Kashima Yukie 鹿島幸恵

Researcher Number	80831883
Other IDs	https://orcid.org/0000-0002-2240-5418
Affiliation (Current)	2025: 東京大学, 大学院新領域創成科学研究科, 准教授
Affiliation (based on the past Project Information) *help	2025: 東京大学, 大学院新領域創成科学研究科, 准教授 2020 – 2023: 東京大学, 大学院新領域創成科学研究科, 特任助教 2019 – 2020: 国立研究開発法人国立がん研究センター, 先端医療開発センター, 研究員
Review Section/Research Field	Principal Investigator Basic Section 49060:Virology-related / Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Medium-sized Section 50:Oncology and related fields / Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator ロングリード / MinION / がん薬剤 / scRNA-seq / RNA-seq / 一細胞解析 / 薬剤耐性 / オシメルチニブ / EGFR-TKI / がん不均一性 / シングルセル解析 … More Except Principal Investigator … More 家族性乳がん・卵巣がん / 新規生殖細胞突然変異 / スプライシング異常 / 5’非翻訳領域に位置する新規BRCA2変異 / 家族性乳癌・卵巣癌症候群（HBOC） / 意義不明変異（VUS） / BRCA2 / 新規併用療法の開発戦略 / オミックス統合解析 / DNA損傷反応 / CDC7阻害剤TAK-931 / マルチオミックス解析 / 併用療法戦略 / がん治療薬 / 複製ストレス / TAK-931 / CDC7阻害剤 / 薬効・薬理研究 / バイオマーカー / トランスクリプトーム解析 / 橋渡し研究 / Drug Discovery / 低分子阻害剤 / CDC7キナーゼ / DNA複製ストレス Less

空間オミクス解析に免疫反応多様性の解明Principal Investigator
- Principal Investigator
  
  鹿島幸恵
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  The University of Tokyo
Combination treatment with CDC7 inhibitor and DNA damage agents enhances antiproliferative activity in multiple preclinical models
- Principal Investigator
  
  Akihiro Ohashi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Cancer Center Japan
A novel germline mutation in the non-coding region of BRCA2 is associated with hereditary breast cancer
- Principal Investigator
  
  Ohashi Akihiro
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  National Cancer Center Japan
Single-cell analyses reveal diverse mechanisms of resistance to EGFR-TKI in lung cancerPrincipal Investigator
- Principal Investigator
  
  Kashima Yukie
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  The University of Tokyo
  National Cancer Center Japan

All 2021 2019

All Journal Article Presentation

[Journal Article] Single-Cell Analyses Reveal Diverse Mechanisms of Resistance to EGFR Tyrosine Kinase Inhibitors in Lung Cancer2021
- Author(s)
  Kashima Yukie、Shibahara Daisuke、Suzuki Ayako、Muto Kyoko、Kobayashi Ikei S.、Plotnick David、Udagawa Hibiki、Izumi Hiroki、Shibata Yuji、Tanaka Kosuke、Fujii Masanori、Ohashi Akihiro、Seki Masahide、Goto Koichi、Tsuchihara Katsuya、Suzuki Yutaka、Kobayashi Susumu S.
- Journal Title
  
  Cancer Research
  
  Volume: 81 Issue: 18 Pages: 4835-4848
- DOI
  10.1158/0008-5472.can-20-2811
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16879, KAKENHI-PROJECT-20H03541
[Journal Article] A CDC7 inhibitor sensitizes DNA-damaging chemotherapies by suppressing homologous recombination repair to delay DNA damage recovery2021
- Author(s)
  Iwai Kenichi、Nambu Tadahiro、Kashima Yukie、Yu Jie、Eng Kurt、Miyamoto Kazumasa、Kakoi Kazuyo、Gotou Masamitsu、Takeuchi Toshiyuki、Kogame Akifumi、Sappal Jessica、Murai Saomi、Haeno Hiroshi、Kageyama Shun-Ichiro、Kurasawa Osamu、Niu Huifeng、Kannan Karuppiah、Ohashi Akihiro
- Journal Title
  
  Science Advances
  
  Volume: 7 Issue: 21 Pages: 0-0
- DOI
  10.1126/sciadv.abf0197
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03541
[Journal Article] Single-cell and spatial analyses of cancer cells: toward elucidating the molecular mechanisms of clonal evolution and drug resistance acquisition2021
- Author(s)
  Nagasawa Satoi、Kashima Yukie、Suzuki Ayako、Suzuki Yutaka
- Journal Title
  
  Inflammation and Regeneration
  
  Volume: 41 Issue: 1
- DOI
  10.1186/s41232-021-00170-x
- Open Access
- Data Source
  KAKENHI-PROJECT-19K16879
[Presentation] CDC7 inhibitor-induced replication stress generates inflamed aneuploid cells to sensitize immune checkpoint inhibitors2021
- Author(s)
  Morita T.Y., Yu J., Kashima Y., Tanaka K., Hakozaki Y., Kageyama S., Nakamura A., Lightcap E., Niu H., Kannan K., and Ohashi A.
- Organizer
  The 32nd EORTC-NCI-AACR symposium, 2021.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03541
[Presentation] CENP-E inhibition generates micronucleus formation activating the cGAS-STING pathway in cancer cell.2021
- Author(s)
  Hakozaki Y., Kashima Y., Morita T.Y., Tanaka K, Kobayashi S.S. and Ohashi A.
- Organizer
  AACR Annual meeting, 2021.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03541
[Presentation] The CDC7 inhibitor-induced replication stress inflames the aneuploid cells to sensitize immune checkpoint inhibitors2021
- Author(s)
  Tomoko Yamamori Morita, Jie Yu, Yukie Kashima, Kosuke Tanaka, Tatsunori Minamide, Yumi Hakozaki, Shun-ichiro Kageyama, Akito Nakamura, Eric Lightcap, Huifeng Niu, Karuppiah Kannan, and Akihiro Ohashi
- Organizer
  The 44th Annual Meeting of the Molecular Biology Society of Japan., 2021
- Data Source
  KAKENHI-PROJECT-20H03541
[Presentation] 一細胞解析による肺がん薬剤耐性メカニズムの解明2019
- Author(s)
  鹿島幸恵
- Organizer
  第29回日本サイトメトリー学会
- Data Source
  KAKENHI-PROJECT-19K16879

1. Akihiro Ohashi (80835249)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
2. 影山俊一郎 (60644979)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 小林進 (70792836)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 向原徹 (80435718)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 桑田健 (00327321)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 堀居拓郎 (00361387)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kashima Yukie 鹿島 幸恵

Research Projects

Research Products

Co-Researchers

空間オミクス解析に免疫反応多様性の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Combination treatment with CDC7 inhibitor and DNA damage agents enhances antiproliferative activity in multiple preclinical models

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A novel germline mutation in the non-coding region of BRCA2 is associated with hereditary breast cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Single-cell analyses reveal diverse mechanisms of resistance to EGFR-TKI in lung cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Single-Cell Analyses Reveal Diverse Mechanisms of Resistance to EGFR Tyrosine Kinase Inhibitors in Lung Cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A CDC7 inhibitor sensitizes DNA-damaging chemotherapies by suppressing homologous recombination repair to delay DNA damage recovery2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Single-cell and spatial analyses of cancer cells: toward elucidating the molecular mechanisms of clonal evolution and drug resistance acquisition2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] CDC7 inhibitor-induced replication stress generates inflamed aneuploid cells to sensitize immune checkpoint inhibitors2021

Author(s)

Organizer

Data Source

[Presentation] CENP-E inhibition generates micronucleus formation activating the cGAS-STING pathway in cancer cell.2021

Author(s)

Organizer

Data Source

[Presentation] The CDC7 inhibitor-induced replication stress inflames the aneuploid cells to sensitize immune checkpoint inhibitors2021

Author(s)

Organizer

Data Source

[Presentation] 一細胞解析による肺がん薬剤耐性メカニズムの解明2019

Author(s)

Organizer

Data Source

Kashima Yukie 鹿島幸恵