H03541
[Journal Article] A CDC7 inhibitor sensitizes DNA-damaging chemotherapies by suppressing homologous recombination repair to delay DNA damage recovery2021
- Author(s)
  Iwai Kenichi、Nambu Tadahiro、Kashima Yukie、Yu Jie、Eng Kurt、Miyamoto Kazumasa、Kakoi Kazuyo、Gotou Masamitsu、Takeuchi Toshiyuki、Kogame Akifumi、Sappal Jessica、Murai Saomi、Haeno Hiroshi、Kageyama Shun-Ichiro、Kurasawa Osamu、Niu Huifeng、Kannan Karuppiah、Ohashi Akihiro
- Journal Title
  
  Science Advances
  
  Volume: 7 Issue: 21 Pages: 0-0
- DOI
  10.1126/sciadv.abf0197
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03541
[Journal Article] Single-cell and spatial analyses of cancer cells: toward elucidating the molecular mechanisms of clonal evolution and drug resistance acquisition2021
- Author(s)
  Nagasawa Satoi、Kashima Yukie、Suzuki Ayako、Suzuki Yutaka
- Journal Title
  
  Inflammation and Regeneration
  
  Volume: 41 Issue: 1
- DOI
  10.1186/s41232-021-00170-x
- Open Access
- Data Source
  KAKENHI-PROJECT-19K16879
[Presentation] CDC7 inhibitor-induced replication stress generates inflamed aneuploid cells to sensitize immune checkpoint inhibitors2021
- Author(s)
  Morita T.Y., Yu J., Kashima Y., Tanaka K., Hakozaki Y., Kageyama S., Nakamura A., Lightcap E., Niu H., Kannan K., and Ohashi A.
- Organizer
  The 32nd EORTC-NCI-AACR symposium, 2021.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03541
[Presentation] CENP-E inhibition generates micronucleus formation activating the cGAS-STING pathway in cancer cell.2021
- Author(s)
  Hakozaki Y., Kashima Y., Morita T.Y., Tanaka K, Kobayashi S.S. and Ohashi A.
- Organizer
  AACR Annual meeting, 2021.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03541
[Presentation] The CDC7 inhibitor-induced replication stress inflames the aneuploid cells to sensitize immune checkpoint inhibitors2021
- Author(s)
  Tomoko Yamamori Morita, Jie Yu, Yukie Kashima, Kosuke Tanaka, Tatsunori Minamide, Yumi Hakozaki, Shun-ichiro Kageyama, Akito Nakamura, Eric Lightcap, Huifeng Niu, Karuppiah Kannan, and Akihiro Ohashi
- Organizer
  The 44th Annual Meeting of the Molecular Biology Society of Japan., 2021
- Data Source
  KAKENHI-PROJECT-20H03541
[Presentation] 一細胞解析による肺がん薬剤耐性メカニズムの解明2019
- Author(s)
  鹿島幸恵
- Organizer
  第29回日本サイトメトリー学会
- Data Source
  KAKENHI-PROJECT-19K16879

1. Akihiro Ohashi (80835249)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
2. 影山俊一郎 (60644979)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 小林進 (70792836)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 向原徹 (80435718)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 桑田健 (00327321)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 堀居拓郎 (00361387)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kashima Yukie 鹿島 幸恵

Research Projects

Research Products

Co-Researchers

Combination treatment with CDC7 inhibitor and DNA damage agents enhances antiproliferative activity in multiple preclinical models

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A novel germline mutation in the non-coding region of BRCA2 is associated with hereditary breast cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Single-cell analyses reveal diverse mechanisms of resistance to EGFR-TKI in lung cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Single-Cell Analyses Reveal Diverse Mechanisms of Resistance to EGFR Tyrosine Kinase Inhibitors in Lung Cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A CDC7 inhibitor sensitizes DNA-damaging chemotherapies by suppressing homologous recombination repair to delay DNA damage recovery2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Single-cell and spatial analyses of cancer cells: toward elucidating the molecular mechanisms of clonal evolution and drug resistance acquisition2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] CDC7 inhibitor-induced replication stress generates inflamed aneuploid cells to sensitize immune checkpoint inhibitors2021

Author(s)

Organizer

Data Source

[Presentation] CENP-E inhibition generates micronucleus formation activating the cGAS-STING pathway in cancer cell.2021

Author(s)

Organizer

Data Source

[Presentation] The CDC7 inhibitor-induced replication stress inflames the aneuploid cells to sensitize immune checkpoint inhibitors2021

Author(s)

Organizer

Data Source

[Presentation] 一細胞解析による肺がん薬剤耐性メカニズムの解明2019

Author(s)

Organizer

Data Source

Kashima Yukie 鹿島幸恵