YOKOO HIDETOMO 横尾英知

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Yokoo Hidetomo 横尾英知

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Researcher Number	80881424
Other IDs
Affiliation (Current)	2025: 国立医薬品食品衛生研究所, 有機化学部, 室長 2025: 京都府立医科大学, 医学(系)研究科(研究院), 客員講師
Affiliation (based on the past Project Information) *help	2022 – 2024: 国立医薬品食品衛生研究所, 有機化学部, 研究員 2022: 京都府立医科大学, 医学(系)研究科(研究院), 客員講師 2020 – 2021: 京都府立医科大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / 0801:Pharmaceutical sciences and related fields
Keywords	Principal Investigator PROTAC / タンパク質分解剤 / ナノ粒子 / ユビキチンリガーゼ / プロテアソーム / 直接的分解 / キメラ分子 / ユビキチン

Development of degradation inducers that manipulate various ubiquitin ligasesPrincipal Investigator
- Principal Investigator
  
  横尾英知
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  National Institute of Health Sciences
Development of cell-penetrating E3 ligase ligand and its application to nanoparticle-based degraders.Principal Investigator
- Principal Investigator
  
  Yokoo Hidetomo
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  National Institute of Health Sciences
Development of degrader targeting proteins regulated by ubiquitinationPrincipal Investigator
- Principal Investigator
  
  Yokoo Hidetomo
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0801:Pharmaceutical sciences and related fields
- Research Institution
  Kyoto Prefectural University of Medicine

All 2024 2023 2022 2021 2020

All Journal Article Presentation Book Patent

[Book] Cell‐Penetrating Peptides: Design, Development and Applications, Chapter 132022
- Author(s)
  Hidetomo Yokoo
- Total Pages
  416
- Publisher
  Wiley-VCH
- ISBN
  9783527350117
- Data Source
  KAKENHI-PROJECT-20K22711
[Book] Peptide and Protein Delivery, Chapter 13 Cell-Penetrating Peptides.Design, Development and Applications2022
- Author(s)
  H. Yokoo
- Total Pages
  18
- Publisher
  Wiley-VCH
- ISBN
  9783527350117
- Data Source
  KAKENHI-PROJECT-22K15257
[Journal Article] Expansion of targeted degradation by Gilteritinib-Warheaded PROTACs to ALK fusion proteins.2024
- Author(s)
  Yokoo H, Tsuji G, Inoue T, Naito M, Demizu Y, Ohoka N.
- Journal Title
  
  Bioorg Chem.
  
  Volume: 145 Pages: 107204-107204
- DOI
  10.1016/j.bioorg.2024.107204
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06490, KAKENHI-PROJECT-22K15257, KAKENHI-PLANNED-23H04926, KAKENHI-PROJECT-21H02777
[Journal Article] Photo-regulated PROTACs: A novel tool for temporal control of targeted protein degradation.2024
- Author(s)
  Xu H, Ohoka N, Inoue T, Yokoo H, Demizu Y.
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 107 Pages: 129778-129778
- DOI
  10.1016/j.bmcl.2024.129778
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06490, KAKENHI-PROJECT-22K15257
[Journal Article] Innovative peptide architectures: advancements in foldamers and stapled peptides for drug discovery2024
- Author(s)
  Dongrui Zhou、Miyamoto Maho、Yokoo Hidetomo、Demizu Yosuke
- Journal Title
  
  Expert Opinion on Drug Discovery
  
  Volume: 19 Issue: 6 Pages: 699-723
- DOI
  10.1080/17460441.2024.2350568
- Data Source
  KAKENHI-PROJECT-22K15257
[Journal Article] Rational Design of Amphipathic Antimicrobial Peptides with Alternating L-/D-Amino Acids That Form Helical Structures2024
- Author(s)
  Hirano Motoharu、Yokoo Hidetomo、Ohoka Nobumichi、Ito Takahito、Misawa Takashi、Oba Makoto、Inoue Takao、Demizu Yosuke
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 72 Issue: 2 Pages: 149-154
- DOI
  10.1248/cpb.c23-00465
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2024-02-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-22K15257, KAKENHI-PLANNED-23H04926
[Journal Article] Sculpting Secondary Structure of a Cyclic Peptide: Conformational Analysis of a Cyclic Hexapeptide Containing a Combination of <scp>l</scp>-Leu, <scp>d</scp>-Leu, and Aib Residues2023
- Author(s)
  Ito Takahito、Yokoo Hidetomo、Kato Takuma、Doi Mitsunobu、Demizu Yosuke
- Journal Title
  
  ACS Omega
  
  Volume: 8 Issue: 46 Pages: 44106-44111
- DOI
  10.1021/acsomega.3c06397
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-22K15257, KAKENHI-PLANNED-23H04926
[Journal Article] Oligosarcosine Conjugation of Arginine-Rich Peptides Improves the Intracellular Delivery of Peptide/pDNA Complexes2023
- Author(s)
  Yokoo Hidetomo、Dirisala Anjaneyulu、Uchida Satoshi、Oba Makoto
- Journal Title
  
  ACS Biomaterials Science & Engineering
  
  Volume: 10 Issue: 2 Pages: 890-896
- DOI
  10.1021/acsbiomaterials.3c01542
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K11841, KAKENHI-PROJECT-21K18062, KAKENHI-PROJECT-22K15257, KAKENHI-PROJECT-23H05451, KAKENHI-PROJECT-21H04962
[Journal Article] Development of Hydrophobic Cell-Penetrating Stapled Peptides as Drug Carriers2023
- Author(s)
  Tsuchiya Keisuke、Horikoshi Kanako、Fujita Minami、Hirano Motoharu、Miyamoto Maho、Yokoo Hidetomo、Demizu Yosuke
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 14 Pages: 11768-11768
- DOI
  10.3390/ijms241411768
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-22K15257, KAKENHI-PLANNED-23H04926
[Journal Article] Investigating the cell permeability of proteolysis-targeting chimeras (PROTACs)2023
- Author(s)
  Yokoo Hidetomo、Naito Mikihiko、Demizu Yosuke
- Journal Title
  
  Expert Opinion on Drug Discovery
  
  Volume: 18 Issue: 4 Pages: 357-361
- DOI
  10.1080/17460441.2023.2187047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15257, KAKENHI-PROJECT-20K22711, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777
[Journal Article] Development of Rapid and Facile Solid‐Phase Synthesis of PROTACs via a Variety of Binding Styles2022
- Author(s)
  Xu Hanqiao、Kurohara Takashi、Takano Reina、Yokoo Hidetomo、Shibata Norihito、Ohoka Nobumichi、Inoue Takao、Naito Mikihiko、Demizu Yosuke
- Journal Title
  
  ChemistryOpen
  
  Volume: 11 Issue: 7
- DOI
  10.1002/open.202200131
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-21K06075, KAKENHI-PROJECT-21K06490, KAKENHI-PROJECT-20K22711, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777
[Journal Article] Recent Advances in PROTAC Technology Toward New Therapeutic Modalities2022
- Author(s)
  Yokoo Hidetomo、Naganuma Miyako、Oba Makoto、Demizu Yosuke
- Journal Title
  
  Chemistry & Biodiversity
  
  Volume: 19 Issue: 11 Pages: 134-139
- DOI
  10.1002/cbdv.202200828
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-22K15257, KAKENHI-PROJECT-22KJ2565, KAKENHI-PROJECT-20K22711, KAKENHI-PLANNED-18H05502
[Journal Article] Development of delivery carriers for plasmid DNA by conjugation of a helical template to oligoarginine2022
- Author(s)
  Yokoo Hidetomo、Misawa Takashi、Kato Takuma、Tanaka Masakazu、Demizu Yosuke、Oba Makoto
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 72 Pages: 116997-116997
- DOI
  10.1016/j.bmc.2022.116997
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-22K15257
[Journal Article] Peptide Stapling Improves the Sustainability of a Peptide-Based Chimeric Molecule That Induces Targeted Protein Degradation2021
- Author(s)
  Yokoo Hidetomo、Ohoka Nobumichi、Takyo Mami、Ito Takahito、Tsuchiya Keisuke、Kurohara Takashi、Fukuhara Kiyoshi、Inoue Takao、Naito Mikihiko、Demizu Yosuke
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 16 Pages: 8772-8772
- DOI
  10.3390/ijms22168772
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K06567, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777, KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-21K06490, KAKENHI-PROJECT-20K22711
[Journal Article] Development of Antimicrobial Stapled Peptides Based on Magainin 2 Sequence2021
- Author(s)
  Hirano Motoharu、Saito Chihiro、Yokoo Hidetomo、Goto Chihiro、Kawano Ryuji、Misawa Takashi、Demizu Yosuke
- Journal Title
  
  Molecules
  
  Volume: 26 Issue: 2 Pages: 444-444
- DOI
  10.3390/molecules26020444
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22711, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-18K14880, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-21K05320
[Journal Article] Development of a Hematopoietic Prostaglandin D Synthase-Degradation Inducer2021
- Author(s)
  Yokoo Hidetomo、Shibata Norihito、Naganuma Miyako、Murakami Yuki、Fujii Kiyonaga、Ito Takahito、Aritake Kosuke、Naito Mikihiko、Demizu Yosuke
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 12 Issue: 2 Pages: 236-241
- DOI
  10.1021/acsmedchemlett.0c00605
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07311, KAKENHI-PROJECT-20K22711, KAKENHI-PROJECT-17K08385, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777, KAKENHI-PROJECT-21K05320
[Journal Article] Discovery of a Highly Potent and Selective Degrader Targeting Hematopoietic Prostaglandin D Synthase via In Silico Design2021
- Author(s)
  Yokoo Hidetomo、Shibata Norihito、Endo Akinori、Ito Takahito、Yanase Yuta、Murakami Yuki、Fujii Kiyonaga、Hamamura Kengo、Saeki Yasushi、Naito Mikihiko、Aritake Kosuke、Demizu Yosuke
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 64 Issue: 21 Pages: 15868-15882
- DOI
  10.1021/acs.jmedchem.1c01206
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K07311, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777, KAKENHI-PROJECT-20K06568, KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-21K11613, KAKENHI-PROJECT-20K22711
[Journal Article] Helical Antimicrobial Peptide Foldamers Containing Non‐proteinogenic Amino Acids2021
- Author(s)
  Yokoo Hidetomo、Hirano Motoharu、Misawa Takashi、Demizu Yosuke
- Journal Title
  
  ChemMedChem
  
  Volume: 16 Issue: 8 Pages: 1226-1233
- DOI
  10.1002/cmdc.202000940
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K22711, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-18K14880, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-21K05320
[Journal Article] Structure?activity relationship study of amphipathic antimicrobial peptides using helix‐destabilizing sarcosine2021
- Author(s)
  Yokoo Hidetomo、Hirano Motoharu、Ohoka Nobumichi、Misawa Takashi、Demizu Yosuke
- Journal Title
  
  Journal of Peptide Science
  
  Volume: 27 Issue: 12 Pages: 1-6
- DOI
  10.1002/psc.3360
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-20K22711
[Journal Article] Targeted Protein Degrader 合成の戦略2021
- Author(s)
  横尾英知，出水庸介
- Journal Title
  
  細胞（特集：Targeted Protein Degradation、村田茂穂　編）
  
  Volume: 53 Pages: 16-19
- Data Source
  KAKENHI-PROJECT-20K22711
[Journal Article] Development of Selective TGR5 Ligands Based on the 5,6,7,8‐Tetrahydro‐5,5,8,8‐tetramethylnaphthalene Skeleton2020
- Author(s)
  Terui Ryusei、Yanase Yuta、Yokoo Hidetomo、Suhara Yoshitomo、Makishima Makoto、Demizu Yosuke、Misawa Takashi
- Journal Title
  
  ChemMedChem
  
  Volume: 16 Issue: 3 Pages: 458-462
- DOI
  10.1002/cmdc.202000567
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K22711, KAKENHI-PROJECT-18K14880, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-21K05320
[Journal Article] Rational Design of Helix‐Stabilized Antimicrobial Peptide Foldamers Containing α,α‐Disubstituted Amino Acids or Side‐Chain Stapling2020
- Author(s)
  Hirano Motoharu、Saito Chihiro、Goto Chihiro、Yokoo Hidetomo、Kawano Ryuji、Misawa Takashi、Demizu Yosuke
- Journal Title
  
  ChemPlusChem
  
  Volume: 85 Issue: 12 Pages: 2731-2736
- DOI
  10.1002/cplu.202000749
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-20K22711, KAKENHI-PROJECT-18K14880
[Patent] 新規化合物及び医薬組成物2021
- Inventor(s)
  出水庸介，柴田識人，内藤幹彦，有竹浩介，横尾英知
- Industrial Property Rights Holder
  出水庸介，柴田識人，内藤幹彦，有竹浩介，横尾英知
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-20K22711
[Presentation] PROTACの開発に利用する新規E3リガーゼリガンドの構造活性相関研究2024
- Author(s)
  古内志拓，横尾英知，内藤幹彦，井上貴雄，大岡伸通，出水庸介
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K15257
[Presentation] ALKを標的とした分解誘導剤の開発2024
- Author(s)
  横尾英知
- Organizer
  タンパク質寿命が制御するシン・バイオロジー第 1 回班会議(若手の会・ユビキチン研究会共催)
- Data Source
  KAKENHI-PROJECT-22K15257
[Presentation] UBRタンパク質リガンドを活用した新規PROTACの開発2024
- Author(s)
  髙野玲奈，横尾英知，大岡伸通，大金賢司，井上貴雄，出水庸介
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K15257
[Presentation] 活性向上を目指したSPP阻害剤YO01027の誘導体開発2024
- Author(s)
  横尾英知, 伊東祐美, 菱沼知美, 岡本徹, 出水庸介
- Organizer
  「集え、他分野研究者！」感染症キャンプin宮崎
- Data Source
  KAKENHI-PROJECT-22K15257
[Presentation] 疎水性ステープルペプチドを活用したデリバリーキャリアの開発2024
- Author(s)
  横尾英知，土屋圭輔，堀越奏子，藤田陽，平野元春，宮本真歩，周東睿，出水庸介
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K15257
[Presentation] 光分解リンカーを有するPROTACの開発2024
- Author(s)
  許涵喬，横尾英知，大岡伸通，井上貴雄，出水庸介
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K15257
[Presentation] 膜透過性ペプチドを利用したPROTACの効率的細胞内導入2024
- Author(s)
  宮本真歩，横尾英知，出水庸介
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K15257
[Presentation] 核酸医薬品の効率的細胞内輸送を目指した両親媒性ステープルペプチドの開発2024
- Author(s)
  堀越奏子，横尾英知，土屋圭輔，出水庸介
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K15257
[Presentation] ペプトイド核酸の構造特性に関する研究2024
- Author(s)
  武田紗和，横尾英知，出水庸介
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K15257
[Presentation] 造血器型プロスタグランジンD合成酵素分解誘導薬の創出-酵素阻害薬に対する優位性について-2023
- Author(s)
  田村奈月美，小西純，藤井清永，濵村賢吾，横尾英知，柴田識人，内藤幹彦，出水庸介，有竹浩介
- Organizer
  第40回日本薬学会九州山口支部大会
- Data Source
  KAKENHI-PROJECT-22K15257
[Presentation] 膜透過性ペプチドを用いたsiRNAおよびmRNAの細胞内デリバリーキャリアの開発2023
- Author(s)
  横尾英知，内田智士，大庭誠
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K15257
[Presentation] H-PGDSを標的としたPROTACの構造活性相関研究2023
- Author(s)
  大澤陽，黒原崇，横尾英知，柴田識人，有竹浩介，内藤幹彦，出水庸介
- Organizer
  オリゴサルコシン修飾によるキャリアペプチドのプラスミドDNAデリバリー効率の向上
- Data Source
  KAKENHI-PROJECT-22K15257
[Presentation] 膜透過性ペプチドを用いたsiRNAおよびmRNAの細胞内デリバリーキャリアの開発2023
- Author(s)
  横尾英知，内田智士，大庭誠
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K22711
[Presentation] 両親媒性ステープルペプチドを利用した核酸の細胞内輸送2023
- Author(s)
  平野元春，横尾英知，大庭誠，三澤隆史，出水庸介
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K22711
[Presentation] Design of hydrophobic cell-penetrating stapled peptides as drug carriers2023
- Author(s)
  横尾英知，土屋圭輔，堀越奏子，藤田陽，平野元春，宮本真歩，出水庸介
- Organizer
  第60回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-22K15257
[Presentation] PROTAC に利用可能な新規 E3 リガンドの探索2023
- Author(s)
  高野玲奈，横尾英知, 大岡伸通, 大金賢司, 井上貴雄, 出水庸介
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K15257
[Presentation] H-PGDSを標的としたタンパク質分解誘導剤の構造活性相関研究2023
- Author(s)
  大澤陽，横尾英知，齊藤公亮，有竹浩介，伊中浩治，齋藤嘉朗，出水庸介
- Organizer
  第49回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-22K15257
[Presentation] オリゴサルコシン修飾によるキャリアペプチドのプラスミドDNAデリバリー効率の向上2023
- Author(s)
  横尾英知，出水庸介，内田智士，大庭誠
- Organizer
  日本ケミカルバイオロジー学会第17回年会
- Data Source
  KAKENHI-PROJECT-22K15257
[Presentation] タンパク質分解誘導剤の開発研究2023
- Author(s)
  横尾英知
- Organizer
  第30回次世代医工学研究会
- Data Source
  KAKENHI-PROJECT-22K15257
[Presentation] 両親媒ヘリカルペプチドを利用した核酸の細胞内デリバリー2023
- Author(s)
  平野元春，横尾英知，大庭誠，三澤隆史，出水庸介
- Organizer
  日本核酸医薬学会第8回年会
- Data Source
  KAKENHI-PROJECT-22K15257
[Presentation] PROTACへの応用を志向した新たなE3 リガンドの探索2023
- Author(s)
  高野玲奈，横尾英知, 大岡伸通, 大金賢司, 井上貴雄, 出水庸介
- Organizer
  第67回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-22K15257
[Presentation] Development of stapled peptides as dds carriers for intracellular delivery of nucleic acids2023
- Author(s)
  平野元春，横尾英知，大庭誠，三澤隆史，出水庸介
- Organizer
  第60回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-22K15257
[Presentation] アルギニンを豊富に含むペプチドのヘリックス性・疎水性と細胞膜透過性2023
- Author(s)
  大庭誠，中島駿，御竿紅瑠美，横尾英知，田中正一
- Organizer
  第40回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-22K15257
[Presentation] 両親媒性ステープルペプチドを利用した核酸の細胞内輸送2023
- Author(s)
  平野元春，横尾英知，大庭誠，三澤隆史，出水庸介
- Organizer
  日本薬学会第143年会若手研究者が拓くニューモダリティ創薬研究～革新的医薬品の創出に向けて～
- Data Source
  KAKENHI-PROJECT-22K15257
[Presentation] 両親媒性ステープルペプチドを利用した核酸の細胞内輸送2023
- Author(s)
  平野元春，横尾英知，大庭誠，三澤隆史，出水庸介
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K15257
[Presentation] オリゴサルコシンを修飾した細胞膜透過性ペプチドを用いたプラスミドDNAの細胞内送達2023
- Author(s)
  大庭誠，横尾英知，出水庸介，内田智士
- Organizer
  日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-22K15257
[Presentation] 核酸デリバリー機能を有するナノ粒子型タンパク質分解誘導剤の開発研究2023
- Author(s)
  横尾英知，内田智士，大庭誠，出水庸介
- Organizer
  遺伝子デリバリー研究会第21回夏期セミナー
- Data Source
  KAKENHI-PROJECT-22K15257
[Presentation] 両親媒性ステープルペプチドによるpDNA, mRNA, 及びsiRNAの効率的な細胞内輸送2023
- Author(s)
  平野元春，横尾英知，大庭誠，三澤隆史，出水庸介
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K22711
[Presentation] Enhancing cell-penetrating abilities of arginine-rich peptides through helical structure and hydrophobicity2023
- Author(s)
  大庭誠，中島駿，御竿紅瑠美，横尾英知，田中正一
- Organizer
  第60回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-22K15257
[Presentation] リンカー構造に着目したH-PGDS分解誘導剤の構造活性相関研究2022
- Author(s)
  大澤陽，黒原崇，横尾英知，伊藤貴仁，栁瀨雄太，柴田識人，有竹浩介，内藤幹彦，出水庸介
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K22711
[Presentation] Specific degrader of hematopoietic prostaglandin D synthase prevented the progression of dilated cardiomyopathy in Duchenne muscular dystrophy2022
- Author(s)
  Maeyama, Y., Hosokawa, Y., Hamamura, K., Yokoo, H., Shibata, N., Naito,M.,Demizu,Y.,Aritake,K.
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K22711
[Presentation] ナノ粒子型タンパク質分解誘導剤の基盤となる核酸キャリアの開発2022
- Author(s)
  横尾英知，大庭誠
- Organizer
  第38回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-20K22711
[Presentation] 造血器型プロスタグランジンD合成酵素選択的タンパク質分解誘導剤の開発2022
- Author(s)
  柴田識人，横尾英知，遠藤彬則，伊藤貴仁，栁瀨雄太，村上優貴，藤井清永，近藤一成，佐伯泰，内藤幹彦，有竹浩介，出水庸介
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K22711
[Presentation] ペプチド型E3リガンドを基にしたナノ粒子の開発2022
- Author(s)
  横尾英知，鈴木美紀，大庭誠
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K22711
[Presentation] 核酸デリバリーに基づくナノ粒子型タンパク質分解誘導剤の新展開2022
- Author(s)
  横尾英知，内田智士，大庭誠
- Organizer
  第２０回夏期セミナー
- Data Source
  KAKENHI-PROJECT-20K22711
[Presentation] 膜透過性ペプチド型ユビキチンリガーゼリガンドの開発とタンパク質分解誘導剤への展開2022
- Author(s)
  横尾英知，内田智士，大庭誠
- Organizer
  第72回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-20K22711
[Presentation] 核酸デリバリーに基づくナノ粒子型タンパク質分解誘導剤の新展開2022
- Author(s)
  横尾英知，内田智士，大庭誠
- Organizer
  遺伝子・デリバリー研究会第２１回シンポジウム
- Data Source
  KAKENHI-PROJECT-22K15257
[Presentation] siRNAの細胞内デリバリーキャリアとなる両親媒性ヘリカルペプチドの開発2022
- Author(s)
  横尾英知，内田智士，大庭誠
- Organizer
  日本核酸医薬学会第7回年会
- Data Source
  KAKENHI-PROJECT-22K15257
[Presentation] H-PGDS分解誘導剤の構造活性相関研究2022
- Author(s)
  村上優貴，黒原崇，横尾英知，伊藤貴仁，柳瀬雄太，柴田識人，有竹浩介，内藤幹彦，出水庸介
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K22711
[Presentation] 膜透過性ペプチド型ユビキチンリガーゼリガンドの開発とタンパク質分解誘導剤への展開2022
- Author(s)
  横尾英知，内田智士，大庭誠
- Organizer
  第72回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-22K15257
[Presentation] 核酸デリバリーに基づくナノ粒子型タンパク質分解誘導剤の新展開2022
- Author(s)
  横尾英知，内田智士，大庭誠
- Organizer
  遺伝子・デリバリー研究会第２１回シンポジウム
- Data Source
  KAKENHI-PROJECT-20K22711
[Presentation] Intracellular plasmid dna delivery using helical template conjugated oligoarginine2022
- Author(s)
  横尾英知，三澤隆史，加藤巧馬，田中正一，出水庸介，大庭誠
- Organizer
  第59 回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-22K15257
[Presentation] 固相法によるタンパク質分解誘導剤の迅速・効率的合成2022
- Author(s)
  許涵喬，黒原崇，横尾英知，辻厳一郎，柴田識人，大岡伸通，井上貴雄，出水庸介
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K22711
[Presentation] 核酸デリバリーに基づくナノ粒子型タンパク質分解誘導剤の新展開2022
- Author(s)
  横尾英知，内田智士，大庭誠
- Organizer
  第２０回夏期セミナー
- Data Source
  KAKENHI-PROJECT-22K15257
[Presentation] Intracellular plasmid dna delivery using helical template conjugated oligoarginine2022
- Author(s)
  横尾英知，三澤隆史，加藤巧馬，田中正一，出水庸介，大庭誠
- Organizer
  第59 回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-20K22711
[Presentation] ナノ粒子型タンパク質分解誘導剤の基盤となる核酸キャリアの開発2022
- Author(s)
  横尾英知，大庭誠
- Organizer
  第38回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-22K15257
[Presentation] 細胞内siRNAデリバリーのための両親媒性ヘリカルペプチドの開発2022
- Author(s)
  大庭誠，渋谷美佳，山端優仁，横尾英知，内田智士，田中正一
- Organizer
  日本ケミカルバイオロジー学会第16回年会
- Data Source
  KAKENHI-PROJECT-22K15257
[Presentation] 高活性・高選択的な造血器型プロスタグランジン D 合成酵素分解誘導剤の開発2021
- Author(s)
  横尾英知，柴田識人，遠藤彬則，伊藤貴仁，柳瀬雄太，村上優貴，藤井清永，大庭誠，佐伯泰，内藤幹彦，有竹浩介，出水庸介
- Organizer
  ケミカルバイオロジー第 15 回年会
- Data Source
  KAKENHI-PROJECT-20K22711
[Presentation] 5,6,7,8-Tetrahydronaphtalene骨格を用いた選択的TGR5アゴニストの開発2021
- Author(s)
  三澤隆史、照井龍晟、栁瀨　雄太、横尾英知、槇島誠、須原義智、出水庸介
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K22711
[Presentation] 造血器型プロスタグランジンD合成酵素分解誘導剤の創製2021
- Author(s)
  村上優貴，大澤陽，柴田識人，横尾英知，伊藤貴仁，柳瀬雄太，黒原崇，出水庸介
- Organizer
  第 65 回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-20K22711
[Presentation] ペプチドリガンドを利用したタンパク質分解誘導キメラ分子の開発2021
- Author(s)
  大岡伸通、横尾英知、井上貴雄、出水庸介
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K22711
[Presentation] H-PGDS分解誘導剤の構造活性相関研究2021
- Author(s)
  村上優貴，黒原崇，横尾英知，伊藤貴仁，柳瀬雄太，柴田識人，有竹浩介，内藤幹彦，出水庸介
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K22711
[Presentation] 核内受容体を標的とするペプチド型分解誘導剤の開発2021
- Author(s)
  伊藤貴仁、横尾英知、大岡伸通、内藤幹彦、井上貴雄、出水庸介
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K22711
[Presentation] 固相法によるタンパク質分解誘導剤の迅速・効率的合成2021
- Author(s)
  許涵喬，黒原崇，横尾英知，辻厳一郎，柴田識人，大岡伸通，井上貴雄，出水庸介
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K22711
[Presentation] 造血器型プロスタグランジンD合成酵素分解誘導剤の開発2021
- Author(s)
  横尾英知、柴田識人、永沼美弥子、村上優希、藤井清永、伊藤貴仁、有竹浩介、内藤幹彦、出水庸介
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K22711
[Presentation] 造血器型プロスタグランジンD合成酵素を標的とした選択的タンパク質分解誘導剤の開発2021
- Author(s)
  柴田識人、横尾英知、遠藤彬則、伊藤貴仁、栁瀨雄太、村上優貴、藤井清永、佐伯泰、内藤幹彦、有竹浩介、出水庸介
- Organizer
  第94回日本生化学会
- Data Source
  KAKENHI-PROJECT-20K22711
[Presentation] 光異性化に基づくエストロゲン受容体の活性制御2021
- Author(s)
  土屋圭輔、梅野智大、辻厳一郎、横尾英知、福原潔、三澤隆史、出水庸介
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K22711
[Presentation] リンカー構造に着目したH-PGDS分解誘導剤の構造活性相関研究2021
- Author(s)
  大澤陽，黒原崇，横尾英知，伊藤貴仁，栁瀨雄太，柴田識人，有竹浩介，内藤幹彦，出水庸介
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K22711
[Presentation] ペプチド型E3リガンドを基にしたナノ粒子の開発2021
- Author(s)
  横尾英知，鈴木美紀，大庭誠
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K22711

1. 大岡伸通

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. 出水庸介

# of Collaborated Projects: 0 results

# of Collaborated Products: 9 results
3. ディリサラアンジャネユル

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 柴田識人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YOKOO HIDETOMO 横尾 英知

Yokoo Hidetomo 横尾 英知

Research Projects

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Co-Researchers

Development of degradation inducers that manipulate various ubiquitin ligasesPrincipal Investigator

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Development of cell-penetrating E3 ligase ligand and its application to nanoparticle-based degraders.Principal Investigator

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Development of degrader targeting proteins regulated by ubiquitinationPrincipal Investigator

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[Book] Cell‐Penetrating Peptides: Design, Development and Applications, Chapter 132022

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[Book] Peptide and Protein Delivery, Chapter 13 Cell-Penetrating Peptides.Design, Development and Applications2022

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[Journal Article] Expansion of targeted degradation by Gilteritinib-Warheaded PROTACs to ALK fusion proteins.2024

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[Journal Article] Photo-regulated PROTACs: A novel tool for temporal control of targeted protein degradation.2024

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[Journal Article] Innovative peptide architectures: advancements in foldamers and stapled peptides for drug discovery2024

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[Journal Article] Rational Design of Amphipathic Antimicrobial Peptides with Alternating L-/D-Amino Acids That Form Helical Structures2024

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[Journal Article] Sculpting Secondary Structure of a Cyclic Peptide: Conformational Analysis of a Cyclic Hexapeptide Containing a Combination of <scp>l</scp>-Leu, <scp>d</scp>-Leu, and Aib Residues2023

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[Journal Article] Oligosarcosine Conjugation of Arginine-Rich Peptides Improves the Intracellular Delivery of Peptide/pDNA Complexes2023

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[Journal Article] Development of Hydrophobic Cell-Penetrating Stapled Peptides as Drug Carriers2023

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[Journal Article] Investigating the cell permeability of proteolysis-targeting chimeras (PROTACs)2023

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[Journal Article] Development of Rapid and Facile Solid‐Phase Synthesis of PROTACs via a Variety of Binding Styles2022

Author(s)

YOKOO HIDETOMO 横尾英知

Yokoo Hidetomo 横尾英知