Saka Naoki 坂直樹

… Alternative Names

坂直樹サカナオキ

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Researcher Number	80867474
Affiliation (Current)	2025: 和歌山県立医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2020 – 2023: 和歌山県立医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 49060:Virology-related Except Principal Investigator Basic Section 49060:Virology-related
Keywords	Principal Investigator 14-3-3ε / ミトコンドリア / アポトーシス / Bad / V蛋白 / ヒトパラインフルエンザウイルス2型 Except Principal Investigator リコンビナントウイルス / ハザラウイルス / L蛋白 / N蛋白 … More / RNA-binding / N蛋白質 / 宿主因子 / 細胞傷害性 / 持続感染細胞株 / 持続感染 / クリミア・コンゴ出血熱ウイルス Less

モデルウイルスを利用したクリミア・コンゴ出血熱ウイルス転写・複製機構の解明
- Principal Investigator
  
  西尾真智子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Wakayama Medical University
Elucidation of survival strategy of virus by targeting for 14-3-3epsilonPrincipal Investigator
- Principal Investigator
  
  坂直樹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Wakayama Medical University
Analysis of persistant infection of Hazara orthonairovirus as a surrogate model for Crimean-Congo hemorrhagic fever virus
- Principal Investigator
  
  Nishio Machiko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Wakayama Medical University

All 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] Human parainfluenza virus type 2 V protein inhibits mitochondrial apoptosis pathway through two ways2024
- Author(s)
  Saka Naoki、Nishio Machiko、Ohta Keisuke
- Journal Title
  
  Virology
  
  Volume: 594 Pages: 110053-110053
- DOI
  10.1016/j.virol.2024.110053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K06563
[Journal Article] Nairovirus polymerase mutations associated with the establishment of persistent infection in human cells2024
- Author(s)
  Ohta Keisuke、Saka Naoki、Nishi Yuzuha、Nishio Machiko
- Journal Title
  
  Journal of Virology
  
  Volume: 98 Issue: 3
- DOI
  10.1128/jvi.01698-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15476, KAKENHI-PROJECT-23K06563
[Journal Article] The bipartite promoter of Orthonairovirus hazaraense large segment2023
- Author(s)
  Saka Naoki、Ohta Keisuke、Kolakofsky Daniel、Nishio Machiko
- Journal Title
  
  Journal of Virology
  
  Volume: 97 Issue: 11
- DOI
  10.1128/jvi.00918-23
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15476, KAKENHI-PROJECT-23K06563
[Journal Article] Hazara orthonairovirus nucleoprotein facilitates viral cell-to-cell spread by modulating tight junction protein, claudin-12023
- Author(s)
  Ohta Keisuke、Saka Naoki、Fukasawa Masayoshi、Nishio Machiko
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 14 Pages: 1192956-1192956
- DOI
  10.3389/fmicb.2023.1192956
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15476, KAKENHI-PROJECT-23K06563
[Journal Article] A Point Mutation in the Human Parainfluenza Virus Type 2 Nucleoprotein Leads to Two Separate Effects on Virus Replication2022
- Author(s)
  Saka Naoki、Matsumoto Yusuke、Ohta Keisuke、Kolakofsky Daniel、Nishio Machiko
- Journal Title
  
  Journal of Virology
  
  Volume: 96 Issue: 4
- DOI
  10.1128/jvi.02067-21
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07528
[Journal Article] Hazara Orthonairovirus Nucleoprotein Antagonizes Type I Interferon Production by Inhibition of RIG-I Ubiquitination2022
- Author(s)
  Ohta Keisuke、Saka Naoki、Nishio Machiko
- Journal Title
  
  Viruses
  
  Volume: 14 Issue: 9 Pages: 1965-1965
- DOI
  10.3390/v14091965
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15476, KAKENHI-PROJECT-20K07528
[Journal Article] Human Parainfluenza Virus Type 2 V Protein Modulates Iron Homeostasis2021
- Author(s)
  Ohta Keisuke、Saka Naoki、Nishio Machiko
- Journal Title
  
  Journal of Virology
  
  Volume: 95 Issue: 6
- DOI
  10.1128/jvi.01861-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07528
[Presentation] Base complementary in untranslated region of Hazara orthonairovirus L genome affects polymerase activity2023
- Author(s)
  Naoki Saka, Keisuke Ohta, Machiko Nishio
- Organizer
  The 70th Annual Meeting of the Japanese Society for Virology
- Data Source
  KAKENHI-PROJECT-22K15476
[Presentation] Five point mutations in L protein of Hazara orthonairovirus contribute to its persistent infection2023
- Author(s)
  Keisuke Ohta, Naoki Saka, Machiko Nishio
- Organizer
  The 70th Annual Meeting of the Japanese Society for Virology
- Data Source
  KAKENHI-PROJECT-22K15476
[Presentation] ハザラウイルスのL蛋白の5つの点変異は、ウイルスの持続感染成立に関与する2023
- Author(s)
  太田圭介、坂直樹、西尾真智子
- Organizer
  第70回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-23K06563
[Presentation] ハザラウイルスLゲノムの非翻訳領域の塩基相補性はポリメラーゼ活性に影響を与える2023
- Author(s)
  坂直樹、太田圭介、西尾真智子
- Organizer
  第70回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-23K06563
[Presentation] Human parainfluenza virus type 2 V protein inhibits mitochondrial apoptosis2022
- Author(s)
  Naoki Saka, Keisuke Ohta, Machiko Nishio
- Organizer
  The 69th Annual Meeting of the Japanese Society for Virology
- Data Source
  KAKENHI-PROJECT-22K15476
[Presentation] ヒトパラインフルエンザウイルス2型のV蛋白はミトコンドリア系のアポトーシスを阻害している2022
- Author(s)
  坂直樹、太田圭介、西尾真智子
- Organizer
  第69回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07528
[Presentation] ハザラウイルスのN蛋白は、タイトジャンクション蛋白Claudin-1を制御してウイルスの細胞間の広がりを促進する2022
- Author(s)
  太田圭介、坂直樹、西尾真智子
- Organizer
  第69回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07528
[Presentation] Hazara orthonairovirus N protein promotes viral cell-to-cell spread by modulating tight junction protein, Claudin-12022
- Author(s)
  Keisuke Ohta, Naoki Saka, Machiko Nishio
- Organizer
  The 69th Annual Meeting of the Japanese Society for Virology
- Data Source
  KAKENHI-PROJECT-22K15476

1. Nishio Machiko (70156040)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
2. 太田圭介 (90625071)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
3. 松本祐介 (00735912)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Saka Naoki 坂 直樹

坂 直樹 サカ ナオキ

Research Projects

Research Products

Co-Researchers

モデルウイルスを利用したクリミア・コンゴ出血熱ウイルス転写・複製機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of survival strategy of virus by targeting for 14-3-3epsilonPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of persistant infection of Hazara orthonairovirus as a surrogate model for Crimean-Congo hemorrhagic fever virus

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Human parainfluenza virus type 2 V protein inhibits mitochondrial apoptosis pathway through two ways2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nairovirus polymerase mutations associated with the establishment of persistent infection in human cells2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The bipartite promoter of Orthonairovirus hazaraense large segment2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hazara orthonairovirus nucleoprotein facilitates viral cell-to-cell spread by modulating tight junction protein, claudin-12023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Point Mutation in the Human Parainfluenza Virus Type 2 Nucleoprotein Leads to Two Separate Effects on Virus Replication2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hazara Orthonairovirus Nucleoprotein Antagonizes Type I Interferon Production by Inhibition of RIG-I Ubiquitination2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Human Parainfluenza Virus Type 2 V Protein Modulates Iron Homeostasis2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] Base complementary in untranslated region of Hazara orthonairovirus L genome affects polymerase activity2023

Author(s)

Organizer

Data Source

[Presentation] Five point mutations in L protein of Hazara orthonairovirus contribute to its persistent infection2023

Author(s)

Organizer

Data Source

[Presentation] ハザラウイルスのL蛋白の5つの点変異は、ウイルスの持続感染成立に関与する2023

Author(s)

Organizer

Data Source

[Presentation] ハザラウイルスLゲノムの非翻訳領域の塩基相補性はポリメラーゼ活性に影響を与える2023

Author(s)

Organizer

Data Source

[Presentation] Human parainfluenza virus type 2 V protein inhibits mitochondrial apoptosis2022

Author(s)

Organizer

Data Source

[Presentation] ヒトパラインフルエンザウイルス2型のV蛋白はミトコンドリア系のアポトーシスを阻害している2022

Author(s)

Saka Naoki 坂直樹

坂直樹サカナオキ