Ikuta Tatsuya 生田達也

… Alternative Names

生田達也イクタタツヤ

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Researcher Number	80894815
Other IDs
Affiliation (Current)	2025: 東北大学, 薬学研究科, 助教
Affiliation (based on the past Project Information) *help	2022 – 2023: 東北大学, 薬学研究科, 助教 2021: 東北大学, 薬学研究科, 助手
Review Section/Research Field	Except Principal Investigator Transformative Research Areas, Section (II)
Keywords	Except Principal Investigator バイアス / 計算科学 / シグナル伝達 / オピオイド受容体 / オピオイド / GPCR

Identification of pharmacologically relevant signaling pathways at opioid receptors
- Principal Investigator
  
  Inoue Asuka
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Tohoku University

All 2023 2022 2021

All Journal Article Presentation

[Journal Article] Structural basis for ligand recognition and signaling of hydroxy-carboxylic acid receptor 22023
- Author(s)
  Park Jae-Hyun、Kawakami Kouki、Ishimoto Naito、Ikuta Tatsuya、Ohki Mio、Ekimoto Toru、Ikeguchi Mitsunori、Lee Dong-Sun、Lee Young-Ho、Tame Jeremy R. H.、Inoue Asuka、Park Sam-Yong
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 7150-7150
- DOI
  10.1038/s41467-023-42764-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-19H05779, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-21H02449
[Journal Article] Identification and Functional Characterization of Fungal Chalcone Synthase and Chalcone Isomerase2023
- Author(s)
  Furumura Sho、Ozaki Taro、Sugawara Akihiro、Morishita Yohei、Tsukada Kento、Ikuta Tatsuya、Inoue Asuka、Asai Teigo
- Journal Title
  
  Journal of Natural Products
  
  Volume: 86 Issue: 2 Pages: 398-405
- DOI
  10.1021/acs.jnatprod.2c01027
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19095, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-23K24038
[Journal Article] Activation of the urotensin-II receptor by remdesivir induces cardiomyocyte dysfunction2023
- Author(s)
  Ogawa Akiko、Ohira Seiya、Kato Yuri、Ikuta Tatsuya、Yanagida Shota、Mi Xinya、Ishii Yukina、Kanda Yasunari、Nishida Motohiro、Inoue Asuka、Wei Fan-Yan
- Journal Title
  
  Communications Biology
  
  Volume: 6 Issue: 1 Pages: 1-11
- DOI
  10.1038/s42003-023-04888-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18088, KAKENHI-PROJECT-22K19395, KAKENHI-PUBLICLY-22H04628, KAKENHI-PLANNED-21H05269, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-23K24035, KAKENHI-PROJECT-23K24075
[Journal Article] Structural basis of lysophosphatidylserine receptor GPR174 ligand recognition and activation2023
- Author(s)
  Liang Jiale、Inoue Asuka、Ikuta Tatsuya、Xia Ruixue、Wang Na、Kawakami Kouki、Xu Zhenmei、Qian Yu、Zhu Xinyan、Zhang Anqi、Guo Changyou、Huang Zhiwei、He Yuanzheng
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 1012-1012
- DOI
  10.1038/s41467-023-36575-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791
[Journal Article] Function and dynamics of the intrinsically disordered carboxyl terminus of β2 adrenergic receptor2023
- Author(s)
  Heng Jie、Hu Yunfei、Perez-Hernandez Guillermo、Inoue Asuka、Zhao Jiawei、Ma Xiuyan、Sun Xiaoou、Kawakami Kouki、Ikuta Tatsuya、Ding Jienv、Yang Yujie、Zhang Lujia、Peng Sijia、Niu Xiaogang、Li Hongwei、Guixa-Gonzalez Ramon、Jin Changwen、Hildebrand Peter W.、Chen Chunlai、Kobilka Brian K.
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 2005-2005
- DOI
  10.1038/s41467-023-37233-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791
[Journal Article] Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface2022
- Author(s)
  Heo Yunseok、Ishimoto Naito、Jeon Ye-Eun、Yun Ji-Hye、Ohki Mio、Anraku Yuki、Sasaki Mina、Kita Shunsuke、Fukuhara Hideo、Ikuta Tatsuya、Kawakami Kouki、Inoue Asuka、Maenaka Katsumi、Tame Jeremy R. H.、Lee Weontae、Park Sam-Yong
- Journal Title
  
  PLOS Biology
  
  Volume: 20 Issue: 8 Pages: e3001714-e3001714
- DOI
  10.1371/journal.pbio.3001714
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-21H02449, KAKENHI-PLANNED-19H05779
[Journal Article] Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism2021
- Author(s)
  Xu Zhenmei、Ikuta Tatsuya、Kawakami Kouki、Kise Ryoji、Qian Yu、Xia Ruixue、Sun Ming-Xia、Zhang Anqi、Guo Changyou、Cai Xue-Hui、Huang Zhiwei、Inoue Asuka、He Yuanzheng
- Journal Title
  
  Nature Chemical Biology
  
  Volume: 18 Issue: 3 Pages: 281-288
- DOI
  10.1038/s41589-021-00930-3
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-21H05111, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791
[Presentation] GPCR におけるバイアスシグナル創出基点とその機構の解析2023
- Author(s)
  中村楽、川上耕季、生田達也、井上飛鳥
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PLANNED-21H05113
[Presentation] βアレスチンの新規PIP2結合部位2022
- Author(s)
  倉本律輝、生田達也、川上耕季
- Organizer
  第60回日本生物物理学会年会
- Data Source
  KAKENHI-PLANNED-21H05113
[Presentation] 固有振動解析によるGPCRの多様なリガンドポケットの生成2022
- Author(s)
  生田達也、井上飛鳥
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PLANNED-21H05113
[Presentation] 日本人に特徴的なGPCR遺伝子バリアントの探索2022
- Author(s)
  鈴木璃子、生田達也、川上耕季、井上飛鳥
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PLANNED-21H05113
[Presentation] 固有振動解析によって生成したGPCRコンフォメーションの評価2022
- Author(s)
  生田達也、井上飛鳥
- Organizer
  第17回 GPCR研究会
- Data Source
  KAKENHI-PLANNED-21H05113
[Presentation] 第三の結合様式におけるアレスチンの機能の解明2022
- Author(s)
  桑原莉来、川上耕季、倉本律輝、生田達也、井上飛鳥
- Organizer
  第17回 GPCR研究会
- Data Source
  KAKENHI-PLANNED-21H05113

1. Inoue Asuka (50525813)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
2. OZAKI Taro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 朴三用

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 小川亜希子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ikuta Tatsuya 生田 達也

生田 達也 イクタ タツヤ

Research Projects

Research Products

Co-Researchers

Identification of pharmacologically relevant signaling pathways at opioid receptors

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Structural basis for ligand recognition and signaling of hydroxy-carboxylic acid receptor 22023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification and Functional Characterization of Fungal Chalcone Synthase and Chalcone Isomerase2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activation of the urotensin-II receptor by remdesivir induces cardiomyocyte dysfunction2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural basis of lysophosphatidylserine receptor GPR174 ligand recognition and activation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Function and dynamics of the intrinsically disordered carboxyl terminus of β2 adrenergic receptor2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] GPCR におけるバイアスシグナル創出基点とその機構の解析2023

Author(s)

Organizer

Data Source

[Presentation] βアレスチンの新規PIP2結合部位2022

Author(s)

Organizer

Data Source

[Presentation] 固有振動解析によるGPCRの多様なリガンドポケットの生成2022

Author(s)

Organizer

Data Source

[Presentation] 日本人に特徴的なGPCR遺伝子バリアントの探索2022

Author(s)

Organizer

Data Source

[Presentation] 固有振動解析によって生成したGPCRコンフォメーションの評価2022

Author(s)

Organizer

Data Source

[Presentation] 第三の結合様式におけるアレスチンの機能の解明2022

Author(s)

Organizer

Data Source

Ikuta Tatsuya 生田達也

生田達也イクタタツヤ