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Miki Toshio  三木 敏生

… Alternative Names

MIKI Toshio  三木 敏生

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Researcher Number 80845305
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-8332-7401
Affiliation (Current) 2025: 日本大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2022 – 2025: 日本大学, 医学部, 教授
2019 – 2020: 日本大学, 医学部, 教授
Review Section/Research Field
Principal Investigator
Basic Section 55010:General surgery and pediatric surgery-related / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields / 0701:Biology at molecular to cellular levels, and related fields
Except Principal Investigator
Basic Section 55010:General surgery and pediatric surgery-related
Keywords
Principal Investigator
羊膜上皮細胞 / 細胞移植 / 遺伝子改変ブタ / 幹細胞 / 細胞外小胞 / 細胞膜ナノチューブ / 移送開始シグナル / 網羅的遺伝子解析 / 細胞間水平移動 / ミトコンドリア … More / プロテオミックス / 肝星細胞 / マイクロRNA / エクソソーム / 肝線維化 … More
Except Principal Investigator
生着環境 / 細胞移植 / 即時型炎症反応 / 拒絶反応 / 血管新生促進作用 / 膵島移植 / 抗炎症作用 / 羊膜由来幹細胞 Less
  • Research Projects

    (5 results)
  • Research Products

    (26 results)
  • Co-Researchers

    (13 People)
  •  細胞間ミトコンドリア水平移動メカニズムの解明Principal Investigator

    • Principal Investigator
      三木 敏生
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Nihon University
  •  羊膜由来幹細胞が肝内膵島生着環境に与える影響の解明

    • Principal Investigator
      戸子台 和哲
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Tohoku University
  •  Understanding of initiation signals of intercellular mitochondria transferPrincipal Investigator

    • Principal Investigator
      三木 敏生
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
    • Research Institution
      Nihon University
  •  Evaluation of in vivo kinetics and fate of amnion epithelial stem cells after intraportal transplantation using transgenic pigsPrincipal Investigator

    • Principal Investigator
      三木 敏生
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Nihon University
  •  The Role of Amniotic Epithelial Cell-derived miRNAs in the Regulation of Hepatic Stellate Cell ActivationPrincipal Investigator

    • Principal Investigator
      MIKI Toshio
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Review Section
      0701:Biology at molecular to cellular levels, and related fields
    • Research Institution
      Nihon University

All 2024 2023 2022 2020

All Journal Article Presentation

  • [Journal Article] Human Amniotic Epithelial Cells Secretome: Components, Bioactivity, and Challenges2022

    • Author(s)
      Fathi Ibrahim、Miki Toshio
    • Journal Title

      Frontiers in Medicine

      Volume: 8

    • DOI

      10.3389/fmed.2021.763141

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K19574, KAKENHI-PROJECT-23K24398
  • [Journal Article] Distribution of amniotic epithelial cells after intraportal infusion in a rat model2022

    • Author(s)
      Tanaka M, Tokodai K, Sato M, Yamada S, Okita H, Ito T, Saito M, Hoshiai T, Miyagi S, Miki T, Unno M, Kamei T, Goto M
    • Journal Title

      Transplantation Proceedings

      Volume: - Issue: 2 Pages: 513-515

    • DOI

      10.1016/j.transproceed.2021.09.077

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H04056, KAKENHI-PROJECT-20K21624, KAKENHI-PROJECT-22K19574, KAKENHI-PROJECT-23K24398
  • [Journal Article] Inhibition of Epithelial-Mesenchymal Transition Maintains Stemness in Human Amniotic Epithelial Cells2022

    • Author(s)
      Takano Chika、Horie Masafumi、Taiko Isamu、Trinh Quang Duy、Kanemaru Kazunori、Komine-Aizawa Shihoko、Hayakawa Satoshi、Miki Toshio
    • Journal Title

      Stem Cell Reviews and Reports

      Volume: 18 Issue: 8 Pages: 3083-3091

    • DOI

      10.1007/s12015-022-10420-1

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K19574, KAKENHI-PROJECT-20H03423, KAKENHI-PROJECT-20H03430, KAKENHI-PROJECT-20K08829, KAKENHI-PROJECT-20K17522, KAKENHI-PROJECT-23K24398
  • [Journal Article] Differences in the stemness characteristics and molecular markers of distinct human oral tissue neural crest‐derived multilineage cells2022

    • Author(s)
      Abe Shigehiro、Kaida Atsushi、Kanemaru Kazunori、Nakazato Keiichiro、Yokomizo Naoko、Kobayashi Yutaka、Miura Masahiko、Miki Toshio、Hidai Chiaki、Kitano Hisataka、Yoda Tetsuya
    • Journal Title

      Cell Proliferation

      Volume: 55 Issue: 10

    • DOI

      10.1111/cpr.13286

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K10025, KAKENHI-PROJECT-22K10231, KAKENHI-PROJECT-22K19574, KAKENHI-PROJECT-20H03423, KAKENHI-PROJECT-20H03430, KAKENHI-PROJECT-19K10183, KAKENHI-PROJECT-23K24398
  • [Journal Article] EGF domain peptide of Developmentally regulated endothelial locus1 facilitates gene expression of extracellularly applied plasmid DNA2022

    • Author(s)
      Kitano Hisataka、Kanemaru Kazunori、Miki Toshio、Hidai Chiaki
    • Journal Title

      Biologicals

      Volume: 75 Pages: 12-15

    • DOI

      10.1016/j.biologicals.2022.01.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H03423, KAKENHI-PROJECT-22K19574, KAKENHI-PROJECT-23K24398
  • [Journal Article] Selection of red fluorescent protein for genetic labeling of mitochondria and intercellular transfer of viable mitochondria2022

    • Author(s)
      Taiko Isamu、Takano Chika、Nomoto Masayuki、Hayashida Shingo、Kanemaru Kazunori、Miki Toshio
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 19841-19841

    • DOI

      10.1038/s41598-022-24297-0

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K06868, KAKENHI-PROJECT-22K19574, KAKENHI-PROJECT-20H03423, KAKENHI-PROJECT-20H03430, KAKENHI-PROJECT-20K17522, KAKENHI-PROJECT-23K24398
  • [Journal Article] A case of breast squamous cell carcinoma following breast augmentation with liquid silicone injection after 16?years2022

    • Author(s)
      Toyonaka Ryosuke、Ozeki Jun、Koyama Yumi、Takahashi Saaya、Tang Xiaoyan、Kobayashi Hiroko、Amano Maki、Tada Keiichiro、Miki Toshio、Tani Mayumi
    • Journal Title

      Surgical Case Reports

      Volume: 8 Issue: 1

    • DOI

      10.1186/s40792-022-01378-w

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K19574, KAKENHI-PROJECT-23K24398
  • [Journal Article] The proliferation of atypical hepatocytes and CDT1 expression in noncancerous tissue are associated with the postoperative recurrence of hepatocellular carcinoma2022

    • Author(s)
      Moriyama Mitsuhiko、Kanda Tatsuo、Midorikawa Yutaka、Matsumura Hiroshi、Masuzaki Ryota、Nakamura Hitomi、Ogawa Masahiro、Matsuoka Shunichi、Shibata Toshikatu、Yamazaki Motomi、Kuroda Kazumichi、Nakayama Hisashi、Higaki Tokio、Kanemaru Kazunori、Miki Toshio、Sugitani Masahiko、Takayama Tadatoshi
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 20508-20508

    • DOI

      10.1038/s41598-022-25201-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K19574, KAKENHI-PROJECT-20H03423, KAKENHI-PROJECT-20H03430, KAKENHI-PROJECT-20K07706, KAKENHI-PROJECT-23K24398
  • [Presentation] 膵島移植におけるヒト羊膜上皮細胞-膵島共移植による膵島生着率向上の検討2024

    • Author(s)
      岡田 薫、戸子台 和哲、星合 哲郎、齋藤 昌利、三木 敏生、海野 倫明、亀井 尚、後藤 昌史
    • Organizer
      第51回日本膵・膵島移植学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K08745
  • [Presentation] 移植後膵島生着促進における羊膜由来幹細胞の効果について2023

    • Author(s)
      岡田 薫、戸子台 和哲、星合 哲郎、齋藤 昌利、海野 倫明、三木 敏生、亀井 尚 、後藤 昌史
    • Organizer
      第50回日本膵・膵島移植学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K08745
  • [Presentation] Unlocking the Potential of Amniotic Epithelial Cells2023

    • Author(s)
      Toshio Miki
    • Organizer
      IPITA-IXA-CTRMS Joint Congress 2023
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K24398
  • [Presentation] ヒト羊膜上皮細胞を用いたII型肺胞上皮細胞への分化誘導2023

    • Author(s)
      野本 正幸, 太向 勇, 高野 智圭, 金丸 和典, 三木 敏生
    • Organizer
      日本生理学会
    • Data Source
      KAKENHI-PROJECT-22K19574
  • [Presentation] シングルセル解析を用いたヒト羊膜上皮細胞の系統学的多様性の解明2023

    • Author(s)
      高野智圭, 堀江真史, エルディーブ ダリア, 早川 智, 三木敏生
    • Organizer
      第31回日本胎盤学会学術集会/第41回日本絨毛性疾患研究会
    • Data Source
      KAKENHI-PROJECT-22K19574
  • [Presentation] Effect of human Amniotic Epithelial Cells on intraportal islet transplantation2023

    • Author(s)
      Kaoru Okada, Kazuaki Tokodai, Miyako Tanaka, Tetsuro Hoshiai, Masatoshi Saito, Michiaki Unno, Toshio Miki, Masafumi Goto, Takashi Kamei
    • Organizer
      IPITA-IXA-CTRMS Joint Congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K08745
  • [Presentation] ヒト羊膜上皮細胞を用いたⅡ型肺胞上皮細胞への分化誘導2023

    • Author(s)
      野本 正幸, 太向 勇, 高野 智圭, 金丸 和典, 三木 敏生
    • Organizer
      日本生理学会
    • Data Source
      KAKENHI-PROJECT-23K24398
  • [Presentation] シングルセル解析を用いたヒト羊膜上皮細胞の系統学的多様性の解明2023

    • Author(s)
      高野智圭, 堀江真史, エルディーブ ダリア, 早川 智, 三木敏生
    • Organizer
      第31回日本胎盤学会学術集会/第41回日本絨毛性疾患研究会
    • Data Source
      KAKENHI-PROJECT-23K24398
  • [Presentation] Unlocking the Potential of Amniotic Epithelial Cells2023

    • Author(s)
      Toshio Miki
    • Organizer
      IPITA-IXA-CTRMS Joint Congress 2023
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K19574
  • [Presentation] 細胞移植による肝臓の再生医療2023

    • Author(s)
      三木敏生
    • Organizer
      日本消化器病学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K24398
  • [Presentation] ヒト羊膜上皮細胞における幹細胞特性維持機構の解明2023

    • Author(s)
      高野 智圭, 加賀 三鈴, 太向 勇, 樋口 雄介, 三木 敏生
    • Organizer
      日本生理学会
    • Data Source
      KAKENHI-PROJECT-22K19574
  • [Presentation] ヒト羊膜上皮細胞における幹細胞特性維持機構の解明2023

    • Author(s)
      高野 智圭, 加賀 三鈴, 太向 勇, 樋口 雄介, 三木 敏生
    • Organizer
      日本生理学会
    • Data Source
      KAKENHI-PROJECT-23K24398
  • [Presentation] 細胞移植による肝臓の再生医療2023

    • Author(s)
      三木敏生
    • Organizer
      日本消化器病学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K19574
  • [Presentation] Expression of Traf2- and Nck-interacting kinase in EMT-inhibited human amniotic epithelial cells2022

    • Author(s)
      Chika Takano、Toshio Miki
    • Organizer
      29th International Congress of The Transplantation Society
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K24398
  • [Presentation] ヒト胎盤由来幹細胞を用いた組織工学と再生医療の可能性2022

    • Author(s)
      三木 敏生
    • Organizer
      第60回 日本人工臓器学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K24398
  • [Presentation] Intraportal co-transplantation of amnion-derived cells and pancreatic islets to promote islet engraftment after transplantation2022

    • Author(s)
      Kaoru Okada, Kazuaki Tokodai, Miyako Tanaka, Tetsuro Hoshiai, Masatoshi Saito, Michiaki Unno, Toshio Miki, Masafumi Goto, Takashi Kamei
    • Organizer
      International Diabetes Federation Congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K08745
  • [Presentation] 羊膜由来幹細胞と膵島の門脈内共移植による移植後膵島生着促進の試み2022

    • Author(s)
      岡田 薫、戸子台 和哲、星合 哲郎、齋藤 昌利、海野 倫明、三木 敏生、後藤 昌史、亀井 尚
    • Organizer
      第58回日本移植学会総会
    • Data Source
      KAKENHI-PROJECT-22K08745
  • [Presentation] 羊膜上皮細胞由来エクソソームマルmiR483-5pによる肝星細胞活性制御機序の解明2020

    • Author(s)
      三木敏生
    • Organizer
      第27回肝細胞研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K23732
  • 1.  戸子台 和哲 (50581641)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 2.  齋藤 昌利 (00451584)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 3.  星合 哲郎 (10569560)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 4.  後藤 昌史 (50400453)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 5.  菅原 宏文 (60451572)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  太向 勇 (20836556)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 7.  堀江 真史 (60732659)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 8.  三角 浩司 (00442682)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  淵本 大一郎 (10343998)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  高野 智圭 (50845310)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 11.  大西 彰 (30414890)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  ABE Shigehiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  KANEMARU Kazunori
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results

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