Miki Toshio 三木敏生

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MIKI Toshio 三木敏生

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Researcher Number	80845305
Other IDs	https://orcid.org/0000-0001-8332-7401
Affiliation (Current)	2025: 日本大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2022 – 2025: 日本大学, 医学部, 教授 2019 – 2020: 日本大学, 医学部, 教授
Review Section/Research Field	Principal Investigator Basic Section 55010:General surgery and pediatric surgery-related / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields / 0701:Biology at molecular to cellular levels, and related fields Except Principal Investigator Basic Section 55010:General surgery and pediatric surgery-related
Keywords	Principal Investigator 羊膜上皮細胞 / ライブイメージング / 小分子化合物ライブラリ / 機能ゲノミクススクリーニング / ヒト羊膜上皮細胞 / 細胞間ミトコンドリア移送 / 細胞移植 / 遺伝子改変ブタ / 幹細胞 / 細胞外小胞 … More / 細胞膜ナノチューブ / 移送開始シグナル / 網羅的遺伝子解析 / 細胞間水平移動 / ミトコンドリア / プロテオミックス / 肝星細胞 / マイクロRNA / エクソソーム / 肝線維化 … More Except Principal Investigator エクソソーム / 免疫応答 / 肝細胞様細胞 / 羊膜上皮幹細胞 / 生着環境 / 細胞移植 / 即時型炎症反応 / 拒絶反応 / 血管新生促進作用 / 膵島移植 / 抗炎症作用 / 羊膜由来幹細胞 Less

Elucidation of the Mechanisms Underlying Intercellular Horizontal Mitochondrial TransferPrincipal Investigator
- Principal Investigator
  
  三木敏生
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Nihon University
ヒト羊膜上皮幹細胞由来肝細胞移植における拒絶反応・即時型炎症反応の解明と制御
- Principal Investigator
  
  戸子台和哲
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Tohoku University
羊膜由来幹細胞が肝内膵島生着環境に与える影響の解明
- Principal Investigator
  
  戸子台和哲
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Tohoku University
Understanding of initiation signals of intercellular mitochondria transferPrincipal Investigator
- Principal Investigator
  
  三木敏生
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Nihon University
Evaluation of in vivo kinetics and fate of amnion epithelial stem cells after intraportal transplantation using transgenic pigsPrincipal Investigator
- Principal Investigator
  
  三木敏生
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Nihon University
The Role of Amniotic Epithelial Cell-derived miRNAs in the Regulation of Hepatic Stellate Cell ActivationPrincipal Investigator
- Principal Investigator
  
  MIKI Toshio
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0701:Biology at molecular to cellular levels, and related fields
- Research Institution
  Nihon University

All 2024 2023 2022 2020

All Journal Article Presentation

[Journal Article] Human Amniotic Epithelial Cells Secretome: Components, Bioactivity, and Challenges2022
- Author(s)
  Fathi Ibrahim、Miki Toshio
- Journal Title
  
  Frontiers in Medicine
  
  Volume: 8
- DOI
  10.3389/fmed.2021.763141
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19574, KAKENHI-PROJECT-23K24398
[Journal Article] Distribution of amniotic epithelial cells after intraportal infusion in a rat model2022
- Author(s)
  Tanaka M, Tokodai K, Sato M, Yamada S, Okita H, Ito T, Saito M, Hoshiai T, Miyagi S, Miki T, Unno M, Kamei T, Goto M
- Journal Title
  
  Transplantation Proceedings
  
  Volume: - Issue: 2 Pages: 513-515
- DOI
  10.1016/j.transproceed.2021.09.077
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H04056, KAKENHI-PROJECT-20K21624, KAKENHI-PROJECT-22K19574, KAKENHI-PROJECT-23K24398
[Journal Article] Inhibition of Epithelial-Mesenchymal Transition Maintains Stemness in Human Amniotic Epithelial Cells2022
- Author(s)
  Takano Chika、Horie Masafumi、Taiko Isamu、Trinh Quang Duy、Kanemaru Kazunori、Komine-Aizawa Shihoko、Hayakawa Satoshi、Miki Toshio
- Journal Title
  
  Stem Cell Reviews and Reports
  
  Volume: 18 Issue: 8 Pages: 3083-3091
- DOI
  10.1007/s12015-022-10420-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19574, KAKENHI-PROJECT-20H03423, KAKENHI-PROJECT-20H03430, KAKENHI-PROJECT-20K08829, KAKENHI-PROJECT-20K17522, KAKENHI-PROJECT-23K24398
[Journal Article] Differences in the stemness characteristics and molecular markers of distinct human oral tissue neural crest‐derived multilineage cells2022
- Author(s)
  Abe Shigehiro、Kaida Atsushi、Kanemaru Kazunori、Nakazato Keiichiro、Yokomizo Naoko、Kobayashi Yutaka、Miura Masahiko、Miki Toshio、Hidai Chiaki、Kitano Hisataka、Yoda Tetsuya
- Journal Title
  
  Cell Proliferation
  
  Volume: 55 Issue: 10
- DOI
  10.1111/cpr.13286
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K10025, KAKENHI-PROJECT-22K10231, KAKENHI-PROJECT-22K19574, KAKENHI-PROJECT-20H03423, KAKENHI-PROJECT-20H03430, KAKENHI-PROJECT-19K10183, KAKENHI-PROJECT-23K24398
[Journal Article] EGF domain peptide of Developmentally regulated endothelial locus1 facilitates gene expression of extracellularly applied plasmid DNA2022
- Author(s)
  Kitano Hisataka、Kanemaru Kazunori、Miki Toshio、Hidai Chiaki
- Journal Title
  
  Biologicals
  
  Volume: 75 Pages: 12-15
- DOI
  10.1016/j.biologicals.2022.01.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03423, KAKENHI-PROJECT-22K19574, KAKENHI-PROJECT-23K24398
[Journal Article] Selection of red fluorescent protein for genetic labeling of mitochondria and intercellular transfer of viable mitochondria2022
- Author(s)
  Taiko Isamu、Takano Chika、Nomoto Masayuki、Hayashida Shingo、Kanemaru Kazunori、Miki Toshio
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 19841-19841
- DOI
  10.1038/s41598-022-24297-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06868, KAKENHI-PROJECT-22K19574, KAKENHI-PROJECT-20H03423, KAKENHI-PROJECT-20H03430, KAKENHI-PROJECT-20K17522, KAKENHI-PROJECT-23K24398
[Journal Article] A case of breast squamous cell carcinoma following breast augmentation with liquid silicone injection after 16?years2022
- Author(s)
  Toyonaka Ryosuke、Ozeki Jun、Koyama Yumi、Takahashi Saaya、Tang Xiaoyan、Kobayashi Hiroko、Amano Maki、Tada Keiichiro、Miki Toshio、Tani Mayumi
- Journal Title
  
  Surgical Case Reports
  
  Volume: 8 Issue: 1
- DOI
  10.1186/s40792-022-01378-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19574, KAKENHI-PROJECT-23K24398
[Journal Article] The proliferation of atypical hepatocytes and CDT1 expression in noncancerous tissue are associated with the postoperative recurrence of hepatocellular carcinoma2022
- Author(s)
  Moriyama Mitsuhiko、Kanda Tatsuo、Midorikawa Yutaka、Matsumura Hiroshi、Masuzaki Ryota、Nakamura Hitomi、Ogawa Masahiro、Matsuoka Shunichi、Shibata Toshikatu、Yamazaki Motomi、Kuroda Kazumichi、Nakayama Hisashi、Higaki Tokio、Kanemaru Kazunori、Miki Toshio、Sugitani Masahiko、Takayama Tadatoshi
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 20508-20508
- DOI
  10.1038/s41598-022-25201-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19574, KAKENHI-PROJECT-20H03423, KAKENHI-PROJECT-20H03430, KAKENHI-PROJECT-20K07706, KAKENHI-PROJECT-23K24398
[Presentation] 膵島移植におけるヒト羊膜上皮細胞-膵島共移植による膵島生着率向上の検討2024
- Author(s)
  岡田薫、戸子台和哲、星合哲郎、齋藤昌利、三木　敏生、海野倫明、亀井尚、後藤昌史
- Organizer
  第51回日本膵・膵島移植学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08745
[Presentation] 移植後膵島生着促進における羊膜由来幹細胞の効果について2023
- Author(s)
  岡田薫、戸子台和哲、星合哲郎、齋藤昌利、海野倫明、三木敏生、亀井尚、後藤昌史
- Organizer
  第50回日本膵・膵島移植学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08745
[Presentation] Unlocking the Potential of Amniotic Epithelial Cells2023
- Author(s)
  Toshio Miki
- Organizer
  IPITA-IXA-CTRMS Joint Congress 2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24398
[Presentation] ヒト羊膜上皮細胞を用いたII型肺胞上皮細胞への分化誘導2023
- Author(s)
  野本正幸, 太向勇, 高野智圭, 金丸和典, 三木敏生
- Organizer
  日本生理学会
- Data Source
  KAKENHI-PROJECT-22K19574
[Presentation] シングルセル解析を用いたヒト羊膜上皮細胞の系統学的多様性の解明2023
- Author(s)
  高野智圭, 堀江真史, エルディーブダリア, 早川智, 三木敏生
- Organizer
  第31回日本胎盤学会学術集会/第41回日本絨毛性疾患研究会
- Data Source
  KAKENHI-PROJECT-22K19574
[Presentation] Effect of human Amniotic Epithelial Cells on intraportal islet transplantation2023
- Author(s)
  Kaoru Okada, Kazuaki Tokodai, Miyako Tanaka, Tetsuro Hoshiai, Masatoshi Saito, Michiaki Unno, Toshio Miki, Masafumi Goto, Takashi Kamei
- Organizer
  IPITA-IXA-CTRMS Joint Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08745
[Presentation] ヒト羊膜上皮細胞を用いたⅡ型肺胞上皮細胞への分化誘導2023
- Author(s)
  野本正幸, 太向勇, 高野智圭, 金丸和典, 三木敏生
- Organizer
  日本生理学会
- Data Source
  KAKENHI-PROJECT-23K24398
[Presentation] シングルセル解析を用いたヒト羊膜上皮細胞の系統学的多様性の解明2023
- Author(s)
  高野智圭, 堀江真史, エルディーブダリア, 早川智, 三木敏生
- Organizer
  第31回日本胎盤学会学術集会/第41回日本絨毛性疾患研究会
- Data Source
  KAKENHI-PROJECT-23K24398
[Presentation] Unlocking the Potential of Amniotic Epithelial Cells2023
- Author(s)
  Toshio Miki
- Organizer
  IPITA-IXA-CTRMS Joint Congress 2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19574
[Presentation] 細胞移植による肝臓の再生医療2023
- Author(s)
  三木敏生
- Organizer
  日本消化器病学会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24398
[Presentation] ヒト羊膜上皮細胞における幹細胞特性維持機構の解明2023
- Author(s)
  高野智圭, 加賀三鈴, 太向勇, 樋口雄介, 三木敏生
- Organizer
  日本生理学会
- Data Source
  KAKENHI-PROJECT-22K19574
[Presentation] ヒト羊膜上皮細胞における幹細胞特性維持機構の解明2023
- Author(s)
  高野智圭, 加賀三鈴, 太向勇, 樋口雄介, 三木敏生
- Organizer
  日本生理学会
- Data Source
  KAKENHI-PROJECT-23K24398
[Presentation] 細胞移植による肝臓の再生医療2023
- Author(s)
  三木敏生
- Organizer
  日本消化器病学会
- Invited
- Data Source
  KAKENHI-PROJECT-22K19574
[Presentation] Expression of Traf2- and Nck-interacting kinase in EMT-inhibited human amniotic epithelial cells2022
- Author(s)
  Chika Takano、Toshio Miki
- Organizer
  29th International Congress of The Transplantation Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24398
[Presentation] ヒト胎盤由来幹細胞を用いた組織工学と再生医療の可能性2022
- Author(s)
  三木敏生
- Organizer
  第60回日本人工臓器学会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24398
[Presentation] Intraportal co-transplantation of amnion-derived cells and pancreatic islets to promote islet engraftment after transplantation2022
- Author(s)
  Kaoru Okada, Kazuaki Tokodai, Miyako Tanaka, Tetsuro Hoshiai, Masatoshi Saito, Michiaki Unno, Toshio Miki, Masafumi Goto, Takashi Kamei
- Organizer
  International Diabetes Federation Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08745
[Presentation] 羊膜由来幹細胞と膵島の門脈内共移植による移植後膵島生着促進の試み2022
- Author(s)
  岡田薫、戸子台和哲、星合哲郎、齋藤昌利、海野倫明、三木敏生、後藤昌史、亀井尚
- Organizer
  第58回日本移植学会総会
- Data Source
  KAKENHI-PROJECT-22K08745
[Presentation] 羊膜上皮細胞由来エクソソームマルmiR483-5pによる肝星細胞活性制御機序の解明2020
- Author(s)
  三木敏生
- Organizer
  第27回肝細胞研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19K23732

1. 戸子台和哲 (50581641)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
2. 齋藤昌利 (00451584)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
3. 後藤昌史 (50400453)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
4. 太向勇 (20836556)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
5. 高野智圭 (50845310)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
6. 星合哲郎 (10569560)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
7. 菅原宏文 (60451572)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 堀江真史 (60732659)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. 三角浩司 (00442682)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 淵本大一郎 (10343998)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 大西彰 (30414890)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. ABE Shigehiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. KANEMARU Kazunori

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Miki Toshio 三木 敏生

MIKI Toshio 三木 敏生

Research Projects

Research Products

Co-Researchers

Elucidation of the Mechanisms Underlying Intercellular Horizontal Mitochondrial TransferPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ヒト羊膜上皮幹細胞由来肝細胞移植における拒絶反応・即時型炎症反応の解明と制御

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

羊膜由来幹細胞が肝内膵島生着環境に与える影響の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Understanding of initiation signals of intercellular mitochondria transferPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Evaluation of in vivo kinetics and fate of amnion epithelial stem cells after intraportal transplantation using transgenic pigsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The Role of Amniotic Epithelial Cell-derived miRNAs in the Regulation of Hepatic Stellate Cell ActivationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Human Amniotic Epithelial Cells Secretome: Components, Bioactivity, and Challenges2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Distribution of amniotic epithelial cells after intraportal infusion in a rat model2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of Epithelial-Mesenchymal Transition Maintains Stemness in Human Amniotic Epithelial Cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Differences in the stemness characteristics and molecular markers of distinct human oral tissue neural crest‐derived multilineage cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] EGF domain peptide of Developmentally regulated endothelial locus1 facilitates gene expression of extracellularly applied plasmid DNA2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Selection of red fluorescent protein for genetic labeling of mitochondria and intercellular transfer of viable mitochondria2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A case of breast squamous cell carcinoma following breast augmentation with liquid silicone injection after 16?years2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The proliferation of atypical hepatocytes and CDT1 expression in noncancerous tissue are associated with the postoperative recurrence of hepatocellular carcinoma2022

Author(s)

Journal Title

DOI

Miki Toshio 三木敏生

MIKI Toshio 三木敏生