SUGA Hiroyuki 菅弘之

Researcher Number	90014117
External Links
Affiliation (based on the past Project Information) *help	2008: 国立循環器病センター研究所, 所長 2000 – 2006: 国立循環器病センター研究所, 所長 2005: 国立循環器病センター(研究所), 所長 2001 – 2002: 国立循環器病センター, 研究所, 所長 2001: 国立循環器病センター, (研究職)研究所長 … More 2001: 岡山大学, 大学院・医歯学総合研究科, 教授 1992 – 1999: 岡山大学, 医学部, 教授 1991: Okayama University Medical School, 2nd Dept. of Physiology, Professor, 医学部・第2生理学, 教授 1989 – 1990: National Cardiovascular Center Research Institute, Department of Cardiovascular Dynamics, Chairman, 循環動態機能部, 部長 1988: 国立循環器病センター研究所, 循環動態機能部・循環動態機 1987: National Cardiovascular Center Research Institute, Director, 循環動態機能部, 部長 1986: 循病セ, その他, 研究員 Less
Review Section/Research Field	Principal Investigator General physiology / Biomedical engineering/Biological material science / Circulatory organs internal medicine / General physiology Except Principal Investigator Biomedical engineering/Biological material science / Circulatory organs internal medicine / Thoracic surgery / Thoracic surgery / 広領域 / 麻酔学 / Biomedical engineering/Biological material science / Circulatory organs internal medicine / Anesthesiology/Resuscitation studies
Keywords	Principal Investigator Emax / 酸素消費量 / 心臓 / 興奮収縮連関 / 収縮性 / 期外収縮 / PVA / カルシウム / excitation-contraction coupling / postextrasystolic potentiation … More / 不全心 / 期外収縮後収縮性増強 / 再循環率 / 心筋 / 心室 / 機械的エネルギー / stunning / ryanodine / 統合生理学 / 筋小胞体 / oxygen consumption / カルシウムハンドリング / 収縮 / 収縮機構 / 心力学 / Optimality / Mechanical efficiency / Contractility / Contraction / Pump function / Circulation / Myocardium / Heart / 全容積面積 / 酸素消毒量 / 最適性 / 機械的効率 / ポンプ機能 / 循環 / oxygen consumplion / mechanical energy / syslolic pressure-volume area / energy efficiency / myocardium / heart / ATP / 圧容積図 / 効率 / エナジェティクス / 収縮期圧容積面積 / 心臓・心筋・エネルギー効率 / tailing heart / transient alternans / myocardial CaィイD12+ィエD1 handling / 心筋メカノエナジェティクス / 心筋酸素消費 / 一過性交互脈 / 心筋細胞Ca動態 / sarcoplasmic reticulum / calcium paradox / heart failure / カルシウム動態 / メカノエナジェティクス / 心機能の評価 / 生体位心 / エネルギー変換効率 / 収縮期末圧容積面積 / 収縮期末圧容積関係 / 血液交叉灌流摘出心臓標本 / スタンド心 / カルシウムパラドックス / リアノジン / total Ca^<2+> handling / recirculation fraction / beat constant / falling heart / 心筋スライス / Emaxの酸素コスト / pentobarbital / pimobendan / cardiotonic agent / left vantricle / ペントバルビタール / ピモベンダン / 強心薬 / 左心室 / energy consumption / excitation-contraction coupling. / calcium transient / cardiac myocyte / 重奮収縮連関 / エネルギー消費量 / カルシウムトランジェント / 心筋細胞 / エネルギー効率 / 興奮収縮率 / クロスブリッジ / エネルギー収縮 / 興奮収縮連 / アルテナンス / アルテルナンス / 心機能 / 一過性収縮性増強 / 統合生理 / 病的心 / 無駄サイクル / 振動 / 弛緩 / 心臓エネルギー / 心臓容積弾性率 / 心室振動 / 心エナジェティクス / 心収縮性 / 心室内圧 / 心室容積 … More Except Principal Investigator SPring-8 / 冠微小循環 / ミオシン / アクチン / 放射光 / LV repair surgery / Heart Failure / 左室形成術 / 外科治療 / 心不全 / mechanical stress / 冠循環 / 心筋酸素消費量 / クロスブリッジ動態 / X線回折法 / フィジオーム / Surgical Treatment / Hepatic Growth Factor / Dilated Cardiomyopathy / Cardiomyopathy / 心尖部温存左室形成術 / 肝細胞増殖因子 / 拡張型心筋症 / 心筋症 / Vascular regUlation / Transmural characteristics / Intravital CCD / Crossbridge Dynamics / Cardiac Contraction / Coronary Circulation / Physiome / 3D-microCT / 心筋クロスブリッジ / 筋線維 / 拍動心臓 / 培養心筋細胞 / 容量血管 / 3次元解析 / 毛細血管可視化 / 冠微小血管 / マクロモレキュール / 心筋線維配向 / X線回折像解析 / アクチン・ミオシン / 分子トレーサー / 心筋内灌流分布 / 冠微小血管造影 / X線回折 / ミオシン格子 / 筋節構造 / 貫壁性 / 血流速度 / Batista method / Dor method / Ischemic cardiomyopathy / Surgical treatment / 酸化ストレス / 心筋梗塞 / ACE阻害薬 / リモデリング / 左心室瘤 / Batista手術 / Dor手術 / 虚血性心筋症 / vascular response / molecular flow tracer / myocardial ischemia / blood flow regulation / coronary microcirculation / 冠微少循環 / 血管反応 / 分子血流トレーサ / 心筋虚血 / メカニカルストレス / 心内膜側 / 血流調節 / molecula biomechanics / needle-probe CCD intravital microscopy / high-resolution icrocirculatory measurement / tissue energetics / intramyocardial microvessels / coronary circulation / 分子生体工学 / ニードル型生体顕微鏡 / 高分解能微小循環計測 / 組織エナ-ジェティクス / 力学的ストレス / 心筋内微小血管 / Santan-clothing / Actomyosin / Myofilament / Muscle contraction / アクトミオシン / 筋フィラメント / 筋収縮 / eHR (equivalent heart rate) / ePVA (equivalent PVA) / ventricular fibrillation / VO2 (myocardial oxygen consumption) / PVA (pressure-volume area) / エネルギー効率 / e'PVA / eHR / ePVA / 心室細動 / PVA / Regional myocardium / Dobutamine / Myocardial energetics / Contractility / Myocardial oxygen consumption / 冠血流量 / 交叉灌流 / 心筋収縮 / 心機能 / 心臓力学 / 局所心筋 / ドブタミン / エナジェティクス / 収縮性 / アクチン・ミオシン架橋 / ラット / 生体内拍動心臓 / 細胞内Ca^<2+>放出機構 / リアノジン / βアドレナリン受容体刺激 / ミオシン間距離 / 心筋収縮タンパク / 心肥大 / 高血圧ラット / ナノテクノロジー / 小角散乱 / 心筋収縮タンパク質 / 分子立体構造 / スターリング機構 / 乳頭筋 / レーザ回折法 / 心筋 / マイクロメカニクス / バイオニック医療 / マイクロイメージング / データマイニング / 生体テンセグリティ / 機能的生体制御 / ゲノーム / cardiac mechanoenergetics / Emax-PVA-Vo_2関係 / fentanyl Less

Promotion of cardiovascular physiome focusing on coronary microcirculation and myocardial crossbridge dynamics
- Principal Investigator
  
  KAJIYA Fumihiko
- Project Period (FY)
  2005 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Kawasaki University of Medical Welfare
  Kawasaki College of Allied Health Professions
拍動心内カルシウム及びクロスブリッジ動態のフィジオーム的解析方法論の開発と評価Principal Investigator
- Principal Investigator
  
  菅弘之
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  National Cardiovascular Center Research Institute
放射光を用いた心筋クロスブリッジ動態の実時間解析法の確立と臨床応用
- Principal Investigator
  
  白井幹康
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Hiroshima International University
Research for effects of corroboration with apex sparing left ventricular repair surgery and hepatic growth factor using delivery sheet
- Principal Investigator
  
  NISHINA Takeshi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Thoracic surgery
- Research Institution
  KYOTO UNIVERSITY
拍動心臓内カルシウム無駄サイクル及び収縮性カルシウム反応性の医用工学的推定法Principal Investigator
- Principal Investigator
  
  菅弘之
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  National Cardiovascular Center Research Institute
Research for Improving Effects of Clinical after Left Ventricle Repair Surgery on Chronic Cardiac Failure
- Principal Investigator
  
  KOMEDA Masashi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Thoracic surgery
- Research Institution
  KYOTO UNIVERSITY
Analysis of coronary microcirculation and myocardial crossbridge dynamic using SPring-8 synchrotron facility
- Principal Investigator
  
  KAJIYA Fumihiko
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Okayama University
高輝度放射光回折法による心筋アクチン・ミオシン相互作用の心周期内経時解析
- Principal Investigator
  
  TSUJIOKA Katsuhiko
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kawasaki Medical School
医学生物学の新しい機能原理:フィジオーム
- Principal Investigator
  
  KAJIYA Fumihiko
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Kawasaki Medical School
統合生理学的分析法による心臓内カルシウム無駄サイクル数の推定法Principal Investigator
- Principal Investigator
  
  菅弘之
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  Okayama University
Micromechanics Control of Coronary Circulation
- Principal Investigator
  
  KAJIYA Fumihiko
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Kawasaki Medical School
Assessment of the total amount of CAィイD12+ィエD1 handled in the E-C coupling by analyzing postextrasystolic potentiation and OィイD22ィエD2 consumption : Systems approachPrincipal Investigator
- Principal Investigator
  
  SUGA Hiroyuki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Okayama University
Macro-micro correspondence in mechanoenagetics of failing heartsPrincipal Investigator
- Principal Investigator
  
  SUGA Hiroyuki
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Okayama University
イヌ摘出交叉潅流心を用いた麻酔薬の心力学及びエネルギー学的影響の解析
- Principal Investigator
  
  難波健利
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Okayama University
Interaction of coronary hemodynamical and biomolecular signals
- Principal Investigator
  
  KAJIYA Fumihiko
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Kawasaki Medical School
The development of increasing the energetic efficiency of failing heart : Application of Emax and PVAPrincipal Investigator
- Principal Investigator
  
  SUGA Hiroyuki
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Okayama University
心臓の能動素子としてのメカノエナジェティクスPrincipal Investigator
- Principal Investigator
  
  菅弘之
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Okayama University
心臓の能動素子としてのバイオメカニクス的研究:心室振動法による容積弾性率とエネルギー消費量の変化Principal Investigator
- Principal Investigator
  
  菅弘之
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Okayama University
Extensive studies on the dynamic aspects of myofilament sliding in muscle as a micromachine.
- Principal Investigator
  
  SUGI Haruo
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  広領域
- Research Institution
  School of Medicine, Teikyo University
心臓の能動素子としてのバイオメカニクス的研究:心室容積振動法による容積弾性等とエネルギー消費量の変化Principal Investigator
- Principal Investigator
  
  菅弘之
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Okayama University
The relation between Ca^<2+>-transient and Ca^<2+>-handling energy in excitation-contraction couplingPrincipal Investigator
- Principal Investigator
  
  SUGA Hiroyuki
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Okayama University Medical School
The development of evaluating method for oxygen wasting effects by cardiotonic agentsPrincipal Investigator
- Principal Investigator
  
  SUGA Hiroyuki
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Okayama University
Mechanoenergetic analysis of ventricular fibrillation in isolated blood perfused dog hearts.
- Principal Investigator
  
  TOKIOKA Hiroaki
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  麻酔学
- Research Institution
  Okayama University Medical School
Regional myocardial mechanics and energetics
- Principal Investigator
  
  GOTO Yoichi
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  National Cardiovascular Center Research Institute
Methods to improve cardiac efficiency and load matching.Principal Investigator
- Principal Investigator
  
  SUGA Hiroyuki
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  National Cardiovascular Center Research Institute
Faclors ioncreasing the energy conversion efficiency of myocardial contractile machineryPrincipal Investigator
- Principal Investigator
  
  SUGA Hiroyuki
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  National Cardiovascular Cenler Research lnstitute,

All 2009 2007 2006 2005 2004 Other

All Journal Article Book

[Book] Sliding Filament Mechanism in Muscle Contraction : Fifty Years of Research.2005
- Author(s)
  Suga H(分担執筆)
- Total Pages
  431
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-16659057
[Journal Article] Mode of frequency distribution of external work efficiency of arrhythmic beats during atrial fibrillation remains normal in canine heart2009
- Author(s)
  Shimizu J, Mohri S, Ito H, Takaki M, Suga H.
- Journal Title
  
  J Physiol Sci. 59(1)
  
  Pages: 75-80
- NAID
  10025218261
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17200033
[Journal Article] Effects of sustained length-dependent activation on in situ cross-bridge dynamics in rat hearts2007
- Author(s)
  Pearson JT, Shirai M, Tsuchimochi H, Schwenke DO, Ishida T, Kangawa K, Suga H, Yagi N
- Journal Title
  
  Biophys J. 93(12)
  
  Pages: 4319-29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17200033
[Journal Article] Celsior preserved cardiac mechanoenergetics better than popular solutions in canine hearts2006
- Author(s)
  Oshima Y, Mohri S, Shimizu J, Iribe G, Imaoka T, Fujinaka W, Kiyooka T, Ishino K, Sano S, Kajiya F, Suga H
- Journal Title
  
  Ann Thorac Surg. 81(2)
  
  Pages: 658-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17200033
[Journal Article] Celsior preserved cardiac mechanoenergetics better than popular solutions in canine hearts.2006
- Author(s)
  Oshima Y, Suga H他9名
- Journal Title
  
  Ann Thorac Surg. 81
  
  Pages: 658-664
- Data Source
  KAKENHI-PROJECT-16659057
[Journal Article] Variable unstressed volume keeps normal distributions of canine left ventricular contractility and total mechanical energy under atrial fibrillation.2005
- Author(s)
  Mohri S, Suga H他5名
- Journal Title
  
  Jpn Physiol (印刷中)
- NAID
  10018623883
- Data Source
  KAKENHI-PROJECT-16659057
[Journal Article] Appraisal of crossbridge cycling in cardiac disease models by X-ray diffraction.2005
- Author(s)
  Pearson TJ, Suga H他5名
- Journal Title
  
  SPring-8 User Experiment Report 14
  
  Pages: 200-200
- Data Source
  KAKENHI-PROJECT-16659057
[Journal Article] Normal distribution of ventricular pressure-volume area of arrhythmic beats under atrial fibrillation in canine heart.2005
- Author(s)
  Mohri S, Suga H 他7名
- Journal Title
  
  Am J Physiol Heart Circ Physiol, 288
- Data Source
  KAKENHI-PROJECT-16659057
[Journal Article] Predictability of O2 consumption from contractility and mechanical energy of absolute arrhythmic beats in canine heart.2005
- Author(s)
  Shimizu J, Suga H他6名
- Journal Title
  
  Jpn J Physiol 55
  
  Pages: 135-142
- Data Source
  KAKENHI-PROJECT-16659057
[Journal Article] Invited Review : Assessment of systolic and diastolic ventricular properties via pressure-volume analysis : a guide for clinical, translational, basic researchers.2005
- Author(s)
  Burkhoff D, Suga H他1名
- Journal Title
  
  Am J Physiol Heart Circ Physiol 289
- Data Source
  KAKENHI-PROJECT-16659057
[Journal Article] Load independence of temperature-dependent Ca2+ recirculation fraction in canine heart.2004
- Author(s)
  Suga H. 他9名
- Journal Title
  
  Jpn J Physiol 54
  
  Pages: 319-329
- Data Source
  KAKENHI-PROJECT-16659057
[Journal Article] Mechanoenergetic estimation of multiple crossbridge steps per ATP in a beating heart.2004
- Author(s)
  Suga H
- Journal Title
  
  Jpn J Physiol 54
  
  Pages: 103-108
- NAID
  80016680300
- Data Source
  KAKENHI-PROJECT-16659057
[Journal Article] Alternans decay of postextrasystolic potentiation in human left ventricle.2004
- Author(s)
  Suga H. 他5名
- Journal Title
  
  Jpn J Physiol 54
  
  Pages: 87-91
- NAID
  80016562014
- Data Source
  KAKENHI-PROJECT-16659057
[Journal Article] Sarcomere-length dependence of lattice volume and radial mass transfer of myosin cross-bridges in rat papillary muscle.2004
- Author(s)
  Suga H. 他10名
- Journal Title
  
  Pfluegers Arch -Eur J physiol 448
  
  Pages: 153-160
- Data Source
  KAKENHI-PROJECT-16659057
[Journal Article] Normal distribution of ventricular pressure-volume area (PVA) of arrhythmic beats under atrial fibrillation in canine heart.
- Author(s)
  Suga H. 他8名
- Journal Title
  
  Am J Physiol Heart & Circ Physiol (In press)
- Data Source
  KAKENHI-PROJECT-16659057
[Journal Article] Starling-effect-independent lusitropism index in canine left ventricle : logistic time constan.
- Author(s)
  Mizuno J, Suga H 他9名
- Journal Title
  
  Anesthesia Analgesia (印刷中)
- Data Source
  KAKENHI-PROJECT-16659057

1. ARAKI Junichi (80271055)

# of Collaborated Projects: 6 results

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2. MOHRI Satoshi (00294413)

# of Collaborated Projects: 5 results

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3. KAJIYA Fumihiko (70029114)

# of Collaborated Projects: 5 results

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4. IRIBE Gentaro (90284885)

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5. MIKANE Takashi (10294406)

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6. TSUJIOKA Katsuhiko (30163801)

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7. YAGI Naoto (80133940)

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8. SHIMIZU Juichiro (80294403)

# of Collaborated Projects: 3 results

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9. GOTO Masami (50148699)

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10. OGASAWARA Yasuo (10152365)

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11. GOTO Yoichi (40142179)

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12. FUTAKI Shiho (60190112)

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13. TAKAKI Miyako (00033358)

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14. SUGIURA Seiryo (10272551)

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15. HIMENO Ryutaro (60342838)

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16. KAWAGUCHI Osamu (80214609)

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17. SUGAWARA Motoaki (60010914)

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18. KOMEDA Masashi (20303810)

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19. HIRAMATSU Osamu (50208849)

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20. TACHIBANA Hiroyuki (00241216)

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21. MOCHIZUKI Seiichi (60259596)

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22. KATAOKA Noriyuki (20250681)

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23. NAKAMURA Kazufumi (10335630)

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24. NINOMIYA Yoshifumi (70126241)

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25. KOBAYASHI Naoya (10325102)

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26. HATA Katsuya (20228464)

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27. TOKIOKA Hiroaki (90127572)

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28. HIRAKAWA Masahisa (70033058)

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SUGA Hiroyuki 菅 弘之

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拍動心内カルシウム及びクロスブリッジ動態のフィジオーム的解析方法論の開発と評価Principal Investigator

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拍動心臓内カルシウム無駄サイクル及び収縮性カルシウム反応性の医用工学的推定法Principal Investigator

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統合生理学的分析法による心臓内カルシウム無駄サイクル数の推定法Principal Investigator

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Assessment of the total amount of CAィイD12+ィエD1 handled in the E-C coupling by analyzing postextrasystolic potentiation and OィイD22ィエD2 consumption : Systems approachPrincipal Investigator

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Macro-micro correspondence in mechanoenagetics of failing heartsPrincipal Investigator

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SUGA Hiroyuki 菅弘之