Kimura Haruka 木村悠

Researcher Number	80895003
Other IDs	https://orcid.org/0000-0001-7477-5819
Affiliation (Current)	2024: 東京慈恵会医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2023 – 2024: 東京慈恵会医科大学, 医学部, 講師 2021 – 2022: 東京慈恵会医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related
Keywords	Principal Investigator 心臓エネルギー代謝 / インスリン抵抗性 / 熱産生 / cGMP / 心臓-脂肪連関 / 甲状腺 / 心不全 / NAFLD / 心臓-脂肪組織連関 / ナトリウム利尿ペプチド

The effects of cGMP activation to thermogenesis and insulin resistancePrincipal Investigator
- Principal Investigator
  
  木村悠
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Jikei University School of Medicine
Natriuretic Peptides Induce Thermogenesis and Improve Insulin ResistancePrincipal Investigator
- Principal Investigator
  
  Kimura Haruka
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Jikei University School of Medicine

All 2023 2022 2021

All Journal Article Presentation

[Journal Article] URAT1 is expressed in cardiomyocytes and dotinurad attenuates the development of diet-induced metabolic heart disease2023
- Author(s)
  Tanaka Yoshiro、Nagoshi Tomohisa、Takahashi Hirotake、Oi Yuhei、Yasutake Rei、Yoshii Akira、Kimura Haruka、Kashiwagi Yusuke、Tanaka Toshikazu D.、Shimoda Masayuki、Yoshimura Michihiro
- Journal Title
  
  iScience
  
  Volume: 26 Issue: 9 Pages: 107730-107730
- DOI
  10.1016/j.isci.2023.107730
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K17813, KAKENHI-PROJECT-22K08113, KAKENHI-PROJECT-23K07563, KAKENHI-PROJECT-21K16038, KAKENHI-PROJECT-21K16099
[Journal Article] Effects of angiotensin receptor‐neprilysin inhibitor on insulin resistance in patients with heart failure2023
- Author(s)
  Kashiwagi Yusuke、Nagoshi Tomohisa、Kimura Haruka、Tanaka Yoshiro、Oi Yuhei、Inoue Yasunori、Ogawa Kazuo、Kawai Makoto、Yoshimura Michihiro
- Journal Title
  
  ESC Heart Failure
  
  Volume: - Issue: 3 Pages: 1860-1870
- DOI
  10.1002/ehf2.14352
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08113, KAKENHI-PROJECT-20K08435, KAKENHI-PROJECT-22K17813, KAKENHI-PROJECT-21K16038, KAKENHI-PROJECT-21K16099
[Journal Article] Substantial impact of 3-iodothyronamine (T1AM) on the regulations of fluorescent thermoprobe-measured cellular temperature and natriuretic peptide expression in cardiomyocytes2022
- Author(s)
  Takahashi Hirotake、Nagoshi Tomohisa、Kimura Haruka、Tanaka Yoshiro、Yasutake Rei、Oi Yuhei、Yoshii Akira、Tanaka Toshikazu D.、Kashiwagi Yusuke、Yoshimura Michihiro
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 12740-12740
- DOI
  10.1038/s41598-022-17086-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08113, KAKENHI-PROJECT-21K16099, KAKENHI-PROJECT-20K08435
[Journal Article] Exogenous ANP Treatment Ameliorates Myocardial Insulin Resistance and Protects against Ischemia?Reperfusion Injury in Diet-Induced Obesity2022
- Author(s)
  Oi Yuhei、Nagoshi Tomohisa、Kimura Haruka、Tanaka Yoshiro、Yoshii Akira、Yasutake Rei、Takahashi Hirotake、Kashiwagi Yusuke、Tanaka Toshikazu D.、Tachibana Toshiaki、Yoshimura Michihiro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 15 Pages: 8373-8373
- DOI
  10.3390/ijms23158373
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08113, KAKENHI-PROJECT-21K16099, KAKENHI-PROJECT-20K08435
[Journal Article] Low triiodothyronine levels correlate with high B-type natriuretic peptide levels in patients with heart failure2021
- Author(s)
  Takahashi Hirotake、Kashiwagi Yusuke、Nagoshi Tomohisa、Tanaka Yoshiro、Oi Yuhei、Kimura Haruka、Minai Kousuke、Yoshimura Michihiro
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 21865-21865
- DOI
  10.1038/s41598-021-01454-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08592, KAKENHI-PROJECT-20K08435, KAKENHI-PROJECT-21K16099
[Journal Article] Treatment with atrial natriuretic peptide induces adipose tissue browning and exerts thermogenic actions in vivo2021
- Author(s)
  Kimura Haruka、Nagoshi Tomohisa、Oi Yuhei、Yoshii Akira、Tanaka Yoshiro、Takahashi Hirotake、Kashiwagi Yusuke、Tanaka Toshikazu D.、Yoshimura Michihiro
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 17466-17466
- DOI
  10.1038/s41598-021-96970-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08592, KAKENHI-PROJECT-20K08435, KAKENHI-PROJECT-21K16099
[Presentation] 3-iodothyronamine (T1AM) exerts a significant impact on the regulations of intracellular temperature and B-type natriuretic peptide expression in cardiomyocytes.2023
- Author(s)
  Hirotake Takahashi, Haruka Kimura, Tomohisa Nagoshi, Michihiro Yoshimura, etal.
- Organizer
  第87回日本循環器学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16099
[Presentation] Featured Research Session 1 Cardiovascular　(basic)2023
- Author(s)
  木村悠
- Organizer
  日本循環器学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16099
[Presentation] Biological effects of 3-iodothyronamine (T1AM) on the regulations of intracellular temperature and B-type natriuretic peptide expression in cardiomyocytes.2022
- Author(s)
  Hirotake Takahashi, Haruka Kimura, Tomohisa Nagoshi, Michihiro Yoshimura, etal.
- Organizer
  CVMW2023 (第39回，国際心臓研究学会日本部会)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16099
[Presentation] Non-Alcoholic Fatty Liver and Adipose Tissue Inflammation Are Improved by Exogenous A-type Natriuretic Peptide Treatment in Diet-Induced Obese Mice.2022
- Author(s)
  Haruka Kimura，Tomohisa Nagoshi, Michihiro Yoshimura, etal.
- Organizer
  CVMW2023 (第39回，国際心臓研究学会日本部会).
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16099
[Presentation] Exogenous Atrial Natriuretic Peptide Treatment Improves Insulin Resistance by Ameliorating Non-Alcoholic Fatty Liver and Adipose Tissue Inflammation in Diet-Induced Obesity2022
- Author(s)
  Haruka Kimura, Tomohisa Nagoshi, Yuhei Oi, Yoshiro Tanaka, Hirotake Takahashi, Rei Yasutake, Yusuke Kashiwagi, Yoshiro Tanaka and Michihiro Yoshimura
- Organizer
  第86回日本循環器学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16099
[Presentation] Treatment with atrial natriuretic peptide ameliorates myocardial insulin resistance and protects against ischemia-reperfusion injury in diet-induced obesity.2022
- Author(s)
  Yuhei Oi，Tomohisa Nagoshi，Haruka Kimura，Michihiro Yoshimura, etal
- Organizer
  CVMW2023 (第6回，BCVR).
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16099
[Presentation] ANP投与は食事性肥満マウスの心筋インスリン抵抗性を改善し、虚血再灌流障害からの保護を示す.2022
- Author(s)
  大井悠平、名越智古、木村悠、吉村道博
- Organizer
  第26回日本心不全学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16099
[Presentation] Treatment with Atrial Natriuretic Peptide Ameliorates Insulin Resistance by Attenuating Hepatic Steatosis and Activating Adipose TissueThermogenic Program in Diet-Induced Obesity2021
- Author(s)
  Haruka Kimura, Tomohisa Nagoshi, Yuhei Oi, Yoshiro Tanaka, Hirotake Takahashi, Yusuke Kashiwagi, Michihiro Yoshimura
- Organizer
  第5回日本循環器学会基礎研究フォーラム（BCVR2021)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16099
[Presentation] 肥満マウスにおけるANP投与はNAFLD改善・脂肪組織browningを介してインスリン抵抗性改善と保温効果を示す2021
- Author(s)
  木村悠、名越智古、大井悠平、田中祥朗、髙橋弘武、柏木雄介、吉村道博
- Organizer
  第263回日本循環器学会関東甲信越地方会
- Data Source
  KAKENHI-PROJECT-21K16099
[Presentation] ANP投与はNAFLD改善と脂肪組織褐色化を介して肥満マウスのインスリン抵抗性改善と寒冷暴露に対する体温保持効果を示す2021
- Author(s)
  木村悠, 名越智古, 大井悠平, 田中祥朗, 高橋弘武, 柏木雄介, 吉村道博
- Organizer
  CVMW2021心血管代謝週間第25回CVEM学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16099

1. 吉村道博

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
2. 田中祥朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kimura Haruka 木村 悠

Research Projects

Research Products

Co-Researchers

The effects of cGMP activation to thermogenesis and insulin resistancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Natriuretic Peptides Induce Thermogenesis and Improve Insulin ResistancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] URAT1 is expressed in cardiomyocytes and dotinurad attenuates the development of diet-induced metabolic heart disease2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of angiotensin receptor‐neprilysin inhibitor on insulin resistance in patients with heart failure2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Substantial impact of 3-iodothyronamine (T1AM) on the regulations of fluorescent thermoprobe-measured cellular temperature and natriuretic peptide expression in cardiomyocytes2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Exogenous ANP Treatment Ameliorates Myocardial Insulin Resistance and Protects against Ischemia?Reperfusion Injury in Diet-Induced Obesity2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Low triiodothyronine levels correlate with high B-type natriuretic peptide levels in patients with heart failure2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Treatment with atrial natriuretic peptide induces adipose tissue browning and exerts thermogenic actions in vivo2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] 3-iodothyronamine (T1AM) exerts a significant impact on the regulations of intracellular temperature and B-type natriuretic peptide expression in cardiomyocytes.2023

Author(s)

Organizer

Data Source

[Presentation] Featured Research Session 1 Cardiovascular (basic)2023

Author(s)

Organizer

Data Source

[Presentation] Biological effects of 3-iodothyronamine (T1AM) on the regulations of intracellular temperature and B-type natriuretic peptide expression in cardiomyocytes.2022

Author(s)

Organizer

Data Source

[Presentation] Non-Alcoholic Fatty Liver and Adipose Tissue Inflammation Are Improved by Exogenous A-type Natriuretic Peptide Treatment in Diet-Induced Obese Mice.2022

Author(s)

Organizer

Data Source

[Presentation] Exogenous Atrial Natriuretic Peptide Treatment Improves Insulin Resistance by Ameliorating Non-Alcoholic Fatty Liver and Adipose Tissue Inflammation in Diet-Induced Obesity2022

Author(s)

Organizer

Data Source

[Presentation] Treatment with atrial natriuretic peptide ameliorates myocardial insulin resistance and protects against ischemia-reperfusion injury in diet-induced obesity.2022

Author(s)

Organizer

Data Source

[Presentation] ANP投与は食事性肥満マウスの心筋インスリン抵抗性を改善し、虚血再灌流障害からの保護を示す.2022

Author(s)

Organizer

Data Source

[Presentation] Treatment with Atrial Natriuretic Peptide Ameliorates Insulin Resistance by Attenuating Hepatic Steatosis and Activating Adipose TissueThermogenic Program in Diet-Induced Obesity2021

Author(s)

Organizer

Data Source

[Presentation] 肥満マウスにおけるANP投与はNAFLD改善・脂肪組織browningを介してインスリン抵抗性改善と保温効 果を示す2021

Author(s)

Kimura Haruka 木村悠

[Presentation] Featured Research Session 1 Cardiovascular　(basic)2023

[Presentation] 肥満マウスにおけるANP投与はNAFLD改善・脂肪組織browningを介してインスリン抵抗性改善と保温効果を示す2021