Tomonobu Nahoko 友信奈保子

Researcher Number	80967638
Affiliation (Current)	2025: 岡山大学, 医学部, 客員研究員
Affiliation (based on the past Project Information) *help	2022 – 2024: 岡山大学, 医歯薬学域, 助教
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / 0901:Oncology and related fields Except Principal Investigator Basic Section 50010:Tumor biology-related / Basic Section 55060:Emergency medicine-related
Keywords	Principal Investigator S100A16 / 悪性中皮腫 / がん / 線維化 / 転移 / S100A11 / 膵臓がん Except Principal Investigator がん / 阻害作用 / 転移 … More / 受容体 / がん転移抑制タンパク質 / HRG / S100A8/A9 / ワクチン / DAMPs / 予防 / 敗血症 Less

DAMPsワクチンの開発と積極的な予防法の確立とその応用
- Principal Investigator
  
  川原幸一
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Osaka Institute of Technology
S100A8/A9-向転移とHRG-抗転移の細胞間・分子間クロストークの解明
- Principal Investigator
  
  阪口政清
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Okayama University
悪性中皮腫の増殖・転移を加速するCaチャネル活性化を介した新しい分子機構の解明Principal Investigator
- Principal Investigator
  
  友信奈保子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Okayama University
Development of a new treatment approach to control fibrosis and metastasis of pancreatic cancerPrincipal Investigator
- Principal Investigator
  
  Tomonobu Nahoko
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0901:Oncology and related fields
- Research Institution
  Okayama University

All 2024 2023 2022

All Journal Article Presentation

[Journal Article] Lysyl oxidase-like 4 promotes the invasiveness of triple-negative breast cancer cells by orchestrating the invasive machinery formed by annexin A2 and S100A11 on the cell surface2024
- Author(s)
  Takahashi Tetta、Tomonobu Nahoko、Kinoshita Rie、Yamamoto Ken-ichi、Murata Hitoshi、Komalasari Ni Luh Gede Yoni、...、Honjo Tomoko、Sakaguchi Yoshihiko、Yamauchi Akira、Kuribayashi Futoshi、Kondo Eisaku、Inoue Yusuke、Futami Junichiro、Toyooka Shinichi、Zamami Yoshito、Sakaguchi Masakiyo
- Journal Title
  
  Frontiers in Oncology
  
  Volume: 14 Pages: 1371342-1371342
- DOI
  10.3389/fonc.2024.1371342
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14595, KAKENHI-PROJECT-22K07074, KAKENHI-PROJECT-23K06717, KAKENHI-PROJECT-22K20793, KAKENHI-PROJECT-22H04923, KAKENHI-PROJECT-23K27439
[Journal Article] PD-1 blockade augments CD8+ T cell dependent antitumor immunity triggered by Ad-SGE-REIC in Egfr-mutant lung cancer2023
- Author(s)
  Nakasuka Takamasa、Ohashi Kadoaki、Nishii Kazuya、Hirabae Atsuko、Okawa Sachi、Tomonobu Nahoko、Takada Kenji、Ando Chihiro、Watanabe Hiromi、Makimoto Go、Ninomiya Kiichiro、Fujii Masanori、Kubo Toshio、Ichihara Eiki、Hotta Katsuyuki、Tabata Masahiro、Kumon Hiromi、Maeda Yoshinobu、Kiura Katsuyuki
- Journal Title
  
  Lung Cancer
  
  Volume: 178 Pages: 1-10
- DOI
  10.1016/j.lungcan.2023.01.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K23930, KAKENHI-PROJECT-19H03667, KAKENHI-PROJECT-23K14595, KAKENHI-PROJECT-22K19529, KAKENHI-PROJECT-22K20793, KAKENHI-PROJECT-23K24339
[Journal Article] STAT1/3 signaling suppresses axon degeneration and neuronal cell death through regulation of NAD+-biosynthetic and consuming enzymes2023
- Author(s)
  Murata Hitoshi、Yasui Yu、Oiso Kazuma、Ochi Toshiki、Tomonobu Nahoko、Yamamoto Ken-ichi、Kinoshita Rie、Sakaguchi Masakiyo
- Journal Title
  
  Cellular Signalling
  
  Volume: 108 Pages: 110717-110717
- DOI
  10.1016/j.cellsig.2023.110717
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14595, KAKENHI-PROJECT-23K06717, KAKENHI-PROJECT-22K20793, KAKENHI-PROJECT-22H04923, KAKENHI-PROJECT-23K27439
[Journal Article] LOXL1 and LOXL4 are novel target genes of the Zn2+-bound form of ZEB1 and play a crucial role in the acceleration of invasive events in triple-negative breast cancer cells2023
- Author(s)
  Daisuke Hirabayashi, Ken-ichi Yamamoto, Akihiro Maruyama, Nahoko Tomonobu, Rie Kinoshita, Youyi Chen, Ni Luh Gede Yoni Komalasari, Hitoshi Murata, Yuma Gohara, Fan Jiang, Jin Zhou, I Made Winarsa Ruma, I Wayan Sumardika, Akira Yamauchi, Futoshi Kuribayashi, Shinichi Toyooka, Yusuke Inoue, Masakiyo Sakaguchi
- Journal Title
  
  Frontiers in Oncology
  
  Volume: 13 Pages: 1142886-1142886
- DOI
  10.3389/fonc.2023.1142886
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K20793, KAKENHI-PROJECT-20H03516, KAKENHI-PROJECT-22K06884, KAKENHI-PROJECT-23K06478, KAKENHI-PROJECT-22H04923
[Journal Article] Phosphorylated SARM1 is involved in the pathological process of rotenone-induced neurodegeneration2023
- Author(s)
  Murata Hitoshi、Phoo May Tha Zin、Ochi Toshiki、Tomonobu Nahoko、Yamamoto Ken-ichi、Kinoshita Rie、Miyazaki Ikuko、Nishibori Masahiro、Asanuma Masato、Sakaguchi Masakiyo
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 174 Issue: 6 Pages: 533-548
- DOI
  10.1093/jb/mvad068
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14595, KAKENHI-PROJECT-22K06884, KAKENHI-PROJECT-23K06717, KAKENHI-PROJECT-23K06928, KAKENHI-PROJECT-21K07415, KAKENHI-PROJECT-22K20793, KAKENHI-PROJECT-23K27439
[Journal Article] Lysyl oxidase-like 4 exerts an atypical role in breast cancer progression that is dependent on the enzymatic activity that targets the cell-surface annexin A22023
- Author(s)
  Sakaguchi, M., Komalasari, N. L. G. Y., Tomonobu, N., Kinoshita, R., Chen, Y., Sakaguchi, Y., Gohara, Y., Jiang, F., Yamamoto, K., Murata, H., Ruma, I. M. W., Sumardika, I. W., Zhou, J., Yamauchi, A., Kuribayashi, F., Inoue, Y., Toyooka, S.
- Journal Title
  
  Front. Oncol.
  
  Volume: 13 Pages: 1142907-1142907
- DOI
  10.3389/fonc.2023.1142907
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07074, KAKENHI-PROJECT-23K14595, KAKENHI-PROJECT-22K06884, KAKENHI-PROJECT-23K06717, KAKENHI-PROJECT-22K20793, KAKENHI-PROJECT-23K27439
[Journal Article] SPRED2: A Novel Regulator of Epithelial-Mesenchymal Transition and Stemness in Hepatocellular Carcinoma Cells2023
- Author(s)
  Gao T, Yang X, Fujisawa M, Ohara T, Wang T, Tomonobu N, Sakaguchi M, Yoshimura T, Matsukawa A
- Journal Title
  
  Int J Mol Sci
  
  Volume: 24 Issue: 5 Pages: 4996-4996
- DOI
  10.3390/ijms24054996
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19562, KAKENHI-PROJECT-20H03516, KAKENHI-PROJECT-21H02988, KAKENHI-PROJECT-23K14595, KAKENHI-PROJECT-22K20793, KAKENHI-PROJECT-22H04923
[Journal Article] Novel extracellular role of REIC/Dkk-3 protein in PD-L1 regulation in cancer cells.2023
- Author(s)
  Yuma Gohara, Nahoko Tomonobu, Rie Kinoshita, Junichiro Futami, Lena Audebert, Youyi Chen, Ni Luh Gede Yoni Komalasari, Fan Jiang, Chikako Yoshizawa, Hitoshi Murata, Ken-Ichi Yamamoto, Masami Watanabe, Hiromi Kumon, Masakiyo Sakaguchi
- Journal Title
  
  Journal of molecular medicine (Berlin, Germany)
  
  Volume: 101 Issue: 4 Pages: 431-447
- DOI
  10.1007/s00109-023-02292-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K20793, KAKENHI-PROJECT-20K07636, KAKENHI-PROJECT-23K14595, KAKENHI-PROJECT-22K06884, KAKENHI-PROJECT-22H04923, KAKENHI-PROJECT-19H01064, KAKENHI-PROJECT-23K27439
[Journal Article] Inhibition of pancreatic cancer-cell growth and metastasis in vivo by a pyrazole compound characterized as a cell-migration inhibitor by an in vitro chemotaxis assay2022
- Author(s)
  Shuichiro Okamoto, Kei Miyano, Tominari Choshi, Norihiko Sugisawa, Takashi Nishiyama, Rika Kotouge, Masahiro Yamamura, Masakiyo Sakaguchi, Rie Kinoshita, Nahoko Tomonobu, Naoki Katase, ..., Robert M. Hoffman, Akira Yamauchi, Futoshi Kuribayashi
- Journal Title
  
  Biomedicine & Pharmacotherapy
  
  Volume: 155 Pages: 113733-113733
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K20793
[Journal Article] Histidine-Rich Glycoprotein Suppresses the S100A8/A9-Mediated Organotropic Metastasis of Melanoma Cells2022
- Author(s)
  Nahoko Tomonobu, Rie Kinoshita, Hidenori Wake, Yusuke Inoue, ..., Hitoshi Murata, Ken-ichi Yamamoto, I Wayan Sumardika, Youyi Chen, Junichiro Futami, Akira Yamauchi, Futoshi Kuribayashi, Eisaku Kondo, Shinichi Toyooka, Masahiro Nishibori, Masakiyo Sakaguchi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 18 Pages: 10300-10300
- DOI
  10.3390/ijms231810300
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K20793, KAKENHI-PROJECT-20H03516, KAKENHI-PROJECT-20H03527, KAKENHI-PROJECT-20K07636, KAKENHI-PROJECT-22H04923
[Journal Article] Toll-like receptor 4 promotes bladder cancer progression upon S100A8/A9 binding, which requires TIRAP-mediated TPL2 activation2022
- Author(s)
  Acosta Gonzalez Herik Rodrigo, Nahoko Tomonobu, Haruka Yoneda, Rie Kinoshita, ..., Hitoshi Murata, Ken-ichi Yamamoto, Junichiro Futami, Akira Yamauchi, Futoshi Kuribayashi, Yusuke Inoue, Eisaku Kondo, Shinichi Toyooka, Masahiro Nishibori, Masami Watanabe, Yasutomo Nasu, Masakiyo Sakaguchi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 634 Pages: 83-91
- DOI
  10.1016/j.bbrc.2022.09.116
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K20793, KAKENHI-PROJECT-20H03516, KAKENHI-PROJECT-20H03527, KAKENHI-PROJECT-20K07636, KAKENHI-PROJECT-22H04923
[Presentation] TLR4 accelerates bladder cancer progression upon interaction with S100A8/A92023
- Author(s)
  Fan Jiang、Acosta Gonzalez Herik Rodrigo、Nahoko Tomonobu、Rie Kinoshita、Yuma Gohara、Ni Luh Gede Yoni Komalasari、Ken-ichi Yamamoto、Hitoshi Murata、Akira Yamauchi、Shinichi Toyooka、Masami Watanabe、Yasutomo Nasu、Masakiyo Sakaguchi
- Organizer
  第95回日本組織培養学会
- Data Source
  KAKENHI-PROJECT-23K14595
[Presentation] TLR4 accelerates bladder cancer progression upon interaction with S100A8/A92023
- Author(s)
  Fan Jiang、Acosta Gonzalez Herik Rodrigo、Nahoko Tomonobu、Rie Kinoshita、Yuma Gohara、Ni Luh Gede Yoni Komalasari、Ken-ichi Yamamoto、Hitoshi Murata、Akira Yamauchi、Shinichi Toyooka、Masami Watanabe、Yasutomo Nasu、Masakiyo Sakaguchi
- Organizer
  第95回日本組織培養学会
- Data Source
  KAKENHI-PROJECT-22K20793
[Presentation] STAT1/3シグナル経路によるNAD+代謝酵素制御を介した神経軸索変性と細胞死の抑制2023
- Author(s)
  安井優、村田等、大磯和真、越智俊樹、友信奈保子、山本健一、木下理恵、阪口政清
- Organizer
  第95回日本組織培養学会
- Data Source
  KAKENHI-PROJECT-22K20793
[Presentation] 核内 PD-L1 は MCRIP1 を抑制することでトリプルネガティブ乳がん細胞の浸潤能を促進する2023
- Author(s)
  合原勇馬、友信奈保子、木下理恵、山本建一、村田等、阪口政清
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K27439
[Presentation] ヒトiPS細胞由来神経細胞と動物モデルを用いた軸索変性誘導分子SARM1の阻害剤開発2023
- Author(s)
  村田等、安藤隆幸、安井優、越智俊樹、友信奈保子、山本健一、木下理恵、阪口政清
- Organizer
  第95回日本組織培養学会
- Data Source
  KAKENHI-PROJECT-23K14595
[Presentation] TLR4 accelerates bladder cancer progression upon interaction with S100A8/A92023
- Author(s)
  Fan Jiang,Acosta Gonzalez Herik Rodrigo, Nahoko Tomonobu, Rie Kinoshita, Yuma Gohara, Ni Luh Gede Yoni Komalasari, Ken-ichi Yamamoto, Hitoshi Murata, Akira Yamauchi, Shinichi Toyooka, Masami Watanabe, Yasutomo Nasu, Masakiyo Sakaguchi
- Organizer
  日本組織培養学会第95回大会
- Data Source
  KAKENHI-PROJECT-23K27439
[Presentation] 亜鉛結合により活性化されるZEB1転写因子の乳がん進展における意義の解明2023
- Author(s)
  山本健一、平林大輔、丸山顕嘉、友信奈保子、木下理恵、Ni Luh Gede Yoni Komalasari、村田等、合原勇馬、江帆、山内明、栗林太、豊岡伸一、井上裕介、阪口政清
- Organizer
  第95回日本組織培養学会
- Data Source
  KAKENHI-PROJECT-23K14595
[Presentation] ヒトメラノーマ細胞の増殖と血管新生における冬虫夏草の抗腫瘍作用評価2023
- Author(s)
  長﨑直也, 堀井聡, I Wayan Sumardika, I Made Winarsa Ruma, 友信奈保子, 木下理恵, 山本健一, 村田等, 阪口政清
- Organizer
  日本組織培養学会第95回大会
- Data Source
  KAKENHI-PROJECT-23K27439
[Presentation] 新規化合物14-100とその類似体はCell-based Drug Discoveryの手法で発見された2023
- Author(s)
  山内明、岡本秀一郎、町支臣成、片瀬直樹、友信奈保子、木下理恵、阪口政清、山村真弘
- Organizer
  第82回日本癌学会
- Data Source
  KAKENHI-PROJECT-23K14595
[Presentation] 糞便微生物移植治療から見出した腸内の放射菌の生理活性評価2023
- Author(s)
  阪口義彦、武晃、後藤和義、竹原正也、友信奈保子、山本健一、菊池雄太、坂本光央、加藤はる、大宮直木、阪口政清、長浜政博
- Organizer
  第95回日本組織培養学会
- Data Source
  KAKENHI-PROJECT-23K14595
[Presentation] ヒトiPS細胞由来神経細胞と動物モデルを用いた軸索変性誘導分子SARM1の阻害剤開発2023
- Author(s)
  村田等、安藤隆幸、安井優、越智俊樹、友信奈保子、山本健一、木下理恵、阪口政清
- Organizer
  第95回日本組織培養学会
- Data Source
  KAKENHI-PROJECT-22K20793
[Presentation] Lysyl oxidase-like 4 exerts an atypical role in breast cancer progression that targets the cell-surface annexin A22023
- Author(s)
  Ni Luh Gede Yoni Komalasari、友信奈保子、木下理恵、合原勇馬、山本健一、村田等、山内明、栗林太、井上裕介、豊岡伸一、阪口政清
- Organizer
  第82回日本癌学会
- Data Source
  KAKENHI-PROJECT-22K20793
[Presentation] REICタンパク質によるPD-L1制御を介した抗腫瘍機序の解明2023
- Author(s)
  合原勇馬、友信奈保子、木下理恵、村田等、山本健一、難波正義、許南浩、公文裕巳、阪口政清
- Organizer
  第95回日本組織培養学会
- Data Source
  KAKENHI-PROJECT-23K14595
[Presentation] 核内PD-L1はProtein Xを抑制することでトリプルネガティブ乳がん細胞の浸潤能を促進する2023
- Author(s)
  合原勇馬、友信奈保子、木下理恵、山本建一、村田等、阪口政清
- Organizer
  第82回日本癌学会
- Data Source
  KAKENHI-PROJECT-23K14595
[Presentation] Lysyl oxidase-like 4 exerts an atypical role in breast cancer progression that targets the cell-surface annexin A22023
- Author(s)
  Ni Luh Gede Yoni Komalasari、友信奈保子、木下理恵、合原勇馬、山本健一、村田等、山内明、栗林太、井上裕介、豊岡伸一、阪口政清
- Organizer
  第82回日本癌学会
- Data Source
  KAKENHI-PROJECT-23K14595
[Presentation] 細胞表面アネキシンA2/S100A11結合に着目した乳がん進行の機序解明2023
- Author(s)
  髙橋徹多、友信奈保子、Ni Luh Gede Yoni Komalasari、合原勇馬、山本健一、木下理恵、村田等、阪口政清
- Organizer
  第95回日本組織培養学会
- Data Source
  KAKENHI-PROJECT-22K20793
[Presentation] 膵がん進展におけるS100A8/A9の役割解明と治療方法の開発2023
- Author(s)
  木下理恵、友信奈保子、山内明、二見淳一郎、豊岡伸一、阪口政清
- Organizer
  第82回日本癌学会
- Data Source
  KAKENHI-PROJECT-22K20793
[Presentation] The novel compound 14-100 and its analogues were discovered in Cell-based Drug Discovery approach2023
- Author(s)
  Akira Yamauchi, Shuichiro Okamoto, Tominari Choshi, Naoki Katase, Nahoko Tomonobu, Rie Kinoshita, Masakiyo Sakaguchi, Masahiro Yamamura
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K27439
[Presentation] 糞便微生物移植治療から見出した腸内の放射菌の生理活性評価2023
- Author(s)
  阪口義彦、武晃、後藤和義、竹原正也、友信奈保子、山本健一、菊池雄太、坂本光央、加藤はる、大宮直木、阪口政清、長浜政博
- Organizer
  第95回日本組織培養学会
- Data Source
  KAKENHI-PROJECT-22K20793
[Presentation] Lysyl oxidase-like 4 (LOXL4) empowers integrin b-1 via cross-linking of annexin A2 on the cell surface in promoting promoting breast cancer progression2023
- Author(s)
  Ni Luh Gede Yoni Komalasari、Nahoko Tomonobu、Rie Kinoshita、Yoshihiko Sakaguchi、Yuma Gohara、Fan Jiang、Ken-ichi Yamamoto、Hitoshi Murata、Akira Yamauchi、Yusuke Inoue、Shinichi Toyooka、Masakiyo Sakaguchi
- Organizer
  第95回日本組織培養学会
- Data Source
  KAKENHI-PROJECT-22K20793
[Presentation] 亜鉛結合により活性化されるZEB1転写因子の乳がん進展における意義の解明2023
- Author(s)
  山本健一、平林大輔、丸山顕嘉、友信奈保子、木下理恵、Ni Luh Gede Yoni Komalasari、村田等、合原勇馬、江帆、山内明、栗林太、豊岡伸一、井上裕介、阪口政清
- Organizer
  第95回日本組織培養学会
- Data Source
  KAKENHI-PROJECT-22K20793
[Presentation] REIC タンパク質によるPD-L1 制御を介した抗腫瘍機序の解明2023
- Author(s)
  合原勇馬, 友信奈保子, 木下理恵, 村田等, 山本健一, 難波正義, 許南浩, 公文裕己, 阪口政清
- Organizer
  日本組織培養学会第95回大会
- Data Source
  KAKENHI-PROJECT-23K27439
[Presentation] Novel cancer suppressing role of REIC/DKK3 protein through a downregulation of cell surface PD-L! in breast cells2023
- Author(s)
  Y. Gohara, N. Tomonobu, R. Kinoshita, K. Yamamoto, H. Murata, M. Sakaguch
- Organizer
  AACR2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27439
[Presentation] S100A8/A9 とその新制御分子のバランスで成立するがん転移の機序解明2023
- Author(s)
  友信奈保子, 木下理恵, 合原勇馬, Ni Luh Gede Yoni Komalasari, Fan Jiang, 村田等, 山本健一, 山内明, 近藤英作, 豊岡伸一, 西堀正洋, 阪口政清
- Organizer
  日本組織培養学会第95回大会
- Data Source
  KAKENHI-PROJECT-23K27439
[Presentation] STAT1/3 シグナル経路によるNAD+代謝酵素制御を介した神経軸索変性と細胞死の抑制2023
- Author(s)
  安井優, 村田等, 大磯和真, 越智俊樹, 友信奈保子, 山本健一, 木下理恵, 阪口政清
- Organizer
  日本組織培養学会第95回大会
- Data Source
  KAKENHI-PROJECT-23K27439
[Presentation] S100A8/A9とその新制御分子のバランスで成立するがん転移の機序解明2023
- Author(s)
  友信奈保子、木下理恵、合原勇馬、Ni Luh Gede Yoni Komalasari、Fan Jiang、村田等、山本健一、山内明、近藤英作、豊岡伸一、西堀正洋、阪口政清
- Organizer
  第95回日本組織培養学会
- Data Source
  KAKENHI-PROJECT-23K14595
[Presentation] 膀胱がんの進行におけるS100A8/A9に関わる分子機構の解明2023
- Author(s)
  友信奈保子、木下理恵、合原勇馬、Ni Luh Gede Yoni Komalasari、二見淳一郎、山内明、近藤英作、豊岡伸一、阪口政清
- Organizer
  第82回日本癌学会
- Data Source
  KAKENHI-PROJECT-22K20793
[Presentation] 膀胱がんの進行におけるS100A8/A9に関わる分子機構の解明2023
- Author(s)
  友信奈保子、木下理恵、合原勇馬、Ni Luh Gede Yoni Komalasari、二見淳一郎、山内明、近藤英作、豊岡伸一、阪口政清
- Organizer
  第82回日本癌学会
- Data Source
  KAKENHI-PROJECT-23K14595
[Presentation] S100A8/A9とその新制御分子のバランスで成立するがん転移の機序解明2023
- Author(s)
  友信奈保子、木下理恵、合原勇馬、Ni Luh Gede Yoni Komalasari、Fan Jiang、村田等、山本健一、山内明、近藤英作、豊岡伸一、西堀正洋、阪口政清
- Organizer
  第95回日本組織培養学会
- Data Source
  KAKENHI-PROJECT-22K20793
[Presentation] Lysyl oxidase-like 4 (LOXL4) empowers integrin b-1 via cross-linking of annexin A2 on the cell surface in promoting promoting breast cancer progression2023
- Author(s)
  Ni Luh Gede Yoni Komalasari、Nahoko Tomonobu、Rie Kinoshita、Yoshihiko Sakaguchi、Yuma Gohara、Fan Jiang、Ken-ichi Yamamoto、Hitoshi Murata、Akira Yamauchi、Yusuke Inoue、Shinichi Toyooka、Masakiyo Sakaguchi
- Organizer
  第95回日本組織培養学会
- Data Source
  KAKENHI-PROJECT-23K14595
[Presentation] 膵がん進展におけるS100A8/A9 の機能解析と抗体による治療への応用2023
- Author(s)
  宮本航大, 木下理恵, 小林和子, 友信奈保子, 山本健一, 村田等, 許南浩, 豊岡伸一, 阪口政清
- Organizer
  日本組織培養学会第95回大会
- Data Source
  KAKENHI-PROJECT-23K27439
[Presentation] STAT1/3シグナル経路によるNAD+代謝酵素制御を介した軸索変性と神経細胞死の抑制2023
- Author(s)
  村田; 等、安井優、越智俊樹、友信奈保子、山本健一、木下理恵、阪口政清
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K27439
[Presentation] 核内PD-L1はProtein Xを抑制することでトリプルネガティブ乳がん細胞の浸潤能を促進する2023
- Author(s)
  合原勇馬、友信奈保子、木下理恵、山本建一、村田等、阪口政清
- Organizer
  第82回日本癌学会
- Data Source
  KAKENHI-PROJECT-22K20793
[Presentation] 亜鉛結合により活性化されるZEB1 転写因子の乳がん進展における意義の解明2023
- Author(s)
  山本健一, 平林大輔, 丸山顕嘉, 友信奈保子, 木下理恵, Ni Luh Gade Yoni Komalasari, 村田等, 合原勇馬, 江帆, 山内明, 栗林太, 豊岡伸一, 井上裕介, 阪口政清
- Organizer
  日本組織培養学会第95回大会
- Data Source
  KAKENHI-PROJECT-23K27439
[Presentation] Lysyl oxidase-like 4 exerts an atypical role in breast cancer progression that targets the cell-surface annexin A22023
- Author(s)
  Yoni Komalasari, Nahoko Tomonobu, Rie Kinoshita, Yuma Gohara, Kenichi Yamamoto, Hitoshi Murata, Akira Yamauchi, Futoshi Kuribayashi, Yusuke Inoue, Shinichi Toyooka , Masakiyo Sakaguchi
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K27439
[Presentation] 膵がん進展におけるS100A8/A9の機能解析と抗体による治療への応用2023
- Author(s)
  宮本航大、木下理恵、小林和子、友信奈保子、山本健一、村田等、許南浩、豊岡伸一、阪口政清
- Organizer
  第95回日本組織培養学会
- Data Source
  KAKENHI-PROJECT-23K14595
[Presentation] 膵がん進展における S100A8/A9 の役割解明と治療方法の開発2023
- Author(s)
  木下理恵、友信奈保子、山内明、二見淳一郎、豊岡伸一、阪口政清
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K27439
[Presentation] ヒトメラノーマ細胞の増殖と血管新生における冬虫夏草の抗腫瘍作用評価2023
- Author(s)
  長﨑直也、堀井聡、I Wayan Sumardika、I Made Winarsa Ruma、友信奈保子、木下理恵、山本健一、村田等、阪口政清
- Organizer
  第95回日本組織培養学会
- Data Source
  KAKENHI-PROJECT-23K14595
[Presentation] 膀胱がんの進行における S100A8/A9 に関わる分子機構の解明2023
- Author(s)
  友信奈保子、木下理恵、合原勇馬、Yoni Komalasari、二見淳一郎、山内明、近藤英作、豊岡伸一、阪口政清
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K27439
[Presentation] 膵がん進展におけるS100A8/A9の役割解明と治療方法の開発2023
- Author(s)
  木下理恵、友信奈保子、山内明、二見淳一郎、豊岡伸一、阪口政清
- Organizer
  第82回日本癌学会
- Data Source
  KAKENHI-PROJECT-23K14595
[Presentation] STAT1/3シグナル経路によるNAD+代謝酵素制御を介した神経軸索変性と細胞死の抑制2023
- Author(s)
  安井優、村田等、大磯和真、越智俊樹、友信奈保子、山本健一、木下理恵、阪口政清
- Organizer
  第95回日本組織培養学会
- Data Source
  KAKENHI-PROJECT-23K14595
[Presentation] 細胞表面アネキシンA2/S100A11 結合に着目した乳がん進行の機序解明2023
- Author(s)
  髙橋徹多, 友信奈保子,Ni LuhGede Yoni Komalasari, 合原勇馬, 山本健一, 木下理恵, 村田等, 阪口政清
- Organizer
  日本組織培養学会第95回大会
- Data Source
  KAKENHI-PROJECT-23K27439
[Presentation] 糞便微生物移植治療から見出した腸内の放線菌の生理活性評価2023
- Author(s)
  阪口義彦, 武晃, 後藤和義, 原正也, 友信奈保子, 山本健一, 菊池雄太, 坂本光央, 加藤はる, 大宮直木, 阪口政清, 永浜政博
- Organizer
  日本組織培養学会第95回大会
- Data Source
  KAKENHI-PROJECT-23K27439
[Presentation] 新規化合物14-100とその類似体はCell-based Drug Discoveryの手法で発見された2023
- Author(s)
  山内明、岡本秀一郎、町支臣成、片瀬直樹、友信奈保子、木下理恵、阪口政清、山村真弘
- Organizer
  第82回日本癌学会
- Data Source
  KAKENHI-PROJECT-22K20793
[Presentation] 癌転移抑制を目指した細胞動態解析と創薬2023
- Author(s)
  山内明 ,町支臣成, 岡本秀一郎, 片瀬直樹, 山村真弘, 友信奈保子, 木下理恵, 阪口政清, 栗林太
- Organizer
  日本組織培養学会第95回大会
- Data Source
  KAKENHI-PROJECT-23K27439
[Presentation] ヒトiPS 細胞由来神経細胞と動物モデルを用いた軸索変性誘導分子SARM1 の阻害剤開発2023
- Author(s)
  村田等, 安藤隆幸, 安井優, 越智俊樹, 友信奈保子, 山本健一, 木下理恵, 阪口政清
- Organizer
  日本組織培養学会第95回大会
- Data Source
  KAKENHI-PROJECT-23K27439
[Presentation] 膵がん進展におけるS100A8/A9の機能解析と抗体による治療への応用2023
- Author(s)
  宮本航大、木下理恵、小林和子、友信奈保子、山本健一、村田等、許南浩、豊岡伸一、阪口政清
- Organizer
  第95回日本組織培養学会
- Data Source
  KAKENHI-PROJECT-22K20793
[Presentation] ヒトメラノーマ細胞の増殖と血管新生における冬虫夏草の抗腫瘍作用評価2023
- Author(s)
  長﨑直也、堀井聡、I Wayan Sumardika、I Made Winarsa Ruma、友信奈保子、木下理恵、山本健一、村田等、阪口政清
- Organizer
  第95回日本組織培養学会
- Data Source
  KAKENHI-PROJECT-22K20793
[Presentation] 細胞表面アネキシンA2/S100A11結合に着目した乳がん進行の機序解明2023
- Author(s)
  髙橋徹多、友信奈保子、Ni Luh Gede Yoni Komalasari、合原勇馬、山本健一、木下理恵、村田等、阪口政清
- Organizer
  第95回日本組織培養学会
- Data Source
  KAKENHI-PROJECT-23K14595
[Presentation] REICタンパク質によるPD-L1制御を介した抗腫瘍機序の解明2023
- Author(s)
  合原勇馬、友信奈保子、木下理恵、村田等、山本健一、難波正義、許南浩、公文裕巳、阪口政清
- Organizer
  第95回日本組織培養学会
- Data Source
  KAKENHI-PROJECT-22K20793
[Presentation] A critical role of S100A8/A9-NPTNb axis in the lung cancer dissemination2022
- Author(s)
  Kenichi Yamamoto, Nahoko Tomonobu, Rie Kinoshita, Junichiro Futami, Akira Yamauchi, Shinichi Toyooka, Eisaku Kondo, Masakiyo Sakaguchi
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K20793
[Presentation] Development of therapeutic antibodies based on the elevated S100A8/A9 in tumor microenvironment2022
- Author(s)
  Yuma Gohara, Nahoko Tomonobu, Rie Kinoshita, Kenichi Yamamoto, Masakiyo Sakaguchi
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K20793
[Presentation] Binding of REIC/Dkk-3 to its receptor suppresses PD-L1 expression in triple negative breast cancer2022
- Author(s)
  Chikako Yoshizawa, Yuma Gohara, Nahoko Tomonobu, Rie Kinoshita, Junichiro Futami, Hitoshi Murata, Kenichi Yamamoto, Masakiyo Sakaguchi
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K20793
[Presentation] A chemotaxis inhibitory agent selected using TAXIScan suppresses pancreatic cancer proliferation and metastasis2022
- Author(s)
  Akira Yamauchi, Masahiro Yamamura, Naoki Katase, Nahoko Tomonobu, Rie Kinoshita, Masakiyo Sakaguchi, Shuichiro Okamoto
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K20793
[Presentation] Lysyl Oxidase-Like 4 (LOXL4) Exerts an Atypical Role in Breast Cancer Progression Dependent on the Enzymatic activity2022
- Author(s)
  Yoni Komalasari, Nahoko Tomonobu, Yuma Gohara, Rie Kinoshita, Masakiyo Sakaguchi
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K20793
[Presentation] HRG suppresses the S100A8/A9-mediated brain tropic metastasis of melanoma cells2022
- Author(s)
  Nahoko Tomonobu, Yoni Komalasari, Yuma Gohara, Rie Kinoshita, Kenichi Yamamoto, Akira Yamauchi, Eisaku Kondo, Shinichi Toyooka1, Masakiyo Sakaguchi
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K20793

1. 川原幸一 (10381170)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 西順一郎 (40295241)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 芦高恵美子 (50291802)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 谷口昇 (20626866)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 三浦直樹 (80508036)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 伊藤隆史 (20381171)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 赤塚正幸 (60808161)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 阪口政清 (70379840)

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results
9. 山本健一 (00711798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
10. 近藤英作 (30252951)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. 豊岡伸一 (30397880)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
12. 木下理恵 (40518297)

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results
13. 西堀正洋 (50135943)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 山内明 (80372431)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
15. 村田等 (90579096)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
16. SAKAGUCHI Yoshihiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 藤井昌学

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 松川昭博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tomonobu Nahoko 友信 奈保子

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DAMPsワクチンの開発と積極的な予防法の確立とその応用

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S100A8/A9-向転移とHRG-抗転移の細胞間・分子間クロストークの解明

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悪性中皮腫の増殖・転移を加速するCaチャネル活性化を介した新しい分子機構の解明Principal Investigator

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Development of a new treatment approach to control fibrosis and metastasis of pancreatic cancerPrincipal Investigator

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[Journal Article] Lysyl oxidase-like 4 promotes the invasiveness of triple-negative breast cancer cells by orchestrating the invasive machinery formed by annexin A2 and S100A11 on the cell surface2024

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[Journal Article] PD-1 blockade augments CD8+ T cell dependent antitumor immunity triggered by Ad-SGE-REIC in Egfr-mutant lung cancer2023

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[Journal Article] STAT1/3 signaling suppresses axon degeneration and neuronal cell death through regulation of NAD+-biosynthetic and consuming enzymes2023

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[Journal Article] LOXL1 and LOXL4 are novel target genes of the Zn2+-bound form of ZEB1 and play a crucial role in the acceleration of invasive events in triple-negative breast cancer cells2023

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[Journal Article] Phosphorylated SARM1 is involved in the pathological process of rotenone-induced neurodegeneration2023

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[Journal Article] Lysyl oxidase-like 4 exerts an atypical role in breast cancer progression that is dependent on the enzymatic activity that targets the cell-surface annexin A22023

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[Journal Article] SPRED2: A Novel Regulator of Epithelial-Mesenchymal Transition and Stemness in Hepatocellular Carcinoma Cells2023

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[Journal Article] Novel extracellular role of REIC/Dkk-3 protein in PD-L1 regulation in cancer cells.2023

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[Journal Article] Inhibition of pancreatic cancer-cell growth and metastasis in vivo by a pyrazole compound characterized as a cell-migration inhibitor by an in vitro chemotaxis assay2022

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[Journal Article] Histidine-Rich Glycoprotein Suppresses the S100A8/A9-Mediated Organotropic Metastasis of Melanoma Cells2022

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[Journal Article] Toll-like receptor 4 promotes bladder cancer progression upon S100A8/A9 binding, which requires TIRAP-mediated TPL2 activation2022

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Tomonobu Nahoko 友信奈保子