MOKUDA SHO 茂久田翔

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Mokuda Sho 茂久田翔

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Researcher Number	80837162
Other IDs
Affiliation (Current)	2025: 広島大学, 病院(医), 准教授
Affiliation (based on the past Project Information) *help	2025: 広島大学, 病院(医), 准教授 2023: 広島大学, 病院(医), 准教授 2022: 広島大学, 病院(医), 講師 2019 – 2021: 広島大学, 病院(医), 研究員
Review Section/Research Field	Principal Investigator Basic Section 56020:Orthopedics-related / Basic Section 54030:Infectious disease medicine-related
Keywords	Principal Investigator 発現 / 受容体 / 新型コロナウイルス / 宿主受容体 / 炎症性サイトカイン / 新型コロナウイルス感染症 / ゲノム編集 / スプライスバリアント / サバイビン / 滑膜線維芽細胞 / 細胞増殖 / 炎症 / 関節リウマチ

合成mRNAを応用した関節リウマチの病態解析と核酸治療標的の開発Principal Investigator
- Principal Investigator
  
  茂久田翔
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Hiroshima University
炎症性サイトカインによる宿主受容体発現調節を利用したCOVID-19治療薬の開発Principal Investigator
- Principal Investigator
  
  茂久田翔
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Hiroshima University
Functional analysis of Survivin splice variants in synovium of rheumatoid arthritis using genome editingPrincipal Investigator
- Principal Investigator
  
  Mokuda Sho
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Hiroshima University

All 2023 2022 2021 2020 2019 Other

All Journal Article Presentation Other

[Journal Article] Tumor necrosis factor and interleukin-1β upregulate NRP2 expression and promote SARS-CoV-2 proliferation.2023
- Author(s)
  Michinori Ishitoku & Sho Mokuda, Kei Araki, Hirofumi Watanabe, Hiroki Kohno, Tomohiro Sugimoto, Yusuke Yoshida, Takemasa Sakaguchi, Junya Masumoto, Shintaro Hirata, Eiji Sugiyama.
- Journal Title
  
  Viruses
  
  Volume: 15 Issue: 7 Pages: 1498-1498
- DOI
  10.3390/v15071498
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08599, KAKENHI-PROJECT-22K19438, KAKENHI-PROJECT-23K27635
[Journal Article] Disseminated Mycobacterium abscessus infection with osteoarticular manifestations as an important differential diagnosis of inflammatory arthritis: A case report and literature review2023
- Author(s)
  Chihaya Watanabe, Yusuke Yoshida, Genki Kidoguchi, Hiroki Kitagawa, Takeshi Shoji, Naoki Nakamoto, Naoya Oka, Tomohiro Sugimoto, Sho Mokuda, Shintaro Hirata
- Journal Title
  
  Modern Rheumatology Case Reports
  
  Volume: 8 Issue: 1 Pages: 49-54
- DOI
  10.1093/mrcr/rxad054
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08599
[Journal Article] Expression of factor XIII originating from synovial fibroblasts and macrophages induced by interleukin-6 signaling2023
- Author(s)
  Hirofumi Watanabe & Sho Mokuda, Tadahiro Tokunaga, Hiroki Kohno, Michinori Ishitoku, Kei Araki, Tomohiro Sugimoto, Yusuke Yoshida, Toshihiro Yamamoto, Mayuko Matsumoto, Junya Masumoto, Shintaro Hirata, Eiji Sugiyama
- Journal Title
  
  Inflammation and Regeneration
  
  Volume: 43 Issue: 1 Pages: 2-2
- DOI
  10.1186/s41232-022-00252-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08599, KAKENHI-PROJECT-22K19438, KAKENHI-PROJECT-20H03719
[Journal Article] Anti-spike protein antibody responses to BNT162b2 mRNA vaccine: A single-center survey in a COVID-19 non-epidemic area in Japan2022
- Author(s)
  Sho Mokuda, Namiki Kawanishi, Shintaro Kuroshima, Junko Kono, Hirofumi Nakayama, Hiroshi Mieno, Masashi Kawamoto
- Journal Title
  
  Vaccine: X
  
  Volume: 11 Pages: 100173-100173
- DOI
  10.1016/j.jvacx.2022.100173
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08599
[Journal Article] Comment on: Combination of immunosuppressive therapy and nintedanib improves capillaroscopic changes in systemic sclerosis-interstitial lung disease: a case report2022
- Author(s)
  Tomohiro Sugimoto, Yusuke Yoshida, Sho Mokuda, Shintaro Hirata
- Journal Title
  
  Rheumatol Adv Pract .
  
  Volume: 6 Issue: 1
- DOI
  10.1093/rap/rkac024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18499
[Journal Article] Comment on: Nailfold capillaries and myositis-specific antibodies in anti-melanoma differentiation-associated gene 5 antibody-positive DM. Reply2022
- Author(s)
  Tomohiro Sugimoto, Sho Mokuda, Hiroki Kohno, Michinori Ishitoku, Kei Araki, Hirofumi Watanabe, Tadahiro Tokunaga, Yusuke Yoshida, Shintaro Hirata, Eiji Sugiyama
- Journal Title
  
  Rheumatology (Oxford) .
  
  Volume: 61 Issue: 5 Pages: e122-e124
- DOI
  10.1093/rheumatology/keab822
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K18499
[Journal Article] The Lipopolysaccharide Mutant Re-LPS Is a Useful Tool for Detecting LPS Contamination in Rheumatoid Synovial Cell Cultures2021
- Author(s)
  Kohno Hiroki、Ouhara Kazuhisa、Mokuda Sho、Tokunaga Tadahiro、Sugimoto Tomohiro、Watanabe Hirofumi、Ishitoku Michinori、Yoshida Yusuke、Mizuno Noriyoshi、Ozawa Tatsuhiko、Kawataka Masatoshi、Hirata Shintaro、Kishi Hiroyuki、Sugiyama Eiji
- Journal Title
  
  Pathobiology
  
  Volume: 89 Issue: 2 Pages: 92-100
- DOI
  10.1159/000520022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07940, KAKENHI-PROJECT-19K08908, KAKENHI-PROJECT-19K18499, KAKENHI-PROJECT-21H02962
[Journal Article] Asymptomatic coronary aneurysms in a patient with eosinophilic granulomatosis with polyangiitis who developed a digital gangrene2021
- Author(s)
  Mayu Sato, Yusuke Yoshida, Tomohiro Sugimoto, Shinji Kishimoto, Takuji Omoto, Hirofumi Watanabe, Tadahiro Tokunaga, Kazutoshi Yukawa, Hiroki Kohno, Sho Mokuda, Takaki Nojima, Shintaro Hirata, Eiji Sugiyama
- Journal Title
  
  Modern Rheumatology Case Reports
  
  Volume: 5 Issue: 1 Pages: 130-136
- DOI
  10.1080/24725625.2020.1810404
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18499
[Journal Article] Lower CH50 as a predictor for intractable or recurrent lupus enteritis: A retrospective observational study2021
- Author(s)
  Yusuke Yoshida, Takuji Omoto, Hiroki Kohno, Tadahiro Tokunaga, Tatsuomi Kuranobu, Kazutoshi Yukawa, Hirofumi Watanabe, Katsuhiro Oi, Tomohiro Sugimoto, Sho Mokuda, Takaki Nojima, Shintaro Hirata, Eiji Sugiyama
- Journal Title
  
  Modern Rheumatology
  
  Volume: 31 Issue: 3 Pages: 643-648
- DOI
  10.1080/14397595.2020.1812871
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K18499
[Journal Article] Tapering and discontinuation of oral glucocorticoids without deterioration of disease status in patients with rheumatoid arthritis under a stable treatment2021
- Author(s)
  Shintaro Hirata, Hiroki Kohno, Hirofumi Watanabe, Tadahiro Tokunaga, Yusuke Yoshida, Tomohiro Sugimoto, Sho Mokuda, Keisuke Oda, Takaki Nojima, Eiji Sugiyama
- Journal Title
  
  Modern Rheumatology
  
  Volume: ahead of print Issue: 4 Pages: 803-808
- DOI
  10.1080/14397595.2020.1864914
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K18499, KAKENHI-PROJECT-19K07940
[Journal Article] C-reactive protein and ground-glass opacity as predictors for intractable interstitial lung disease in patients with systemic sclerosis under cyclophosphamide treatment regardless of concomitant glucocorticoids2021
- Author(s)
  Yusuke Yoshida, Tomohiro Sugimoto, Yohei Hosokawa, Harumichi Suma, Hiroki Kobayashi, Michinori Ishitoku, Hiroki Kohno, Tadahiro Tokunaga, Hirofumi Watanabe, Sho Mokuda, Takaki Nojima, Shintaro Hirata, Eiji Sugiyama
- Journal Title
  
  Modern Rheumatology
  
  Volume: ahead of print Issue: 1 Pages: 141-148
- DOI
  10.1080/14397595.2021.1907014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K18499
[Journal Article] Nailfold capillaries and myositis specific antibodies in anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis2021
- Author(s)
  Sugimoto, T. Mokuda, S. Kohno, H. Ishitoku, M. Araki, K. Watanabe, H. Tokunaga, T. Yoshida, Y. Hirata, S. Sugiyama, E.
- Journal Title
  
  Rheumatology (Oxford)
  
  Volume: - Issue: 5 Pages: 2006-2015
- DOI
  10.1093/rheumatology/keab681
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08908, KAKENHI-PROJECT-19K18499
[Journal Article] Rapid changes of nailfold capillary abnormalities during treatment for a patient with dermatomyositis complicated by lung cancer: a case report2021
- Author(s)
  Tomohiro Sugimoto, Sho Mokuda, Kakuhiro Yamaguchi, Kei Araki, Hiroki Kohno, Yusuke Yoshida, Shintaro Hirata, Noboru Hattori, Eiji Sugiyama
- Journal Title
  
  Modern Rheumatology Case Reports
  
  Volume: 5 Issue: 1 Pages: 95-100
- DOI
  10.1080/24725625.2020.1826650
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18499
[Journal Article] Serum CXCL10 levels are associated with better responses to abatacept treatment of rheumatoid arthritis.2020
- Author(s)
  Yukawa K, Mokuda S, Kohno H, Oi K, Kuranobu T, Tokunaga T, Yoshida Y, Yamana J, Iwahashi M, Hirata S, Yamana S, Sugiyama E.
- Journal Title
  
  Clinical and Experimental Rheumatology
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K18499
[Journal Article] Activin A Expressed in Rheumatoid Synovial Cells Downregulates TNFα-Induced CXCL10 Expression and Osteoclastogenesis2020
- Author(s)
  Kuranobu T, Mokuda S, Oi K, Tokunaga T, Yukawa K, Kohno H, Yoshida Y, Hirata S, Sugiyama E
- Journal Title
  
  Pathobiology
  
  Volume: - Issue: 3 Pages: 198-207
- DOI
  10.1159/000506260
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07940, KAKENHI-PROJECT-19K08908, KAKENHI-PROJECT-19K18499
[Journal Article] TGFβ1 Regulates Human RANKL-Induced Osteoclastogenesis via Suppression of NFATc1 Expression2020
- Author(s)
  Tokunaga T, Mokuda S, Kohno H, Yukawa K, Kuranobu T, Oi K, Yoshida Y, Hirata S, Sugiyama E
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 3 Pages: 800-800
- DOI
  10.3390/ijms21030800
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07940, KAKENHI-PROJECT-19K08908, KAKENHI-PROJECT-19K18499
[Journal Article] Angiotensin-converting Enzyme 2, a SARS-CoV-2 Receptor, Is Upregulated by Interleukin 6 through STAT3 Signaling in Synovial Tissues.2020
- Author(s)
  Mokuda S, Tokunaga T, Masumoto J, Sugiyama E.
- Journal Title
  
  J Rheumatol.
  
  Volume: 47 Issue: 10 Pages: 2553-2558
- DOI
  10.3899/jrheum.200547
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08908, KAKENHI-PROJECT-19K18499, KAKENHI-PROJECT-20H03719
[Journal Article] Wwp2 maintains cartilage homeostasis through regulation of Adamts5.2019
- Author(s)
  Mokuda S, Nakamichi R, Matsuzaki T, Ito Y, Sato T, Miyata K, Inui M, Olmer M, Sugiyama E, Lotz M, Asahara H,
- Journal Title
  
  Nature Communications
  
  Volume: 10 Pages: 2429-2429
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K18499
[Journal Article] Large-vessel vasculitis associated with PEGylated granulocyte-colony stimulating factor.2019
- Author(s)
  Yukawa K, Mokuda S, Yoshida Y, Hirata S, Sugiyama E.
- Journal Title
  
  The Netherlands Journal of Medicine
  
  Volume: 77 Pages: 224-226
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18499
[Presentation] 炎症性サイトカインによるSARS-CoV-2宿主受容体発現調節機構の解明2023
- Author(s)
  茂久田翔
- Organizer
  第63回日本呼吸器学会・学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K08599
[Presentation] ニューロピリン2は滑膜線維芽細胞においてTNFα＋IL-1βにより誘導され、SARS-CoV-2デルタ株の増殖に関与する2023
- Author(s)
  石徳理訓、茂久田翔、小林弘樹、細川洋平、荒木慧、木戸口元気、渡辺裕文、杉本智裕、吉田雄介、平田信太郎
- Organizer
  第38回日本臨床リウマチ学会
- Data Source
  KAKENHI-PROJECT-22K08599
[Presentation] TNFα+IL-1β共刺激により誘導される宿主受容体ニューロピリン2の制御を介した新型コロナウイルス感染機序に関する検討2023
- Author(s)
  石徳理訓、茂久田翔、細川洋平、荒木慧、木戸口元気、渡辺裕文、杉本智裕、吉田雄介、平田信太郎
- Organizer
  第51回日本臨床免疫学会総会
- Data Source
  KAKENHI-PROJECT-22K08599
[Presentation] 炎症性サイトカインによるSARS-CoV-2宿主受容体発現調節機構の解明2023
- Author(s)
  茂久田翔
- Organizer
  第63回日本呼吸器学会学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-22K08599
[Presentation] 関節リウマチ患者由来滑膜細胞株MH7Aにおける炎症性サイトカインによるNFκ-B(p65)を介したニューロピリンの発現誘導2022
- Author(s)
  石徳理訓、茂久田翔、荒木慧、渡辺裕文、河野紘輝、平田信太郎、杉山英二
- Organizer
  第50回日本臨床免疫学会総会
- Data Source
  KAKENHI-PROJECT-22K08599
[]

1. HIRATA Shintaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
2. 杉山英二

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

MOKUDA SHO 茂久田 翔

Mokuda Sho 茂久田 翔

Research Projects

Research Products

Co-Researchers

合成mRNAを応用した関節リウマチの病態解析と核酸治療標的の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

炎症性サイトカインによる宿主受容体発現調節を利用したCOVID-19治療薬の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis of Survivin splice variants in synovium of rheumatoid arthritis using genome editingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Tumor necrosis factor and interleukin-1β upregulate NRP2 expression and promote SARS-CoV-2 proliferation.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Disseminated Mycobacterium abscessus infection with osteoarticular manifestations as an important differential diagnosis of inflammatory arthritis: A case report and literature review2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Expression of factor XIII originating from synovial fibroblasts and macrophages induced by interleukin-6 signaling2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anti-spike protein antibody responses to BNT162b2 mRNA vaccine: A single-center survey in a COVID-19 non-epidemic area in Japan2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comment on: Combination of immunosuppressive therapy and nintedanib improves capillaroscopic changes in systemic sclerosis-interstitial lung disease: a case report2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comment on: Nailfold capillaries and myositis-specific antibodies in anti-melanoma differentiation-associated gene 5 antibody-positive DM. Reply2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Lipopolysaccharide Mutant Re-LPS Is a Useful Tool for Detecting LPS Contamination in Rheumatoid Synovial Cell Cultures2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Asymptomatic coronary aneurysms in a patient with eosinophilic granulomatosis with polyangiitis who developed a digital gangrene2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lower CH50 as a predictor for intractable or recurrent lupus enteritis: A retrospective observational study2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tapering and discontinuation of oral glucocorticoids without deterioration of disease status in patients with rheumatoid arthritis under a stable treatment2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] C-reactive protein and ground-glass opacity as predictors for intractable interstitial lung disease in patients with systemic sclerosis under cyclophosphamide treatment regardless of concomitant glucocorticoids2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nailfold capillaries and myositis specific antibodies in anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis2021

Author(s)

MOKUDA SHO 茂久田翔

Mokuda Sho 茂久田翔

[Presentation] 関節リウマチ患者由来滑膜細胞株MH7Aにおける炎症性サイトカインによるNFκ-B(p65)を介したニューロピリンの発現誘導2022